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Cited by 274

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

High Amylose Resistant Starch Diet Ameliorates Oxidative Stress, Inflammation, and Progression of Chronic Kidney Disease

Open access
Vaziri, Nosratola D., Liu, Shu-Man, Lau, Wei Ling, Khazaeli, Mahyar, Nazertehrani, Sohrab, Farzaneh, Seyed H., Kieffer, Dorothy A., Adams, Sean H., Martin, Roy J.·2014·PLoS ONE
DOI 10.1371/journal.pone.0114881
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Abstract

Inflammation is a major mediator of CKD progression and is partly driven by altered gut microbiome and intestinal barrier disruption, events which are caused by: urea influx in the intestine resulting in dominance of urease-possessing bacteria; disruption of epithelial barrier by urea-derived ammonia leading to endotoxemia and bacterial translocation; and restriction of potassium-rich fruits and vegetables which are common sources of fermentable fiber. Restriction of these foods leads to depletion of bacteria that convert indigestible carbohydrates to short chain fatty acids which are important nutrients for colonocytes and regulatory T lymphocytes. We hypothesized that a high resistant starch diet attenuates CKD progression. Male Sprague Dawley rats were fed a chow containing 0.7% adenine for 2 weeks to induce CKD. Rats were then fed diets supplemented with amylopectin (low-fiber control) or high fermentable fiber (amylose maize resistant starch, HAM-RS2) for 3 weeks. CKD rats consuming low fiber diet exhibited reduced creatinine clearance, interstitial fibrosis, inflammation, tubular damage, activation of NFkB, upregulation of pro-inflammatory, pro-oxidant, and pro-fibrotic molecules; impaired Nrf2 activity, down-regulation of antioxidant enzymes, and disruption of colonic epithelial tight junction. The high resistant starch diet significantly attenuated these abnormalities. Thus high resistant starch diet retards CKD progression and attenuates oxidative stress and inflammation in rats. Future studies are needed to explore the impact of HAM-RS2 in CKD patients.

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Metadata

Authors
Vaziri, N. D., Liu, S.-M., Lau, W. L., Khazaeli, M., Nazertehrani, S., Farzaneh, S. H., Kieffer, D. A., Adams, S. H., & Martin, R. J.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2014-12-09
Volume
9
Issue
12
Pages
e114881
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0114881
OpenAlex
W1975411336
Cited by
274
References
35
FWCI
15.18
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: High Amylose Resistant Starch Diet Ameliorates Oxidative Stress, Inflammation, and Progression of Chronic Kidney Disease. https://app.cochat.ai/papers/10.1371/journal.pone.0114881
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Vaziri, N. D., Liu, S.-M., Lau, W. L., Khazaeli, M., Nazertehrani, S., Farzaneh, S. H., Kieffer, D. A., Adams, S. H., & Martin, R. J. (2014). High Amylose Resistant Starch Diet Ameliorates Oxidative Stress, Inflammation, and Progression of Chronic Kidney Disease. PLoS ONE. https://doi.org/10.1371/journal.pone.0114881

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.