Chronic kidney disease alters intestinal microbial flora
Open accessAbstract
The population of microbes (microbiome) in the intestine is a symbiotic ecosystem conferring trophic and protective functions. Since the biochemical environment shapes the structure and function of the microbiome, we tested whether uremia and/or dietary and pharmacologic interventions in chronic kidney disease alters the microbiome. To identify different microbial populations, microbial DNA was isolated from the stools of 24 patients with end-stage renal disease (ESRD) and 12 healthy persons, and analyzed by phylogenetic microarray. There were marked differences in the abundance of 190 bacterial operational taxonomic units (OTUs) between the ESRD and control groups. OTUs from Brachybacterium, Catenibacterium, Enterobacteriaceae, Halomonadaceae, Moraxellaceae, Nesterenkonia, Polyangiaceae, Pseudomonadaceae, and Thiothrix families were markedly increased in patients with ESRD. To isolate the effect of uremia from inter-individual variations, comorbid conditions, and dietary and medicinal interventions, rats were studied 8 weeks post 5/6 nephrectomy or sham operation. This showed a significant difference in the abundance of 175 bacterial OTUs between the uremic and control animals, most notably as decreases in the Lactobacillaceae and Prevotellaceae families. Thus, uremia profoundly alters the composition of the gut microbiome. The biological impact of this phenomenon is unknown and awaits further investigation.
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Changes in the composition of the gut microbiota are associated with CKD and ESRD.
“As gut dysbiosis and altered gut pathology are associated with hypertension, and hypertension is an important factor that contributes to the development of CKD, the finding that changes in the composition of the gut microbiota (TABLE 1) are associated with CKD and ESRD is not surprising101,102.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [101]
The abundance of Lactobacillus is decreased in chronic kidney disease.
“As the abundance of Lactobacillus is decreased in CKD101,106”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [101]
The population of Enterobacteriaceae of the Proteobacteria phylum is expanded in chronic kidney disease.
“In contrast to Lactobacillus, the population of Enterobacteriaceae of the Proteobacteria phylum is expanded in CKD101,105.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [101]
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- Authors
- Vaziri, N. D., Wong, J., Pahl, M., Piceno, Y. M., Yuan, J., DeSantis, T. Z., Ni, Z., Nguyen, T.-H., & Andersen, G. L.
- Affiliations
- University of California, Irvine (US)
- Lawrence Berkeley National Laboratory (US)
- Second Genome (United States) (US)
- Corresponding author
- Vaziri, Nosratola D.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 83
- Issue
- 2
- Pages
- 308-315
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2171060095
- Cited by
- 1,164
- References
- 47
- Citations by year
- 2026: 82 · 2025: 86 · 2024: 104 · 2023: 101 · 2022: 137 · 2021: 128 · 2020: 114 · 2019: 86 · 2018: 98 · 2017: 63 · 2016: 53 · 2015: 45 · 2014: 43 · 2013: 17 · 2012: 5
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- chronic kidney disease, gut microbiota, end-stage renal disease, uremia, intestinal bacterial flora, 5/6 nephrectomy, Lactobacillaceae, Prevotellaceae, Enterobacteriaceae, Pseudomonadaceae
- MeSH terms
- Adult, Aged, Animals, Bacteria, Feces, Female, Humans, Intestines, Kidney Failure, Chronic, Male, Middle Aged, Uremia, Rats, Sprague-Dawley, Rats
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