The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Exosomes Released from Breast Cancer Carcinomas Stimulate Cell Movement
Open accessAbstract
For metastasis to occur cells must communicate with to their local environment to initiate growth and invasion. Exosomes have emerged as an important mediator of cell-to-cell signalling through the transfer of molecules such as mRNAs, microRNAs, and proteins between cells. Exosomes have been proposed to act as regulators of cancer progression. Here, we study the effect of exosomes on cell migration, an important step in metastasis. We performed cell migration assays, endocytosis assays, and exosome proteomic profiling on exosomes released from three breast cancer cell lines that model progressive stages of metastasis. Results from these experiments suggest: (1) exosomes promote cell migration and (2) the signal is stronger from exosomes isolated from cells with higher metastatic potentials; (3) exosomes are endocytosed at the same rate regardless of the cell type; (4) exosomes released from cells show differential enrichment of proteins with unique protein signatures of both identity and abundance. We conclude that breast cancer cells of increasing metastatic potential secrete exosomes with distinct protein signatures that proportionally increase cell movement and suggest that released exosomes could play an active role in metastasis.
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Cites
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
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Amphiregulin exosomes increase cancer cell invasion
Higginbotham, J. N., Demory Beckler, M., Gephart, J. D., Franklin, J. L., Bogatcheva, G., Kremers, G.-J., Piston, D. W., Ayers, G. D., McConnell, R. E., Tyska, M. J., et al. (2011) · Current Biology · doi:10.1016/j.cub.2011.03.043 · Cited by 360
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Fares, J., Fares, M. Y., Khachfe, H. H., Salhab, H. A., & Fares, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0134-x · Cited by 2,379
Engineering exosomes as refined biological nanoplatforms for drug delivery
Luan, X., Sansanaphongpricha, K., Myers, I., Chen, H., Yuan, H., & Sun, D. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.12 · Cited by 1,163
Using exosomes, naturally-equipped nanocarriers, for drug delivery
Batrakova, E. V., & Kim, M. S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.030 · Cited by 1,041
Mahmood, N., Mihalcioiu, C., & Rabbani, S. A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00024 · Cited by 478
Clinical applications for exosomes: Are we there yet?
Perocheau, D., Touramanidou, L., Gurung, S., Gissen, P., & Baruteau, J. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15432 · Cited by 123
Metadata
- Authors
- Harris, D. A., Patel, S. H., Gucek, M., Hendrix, A., Westbroek, W., & Taraska, J. W.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-03-23
- Volume
- 10
- Issue
- 3
- Pages
- e0117495
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2014822965
- Cited by
- 169
- References
- 5
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- gold
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- Harris, D. A., Patel, S. H., Gucek, M., Hendrix, A., Westbroek, W., & Taraska, J. W. (2015). Exosomes Released from Breast Cancer Carcinomas Stimulate Cell Movement. PLOS ONE. https://doi.org/10.1371/journal.pone.0117495
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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