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Clinical applications for exosomes: Are we there yet?

Perocheau, Dany, Touramanidou, Loukia, Gurung, Sonam, Gissen, Paul, Baruteau, Julien·2021·British Journal of Pharmacology
DOI 10.1111/bph.15432PMC PMC8432553
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Abstract

Exosomes are a subset of extracellular vesicles essential for cell–cell communication in health and disease with the ability to transport nucleic acids, functional proteins and other metabolites. Their clinical use as diagnostic biomarkers and therapeutic carriers has become a major field of research over recent years, generating rapidly expanding scientific interest and financial investment. Their reduced immunogenicity compared to liposomes or viral vectors and their ability to cross major physiological barriers like the blood–brain barrier make them an appealing and innovative option as biomarkers and therapeutic agents. Here, we review the latest clinical developments of exosome biotechnology for diagnostic and therapeutic purposes, including the most recent COVID‐19‐related exosome‐based clinical trials. We present current exosome engineering strategies for optimal clinical safety and efficacy, and assess the technology developed for good manufacturing practice compliant scaling up and storage approaches along with their limitations in pharmaceutical industry.

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Metadata

Authors
Perocheau, D., Touramanidou, L., Gurung, S., Gissen, P., & Baruteau, J.
Venue
British Journal of Pharmacology
Publisher
Wiley
Published
2021-05-03
Volume
178
Issue
12
Pages
2375-2392
ISSN
  • 0007-1188
  • 1476-5381
DOI
10.1111/bph.15432
PMC
PMC8432553
Cited by
123
References
16
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Medical Research Council Canada (MR/T008024/1)
  • NIHR Great Ormond Street Hospital Biomedical Research Centre

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