Efficient mating-type switching in Candida glabrata induces cell death
Open accessAbstract
Candida glabrata is an apparently asexual haploid yeast that is phylogenetically closer to Saccharomyces cerevisiae than to Candida albicans. Its genome contains three MAT-like cassettes, MAT, which encodes either MATa or MATalpha information in different strains, and the additional loci, HML and HMR. The genome also contains an HO gene homolog, but this yeast has never been shown to switch mating-types spontaneously, as S. cerevisiae does. We have recently sequenced the genomes of the five species that, together with C. glabrata, make up the Nakaseomyces clade. All contain MAT-like cassettes and an HO gene homolog. In this work, we express the HO gene of all Nakaseomyces and of S. cerevisiae in C. glabrata. All can induce mating-type switching, but, despite the larger phylogenetic distance, the most efficient endonuclease is the one from S. cerevisiae. Efficient mating-type switching in C. glabrata is accompanied by a high cell mortality, and sometimes results in conversion of the additional cassette HML. Mortality probably results from the cutting of the HO recognition sites that are present, in HML and possibly HMR, contrary to what happens naturally in S. cerevisiae. This has implications in the life-cycle of C. glabrata, as we show that efficient MAT switching is lethal for most cells, induces chromosomal rearrangements in survivors, and that the endogenous HO is probably rarely active indeed.
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Despite having two mating types, a and α, C. glabrata lacks spontaneous mating-type switching.
“Despite having two mating types, a and α, C. glabrata lacks spontaneous mating-type switching.”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [78]
Ectopic expression of the S. cerevisiae endonuclease-encoding HO gene results in efficient mating-type switching and lethality in C. glabrata.
“However, ectopic expression of the S. cerevisiae endonuclease-encoding HO gene is known to result in efficient mating-type switching and lethality in C. glabrata [78].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [78]
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- Authors
- Boisnard, S., Zhou Li, Y., Arnaise, S., Sequeira, G., Raffoux, X., Enache-Angoulvant, A., Bolotin-Fukuhara, M., & Fairhead, C.
- Affiliations
- Université Paris-Sud (FR)
- Corresponding author
- Boisnard, Stéphanie
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-10-22
- Volume
- 10
- Issue
- 10
- Pages
- e0140990
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4619647
- OpenAlex
- W2169483854
- Cited by
- 29
- References
- 73
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Candida glabrata, mating-type switching, HO endonuclease, mating-type locus, Saccharomyces cerevisiae, cell death, chromosomal rearrangements, life cycle
- MeSH terms
- Cell Death, Candida glabrata, Genes, Mating Type, Fungal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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