Three Mating Type-Like Loci in Candida glabrata

Srikantha, Thyagarajan; Lachke, Salil A.; Soll, David R.

doi:10.1128/ec.2.2.328-340.2003

Cited by 78Fungal and yeast genetics researchYeasts and Rust Fungi StudiesAntifungal resistance and susceptibility

Three Mating Type-Like Loci in Candida glabrata

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Srikantha, Thyagarajan, Lachke, Salil A., Soll, David R.·2003·Eukaryotic Cell

DOI 10.1128/ec.2.2.328-340.2003PMC PMC154844

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Abstract

Candida glabrata, the second most prevalent Candida species colonizing humans, possesses three mating type-like (MTL) loci (MTL1, MTL2, and MTL3). These loci contain pairs of MTL genes with their respective coding regions on complementary Crick and Watson DNA strands. Each pair of genes is separated by a shared intergenic promoter region, the same configuration found at the mating type loci of Saccharomyces cerevisiae. Two of the MTL loci, MTL1 and MTL2, contain either the MTLa1/MTLa2 configuration or the MTLalpha1/MTLalpha2 configuration in different strains. All but one of the 38 tested C. glabrata strains were either aaalpha or aalphaalpha. One test strain was alphaalphaalpha. Based on the mating type genotype, the MTL genes at the MTL1 or MTL2 loci, and the size of the XbaI fragment harboring MTL1 or MTL2, four classes of C. glabrata strains (I, II, III, and IV) were distinguished. Northern analysis revealed that strains were either a-expressors or alpha-expressors and that expression always reflected the genotype of either the MTL1 or MTL2 locus, depending on the class. The expression pattern in each class, therefore, is similar to that observed in S. cerevisiae, which harbors two silent cassette loci, HMR and HML, and the expression locus MAT. High-frequency phenotypic switching between core phenotypes in an alpha-expressing, but not in an a-expressing, strain modulated the level of MTL expression, suggesting a possible relationship between core phenotypic switching and mating.

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C. glabrata has three mating type (MAT)-like loci, CgMTL1 (MAT), CgMTL2 (HMR) and CgMTL3 (HML), whose genomic configuration is similar to that of the S. cerevisiae MTL loci.
“C. glabrata has three mating type (MAT)-like loci, CgMTL1 (MAT), CgMTL2 (HMR) and CgMTL3 (HML), whose genomic configuration is similar to that of the S. cerevisae MTL loci [74].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [74]

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Authors: Srikantha, T., Lachke, S. A., & Soll, D. R.
Affiliations: University of Iowa (US)
ORCID: Lachke, Salil A.
Soll, David R.
Venue: Eukaryotic Cell
Publisher: American Society for Microbiology
Published: 2003-04
Volume: 2
Issue: 2
Pages: 328-340
ISSN: 1535-9778 (ISSN-L)
1535-9786
DOI: 10.1128/ec.2.2.328-340.2003
PMC: PMC154844
OpenAlex: W2002424030
Cited by: 78
References: 49
Citations by year: 2026: 1 · 2025: 1 · 2024: 5 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 4 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 14 · 2013: 4 · 2012: 1
FWCI: 2.07
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Eukaryotic Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Francis Crick Institute
National Institute of Allergy and Infectious Diseases (AI-2392)
National Institute of Dental and Craniofacial Research (DE014219, R01DE014219)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords: Candida glabrata, mating-type locus, mating-type switching, silent mating-type loci, phenotypic switching
MeSH terms: Amino Acid Sequence, Base Sequence, Cell Division, Cells, Cultured, Fungal Proteins, Genes, Fungal, Genes, Switch, Genotype, Molecular Sequence Data, Phenotype, Sequence Homology, Nucleic Acid, Species Specificity, Transcription, Genetic, Gene Expression Regulation, Fungal, Genome, Fungal, Sequence Homology, Amino Acid, Candida glabrata, Genes, Mating Type, Fungal

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Three Mating Type-Like Loci in Candida glabrata

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