Cited by 46Fungal and yeast genetics researchAntifungal resistance and susceptibilityYeasts and Rust Fungi Studies

Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survival

Open access
Mba, Ifeanyi Elibe, Nweze, Emeka Innocent, Eze, Emmanuel Aniebonam, Anyaegbunam, Zikora Kizito Glory·2022·Infection, Genetics and Evolution

Abstract

Candida albicans is the most implicated fungal species that grows as a commensal or opportunistic pathogen in the human host. It is associated with many life-threatening infections, especially in immunocompromised persons. The genome of Candida albicans is very flexible and can withstand a wide assortment of variations in a continuously changing environment. Thus, genome plasticity is central to its adaptation and has long been of considerable interest. C. albicans has a diploid heterozygous genome that is highly dynamic and can display variation from small to large scale chromosomal rearrangement and aneuploidy, which have implications in drug resistance, virulence, and pathogenicity. This review presents an up-to-date overview of recent genomic studies involving C. albicans. It discusses the accumulating evidence that shows how mitotic recombination events, ploidy dynamics, aneuploidy, and loss of heterozygosity (LOH) influence evolution, adaptation, and survival in C. albicans. Understanding the factors that affect the genome is crucial for a proper understanding of species and rapid development and adjustment of therapeutic strategies to mitigate their spread.

Integrity signals

Registry

Crossref · 10.1016/j.meegid.2022.105256

Cites

223 of 223 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Mutations in ERG11 gene and overexpression of ergosterol in plasma membrane contribute to antifungal resistance.

    “Furthermore, mutations in the ERG11 gene, which encodes the essential enzyme 14α‐demethylase (Erg11p) for ergosterol biosynthesis, along with overexpression of ergosterol in the plasma membrane, further contribute to antifungal resistance [2, 46].”

Cites

Flagged first, then by citations

1 of the 224 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Mba, I. E., Nweze, E. I., Eze, E. A., & Anyaegbunam, Z. K. G.
Affiliations
University of Nigeria (NG)
Corresponding author
Nweze, Emeka Innocent
Venue
Infection, Genetics and Evolution
Publisher
Elsevier BV
Published
2022-04
Volume
99
Pages
105256
ISSN
1567-1348 (ISSN-L)
OpenAlex
W4214710995
Cited by
46
References
224
Citations by year
2026: 6 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 3
FWCI
1.04
Type
journal article
Language
en
Open access
Locations
  • Infection Genetics and Evolution (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords
Candida albicans, genome plasticity, chromosomal rearrangements, aneuploidy, mitotic recombination, loss of heterozygosity, drug resistance, virulence, fungal evolution, opportunistic fungal pathogens, diploid genome
MeSH terms
Aneuploidy, Candida albicans, Humans, Virulence, Genome, Genome, Fungal, Loss of Heterozygosity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review