Suppressor of Cytokine Signaling-2 (SOCS2) Regulates the Microglial Response and Improves Functional Outcome after Traumatic Brain Injury in Mice
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SOCS2 is involved in STAT3 pathway activation and can mediate microglial polarization regulation.
“We identified miR-9-5p binding sites in the 3'-UTR of SOCS2 mRNA (Fig. 5a), which was involved in STAT3 pathway activation and able to mediate microglial polarization regulation [35–37].”
From Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression (2022) · cites this paper as [37]
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Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed
Cherry, J. D., Olschowka, J. A., & O’Banion, M. K. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-98 · Cited by 1,748 · see citing works
Macrophagic and microglial responses after focal traumatic brain injury in the female rat
Turtzo, L., Lescher, J., Janes, L., Dean, D. D., Budde, M. D., & Frank, J. A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-82 · Cited by 167 · see citing works
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Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression
Xian, X., Cai, L.-L., Li, Y., Wang, R.-C., Xu, Y.-H., Chen, Y.-J., Xie, Y.-H., Zhu, X.-L., & Li, Y.-F. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01332-w · Cited by 169 · see citing works
- Authors
- Basrai, H. S., Christie, K. J., Turbic, A., Bye, N., & Turnley, A. M.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-04-12
- Volume
- 11
- Issue
- 4
- Pages
- e0153418
- ISSN
- 1932-6203
- PMC
- PMC4829250
- Cited by
- 31
- References
- 2
- Language
- en
- Funders
- NH&MRC (1045125, 628344)
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