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Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia
Open accessAbstract
Preeclampsia (PE) is considered the leading cause of maternal and perinatal morbidity and mortality. The placenta seems to play an essential role in this disease, probably due to factors involved in its formation and development. The present study aimed to investigate the association between placental lesions, cytokines and angiogenic factors in pregnant women with preeclampsia (PE). We evaluated 20 normotensive pregnant women, 40 with early-onset PE and 80 with late-onset PE. Placental samples were analyzed for histopathology, immunohistochemistry and determination of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-10 (IL-10), transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), placental growth factor (PlGF), vascular endothelial growth factor (VEGF), fms-like tyrosine-kinase-1 (Flt-1) and endoglin (Eng) levels. Higher percentages of increased syncytial knots and increased perivillous fibrin deposits, and greater levels of TNF-α, TGF-β1and Flt-1 were detected in placentas from early-onset PE. Levels of IL-10, VEGF and PlGF were decreased in PE versus normotensive placentas. Both the TNF-α/IL-10 and sFlt-1/PlGF ratios were higher in placental homogenate of early-onset PE than late-onset PE and control groups. The more severe lesions and the imbalance between TNF-α/IL-10 and PlGF/sFlt-1 in placentas from early-onset PE allows differentiation of early and late-onset PE and suggests higher placental impairment in early-onset PE.
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“Although the emphasis on the toxic factors produced by an ischemic placenta has been on the balance between angiogenic and anti-angiogenic factors, evidence now suggests that cytokines, such as TNF-α and IL-10, are altered in early and late preeclampsia, and the changes correlate with the type of histopathological changes in the placenta(185).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [185]
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Self-citation
Metadata
- Authors
- Weel, I. C., Baergen, R. N., Romão-Veiga, M., Borges, V. T., Ribeiro, V. R., Witkin, S. S., Bannwart-Castro, C., Peraçoli, J. C., De Oliveira, L., & Peraçoli, M. T.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- NewYork–Presbyterian Hospital (US)
- Weill Cornell Medicine (US)
- Corresponding author
- Peraçoli, Maria T.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-06-17
- Volume
- 11
- Issue
- 6
- Pages
- e0157584
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4912084
- OpenAlex
- W2430003272
- Cited by
- 131
- References
- 50
- Citations by year
- 2026: 11 · 2025: 7 · 2024: 11 · 2023: 5 · 2022: 11 · 2021: 15 · 2020: 17 · 2019: 15 · 2018: 22 · 2017: 17
- FWCI
- 23.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- preeclampsia, placental lesions, cytokines, angiogenic factors, early-onset preeclampsia, late-onset preeclampsia, syncytiotrophoblastic knots, TNF-α, IL-10, TGF-β1, soluble fms-like tyrosine kinase-1, placental growth factor, vascular endothelial growth factor, CD105, TNF-α/IL-10 ratio, sFlt-1/PlGF ratio, placental pathology
- MeSH terms
- Placenta Growth Factor, Adult, Female, Humans, Placenta, Pre-Eclampsia, Pregnancy, Tumor Necrosis Factor-alpha, Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-10, Age of Onset, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor A
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