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Cited by 14

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Depression Amplifies the Influence of Central Obesity on 10-Year Incidence of Diabetes: Findings from MIDUS

Tsenkova, Vera K., Karlamangla, Arun·2016·PLOS ONE
DOI 10.1371/journal.pone.0164802PMC PMC5068737
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Abstract

BACKGROUND: Central obesity is a major risk factor for diabetes but many obese individuals never develop diabetes, suggesting the presence of important effect modifiers. Depression has emerged as a key risk factor for poor glycemic control, but to our knowledge, no previous work has investigated whether depression amplifies the effect of central obesity on glucoregulation. METHODS AND FINDINGS: We used a national sample of adults without prevalent diabetes (MIDUS; N = 919) to test for synergy between central obesity and depression in the development of diabetes 10 years later. We found that depression amplified the association of waist-to-hip ratio (WHR) with incident diabetes adjusted for age, race, gender, education, physical activity, and sleep problems (p = 0.01 for test of interaction). The relative risk for incident diabetes per every 0.1 increment in WHR was 1.75 (95% CI: 1.31; 2.33) in those without depression and 3.78 in those with depression (95% CI: 2.14; 6.66). CONCLUSIONS: These results confirm the role of depression as a robust risk factor for the development of diabetes and for the first time, demonstrate a synergy between depression and central obesity. Identifying and addressing depression could prove to be an effective approach to preventing diabetes in at risk individuals. Ultimately, elucidating the interplay among risk factors from different domains will be key to understanding multifactorial diseases such as diabetes and informing theory-based, patient-centered interventions aimed at reducing diabetes risk.

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Figures

Fig 1 Model-predicted diabetes incidence risk as function of baseline depression (yes/no) and waist-to-hip ratio.
Fig 1 Model-predicted diabetes incidence risk as function of baseline depression (yes/no) and waist-to-hip ratio.CC BY · PubMed Central
Fig 2 Model-predicted level of glucose dysregulation levels 10 years later as function of baseline depression (yes/no) and waist-to-hip ratio. Legend: The effect size reported is the rate ratio at which an individual moves up a level of glucose dysregulation.
Fig 2 Model-predicted level of glucose dysregulation levels 10 years later as function of baseline depression (yes/no) and waist-to-hip ratio. Legend: The effect size reported is the rate ratio at which an individual moves up a level of glucose dysregulation.CC BY · PubMed Central

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Metadata

Authors
Tsenkova, V. K., & Karlamangla, A.
ORCID
Tsenkova, Vera K.
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2016-10-18
Volume
11
Issue
10
Pages
e0164802
ISSN
1932-6203
DOI
10.1371/journal.pone.0164802
PMC
PMC5068737
Cited by
14
References
39
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
National Institute on Aging (K01AG041179, P01-AG020166)

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