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Cited by 40Stress Responses and CortisolNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Dynamic glucocorticoid-dependent regulation of Sgk1 expression in oligodendrocytes of adult male rat brain by acute stress and time of day

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Hinds, Laura R., Chun, Lauren E., Woodruff, Elizabeth R., Christensen, Jennifer A., Hartsock, Matthew J., Spencer, Robert L.·2017·PLOS ONE
DOI 10.1371/journal.pone.0175075PMC PMC5380358
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Abstract

Recent studies support plasticity in adult brain white matter structure and myelination in response to various experiential factors. One possible contributor to this plasticity may be activity-dependent modulation of serum- and glucocorticoid-inducible kinase 1 (Sgk1) expression in oligodendrocytes. We examined whether Sgk1 expression in adult rat brain white matter is increased by acute stress-induced elevations in endogenous corticosterone and whether it fluctuates with diurnal variations in corticosterone. We observed rapid increases (within 30 min) in Sgk1 mRNA in the corpus callosum in response to acute stress, as well as large increases at the beginning of the rat's active period (the time of peak corticosterone secretion). These increases were absent in adrenalectomized rats. Corticosterone treatment of adrenalectomized rats also rapidly increased corpus callosum Sgk1 mRNA. The majority of Sgk1 mRNA in corpus callosum was co-localized with myelin basic protein mRNA, suggesting that mature oligodendrocytes respond dynamically to acute stress and circadian rhythms. The regulation of Sgk1 expression by acute stress and time of day was selective for white matter, with limited alteration of Sgk1 expression by these factors in hippocampus and somatosensory cortex. These results indicate a unique sensitivity of oligodendrocyte Sgk1 expression to activity-dependent fluctuations in corticosterone hormone secretion, and raises the prospect that hypothalamic-pituitary-adrenal axis dysregulation or glucocorticoid pharmacotherapy may compromise the normal activity-dependent interactions between oligodendrocytes and neurons.

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  • Plasticity of white matter architecture and myelination is regulated by activity-dependent modulation of SGK1 expression in oligodendrocytes.

    “the plasticity of white matter architecture and myelination is regulated by activity-dependent modulation of SGK1 expression in oligodendrocytes”

    From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Hinds et al., 2017

    The Introduction (page not supplied) describes activity-dependent myelination and identifies SGK1 as a potential contributor to oligodendrocyte plasticity. The Discussion (page not supplied) says stress- and time-of-day regulation of Sgk1 expression may contribute to experience-dependent changes. Neither passage establishes that modulation of SGK1 expression regulates white matter architecture or myelination, as the claim states. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • SGK1 is present in microglia, oligodendrocytes, and astrocytes.

    “Currently, reports indicate that SGK1 is present in microglia (Inoue et al., 2016b), oligodendrocytes (Hinds et al., 2017), and astrocytes (Tertil et al., 2018).”

    From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Hinds et al., 2017

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Cited by

Sorted by citations

Authors
Hinds, L. R., Chun, L. E., Woodruff, E. R., Christensen, J. A., Hartsock, M. J., & Spencer, R. L.
Affiliations
University of Colorado Boulder (US)
Corresponding author
Spencer, Robert L.
ORCID
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2017-04-04
Volume
12
Issue
4
Pages
e0175075
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0175075
PMC
PMC5380358
OpenAlex
W2604121546
Cited by
40
References
4
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 4
FWCI
1.49
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • CU Scholar (University of Colorado Boulder) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Division of Integrative Organismal Systems (IOS1456706)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
SGK1, serum- and glucocorticoid-inducible kinase 1, oligodendrocytes, acute stress, corticosterone, glucocorticoids, diurnal variation, circadian rhythm, white matter plasticity, myelination, corpus callosum, myelin basic protein, adrenalectomy, hypothalamic-pituitary-adrenal axis, hippocampus, somatosensory cortex
MeSH terms
Serum-Glucocorticoid Regulated Kinases, Adrenalectomy, Animals, Brain, Circadian Rhythm, Corpus Callosum, Corticosterone, Glucocorticoids, Hypothalamo-Hypophyseal System, Male, Oligodendroglia, Pituitary-Adrenal System, RNA, Messenger, Stress, Physiological, Gene Expression Regulation, Enzymologic, Rats, Sprague-Dawley, Protein Serine-Threonine Kinases, Immediate-Early Proteins, Rats

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