Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling
Open accessAbstract
Prion diseases are neurodegenerative conditions caused by misfolding of the prion protein, leading to conspicuous neuronal loss and intense microgliosis. Recent experimental evidence point towards a protective role of microglia against prion-induced neurodegeneration, possibly through elimination of prion-containing apoptotic bodies. The molecular mechanisms by which microglia recognize and eliminate apoptotic cells in the context of prion diseases are poorly defined. Here we investigated the possible involvement of signal regulatory protein α (SIRPα), a key modulator of host cell phagocytosis; SIRPα is encoded by the Sirpa gene that is genetically linked to the prion gene Prnp. We found that Sirpa transcripts are highly enriched in microglia cells within the brain. However, Sirpa mRNA levels were essentially unaltered during the course of experimental prion disease despite upregulation of other microglia-enriched transcripts. To study the involvement of SIRPα in prion pathogenesis in vivo, mice expressing a truncated SIRPα protein unable to inhibit phagocytosis were inoculated with rodent-adapted scrapie prions of the 22L strain. Homozygous and heterozygous Sirpa mutants and wild-type mice experienced similar incubation times after inoculation with either of two doses of 22L prions. Moreover, the extent of neuronal loss, microgliosis and abnormal prion protein accumulation was not significantly affected by Sirpa genotypes. Collectively, these data indicate that SIRPα-mediated phagocytosis is not a major determinant in prion disease pathogenesis. It will be important to search for additional candidates mediating prion phagocytosis, as this mechanism may represent an important target of antiprion therapies.
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Neither the 'eat me'-protein developmental endothelial locus-1 nor the 'don't eat me'-receptor signal regulatory protein SIRPa, nor the macrophage scavenger receptor 1 (Msr1) influence the prion disease course, since their depletion had no effect on disease pathophysiology.
“However, neither the “eat me”-protein developmental endothelial locus-1 nor the “don’t eat me”-receptor signal regulatory protein SIRPa, nor the macrophage scavenger receptor 1 (Msr1) influence the prion disease course, since their depletion had no effect on disease pathophysiology [85,86,87].”
From Loss of Homeostatic Microglia Signature in Prion Diseases (2022) · cites this paper as [85]
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Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works
Role of CD47 as a Marker of Self on Red Blood Cells
Oldenborg, P., Zheleznyak, A., Fang, Y., Lagenaur, C. F., Gresham, H. D., & Lindberg, F. P. (2000) · Science · doi:10.1126/science.288.5473.2051 · Cited by 1,975 · see citing works
New tools for studying microglia in the mouse and human CNS
Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804 · see citing works
Majeti, R., Chao, M. P., Alizadeh, A. A., Pang, W. W., Jaiswal, S., Gibbs, K. D., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.045 · Cited by 1,752 · see citing works
Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P. D., Mitra, S. S., Wang, J., Contreras-Trujillo, H., Martin, R. K., Cohen, J. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121623109 · Cited by 1,667 · see citing works
Chao, M. P., Alizadeh, A. A., Tang, C. Z., Myklebust, J. H., Varghese, B., Gill, S. I., Jan, M., Cha, A. C., Chan, C. K. F., Tan, B. T., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.044 · Cited by 1,095 · see citing works
Barclay, A. N., & van den Berg, T. K. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120142 · Cited by 841 · see citing works
Microglia: Scapegoat, saboteur, or something else?
Aguzzi, A., Barres, B. A., & Bennett, M. L. (2013) · Science · doi:10.1126/science.1227901 · Cited by 836 · see citing works
Self-citationPolymorphism in Sirpa modulates engraftment of human hematopoietic stem cells
Takenaka, K., Prasolava, T. K., Wang, J. C. Y., Mortin-Toth, S. M., Khalouei, S., Gan, O. I., Dick, J. E., & Danska, J. S. (2007) · Nature Immunology · doi:10.1038/ni1527 · Cited by 510 · see citing works
A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation
Bamberger, M. E., Harris, M. E., McDonald, D. R., Husemann, J., & Landreth, G. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02665.2003 · Cited by 501 · see citing works
Engineered SIRPα Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies
Weiskopf, K., Ring, A. M., Ho, C. C. M., Volkmer, J.-P., Levin, A. M., Volkmer, A. K., Özkan, E., Fernhoff, N. B., van de Rijn, M., Weissman, I. L., et al. (2013) · Science · doi:10.1126/science.1238856 · Cited by 493 · see citing works
Distinct prion proteins in short and long scrapie incubation period mice
Westaway, D. A., Goodman, P. A., Mirenda, C. A., McKinley, M. P., Carlson, G. A., & Prusiner, S. B. (1987) · Cell · doi:10.1016/0092-8674(87)90134-6 · Cited by 477 · see citing works
Functions and molecular mechanisms of the CD47–SIRPα signalling pathway
Matozaki, T., Murata, Y., Okazawa, H., & Ohnishi, H. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.12.001 · Cited by 477 · see citing works
Self-citationMicroglial Phagocytosis of Fibrillar β-Amyloid through a β1Integrin-Dependent Mechanism
Koenigsknecht-Talboo, J., & Landreth, G. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2557-04.2004 · Cited by 444 · see citing works
Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia
Chao, M. P., Alizadeh, A. A., Tang, C. Z., Jan, M., Weissman-Tsukamoto, R., Zhao, F., Park, C. Y., Weissman, I. L., & Majeti, R. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2238 · Cited by 381 · see citing works
CD47 functions as a molecular switch for erythrocyte phagocytosis
Burger, P., Hilarius-Stokman, P., de Korte, D., van den Berg, T. K., & van Bruggen, R. (2012) · Blood · doi:10.1182/blood-2011-10-386805 · Cited by 338 · see citing works
Negative Regulation of Phagocytosis in Macrophages by the CD47-SHPS-1 System
Okazawa, H., Motegi, S., Ohyama, N., Ohnishi, H., Tomizawa, T., Kaneko, Y., Oldenborg, P., Ishikawa, O., & Matozaki, T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2004 · Cited by 303 · see citing works
Self-citationA systems approach to prion disease
Hwang, D., Lee, I. Y., Yoo, H., Gehlenborg, N., Cho, J., Petritis, B., Baxter, D., Pitstick, R., Young, R., Spicer, D., et al. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.10 · Cited by 287 · see citing works
Büeler, H., Raeber, A. J., Sailer, A. W., Fischer, M., Aguzzi, A., & Weissmann, C. (1994) · Molecular Medicine · doi:10.1007/bf03403528 · Cited by 244 · see citing works
Self-citationStrowig, T., Rongvaux, A., Rathinam, C., Takizawa, H., Borsotti, C., Philbrick, W. M., Eynon, E. E., Manz, M. G., & Flavell, R. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109769108 · Cited by 228 · see citing works
PrP Deposition, Microglial Activation, and Neuronal Apoptosis in Murine Scrapie
Williams, A., Lucassen, P. J., Ritchie, D., & Bruce, M. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6424 · Cited by 204 · see citing works
Mice with gene targetted prion protein alterations show that Prnp, Sine and Prni are congruent
Moore, R. C., Hope, J., McBride, P., McConnell, I., Selfridge, J., Melton, D. W., & Manson, J. C. (1998) · Nature Genetics · doi:10.1038/ng0298-118 · Cited by 188 · see citing works
The POM Monoclonals: A Comprehensive Set of Antibodies to Non-Overlapping Prion Protein Epitopes
Polymenidou, M., Moos, R., Scott, M., Sigurdson, C. J., Shi, Y., Yajima, B., Hafner‐Bratkovič, I., Jerala, R., Hornemann, S., Kurt Wüthrich, A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003872 · Cited by 181 · see citing works
Self-citationThe CD47-SIRP signalling system: its physiological roles and therapeutic application
Murata, Y., Kotani, T., Ohnishi, H., & Matozaki, T. (2014) · The Journal of Biochemistry · doi:10.1093/jb/mvu017 · Cited by 171 · see citing works
Self-citationPassenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice
Berghe, T. V., Hulpiau, P., Martens, L., Vandenbroucke, R. E., Wonterghem, E. V., Perry, S. W., Bruggeman, I., Divert, T., Choi, S. M., Vuylsteke, M., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.011 · Cited by 165 · see citing works
Microglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils
Floden, A. M., & Combs, C. K. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101014 · Cited by 160 · see citing works
Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy
Yanagita, T., Murata, Y., Tanaka, D., Motegi, S., Arai, E., Daniwijaya, E. W., Hazama, D., Washio, K., Saito, Y., Kotani, T., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.89140 · Cited by 151 · see citing works
Self-citationGitik, M., Zaltsman, S. L., Oldenborg, P., Reichert, F., & Rotshenker, S. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-24 · Cited by 148 · see citing works
The immunobiology of prion diseases
Aguzzi, A., Nuvolone, M., & Zhu, C. (2013) · Nature reviews. Immunology · doi:10.1038/nri3553 · Cited by 146 · see citing works
Self-citationA versatile prion replication assay in organotypic brain slices
Falsig, J., Julius, C., Margalith, I., Schwarz, P., Heppner, F. L., & Aguzzi, A. (2007) · Nature Neuroscience · doi:10.1038/nn2028 · Cited by 145 · see citing works
Self-citationYamauchi, T., Takenaka, K., Urata, S., Shima, T., Kikushige, Y., Tokuyama, T., Iwamoto, C., Nishihara, M., Iwasaki, H., Miyamoto, T., et al. (2013) · Blood · doi:10.1182/blood-2012-06-440354 · Cited by 143 · see citing works
Self-citationEvolution of a Strain of CJD That Induces BSE-Like Plaques
Manuelidis, L., Fritch, W., & Xi, Y. (1997) · Science · doi:10.1126/science.277.5322.94 · Cited by 141 · see citing works
Yamao, T., Noguchi, T., Takeuchi, O., Nishiyama, U., Morita, H., Hagiwara, T., Akahori, H., Kato, T., Inagaki, K., Okazawa, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203287200 · Cited by 139 · see citing works
Self-citationSHPS‐1 regulates integrin‐mediated cytoskeletal reorganization and cell motility
Inagaki, K., Yamao, T., Noguchi, T., Matozaki, T., Fukunaga, K., Takada, T., Hosooka, T., Akira, S., & Kasuga, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6721 · Cited by 138 · see citing works
Self-citationA neuroprotective role for microglia in prion diseases
Zhu, C., Herrmann, U. S., Falsig, J., Abakumova, I., Nuvolone, M., Schwarz, P., Frauenknecht, K., Rushing, E. J., & Aguzzi, A. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151000 · Cited by 134 · see citing works
Self-citationStrictly co-isogenic C57BL/6J- Prnp −/− mice: A rigorous resource for prion science
Nuvolone, M., Hermann, M., Sorce, S., Russo, G., Tiberi, C., Schwarz, P., Minikel, E. V., Sanoudou, D., Pelczar, P., & Aguzzi, A. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151610 · Cited by 131 · see citing works
Self-citationIshikawa-Sekigami, T., Kaneko, Y., Okazawa, H., Tomizawa, T., Okajo, J., Saito, Y., Okuzawa, C., Sugawara-Yokoo, M., Nishiyama, U., Ohnishi, H., et al. (2005) · Blood · doi:10.1182/blood-2005-05-1896 · Cited by 119 · see citing works
Self-citationLv, Z., Bian, Z., Shi, L., Niu, S., Ha, B., Tremblay, A., Li, L., Zhang, X., Paluszynski, J. P., Liu, M., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401719 · Cited by 114 · see citing works
Kranich, J., Krautler, N. J., Falsig, J., Ballmer, B., Li, S., Hutter, G., Schwarz, P., Moos, R., Julius, C., Miele, G., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20092401 · Cited by 110 · see citing works
Self-citationHughes, M. M., Field, R. H., Perry, V. H., Murray, C. L., & Cunningham, C. (2010) · Glia · doi:10.1002/glia.21070 · Cited by 94 · see citing works
Carroll, J. A., Striebel, J. F., Rangel, A., Woods, T., Phillips, K., Peterson, K. E., Race, B., & Chesebro, B. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005551 · Cited by 92 · see citing works
Microglial Activation Varies in Different Models of Creutzfeldt-Jakob Disease
Baker, C. A., Lu, Z.-Y., Zaitsev, I., & Manuelidis, L. (1999) · Journal of Virology · doi:10.1128/jvi.73.6.5089-5097.1999 · Cited by 91 · see citing works
Andréoletti, O., Berthon, P., Levavasseur, E., Marc, D., Lantier, F., Monks, E., Elsen, J.-M., & Schelcher, F. (2002) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540205001009 · Cited by 78 · see citing works
Horrigan, S. K., & Reproducibility Project: Cancer Biology (2017) · eLife · doi:10.7554/elife.18173 · Cited by 72 · see citing works
Tada, K., Tanaka, M., Hanayama, R., Miwa, K., Shinohara, A., Iwamatsu, A., & Nagata, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.5718 · Cited by 70 · cited 1× · see citing works
“Binding of CD47 to SIRPα mediates tethering of apoptotic cells to phagocytes [21,22].”
SIRP/CD47 signaling in neurological disorders
Zhang, H., Li, F., Yang, Y., Chen, J., & Hu, X. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.012 · Cited by 67 · see citing works
SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells
Nuvolone, M., Kana, V., Hütter, G., Sakata, D., Mortin-Toth, S. M., Russo, G., Danska, J. S., & Aguzzi, A. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131274 · Cited by 67 · see citing works
Self-citationThe Role of the NADPH Oxidase NOX2 in Prion Pathogenesis
Sorce, S., Nuvolone, M., Keller, A., Falsig, J., Varol, A., Schwarz, P., Bieri, M., Budka, H., & Aguzzi, A. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004531 · Cited by 62 · see citing works
Self-citationAmyloid β Peptides Trigger CD47-Dependent Mast Cell Secretory and Phagocytic Responses
Niederhoffer, N., Levy, R., Sick, É., André, P., Coupin, G., Lombard, Y., & Gies, J. (2009) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200902200224 · Cited by 46 · see citing works
Iwamoto, C., Takenaka, K., Urata, S., Yamauchi, T., Shima, T., Kuriyama, T., Daitoku, S., Saito, Y., Miyamoto, T., Iwasaki, H., et al. (2013) · Experimental Hematology · doi:10.1016/j.exphem.2013.11.005 · Cited by 43 · see citing works
Self-citationGene structure of mouse BIT/SHPS-1
Sano, S., Ohnishi, H., & Kubota, M. (1999) · Biochemical Journal · doi:10.1042/bj3440667 · Cited by 35 · see citing works
Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs
Washio, K., Kotani, T., Saito, Y., Respatika, D., Murata, Y., Kaneko, Y., Okazawa, H., Ohnishi, H., Fukunaga, A., Nishigori, C., et al. (2015) · Genes to Cells · doi:10.1111/gtc.12238 · Cited by 27 · see citing works
Self-citationIdentification and characterization of a novel mouse prion gene allele
Lloyd, S. E., Thompson, S. R., Beck, J. A., Linehan, J. M., Wadsworth, J. D. F., Brandner, S., Collinge, J., & Fisher, E. (2004) · Mammalian Genome · doi:10.1007/s00335-004-3041-5 · Cited by 25 · see citing works
Cystatin F is a biomarker of prion pathogenesis in mice
Nuvolone, M., Schmid, N., Miele, G., Sorce, S., Moos, R., Schori, C., Beerli, R. R., Bauer, M., Saudan, P., Dietmeier, K., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0171923 · Cited by 25 · see citing works
Self-citationGehlenborg, N., Hwang, D., Lee, I. Y., Yoo, H., Baxter, D. H., Petritis, B. O., Pitstick, R., Marzolf, B., DeArmond, S. J., Carlson, G. A., et al. (2009) · Database · doi:10.1093/database/bap011 · Cited by 21 · see citing works
Szabo, R., Samson, A. L., Lawrence, D. A., Medcalf, R. L., & Bugge, T. H. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13338 · Cited by 18 · see citing works
CD47 does not mediate amyloid-β(1–42) protofibril-stimulated microglial cytokine release
Karki, S., & Nichols, M. R. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.10.081 · Cited by 10 · see citing works
de Souza, H. A. D. S., Costa-Correa, E. H., Bianco‐Júnior, C., Andrade, M. C. R., Lima‐Junior, J. D. C., Pratt-Riccio, L. R., Daniel‐Ribeiro, C. T., & Totino, P. R. R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01814 · Cited by 4 · see citing works
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Anand, C., Maia, P. D., Torok, J., Mezias, C., & Raj, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-25131-3 · Cited by 25 · see citing works
The Effects of Immune System Modulation on Prion Disease Susceptibility and Pathogenesis
Mabbott, N. A., Bradford, B. M., Pal, R., Young, R. A., & Donaldson, D. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197299 · Cited by 20 · see citing works
Matamoros‐Angles, A., Hervera, A., Soriano, J., Martı́, E., Carulla, P., Llorens, F., Nuvolone, M., Aguzzi, A., Ferrer, I., Gruart, A., et al. (2022) · BMC Biology · doi:10.1186/s12915-021-01203-0 · Cited by 15 · see citing works
Self-citationLoss of Homeostatic Microglia Signature in Prion Diseases
Wang, Y., Hartmann, K., Thies, E., Mohammadi, B., Altmeppen, H., Sepulveda-Falla, D., Glatzel, M., & Krasemann, S. (2022) · Cells · doi:10.3390/cells11192948 · Cited by 12 · see citing works
Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes
Küçükali, F., Hill, E., Watzeels, T., Hummerich, H., Campbell, T., Darwent, L., Collins, S. J., Stehmann, C., Kovács, G. G., Geschwind, M. D., et al. (2025) · Brain · doi:10.1093/brain/awaf032 · Cited by 10 · see citing works
Self-citationde Souza, H. A. D. S., Costa-Correa, E. H., Bianco‐Júnior, C., Andrade, M. C. R., Lima‐Junior, J. D. C., Pratt-Riccio, L. R., Daniel‐Ribeiro, C. T., & Totino, P. R. R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01814 · Cited by 4 · see citing works
McFarlin, B. K., Curtis, J. H., Vingren, J. L., Hill, D. W., & Bridgeman, E. A. (2025) · BioTech · doi:10.3390/biotech14010004 · Cited by 1 · see citing works
Matamoros‐Angles, A., Hervera, A., Soriano, J., Martı́, E., Carulla, P., Llorens, F., Nuvolone, M., Aguzzi, A., Ferrer, I., Gruart, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.20.432083 · Cited by 1 · see citing works
Self-citationReactive Changes in Rat Spinal Cord Microgliocytes under Acute Systemic Inflammation
Kolos, E. A., & Korzhevsky, D. E. (2023) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s002209302304021x
Reactive Changes of Rat Spinal Cord Microgliocytes after Acute Systemic Inflammation
Kolos, E. A., & Korzhevsky, D. E. (2023) · Российский физиологический журнал им И М Сеченова · doi:10.31857/s0869813923070063
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Küçükali, F., Hill, E., Watzeels, T., Hummerich, H., Campbell, T., Darwent, L., Collins, S. J., Stehmann, C., Kovács, G. G., Geschwind, M. D., et al. (2024) · medRxiv · doi:10.1101/2024.07.19.24310476
Self-citationMatamoros‐Angles, A., Hervera, A., Soriano, J., Martí, E., Carulla, P., Llorens, F., Nuvolone, M., Aguzzi, A., Ferrer, I., Gruart, A., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18393239
Self-citationMatamoros‐Angles, A., Hervera, A., Soriano, J., Martí, E., Carulla, P., Llorens, F., Nuvolone, M., Aguzzi, A., Ferrer, I., Gruart, A., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18393242
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Küçükali, F., & Sleegers, K. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.12507354
- Authors
- Nuvolone, M., Paolucci, M., Sorce, S., Kana, V., Moos, R., Matozaki, T., & Aguzzi, A.
- Affiliations
- University of Pavia (IT)
- University Hospital Zurich (CH)
- Kobe University (JP)
- Corresponding author
- Nuvolone, Mario
- Aguzzi, Adriano
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-05-17
- Volume
- 12
- Issue
- 5
- Pages
- e0177876
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5435345
- OpenAlex
- W2616831870
- Cited by
- 13
- References
- 59
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 1 · 2017: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (publishedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
- Kobe University Repository Kernel (Kobe University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- European Commission
- SystemsX.ch
- Japan Society for the Promotion of Science (16K15219)
- FP7 Ideas: European Research Council (250356)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- prion disease, SIRPα, microglia, phagocytosis, prion pathogenesis, scrapie, microglial activation, neuronal loss, apoptotic bodies
- MeSH terms
- Prion Proteins, Animals, Gene Expression Regulation, Mutation, Phagocytosis, Receptors, Immunologic, Prion Diseases, Microglia, Disease Progression, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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