3D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby
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OBJECTIVE: To undertake an observational study to see whether first trimester placental vascularity, measured with a standardized power Doppler index: 3D-FMBV, is different in pregnancies which either develop pre-eclampsia or lead to term, normotensive small for gestational age (SGA) babies. METHODS: Women were scanned between 11 and 13+6 weeks. The placental volume (sPlaV) was estimated using our previously validated semi-automated tool. Estimates of 3D-FMBV were generated from the raw power Doppler signal for the whole utero-placental interface, UPI (FMBV-UPI) and 5mm into the placenta (FMBV-IVS). Differences in the placental volume and FMBV for pregnancies developing pre-eclampsia and resulting in term, normotensive SGA babies were compared with term, normotensive, appropriate for gestational age (AGA), controls. RESULTS: Results were available for 143 women. The placental volume (sPlaV) was reduced in both pre-eclampsia (p = 0.007) and term, normotensive SGA (p = 0.001) when compared with term normotensive AGA controls. 3D-FMBV estimates were significantly lower for pregnancies developing pre-eclampsia (FMBV-UPI, p = 0.03, FMBV-IVS, p = 0.01) but not for the normotensive SGA pregnancies (FMBV-UPI, p = 0.16, FMBV-IVS, p = 0.27). CONCLUSION: Pregnancies destined to develop pre-eclampsia are more likely to have small placentas with significantly reduced vascularity at 11-13 weeks. Those pregnancies which were normotensive throughout but resulted in an SGA baby delivered at term, had significantly smaller placentas but with similar vascularity to normotensive AGA pregnancies.
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Standardisation of 2-D power Doppler imaging is possible using the validated technique of fractional moving blood volume (FMBV), in which a large blood vessel is identified and used as a point of reference.
“Standardisation of 2-D power Doppler imaging is possible using the validated technique of fractional moving blood volume (FMBV), in which a large blood vessel is identified and used as a point of reference.”
From Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta (2019) · cites this paper as [63]
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- Authors
- Collins, S. L., Welsh, A. W., Impey, L., Noble, J. A., & Stevenson, G. N.
- Affiliations
- John Radcliffe Hospital (GB)
- Royal Hospital for Women (AU)
- University of Oxford (GB)
- UNSW Sydney (AU)
- Corresponding author
- Collins, Sally L.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-06-01
- Volume
- 12
- Issue
- 6
- Pages
- e0178675
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5453560
- OpenAlex
- W2620641796
- Cited by
- 25
- References
- 35
- Citations by year
- 2026: 4 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 3
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U01 HD 087209)
- Lesley Stevens Fund
- National Institute for Health Research
- National Institute for Health Research (GB)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Keywords
- preeclampsia, placental vascularization, fractional moving blood volume, 3D power Doppler, first trimester, small for gestational age, placental volume
- MeSH terms
- Female, Humans, Infant, Newborn, Infant, Small for Gestational Age, Placenta, Pre-Eclampsia, Pregnancy, Pregnancy Trimester, First
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