Incidence of thromboembolic events in asymptomatic carriers of IgA anti ß2 glycoprotein-I antibodies
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BACKGROUND: The antiphospholipid syndrome (APS) is defined by simultaneous presence of vascular clinical events and antiphospholipid antibodies (aPL). The aPL considered as diagnostics are lupus anticoagulant and antibodies anticardiolipin (aCL) and anti-ß2 glycoprotein-I (aB2GP1). During recent years, IgA aB2GP1 antibodies have been associated with thrombotic events both in patients positive, and mainly negative for other aPL, however its value as a pro-thrombotic risk-factor in asymptomatic patients has not been well defined. OBJECTIVE: To test the role of IgA anti B2GP1 as a risk factor for the development of APS-events (thrombosis or pregnancy morbidity) in asymptomatic population with a 5-year follow-up. METHODS: 244 patients isolated positive for anti-beta2-glycoprotein I IgA (Group-1 study) and 221 negative patients (Group-2 control) were studied. All the patients were negative for IgG and IgM aCL. RESULTS: During the follow-up, 45 patients (9.7%) had APS-events, 38 positive for IgA-aB2GP1 and 7 negative (15.6% vs 3.2%, p<0.001). The incidence rate of APS-events was 3.1% per year in IgA-aB2GP1 positive patients and 0.6% per year in the control group. Arterial thrombosis were the most frequent APS-events (N = 25, 55%) and were mainly observed in Group-1 patients (21 vs 4, p = 0.001). Multivariate analysis were shown as independent risk-factors for the development of APS-events, age, sex (men) and presence of IgA-aB2GP1 (odds ratio 5.25, 95% CI 2.24 to 12.32). CONCLUSION: The presence of IgA-aB2GP1 in people with no history of APS-events is the main independent risk factor for the development of these types of events, mainly arterial thrombosis.
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In a 5-year follow-up of 248 asymptomatic individuals with isolated IgA anti-β2-glycoprotein I positivity, the presence of anti-β2-glycoprotein I IgA was an independent risk factor for APS events.
“A 5-year follow-up of 248 asymptomatic individuals with isolated IgA anti-β2-glycoprotein I positivity showed that the presence of anti-β2-glycoprotein I IgA was an independent risk factor for APS events [18].”
From Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus (2021) · cites this paper as [18]
The Abstract (Methods) reports 244 asymptomatic IgA-positive patients, not 248, alongside 221 antibody-negative controls. The Abstract (Objective) specifies a five-year follow-up, and the Results section identifies IgA-aB2GP1 positivity as an independent risk factor for APS events. The finding is supported, but the stated number of positive individuals is incorrect. (LLM, conf=0.95)
Experimental — accuracy not yet measuredAnti-β2-glycoprotein I IgA is a risk factor for the development of APS thrombosis.
“Recent publications have confirmed that anti-β2-glycoprotein I IgA is a risk factor for the development of APS thrombosis [17–20].”
From Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus (2021) · cites this paper as [18]
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- [51]Martinez-Flores JA, Serrano M, Perez D, Camara AG, Lora D, Morillas L, et al Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein are Strongly Associated with the Occurrence of Acute Thrombotic Events. J Atheroscler Thromb. 2016; 23(10): 1242– 53. Epub 2016/04/12. doi: 10.5551/jat.34488. 27063992 PMC5098924 · DOI
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Pulmonary Embolism in Antiphospholipid Syndrome (APS)—Where Are We and Where Are We Going?
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Antibodies and Diagnostic Tests in Antiphospholipid Syndrome
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- Authors
- Tortosa, C., Cabrera-Marante, O., Serrano, M., Martínez-Flores, J. A., Pérez, D., Lora, D., Morillas, L., Paz-Artal, E., Morales, J. M., Pleguezuelo, D., & Serrano, A.
- Affiliations
- Research Institute Hospital 12 de Octubre (ES)
- Corresponding author
- Serrano, Antonio
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-07-20
- Volume
- 12
- Issue
- 7
- Pages
- e0178889
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5519006
- OpenAlex
- W2737936804
- Cited by
- 44
- References
- 51
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 1 · 2016: 1
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Fondo de Investigaciones Sanitarias and cofunded by EU FEDER funds (Grant: PI14-00360)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- antiphospholipid syndrome, thromboembolic events, arterial thrombosis, asymptomatic carriers, thrombosis risk factors, pregnancy morbidity, anticardiolipin antibodies, lupus anticoagulant, long-term follow-up
- MeSH terms
- Adolescent, Adult, Aged, Autoantibodies, Female, Humans, Male, Middle Aged, Thromboembolism, Incidence, Antiphospholipid Syndrome, beta 2-Glycoprotein I, Young Adult
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