The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults
Open accessAbstract
BACKGROUND: High amounts of time spent sitting can increase cardiovascular disease risk and are deleteriously associated cardio-metabolic risk biomarkers. Though evidence suggests that accruing sitting time in prolonged periods may convey additional risk, verification using high-quality measures is needed. We examined this issue in adults from the Australian Diabetes, Obesity and Lifestyle Study, using accurate measures of sitting accumulation. METHODS: In 2011/12, 739 adults aged 36 to 89 years (mean±SD 58±10 years) wore activPAL3™ monitors (which provide accurate objective measures of sitting); 678 provided ≥4 valid days of monitor data and complete cardio-metabolic biomarker and confounder data. Multivariable linear regression models examined associations of sitting time, sitting time accrued in ≥30 minute bouts (prolonged sitting time), and three measures of sitting accumulation patterns with cardio-metabolic risk markers: body mass index (BMI), waist circumference, blood pressure, high- and low- density lipoprotein (HDL and LDL) cholesterol, triglycerides, glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and 2-hour post-load glucose (PLG). Interactions tests examined whether associations of sitting time with biomarkers varied by usual sitting bout duration. RESULTS: Adjusted for potential confounders, greater amounts of sitting time and prolonged sitting time were significantly (p<0.05) deleteriously associated with BMI, waist circumference, HDL cholesterol, and triglycerides. Total sitting time was also significantly associated with higher PLG. Sitting accumulation patterns of frequently interrupted sitting (compared to patterns with relatively more prolonged sitting) were significantly beneficially associated with BMI, waist circumference, HDL cholesterol, triglycerides, PLG, and with FPG. Effect sizes were typically larger for accumulation patterns than for sitting time. Significant interactions (p<0.05) showed that associations of sitting time with HDL, triglycerides and PLG became more deleterious the longer at a time sitting was usually accumulated. CONCLUSIONS: Adding to previous evidence reliant on low-quality measures, our study showed that accumulating sitting in patterns where sitting was most frequently interrupted had significant beneficial associations with several cardio-metabolic biomarkers and that sitting for prolonged periods at a time may exacerbate some of the effects of sitting time. The findings support sedentary behavior guidelines that promote reducing and regularly interrupting sitting.
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“Prolonged, uninterrupted sitting is more strongly associated with adverse cardiometabolic outcomes than interrupted sitting [40,41].”
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Cites
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“The residuals method [40,41] was used to correct sitting time, prolonged sitting time, and MVPA for waking wear time, and to correct sit-stand transitions for sitting time.”
MethodBiswas, A., Oh, P. I., Faulkner, G. E., Bajaj, R. R., Silver, M. A., Mitchell, M. S., & Alter, D. A. (2015) · Annals of Internal Medicine · doi:10.7326/m14-1651 · Cited by 2,726
RE: “TOTAL ENERGY INTAKE: IMPLICATIONS FOR EPIDEMIOLOGIC ANALYSES”
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“Models do not adjust for sitting time as a confounder [44] because increasing the volume of sitting is one of the ways in which sitting for long periods may impact biomarkers.”
BackgroundLetter to the Editor: Standardized use of the terms “sedentary” and “sedentary behaviours”
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Loh, R., Stamatakis, E., Folkerts, D., Allgrove, J. E., & Moir, H. J. (2020) · Sports Medicine · doi:10.1007/s40279-019-01183-w · Cited by 326
““Physically active” was defined as either exceeding the recommended 150 min of moderate to vigorous physical activity (MVPA) per week, or reported as “recreationally active” [7, 8, 45].”
BackgroundSedentary Behavior and Cardiovascular Disease in Older Women: The OPACH Study
Bellettiere, J., LaMonte, M. J., Evenson, K. R., Rillamas-Sun, E., Kerr, J., Lee, I.-M., Di, C., Rosenberg, D. E., Stefanick, M. L., Buchner, D. M., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.035312 · Cited by 252
Self-citationSitting Less and Moving More: Implications for Hypertension
Dempsey, P. C., Larsen, R. N., Dunstan, D. W., Owen, N., & Kingwell, B. A. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11190 · Cited by 170
Self-citationSedentary Behavior and Chronic Disease: Mechanisms and Future Directions
Dempsey, P. C., Matthews, C. E., Dashti, S. G., Doherty, A., Bergouignan, A., van Roekel, E. H., Dunstan, D. W., Wareham, N. J., Yates, T. E., Wijndaele, K., et al. (2019) · Journal of Physical Activity and Health · doi:10.1123/jpah.2019-0377 · Cited by 150
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Self-citation
Metadata
- Authors
- Bellettiere, J., Winkler, E. A. H., Chastin, S. F. M., Kerr, J., Owen, N., Dunstan, D. W., & Healy, G. N.
- Affiliations
- San Diego State University (US)
- The University of Queensland (AU)
- Glasgow Caledonian University (GB)
- University of California San Diego (US)
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Bellettiere, John
- Winkler, Elisabeth A. H.
- Chastin, Sebastien F. M.
- Kerr, Jacqueline
- Owen, Neville
- Dunstan, David W.
- Healy, Genevieve N.
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-06-29
- Volume
- 12
- Issue
- 6
- Pages
- e0180119
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5491133
- OpenAlex
- W2729779756
- Cited by
- 169
- References
- 45
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 14 · 2023: 13 · 2022: 19 · 2021: 38 · 2020: 22 · 2019: 29 · 2018: 18 · 2017: 3
- FWCI
- 14.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UniSA Research Outputs Repository (University of South Australia) (acceptedVersion, other-oa)
- ResearchOnline (Glasgow Caledonian University) (acceptedVersion, cc-by)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Research Bank (Australian Catholic University) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Own your potential (DEAKIN) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (cc-by)
- Funders
- National Health and Medical Research Council (566940, 1000986, 1003960, 1078360, 108029, 233200)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Social Sciences › Human Factors and Ergonomics › Ergonomics and Musculoskeletal Disorders
- Keywords
- sedentary behavior, prolonged sitting, body mass index, waist circumference, HDL cholesterol, triglycerides, HbA1c, post-load glucose, blood pressure, Australian adults
- MeSH terms
- Adult, Aged, Aged, 80 and over, Australia, Cardiovascular Diseases, Female, Humans, Male, Middle Aged, Posture, Biomarkers, Young Adult, Sedentary Behavior
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