Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis

Wilmot, E. G.; Edwardson, C. L.; Achana, F. A.; Davies, M. J.; Gorely, T.; Gray, L. J.; Khunti, K.; Yates, T.; Biddle, S. J. H.

doi:10.1007/s00125-012-2677-z

Cited by 1,789Physical Activity and HealthNutritional Studies and DietCoffee research and impacts

Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis

Wilmot, E. G., Edwardson, C. L., Achana, F. A., Davies, M. J., Gorely, T., Gray, L. J., Khunti, K., Yates, T. +1 more·2012·Diabetologia

DOI 10.1007/s00125-012-2677-z

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Abstract

Aims/hypothesis Sedentary (sitting) behaviours are ubiquitous in modern society. We conducted a systematic review and meta-analysis to examine the association of sedentary time with diabetes, cardiovascular disease and cardiovascular and all-cause mortality. Methods Medline, Embase and the Cochrane Library databases were searched for terms related to sedentary time and health outcomes. Cross-sectional and prospective studies were included. RR/HR and 95% CIs were extracted by two independent reviewers. Data were adjusted for baseline event rate and pooled using a random-effects model. Bayesian predictive effects and intervals were calculated to indicate the variance in outcomes that would be expected if new studies were conducted in the future. Results Eighteen studies (16 prospective, two cross-sectional) were included, with 794,577 participants. Fifteen of these studies were moderate to high quality. The greatest sedentary time compared with the lowest was associated with a 112% increase in the RR of diabetes (RR 2.12; 95% credible interval [CrI] 1.61, 2.78), a 147% increase in the RR of cardiovascular events (RR 2.47; 95% CI 1.44, 4.24), a 90% increase in the risk of cardiovascular mortality (HR 1.90; 95% CrI 1.36, 2.66) and a 49% increase in the risk of all-cause mortality (HR 1.49; 95% CrI 1.14, 2.03). The predictive effects and intervals were only significant for diabetes. Conclusions/interpretation Sedentary time is associated with an increased risk of diabetes, cardiovascular disease and cardiovascular and all-cause mortality; the strength of the association is most consistent for diabetes.

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Sedentary behaviour and physical inactivity are modifiable risk factors for the prevention, development and management of glucose intolerance and type 2 diabetes.
“Sedentary behaviour (SB) and physical inactivity -promoted by increasingly sedentary jobs [6]-have a high prevalence in adults with T2D [7,8] and are two of the main modifiable risk factors for the prevention, development and management of glucose intolerance (IGT or prediabetes) and T2D [9].”
From Impact of a primary care-based mobile health intervention to ‘sit less and move more’ on HbA1c, blood pressure, and other clinical outcomes in office employees with type 2 diabetes: A randomized controlled trial (2025) · cites this paper as [9]
In adults with type 2 diabetes, the prevalence of sedentary behaviour and physical inactivity is related to a higher rate of cardiovascular morbidity and mortality.
“In adults with T2D, the prevalence of SB and physical inactivity is related to a higher rate of cardiovascular morbidity and mortality [9].”
From Impact of a primary care-based mobile health intervention to ‘sit less and move more’ on HbA1c, blood pressure, and other clinical outcomes in office employees with type 2 diabetes: A randomized controlled trial (2025) · cites this paper as [9]
More time spent in sedentary behaviors is associated with increased risk of developing diabetes and poorer metabolic and inflammatory profiles in people with type 2 diabetes.
“More time spent in sedentary behaviors was associated with an increased risk of developing diabetes and poorer metabolic and inflammatory profiles in those with T2DM.”
From The Impact of Physical Activity in Patients With Type 2 Diabetes (2025) · cites this paper as [79]
Prior meta-analyses combined different measures of sedentary behavior and did not examine dose-response relationships for daily total sitting time.
“However, both studies combined different measures of sedentary behavior (TV-viewing mostly, and sitting time) in their analyses, and neither study examined dose-response relationships for daily total sitting time.”
From Daily Sitting Time and All-Cause Mortality: A Meta-Analysis (2013) · cites this paper as [18]
Other meta-analyses have reported pooled HRs of 1.18-1.45 and 1.49 for highest versus lowest sitting/sedentary time.
“Other meta-analyses have shown pooled HRs of 1.18-1.45 [15] and 1.49 [18] for the group with the highest level of sitting or sedentary time compared with the lowest group, respectively.”
From Daily Sitting Time and All-Cause Mortality: A Meta-Analysis (2013) · cites this paper as [18]

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Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association
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The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level
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Correlates, facilitators and barriers of physical activity among primary care patients with prediabetes in Singapore – a mixed methods approach
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Trends in Sedentary Behavior Among the US Population, 2001-2016
Yang, L., Cao, C., Kantor, E. D., Nguyen, L. H., Zheng, X., Park, Y., Giovannucci, E. L., Matthews, C. E., Colditz, G. A., & Cao, Y. (2019) · JAMA · doi:10.1001/jama.2019.3636 · Cited by 602 · see citing works
Compositional data analysis for physical activity, sedentary time and sleep research
Dumuid, D., Stanford, T., Fernández, J. A. M., Pedišić, Ž., Maher, C. A., Lewis, L. K., Hron, K., Katzmarzyk, P. T., Chaput, J., Fogelholm, M., et al. (2017) · Statistical Methods in Medical Research · doi:10.1177/0962280217710835 · Cited by 548 · see citing works
Patterns of Sedentary Behavior and Mortality in U.S. Middle-Aged and Older Adults
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Physical Activity and the Prevention of Hypertension
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How to reduce sitting time? A review of behaviour change strategies used in sedentary behaviour reduction interventions among adults
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Considerations when using the activPAL monitor in field-based research with adult populations
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Interrupting long periods of sitting: good STUFF
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Sedentary behaviour and the risk of depression: a meta-analysis
Zhai, L., Zhang, Y., & Zhang, D. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2014-093613 · Cited by 500 · see citing works
From pre-diabetes to diabetes: diagnosis, treatments and translational research
Khan, R., Chua, Z., Tan, J., Yang, Y., Liao, Z., & Zhao, Y. (2019) · Medicina · doi:10.3390/medicina55090546 · Cited by 484 · see citing works
A systematic review of correlates of sedentary behaviour in adults aged 18–65 years: a socio-ecological approach
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Impact of sedentarism due to the COVID‐19 home confinement on neuromuscular, cardiovascular and metabolic health: Physiological and pathophysiological implications and recommendations for physical and nutritional countermeasures
Narici, M. V., VITO, G. D., Franchi, M. V., Paoli, A., Moro, T., Marcolin, G., Grassi, B., Baldassarre, G., Zuccarelli, L., Biolo, G., et al. (2020) · European Journal of Sport Science · doi:10.1080/17461391.2020.1761076 · Cited by 470 · see citing works
The Maastricht Study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities
Schram, M. T., Sep, S. J. S., Kallen, C., Dagnelie, P. C., Koster, A., Schaper, N. C., Henry, R. M. A., & Stehouwer, C. D. A. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9889-0 · Cited by 451 · see citing works
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
Pillon, N. J., Gabriel, B. M., Dollet, L., Smith, J. A. B., Sardón Puig, L., Botella, J., Bishop, D. J., Krook, A., & Zierath, J. R. (2020) · Nature Communications · doi:10.1038/s41467-019-13869-w · Cited by 457 · see citing works
The sedentary office: an expert statement on the growing case for change towards better health and productivity
Buckley, J., Hedge, A., Yates, T. E., Copeland, R. J., Loosemore, M. P., Hamer, M., Bradley, G., & Dunstan, D. W. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-094618 · Cited by 439 · see citing works
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Routine assessment and promotion of physical activity in healthcare settings: A scientific statement from the American Heart Association
Lobelo, F., Rohm Young, D., Sallis, R., Garber, M. D., Billinger, S. A., Duperly, J., Hutber, A., Pate, R. R., Thomas, R. J., Widlansky, M. E., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000559 · Cited by 402 · see citing works
Using accelerometers to measure physical activity in large-scale epidemiological studies: issues and challenges
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“…of epidemiological literature over the past 5 – 10 years has described the associations between sedentary behaviour and increased risks of all-cause mortality and cardio-metabolic diseases, 11 with plausible biological mechanisms (eg, lipoprotein lipase regulation) proposed from animal studies.”
Background
Systematic review of the relationships between sedentary behaviour and health indicators in the early years (0–4 years)
Poitras, V. J., Gray, C. E., Janssen, X., Aubert, S., Carson, V., Faulkner, G., Goldfield, G. S., Reilly, J. J., Sampson, M., & Tremblay, M. S. (2017) · BMC Public Health · doi:10.1186/s12889-017-4849-8 · Cited by 389 · see citing works
A comparison of the effectiveness of physical activity and sedentary behaviour interventions in reducing sedentary time in adults: a systematic review and meta‐analysis of controlled trials
Prince, S. A., Saunders, T. J., Gresty, K., & Reid, R. D. (2014) · Obesity Reviews · doi:10.1111/obr.12215 · Cited by 382 · see citing works
Physiology of sedentary behavior
Pinto, A. J., Bergouignan, A., Dempsey, P. C., Roschel, H., Owen, N. G., Gualano, B., & Dunstan, D. W. (2023) · Physiological Reviews · doi:10.1152/physrev.00022.2022 · Cited by 403 · see citing works
Associations between sedentary behaviour and physical activity in children and adolescents: a meta‐analysis
Pearson, N., Braithwaite, R. E., Biddle, S., van Sluijs, E. M. F., & Atkin, A. J. (2014) · Obesity Reviews · doi:10.1111/obr.12188 · Cited by 376 · see citing works
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The compositional isotemporal substitution model: A method for estimating changes in a health outcome for reallocation of time between sleep, physical activity and sedentary behaviour
Dumuid, D., Pedišić, Ž., Stanford, T., Fernández, J. A. M., Hron, K., Maher, C. A., Lewis, L. K., & Olds, T. (2017) · Statistical Methods in Medical Research · doi:10.1177/0962280217737805 · Cited by 369 · see citing works
Meta‐analysis of the relationship between breaks in sedentary behavior and cardiometabolic health
Chastin, S. F. M., Egerton, T., Leask, C., & Stamatakis, E. (2015) · Obesity · doi:10.1002/oby.21180 · Cited by 363 · see citing works
Television Viewing and Time Spent Sedentary in Relation to Cancer Risk: A Meta-Analysis
Schmid, D., & Leitzmann, M. F. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju098 · Cited by 359 · see citing works
Breaking up prolonged sitting with light-intensity walking improves postprandial glycemia, but breaking up sitting with standing does not
Bailey, D. P., & Locke, C. D. (2014) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2014.03.008 · Cited by 358 · see citing works
How Sedentary Are University Students? A Systematic Review and Meta-Analysis
Castro, Ó., Bennie, J. A., Vergeer, I., Bosselut, G., & Biddle, S. (2020) · Prevention Science · doi:10.1007/s11121-020-01093-8 · Cited by 392 · see citing works
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Recommendations for physical activity in older adults
Sparling, P. B., Howard, B. J., Dunstan, D. W., & Owen, N. G. (2015) · BMJ · doi:10.1136/bmj.h100 · Cited by 351 · see citing works
Office Workers' Objectively Measured Sedentary Behavior and Physical Activity During and Outside Working Hours
Clemes, S. A., O'Connell, S. E., & Edwardson, C. L. (2014) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000000101 · Cited by 351 · see citing works
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Reducing sitting time in office workers: Short-term efficacy of a multicomponent intervention
Healy, G. N., Eakin, E., LaMontagne, A. D., Owen, N. G., WINKLER, E. A. H., Wiesner, G., Gunning, L., Neuhaus, M., Lawler, S., Fjeldsoe, B. S., et al. (2013) · Preventive Medicine · doi:10.1016/j.ypmed.2013.04.004 · Cited by 340 · see citing works
Associations of objectively measured sedentary behaviour and physical activity with markers of cardiometabolic health
Henson, J., Yates, T., Biddle, S. J. H., Edwardson, C. L., Khunti, K., Wilmot, E. G., Gray, L. J., Gorely, T., Nimmo, M. A., & Davies, M. J. (2013) · Diabetologia · doi:10.1007/s00125-013-2845-9 · Cited by 337 · see citing works
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Physical activity in the treatment of Post-traumatic stress disorder: A systematic review and meta-analysis
Rosenbaum, S., Vancampfort, D., Steel, Z., Newby, J., Ward, P. B., & Stubbs, B. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.10.017 · Cited by 333 · see citing works
Sedentary Behaviour as an Emerging Risk Factor for Cardiometabolic Diseases in Children and Youth
Saunders, T. J., Chaput, J., & Tremblay, M. S. (2014) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.08.266 · Cited by 331 · see citing works
Reducing occupational sedentary time: a systematic review and meta‐analysis of evidence on activity‐permissive workstations
Neuhaus, M., Eakin, E., Straker, L. M., Owen, N. G., Dunstan, D. W., Reid, N., & Healy, G. N. (2014) · Obesity Reviews · doi:10.1111/obr.12201 · Cited by 329 · see citing works
Interventions with potential to reduce sedentary time in adults: systematic review and meta-analysis
Martin, A., Fitzsimons, C., Jepson, R., Saunders, D. H., van der Ploeg, H. P., Teixeira, P. J., Gray, C. M., & Mutrie, N. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2014-094524 · Cited by 326 · see citing works
Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers
Healy, G. N., WINKLER, E. A. H., Owen, N. G., Anuradha, S., & Dunstan, D. W. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv308 · Cited by 306 · see citing works
Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022
Okamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 317 · see citing works
Beyond BMI: The “Metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review
Roberson, L. L., Aneni, E. C., Maziak, W., Agatston, A. S., Feldman, T., Rouseff, M., Tran, T. H., Blaha, M. J., Santos, R. D., Sposito, A. C., et al. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-14 · Cited by 305 · see citing works
Associations of total amount and patterns of sedentary behaviour with type 2 diabetes and the metabolic syndrome: The Maastricht Study
van der Berg, J. D., Stehouwer, C. D. A., Bosma, H., van der Velde, J. H. P. M., Willems, P. J. B., Savelberg, H. H. C. M., Schram, M. T., Sep, S. J. S., van der Kallen, C. J. H., Henry, R. M. A., et al. (2016) · Diabetologia · doi:10.1007/s00125-015-3861-8 · Cited by 299 · see citing works
The Effect of Physical Activity Interventions Comprising Wearables and Smartphone Applications on Physical Activity: a Systematic Review and Meta-analysis
Gal, R., May, A. M., van Overmeeren, E. J., Simons, M., & Monninkhof, E. M. (2018) · Sports Medicine - Open · doi:10.1186/s40798-018-0157-9 · Cited by 257 · see citing works
Identifying adults’ valid waking wear time by automated estimation in activPAL data collected with a 24 h wear protocol
WINKLER, E. A. H., Bodicoat, D. H., Healy, G. N., Bakrania, K., Yates, T. E., Owen, N. G., Dunstan, D. W., & Edwardson, C. L. (2016) · Physiological Measurement · doi:10.1088/0967-3334/37/10/1653 · Cited by 290 · see citing works
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The Acute Relationships Between Affect, Physical Feeling States, and Physical Activity in Daily Life: A Review of Current Evidence
Liao, Y., Shonkoff, E. T., & Dunton, G. F. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01975 · Cited by 280 · see citing works
Definition, Measurement, and Health Risks Associated with Sedentary Behavior
Gibbs, B. B., Hergenroeder, A. L., Katzmarzyk, P. T., Lee, I.-M. M., & Jakicic, J. M. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000517 · Cited by 275 · see citing works
Effectiveness of the Stand More AT (SMArT) Work intervention: cluster randomised controlled trial
Edwardson, C. L., Yates, T. E., Biddle, S., Davies, M. J., Dunstan, D. W., Esliger, D., Gray, L. J., Jackson, B., O'Connell, S. E., Waheed, G., et al. (2018) · BMJ · doi:10.1136/bmj.k3870 · Cited by 272 · see citing works
Self-citation
Pathways from built environment to health: A conceptual framework linking behavior and exposure-based impacts
Frank, L. D., Iroz‐Elardo, N., MacLeod, K. E., & Hong, A. (2019) · Journal of Transport & Health · doi:10.1016/j.jth.2018.11.008 · Cited by 272 · see citing works
Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study
Henson, J., Davies, M. J., Bodicoat, D. H., Edwardson, C. L., Gill, J. M. R., Stensel, D. J., Tolfrey, K., Dunstan, D. W., Khunti, K., & Yates, T. (2016) · Diabetes Care · doi:10.2337/dc15-1240 · Cited by 270 · see citing works
Self-citation
Continuous Dose-Response Association Between Sedentary Time and Risk for Cardiovascular Disease: A Meta-analysis
Pandey, A., Salahuddin, U., Garg, S., Ayers, C., Kulinski, J., Anand, V., Mayo, H., Kumbhani, D. J., de Lemos, J., & Berry, J. D. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.1567 · Cited by 272 · see citing works
Physical activity prescription: a critical opportunity to address a modifiable risk factor for the prevention and management of chronic disease: a position statement by the Canadian Academy of Sport and Exercise Medicine
Thornton, J. S., Frémont, P., Khan, K., Poirier, P., Fowles, J. R., Wells, G. D., & Frankovich, R. J. (2016) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-096291 · Cited by 270 · see citing works
Statistical machine learning of sleep and physical activity phenotypes from sensor data in 96,220 UK Biobank participants
Willetts, M., Hollowell, S., Aslett, L., Holmes, C., & Doherty, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-26174-1 · Cited by 250 · see citing works
“learning methods have not been assessed in large scale health sensor datasets for face validity or investigated to evaluate if they offer behavioural insight.”
Background
2021 EULAR recommendations regarding lifestyle behaviours and work participation to prevent progression of rheumatic and musculoskeletal diseases
Gwinnutt, J. M., Wieczorek, M., Balanescu, A. R., Bischoff-Ferrari, H. A., Boonen, A. E. R. C. H., Cavalli, G., de Souza, S., de Thurah, A. L., Dorner, T. E., Moe, R. H., et al. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-222020 · Cited by 269 · see citing works
A systematic review of school-based interventions targeting physical activity and sedentary behaviour among older adolescents
Hynynen, S.-T., van Stralen, M. M., Sniehotta, F. F., Araújo-Soares, V., Hardeman, W., Chinapaw, M. J. M., Vasankari, T., & Hankonen, N. (2016) · International Review of Sport and Exercise Psychology · doi:10.1080/1750984x.2015.1081706 · Cited by 253 · see citing works
“If non-sedentary lifestyle habits can be initiated in adolescence, this may have beneficial preventive value, as the effects on mortality and morbidity among adults have already been established (Thorp, Owen, Neuhaus, & Dunstan, 2011; Wilmot et al., 2012).”
Background
Traditional and Emerging Lifestyle Risk Behaviors and All-Cause Mortality in Middle-Aged and Older Adults: Evidence from a Large Population-Based Australian Cohort
Ding, D., Rogers, K. D., van der Ploeg, H. P., Stamatakis, E. A., & Bauman, A. E. (2015) · PLoS Medicine · doi:10.1371/journal.pmed.1001917 · Cited by 256 · see citing works
Tracking of Physical Activity and Sedentary Behavior From Adolescence to Young Adulthood: A Systematic Literature Review
Hayes, G., Dowd, K., MacDonncha, C., & Donnelly, A. (2019) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2019.03.013 · Cited by 256 · see citing works
The impact of the coronavirus disease 2019 (COVID-19) pandemic on university students’ dietary intake, physical activity, and sedentary behaviour
Bertrand, L., Shaw, K. A., Ko, J., Deprez, D., Chilibeck, P. D., & Zello, G. A. (2021) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2020-0990 · Cited by 265 · see citing works
Workplace Sitting Breaks Questionnaire (SITBRQ): an assessment of concurrent validity and test-retest reliability
Pedišić, Ž., Bennie, J. A., Timperio, A. F., Crawford, D. A., Dunstan, D. W., Bauman, A. E., & Salmon, J. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-1249 · Cited by 254 · see citing works
Physical Activity and Diabetes
Sigal, R. J., Armstrong, M. J., Bacon, S., Boulé, N. G., Dasgupta, K., Kenny, G. P., & Riddell, M. C. (2018) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.10.008 · Cited by 258 · see citing works
Association of Daily Sitting Time and Leisure-Time Physical Activity With Survival Among US Cancer Survivors
Cao, C., Friedenreich, C. M., & Yang, L. (2022) · JAMA Oncology · doi:10.1001/jamaoncol.2021.6590 · Cited by 248 · see citing works
Systematic literature review of determinants of sedentary behaviour in older adults: a DEDIPAC study
CHASTIN, S. F. M., Buck, C., Freiberger, E., MURPHY, M. H., Brug, J., Cardon, G., O’Donoghue, G., Pigeot, I., & Oppert, J. (2015) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-015-0292-3 · Cited by 243 · see citing works
Sedentary behaviour and adiposity in youth: a systematic review of reviews and analysis of causality
Biddle, S., Bengoechea, E. G., & Wiesner, G. (2017) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-017-0497-8 · Cited by 245 · see citing works
Self-citation
Screen Time, Other Sedentary Behaviours, and Obesity Risk in Adults: A Review of Reviews
Biddle, S., García, E. B., Pedišić, Ž., Bennie, J. A., Vergeer, I., & Wiesner, G. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0256-9 · Cited by 250 · see citing works
Self-citation
Energy expenditure during common sitting and standing tasks: examining the 1.5 MET definition of sedentary behaviour
Mansoubi, M., Pearson, N., Clemes, S. A., Biddle, S., Bodicoat, D. H., Tolfrey, K., Edwardson, C. L., & Yates, T. E. (2015) · BMC Public Health · doi:10.1186/s12889-015-1851-x · Cited by 242 · see citing works
Self-citation
The prevalence and predictors of type two diabetes mellitus in people with schizophrenia: a systematic review and comparative meta‐analysis
Stubbs, B., Vancampfort, D., Hert, M. D., & Mitchell, A. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12439 · Cited by 232 · see citing works
Is the time right for quantitative public health guidelines on sitting? A narrative review of sedentary behaviour research paradigms and findings
Stamatakis, E., Ekelund, U., Ding, D., Hamer, M., Bauman, A. E., & Lee, I.-M. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099131 · Cited by 284 · see citing works
Daily physical activity and type 2 diabetes: A review
Hamasaki, H. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i12.243 · Cited by 228 · see citing works
Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study
Chen, X., Hong, X., Gao, W., Luo, S., Cai, J., Liu, G., & Huang, Y. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03407-6 · Cited by 228 · see citing works
Accelerometer-measured sedentary time and cardiometabolic biomarkers: A systematic review
Brocklebank, L. A., Falconer, C., Page, A. S., Perry, R. A., & Cooper, A. R. (2015) · Preventive Medicine · doi:10.1016/j.ypmed.2015.04.013 · Cited by 227 · see citing works
Cellular and molecular mechanisms of endothelial dysfunction in diabetes
Roberts, A., & Porter, K. E. (2013) · Diabetes and Vascular Disease Research · doi:10.1177/1479164113500680 · Cited by 223 · see citing works
Sitting and Activity Time in People With Stroke
English, C., Healy, G. N., Coates, A. M., Lewis, L. K., Olds, T., & Bernhardt, J. A. (2015) · Physical Therapy · doi:10.2522/ptj.20140522 · Cited by 226 · see citing works
Sedentary Time and Markers of Chronic Low-Grade Inflammation in a High Risk Population
Henson, J. J., Yates, T. E., Edwardson, C. L., Khunti, K. K., Talbot, D. C. S., Gray, L. J., Leigh, T. M., Carter, P., & Davies, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078350 · Cited by 219 · see citing works
Self-citation
The relationship between sedentary behaviour and physical activity in adults: A systematic review
Mansoubi, M., Pearson, N., Biddle, S., & Clemes, S. A. (2014) · Preventive Medicine · doi:10.1016/j.ypmed.2014.08.028 · Cited by 226 · see citing works
Self-citation
Sitting Time and Risk of Cardiovascular Disease and Diabetes: A Systematic Review and Meta-Analysis
Bailey, D. P., Hewson, D. J., Champion, R. B., & Sayegh, S. (2019) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2019.04.015 · Cited by 219 · see citing works
Workplace Sitting and Height-Adjustable Workstations
Neuhaus, M., Healy, G. N., Dunstan, D. W., Owen, N. G., & Eakin, E. (2013) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2013.09.009 · Cited by 216 · see citing works
Impact of the COVID-19 Pandemic on Sedentary Time and Behaviour in Children and Adults: A Systematic Review and Meta-Analysis
Runacres, A., Mackintosh, K. A., Knight, R. L., Sheeran, L., Thatcher, R., Shelley, J., & McNarry, M. A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182111286 · Cited by 220 · see citing works
Musculoskeletal pain and sedentary behaviour in occupational and non-occupational settings: a systematic review with meta-analysis
Dzakpasu, F. Q. S., Carver, A., Brakenridge, C. J., Cicuttini, F., Urquhart, D. M., Owen, N. G., & Dunstan, D. W. (2021) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-021-01191-y · Cited by 214 · see citing works
Sedentary Behavior and Public Health: Integrating the Evidence and Identifying Potential Solutions
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The prevalence and correlates of sitting in European adults - a comparison of 32 Eurobarometer-participating countries
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The health risks associated with prolonged sedentary behaviour: a systematic review.
Heaslop, M. J. A. (2012) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)

Authors: Wilmot, E. G., Edwardson, C. L., Achana, F. A., Davies, M. J., Gorely, T., Gray, L. J., Khunti, K., Yates, T., & Biddle, S. J. H.
Affiliations: University of Leicester (GB)
Loughborough University (GB)
Corresponding author: Yates, T.
ORCID: Wilmot, E. G.
Edwardson, C. L.
Achana, F. A.
Davies, M. J.
Gorely, T.
Gray, L. J.
Khunti, K.
Yates, T.
Biddle, S. J. H.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2012-08-14
Volume: 55
Issue: 11
Pages: 2895-2905
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-012-2677-z
OpenAlex: W2141398296
Semantic Scholar: 844e192c1ec7573f36b0c3299ff56059c77ca737
Cited by: 1,789
References: 61
Citations by year: 2026: 55 · 2025: 82 · 2024: 75 · 2023: 112 · 2022: 146 · 2021: 153 · 2020: 165 · 2019: 169 · 2018: 165 · 2017: 186 · 2016: 155 · 2015: 163 · 2014: 96 · 2013: 63
FWCI: 11.23
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
Stirling Online Research Repository (University of Stirling) (submittedVersion)
Victoria University Research Repository (Victoria University) (submittedVersion)
Leicester Research Archive (University of Leicester) (submittedVersion)
Funders: National Institute for Health and Care Research (RP-DG-1210-10183, RP-PG-0606-1272)
Topics: Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Keywords: sedentary behavior, sitting time, diabetes mellitus, cardiovascular disease, cardiovascular mortality, all-cause mortality, health risks
MeSH terms: Adult, Cardiovascular Diseases, Diabetes Mellitus, Humans, Risk Factors, Sedentary Behavior

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Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis

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