Transiently antigen primed B cells can generate multiple subsets of memory cells
Open accessAbstract
Memory B cells are long-lived cells that generate a more vigorous response upon recognition of antigen (Ag) and T cell help than naïve B cells and ensure maintenance of durable humoral immunity. Functionally distinct subsets of murine memory B cells have been identified based on isotype switching of BCRs and surface expression of the co-stimulatory molecule CD80 and co-inhibitory molecule PD-L2. Memory B cells in a subpopulation with low surface expression of CD80 and PD-L2 are predominantly non-isotype switched and can be efficiently recruited into germinal centers (GCs) in secondary responses. In contrast, a CD80 and PD-L2 positive subset arises predominantly from GCs and can quickly differentiate into antibody-secreting plasma cells (PCs). Here we demonstrate that single transient acquisition of Ag by B cells may be sufficient for their long-term participation in GC responses and for development of various memory B cell subsets including CD80 and PD-L2 positive effector-like memory cells that rapidly differentiate into class-switched PCs during recall responses.
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Germinal centre responses induced by more robust adjuvants such as sheep red blood cells, complete Freund's adjuvant or saponin-based adjuvants tend to peak at 2-4 weeks after vaccination and can persist at low frequencies for several months.
“Germinal centre responses induced by immunization with more robust adjuvants such as sheep red blood cells, complete Freund’s adjuvant or saponin-based adjuvants tend to peak slightly later, at 2–4 weeks after vaccination, and can persist at low frequencies for several months27–33.”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [31]
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B cell receptor crosslinking can augment T cell help-mediated germinal center B cell selectionPreprint
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- Authors
- Turner, J. S., Benet, Z. L., & Grigorova, I.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Grigorova, Irina
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-08-29
- Volume
- 12
- Issue
- 8
- Pages
- e0183877
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5574538
- OpenAlex
- W2752162868
- Cited by
- 10
- References
- 21
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health (R01 AI106806)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- memory B cells, CD80, PD-L2, germinal center, class switch recombination, plasma cell differentiation, humoral immunity, secondary immune response, B cell subsets
- MeSH terms
- Animals, B-Lymphocytes, Cell Differentiation, Immunologic Memory, Male, Plasma Cells, B-Lymphocyte Subsets, Immunoglobulin Class Switching, B7-1 Antigen, Germinal Center, Mice, Programmed Cell Death 1 Ligand 2 Protein
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