Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response
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A cell enrichment technique reveals the dynamics of the endogenous memory B cell response.
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Antigen-specific germinal centre B cells have been found to persist for at least one year, albeit at very low levels.
“antigen-specific germinal centre B cells have been found to persist for at least one year, albeit at very low levels28,30.”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [30]
Germinal centre responses induced by more robust adjuvants such as sheep red blood cells, complete Freund's adjuvant or saponin-based adjuvants tend to peak at 2-4 weeks after vaccination and can persist at low frequencies for several months.
“Germinal centre responses induced by immunization with more robust adjuvants such as sheep red blood cells, complete Freund’s adjuvant or saponin-based adjuvants tend to peak slightly later, at 2–4 weeks after vaccination, and can persist at low frequencies for several months27–33.”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [30]
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Cites
Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00078-7 · Cited by 3,475 · see citing works
Goodnow, C. C., Crosbie, J. C., Adelstein, S., Lavoie, T., Smith‐Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., Raphael, K., et al. (1988) · Nature · doi:10.1038/334676a0 · Cited by 1,568 · see citing works
Duration of Humoral Immunity to Common Viral and Vaccine Antigens
Amanna, I. J., Carlson, N. E., & Slifka, M. K. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066092 · Cited by 1,286 · see citing works
Martin, F., Oliver, A. M., & Kearney, J. F. (2001) · Immunity · doi:10.1016/s1074-7613(01)00129-7 · Cited by 987 · see citing works
Antigen-specific memory B cell development.
McHeyzer-Williams, L. J., & McHeyzer-Williams, M. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115732 · Cited by 771 · see citing works
Multiple layers of B cell memory with different effector functions
Dogan, I., Bertocci, B., Vilmont, V., Delbos, F., Mégret, J., Storck, S., Reynaud, C.-A., & Weill, J.-C. (2009) · Nature Immunology · doi:10.1038/ni.1814 · Cited by 635 · see citing works
Seshasayee, D., Valdez, P. A., Yan, M., et al. (2003) · Immunity · doi:10.1016/s1074-7613(03)00025-6 · Cited by 400 · see citing works
Maintenance of B-cell memory by long-lived cells generated from proliferating precursors
Schittek, B., & Rajewsky, K. (1990) · Nature · doi:10.1038/346749a0 · Cited by 322 · see citing works
Sensitization and Antibody Formation after Injection of Tubercle Bacilli and Paraffin Oil.
Freund, J., Casals, J., & Hosmer, E. P. (1937) · Experimental Biology and Medicine · doi:10.3181/00379727-37-9625 · Cited by 311 · see citing works
Memory B and memory plasma cells
Yoshida, T., Mei, H. E., Dörner, T., Hiepe, F., Radbruch, A., Fillatreau, S., & Hoyer, B. F. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00938.x · Cited by 288 · see citing works
New markers for murine memory B cells that define mutated and unmutated subsets
Anderson, S. M., Tomayko, M. M., Ahuja, A., Haberman, A. M., & Shlomchik, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062571 · Cited by 258 · see citing works
Human IgM+CD27+ B Cells: Memory B Cells or “Memory” B Cells?
Tangye, S. G., & Good‐Jacobson, K. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.13 · Cited by 246 · see citing works
Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets
Tomayko, M. M., Steinel, N. C., Anderson, S. M., & Shlomchik, M. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002163 · Cited by 244 · see citing works
Todd, D. J., McHeyzer-Williams, L. J., Kowal, C., Lee, A.-H., Volpe, B. T., Diamond, B., McHeyzer-Williams, M. G., & Glimcher, L. H. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20090738 · Cited by 233 · see citing works
Goodnow, C. C., Crosbie, J., Adelstein, S., Lavoie, T., Smith‐Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., Raphael, K., et al. (2009) · PubMed · Cited by 221 · see citing works
Maul, R. W., & Gearhart, P. J. (2010) · Advances in immunology · doi:10.1016/s0065-2776(10)05006-6 · Cited by 206 · see citing works
Self-citationRavetch, J. V. (1997) · Current Opinion in Immunology · doi:10.1016/s0952-7915(97)80168-9 · Cited by 196 · see citing works
Kinetics of Establishing the Memory B Cell Population as Revealed by CD38 Expression
Ridderstad, A., & Tarlinton, D. M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.4688 · Cited by 147 · see citing works
B-cell memory: are subsets necessary?
Tarlinton, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1938 · Cited by 141 · see citing works
Isolation of high-affinity memory B cells: phycoerythrin as a probe for antigen-binding cells.
Hayakawa, K., Ishii, R., Yamasaki, K., Kishimoto, T., & Hardy, R. R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1379 · Cited by 129 · see citing works
Hasham, M. G., Donghia, N. M., Coffey, E. L., Maynard, J. A., Snow, K. J., Ames, J. J., Wilpan, R. Y., He, Y., King, B. L., & Mills, K. D. (2010) · Nature Immunology · doi:10.1038/ni.1909 · Cited by 99 · see citing works
Tarlinton, D. M. (2008) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100148 · Cited by 95 · see citing works
Crystal Structure of Allophycocyanin from Red AlgaePorphyra yezoensis at 2.2-Å Resolution
Liu, J., Jiang, T., Zhang, J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.16945 · Cited by 82 · see citing works
Identification of an antigen-specific B cell population
Newman, J., Rice, J. S., Wang, C., Harris, S. L., & Diamond, B. (2003) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00499-4 · Cited by 73 · see citing works
Antigen-capturing Cells Can Masquerade as Memory B Cells
Bell, J., & Gray, D. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20020270 · Cited by 61 · see citing works
Intraclonal Competition Inhibits the Formation of High-Affinity Antibody-Secreting Cells
Le, T.-V. L., Kim, T. H., & Chaplin, D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6027 · Cited by 31 · see citing works
Travelling with the BAFF/BLyS family: Are we there yet?
Mackay, F., & Cancro, M. P. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.07.003 · Cited by 21 · see citing works
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Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878 · see citing works
SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses
Turner, J. S., O’Halloran, J. A., Kalaidina, E., Kim, W., Schmitz, A. J., Zhou, J. Q., Lei, T., Thapa, M., Chen, R. E., Case, J. B., et al. (2021) · Nature · doi:10.1038/s41586-021-03738-2 · Cited by 831 · see citing works
B cell memory: building two walls of protection against pathogens
Akkaya, M., Kwak, K., & Pierce, S. K. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0244-2 · Cited by 626 · see citing works
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells
Weisel, F. J., Zuccarino-Catania, G. V., Chikina, M., & Shlomchik, M. J. (2016) · Immunity · doi:10.1016/j.immuni.2015.12.004 · Cited by 524 · see citing works
Molecular programming of B cell memory
McHeyzer-Williams, M., Okitsu, S., Wang, N., & McHeyzer-Williams, L. (2012) · Nature Reviews Immunology · doi:10.1038/nri3128 · Cited by 449 · see citing works
Human germinal centres engage memory and naive B cells after influenza vaccination
Turner, J. S., Zhou, J. Q., Han, J., Schmitz, A. J., Rizk, A. A., Alsoussi, W. B., Lei, T., Amor, M., McIntire, K. M., Meade, P., et al. (2020) · Nature · doi:10.1038/s41586-020-2711-0 · Cited by 304 · see citing works
Kaji, T., Ishige, A., Hikida, M., Taka, J., Hijikata, A., Kubo, M., Nagashima, T., Takahashi, Y., Kurosaki, T., Okada, M., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120127 · Cited by 263 · see citing works
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
Goel, R. R., Painter, M. M., Lundgreen, K. A., Apostolidis, S. A., Baxter, A. E., Giles, J. R., Mathew, D., Pattekar, A., Reynaldi, A., Khoury, D. S., et al. (2022) · Cell · doi:10.1016/j.cell.2022.04.009 · Cited by 207 · see citing works
Generation of memory B cells and their reactivation
Inoue, T., Moran, I., Shinnakasu, R., Phan, T. G., & Kurosaki, T. (2018) · Immunological Reviews · doi:10.1111/imr.12640 · Cited by 181 · see citing works
Apoptosis and antigen affinity limit effector cell differentiation of a single naïve B cell
Taylor, J. J., Pape, K. A., Steach, H. R., & Jenkins, M. K. (2015) · Science · doi:10.1126/science.aaa1342 · Cited by 161 · see citing works
Self-citationAntibody Responses to SARS-CoV-2: Let’s Stick to Known Knowns
Baumgarth, N., Nikolich-Žugich, J., Lee, F. E.-H., & Bhattacharya, D. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000839 · Cited by 84 · see citing works
Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ
Good-Jacobson, K. L., Chen, Y., Voss, A. K., Smyth, G. K., Thomas, T., & Tarlinton, D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402485111 · Cited by 64 · see citing works
Anti- SARS-CoV-2 Receptor Binding Domain Antibody Evolution after mRNA Vaccination
Cho, A., Muecksch, F., Schaefer-Babajew, D., Wang, Z., Finkin, S., Gaebler, C., Ramos, V., Cipolla, M., Mendoza, P., Agudelo, M., et al. (2021) · doi:10.1101/2021.07.29.454333 · Cited by 275 · see citing works
Transiently antigen primed B cells can generate multiple subsets of memory cells
Turner, J. S., Benet, Z. L., & Grigorova, I. (2017) · PLOS ONE · doi:10.1371/journal.pone.0183877 · Cited by 10 · see citing works
- Authors
- Pape, K. A., Taylor, J. J., Maul, R. W., Gearhart, P. J., & Jenkins, M. K.
- Affiliations
- University of Minnesota (US)
- National Institutes of Health (US)
- Corresponding author
- Jenkins, Marc K.
- Venue
- Science
- Published
- 2011-03-04
- Volume
- 331
- Issue
- 6021
- Pages
- 1203-1207
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3993090
- OpenAlex
- W2079574749
- Cited by
- 572
- References
- 27
- Citations by year
- 2026: 24 · 2025: 29 · 2024: 39 · 2023: 29 · 2022: 45 · 2021: 48 · 2020: 43 · 2019: 46 · 2018: 41 · 2017: 45 · 2016: 42 · 2015: 40 · 2014: 39 · 2013: 22 · 2012: 28
- FWCI
- 14.18
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 AI036914, R37 AI027998, F32 AI091033, T32 CA009138)
- National Institute on Aging
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- memory B cells, class switch recombination, immunoglobulin M, secondary immune response, serum immunoglobulins, antigen-specific B cells, B cell activation
- MeSH terms
- Animals, Antigens, Cell Survival, Female, Immunoglobulin M, Immunization, Immunologic Memory, Lymph Nodes, Lymphocyte Activation, Male, Mice, Inbred C57BL, Mutation, Phycocyanin, Phycoerythrin, Spleen, B-Lymphocyte Subsets, Immunoglobulin Class Switching, Germinal Center, Mice, ADP-ribosyl Cyclase 1
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