Multiple layers of B cell memory with different effector functions

Dogan, Ismail; Bertocci, Barbara; Vilmont, Valérie; Delbos, Frédéric; Mégret, Jérome; Storck, Sébastien; Reynaud, Claude-Agnès; Weill, Jean-Claude

doi:10.1038/ni.1814

Cited by 635T-cell and B-cell ImmunologyImmune responses and vaccinationsImmunotherapy and Immune Responses

Multiple layers of B cell memory with different effector functions

Dogan, Ismail, Bertocci, Barbara, Vilmont, Valérie, Delbos, Frédéric, Mégret, Jérome, Storck, Sébastien, Reynaud, Claude-Agnès, Weill, Jean-Claude·2009·Nature Immunology

DOI 10.1038/ni.1814

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Abstract

Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on the cytidine deaminase AID, we show that after immunization with a particulate antigen, B cell memory appeared in several subsets, comprising clusters of immunoglobulin M-positive (IgM(+)) and IgG1(+) B cells in germinal center-like structures that persisted up to 8 months after immunization, as well as IgM(+) and IgG1(+) B cells with a memory phenotype outside of B cell follicles. After challenge, the IgG subset differentiated into plasmocytes, whereas the IgM subset reinitiated a germinal center reaction. This model, in which B cell memory appears in several layers with different functions, reconciles previous conflicting propositions.

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Germinal centre responses induced by more robust adjuvants such as sheep red blood cells, complete Freund's adjuvant or saponin-based adjuvants tend to peak at 2-4 weeks after vaccination and can persist at low frequencies for several months.
“Germinal centre responses induced by immunization with more robust adjuvants such as sheep red blood cells, complete Freund’s adjuvant or saponin-based adjuvants tend to peak slightly later, at 2–4 weeks after vaccination, and can persist at low frequencies for several months27–33.”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [28]
Antigen-specific germinal centre B cells have been found to persist for at least one year, albeit at very low levels.
“antigen-specific germinal centre B cells have been found to persist for at least one year, albeit at very low levels28,30.”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [28]

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Authors: Dogan, I., Bertocci, B., Vilmont, V., Delbos, F., Mégret, J., Storck, S., Reynaud, C.-A., & Weill, J.-C.
Affiliations: Hôpital Necker-Enfants Malades (FR)
Corresponding author: Reynaud, Claude-Agnès
Weill, Jean-Claude
ORCID: Bertocci, Barbara
Storck, Sébastien
Reynaud, Claude-Agnès
Weill, Jean-Claude
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-10-25
Volume: 10
Issue: 12
Pages: 1292-1299
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.1814
OpenAlex: W2053095572
Cited by: 635
References: 45
Citations by year: 2026: 22 · 2025: 22 · 2024: 37 · 2023: 32 · 2022: 27 · 2021: 45 · 2020: 53 · 2019: 44 · 2018: 48 · 2017: 49 · 2016: 37 · 2015: 51 · 2014: 35 · 2013: 35 · 2012: 40
FWCI: 14.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: memory B cells, IgM memory B cells, germinal center, cytidine deaminase, secondary immune response, B cell follicles
MeSH terms: Animals, B-Lymphocytes, Cell Differentiation, Cytidine Deaminase, Immunoglobulin G, Immunoglobulin M, Immunologic Memory, Mutation, Phenotype, Germinal Center, Models, Animal, Mice

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Multiple layers of B cell memory with different effector functions

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