Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism
Open accessAbstract
Medium Chain Triglycerides (MCT) is a dietary supplement and usually used along with medications for treating food absorption disorders including diarrhea, steatorrhea and liver disease. It has been shown that MCT plays a role in lowering weight, and decreasing metabolic syndrome, abdominal obesity and inflammation. However, it is still unknown whether MCT enhances exercise endurance. Here, we demonstrated that MCT containing diet improves high temperature induced exercise performance impairment. We found that MCT up-regulates the expression and protein levels of genes involved in mitochondrial biogenesis and metabolism. Further investigation demonstrated that the increased mitochondrial biogenesis and metabolism is mediated through the activation of Akt and AMPK signaling pathways and inhibition of TGF-β signaling pathway. Collectively, our findings indicate a beneficial effect of dietary MCT in exercise performance through the increase of mitochondrial biogenesis and metabolism.
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Animal models indicate a potential mechanistic benefit for MCT inclusion to enhance mitochondrial biogenesis through Akt and AMPK signalling, thereby enhancing endurance performance.
“Animal models indicate a potential mechanistic benefit for the inclusion of MCTs to enhance mitochondrial biogenesis through both Akt and AMPK signalling, thereby enhancing endurance performance [161].”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [161]
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Cites
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770 · see citing works
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
Scarpulla, R. C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.019 · Cited by 1,281 · see citing works
Derynck, R., Goeddel, D. V., Ullrich, A., Gutterman, J. U., Williams, R. D., Bringman, T. S., & Berger, W. H. (1987) · PubMed · Cited by 890 · see citing works
Targeting the TGFβ pathway for cancer therapy
Neuzillet, C., Tijeras‐Raballand, A., Cohen, R., Cros, J. F., Faivre, S. J., Raymond, É., & Gramont, A. D. E. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.11.001 · Cited by 610 · see citing works
Medium chain fatty acid metabolism and energy expenditure: obesity treatment implications.
Papamandjaris, A. A., Macdougall, D., & Jones, P. (1998) · Life Science · doi:10.1016/s0024-3205(97)01143-0 · Cited by 387 · see citing works
Mitochondrial Reactive Oxygen Species Regulate Transforming Growth Factor-β Signaling
Jain, M., Rivera, S., Monclus, E. A., Synenki, L., Zirk, A., Eisenbart, J. D., Feghali‐Bostwick, C. A., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.431973 · Cited by 385 · see citing works
Beyond TGFβ: roles of other TGFβ superfamily members in cancer
Wakefield, L. M., & Hill, C. S. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3500 · Cited by 373 · see citing works
Physiological Effects of Medium-Chain Triglycerides: Potential Agents in the Prevention of Obesity
St‐Onge, M., & Jones, P. J. H. (2002) · Journal of Nutrition · doi:10.1093/jn/132.3.329 · Cited by 369 · see citing works
The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis
Neel, J.-C., Humbert, L., & Lebrun, J. J. (2012) · ISRN Molecular Biology · doi:10.5402/2012/381428 · Cited by 353 · see citing works
Regulation of mitochondrial biogenesis through TFAM–mitochondrial DNA interactions
Picca, A., & Lezza, A. M. S. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.10.001 · Cited by 285 · see citing works
Regulation of Mitochondrial Biogenesis in Muscle by Endurance Exercise
Irrcher, I., Adhihetty, P. J., Joseph, A.-M., Ljubicic, V., & Hood, D. A. (2003) · Sports Medicine · doi:10.2165/00007256-200333110-00001 · Cited by 210 · see citing works
Dickson, R. B., Kasid, A., Huff, K. K., Bates, S. E., Knabbe, C., Bronzert, D. A., Gelmann, E. P., & Lippman, M. E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.3.837 · Cited by 194 · see citing works
Yoon, Y., Lee, J., Hwang, S. C., Choi, K. S., & Yoon, G. (2005) · Oncogene · doi:10.1038/sj.onc.1208262 · Cited by 194 · see citing works
Baba, N., Bracco, E., & Hashim, S. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/35.4.678 · Cited by 171 · see citing works
Mumme, K., & Stonehouse, W. (2015) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2014.10.022 · Cited by 170 · see citing works
Scarpulla, R. C. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.10.011 · Cited by 163 · see citing works
Fat metabolism during high-intensity exercise in endurance-trained and untrained men
Coggan, A. R., Raguso, C. A., Gastaldelli, A., Sidossis, L. S., & Yeckel, C. W. (2000) · Metabolism · doi:10.1016/s0026-0495(00)90963-6 · Cited by 121 · see citing works
St‐Onge, M., & Jones, P. J. H. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802467 · Cited by 118 · see citing works
Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle
Montgomery, M. K., Osborne, B., Brown, S. H. J., Small, L., Mitchell, T. W., Cooney, G. J., & Turner, N. A. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m040451 · Cited by 112 · see citing works
Influence of medium-chain and long-chain triacylglycerols on the control of food intake in men.
Wymelbeke, V. V., Himaya, A., Louis-Sylvestre, J., & Fantino, M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.226 · Cited by 111 · see citing works
Transforming Growth Factor-β, Bioenergetics, and Mitochondria in Renal Disease
Casalena, G., Daehn, I. S., & Böttinger, E. P. (2012) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2012.04.009 · Cited by 101 · see citing works
Han, J., Deng, B., Sun, J., Chen, C. G., Corkey, B. E., Kirkland, J. L., Ma, J., & Guo, W. (2007) · Metabolism · doi:10.1016/j.metabol.2007.03.005 · Cited by 100 · see citing works
Nebeling, L. C., & Lerner, E. (1995) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(95)00189-1 · Cited by 89 · see citing works
Weight gain of rats fed medium-chain triglycerides is less than rats fed long-chain triglycerides.
Bray, G. A., Lee, M., & Bray, T. L. (1980) · PubMed · Cited by 88 · see citing works
St‐Onge, M., Mayrsohn, B., O'Keeffe, M. M., Kissileff, H. R., Choudhury, A. R., & Laferrère, B. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.145 · Cited by 82 · see citing works
Clegg, M. (2010) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637481003702114 · Cited by 71 · see citing works
Sayeed, A., Meng, Z., Luciani, G., Chen, L., Bennington, J. L., & Dairkee, S. H. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.30 · Cited by 65 · see citing works
Abe, S., Ezaki, O., & Suzuki, M. (2016) · Journal of Nutrition · doi:10.3945/jn.115.228965 · Cited by 64 · see citing works
Costa, A. C. R., Rosado, E. L., & Soares-Mota, M. (2012) · PubMed · doi:10.1590/s0212-16112012000100011 · Cited by 61 · see citing works
Clegg, M., Golsorkhi, M., & Henry, C. J. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0463-9 · Cited by 51 · see citing works
Stimulation of thermogenesis and brown fat activity in rats fed medium chain triglyceride
Rothwell, N. J., & Stock, M. J. (1987) · Metabolism · doi:10.1016/0026-0495(87)90005-9 · Cited by 46 · see citing works
Goedecke, J. H., Elmer, R., Dennis, S. C., Schloss, I., Noakes, T. D., & Lambert, E. V. (1999) · International Journal of Sport Nutrition · doi:10.1123/ijsn.9.1.35 · Cited by 45 · see citing works
TGF-β suppresses the expression of genes related to mitochondrial function in lung A549 cells.
Sohn, E. J., Kim, J., Hwang, Y., Im, S., Moon, Y., & Kang, D. M. (2012) · PubMed · Cited by 24 · see citing works
Ismael, S., Subhadra, L., Konnottil, R., & Nair, R. R. (2016) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2016.08.001 · Cited by 22 · see citing works
Hot environments decrease exercise capacity and elevate multiple neurotransmitters
Zhao, J., Lai, L., Cheung, S. S., Cui, S., An, N., Feng, W., & Lorenzo, S. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.09.001 · Cited by 21 · see citing works
Flagged first, then by citations
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Machate, D. J., Figueiredo, P. S., Marcelino, G., Guimarães, R. D. C. A., Hiane, P. A., Bogo, D., Pinheiro, V. A. Z., Oliveira, L. C. S. D., & Pott, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114093 · Cited by 243 · see citing works
Tiller, N. B., Roberts, J. D., Beasley, L., Chapman, S., Pinto, J. M., Smith, L., Wiffin, M., Russell, M., Sparks, S. A., Duckworth, L., et al. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0312-9 · Cited by 164 · see citing works
Narayanankutty, A., Illam, S. P., & Raghavamenon, A. C. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.07.025 · Cited by 119 · see citing works
The Ketogenic Diet and Cardiovascular Diseases
Dyńka, D., Kowalcze, K., Charuta, A., & Paziewska, A. (2023) · Nutrients · doi:10.3390/nu15153368 · Cited by 113 · see citing works
Xu, X., Ji, H., Yu, H., & Zhou, J. (2020) · Aquaculture Nutrition · doi:10.1111/anu.13005 · Cited by 95 · see citing works
Applications of Medium-Chain Triglycerides in Foods
Watanabe, S., & Tsujino, S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.802805 · Cited by 102 · see citing works
Wazir, H., Chay, S. Y., Zarei, M., Hussin, F. S., Mustapha, N. A., Ibadullah, W. Z. W., & Saari, N. (2019) · Antioxidants · doi:10.3390/antiox8100486 · Cited by 87 · see citing works
Kou, G., Li, Z., Wu, C., Liu, Y., Hu, Y., Guo, L., Xu, X., & Zhou, Z. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b04124 · Cited by 78 · see citing works
Self-citationSaraswathi, V., Kumar, N., Gopal, T., Bhatt, S., Ai, W., Ma, C., Talmon, G. A., & Desouza, C. V. (2020) · Biology · doi:10.3390/biology9110346 · Cited by 70 · see citing works
Zeng, Y., He, J., Hu, B.-Y., Li, W., Deng, J., Lin, Q., & Fang, Y. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2113361 · Cited by 68 · see citing works
Pham, T. H., Vidal, N. P., Manful, C. F., Fillier, T. A., Pumphrey, R. P., Doody, K. M., & Thomas, R. (2019) · Molecules · doi:10.3390/molecules24020232 · Cited by 56 · see citing works
Rial, S. A., Jutras-Carignan, A., Bergeron, K., & Mounier, C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158582 · Cited by 57 · see citing works
Xia, J., Yu, P., Zeng, Z., Ma, M., Zhang, G., Wan, D., Gong, D., Deng, S., & Wang, J. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c07342 · Cited by 53 · see citing works
Wang, C., Zhang, C., Yu, H., Zan, Z., Li, J., Li, P., Zhang, X., Ji, H., & Gao, Q. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738616 · Cited by 35 · see citing works
Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice
Guimarães, J., Bargut, T. C. L., Mandarim‐de‐Lacerda, C. A., & Águila, M. B. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.11.005 · Cited by 26 · see citing works
Charlot, A., Morel, L., Bringolf, A., Georg, I., Charles, A., Goupilleau, F., Gény, B., & Zoll, J. (2022) · Nutrients · doi:10.3390/nu14132721 · Cited by 24 · see citing works
Shameena Beegum, P. P., Pandiselvam, R., Ramesh, S. V., Thube, S. H., Pandian, T. P., Khanashyam, A. C., Manikantan, M. R., & Hebbar, K. B. (2022) · Quality Assurance and Safety of Crops & Foods · doi:10.15586/qas.v14i2.1040 · Cited by 26 · see citing works
Dietary fatty acids activate or deactivate brown and beige fat
Jia, M., Xu, T., Xu, Y., & Liu, Y. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121978 · Cited by 20 · see citing works
Nutrition and Exercise in a Case of Carnitine Palmitoyl-Transferase II Deficiency
Parimbelli, M., Pezzotti, E., Negro, M., Calanni, L., Allemano, S., Bernardi, M., Berardinelli, A. L., & D’Antona, G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.637406 · Cited by 15 · see citing works
Inselberg, H., & Nunes, M. C. D. N. (2020) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2020.111416 · Cited by 15 · see citing works
Tsujino, S., Nosaka, N., Sadamitsu, S., & Kato, K. (2022) · Nutrients · doi:10.3390/nu14030536 · Cited by 12 · see citing works
Wosnick, N., Chaves, A. P., Dias, H. N., Nunes, A. R. O. P., Nunes, J. L. S., & Hauser‐Davis, R. A. (2023) · Frontiers in Marine Science · doi:10.3389/fmars.2023.1116470 · Cited by 10 · see citing works
Dong, Y., Ren, C., Tang, H., Yan, J., Zhang, Y., Fan, L., Kou, G., & Cui, Z. N. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105260 · Cited by 9 · see citing works
Włodarek, D. (2021) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000752 · Cited by 9 · see citing works
Fats in Human Milk: 2022 Updates on Chemical Composition
Maheshwari, A. (2022) · Newborn · doi:10.5005/jp-journals-11002-0050 · Cited by 9 · see citing works
Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy
Moresi, V., Renzini, A., Cavioli, G., Seelaender, M. C. L., Coletti, D., Gigli, G., & Cedola, A. (2022) · Metabolites · doi:10.3390/metabo12111149 · Cited by 9 · see citing works
Jia, M., Yue, H., Wang, X., Zong, A., Xu, T., Xu, Y., & Liu, Y. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109914 · Cited by 8 · see citing works
Pain, E., Snowden, S. G., Oddy, J., Shinhmar, S., Alhammad, Y. M. A., King, J., Müller‐Taubenberger, A., & Williams, R. S. B. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2321874121 · Cited by 8 · see citing works
Tjahjono, Y., Foe, K., Wilianto, Y. R., Khudrati, W. C., Esar, S. Y., Jafet, N., Kusuma, I. M. A. B., Ade, L., Novita, B. D., Wihadmadyatami, H., et al. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106367 · Cited by 7 · see citing works
Coconut Oil and its Constituents as a Treatment for Alzheimer's Dementia
Guttmann, R. P., Sims, P., Churchill, C. L., Waters, C., Berry, B., & Wells, J. (2020) · Journal of Student Research · doi:10.47611/jsr.v9i1.1046 · Cited by 6 · see citing works
Hyman, M. A., & Bradley, E. (2022) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2022.04.002 · Cited by 7 · see citing works
Effect of aerobic exercise and supplementation virgin coconut oil on lipid profile
Sinaga, F. A., Samosir, A. H., Sinaga, R. N., Ayu, E. W. I., Manalu, N., Ginting, A. A., Zulaini, & Zulfachry (2021) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1811/1/012128 · Cited by 6 · see citing works
Mukubwa, G. K., Safari, J. B., Tetana, Z. N., Jones, C. N., Walker, R. B., & Krause, R. W. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-26390-6 · Cited by 6 · see citing works
Manful, C. F., Pham, T. H., Wheeler, E., Nadeem, M., Adigun, O. A., Walsh, N., & Thomas, R. (2022) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.3406 · Cited by 5 · see citing works
Wichai, U., Keawsomnuk, P., Thongin, S., Mukthung, C., Boonthip, C., Pittayakhajonwut, P., Ketsawatsomkron, P., Bunyapraphatsara, N., & Muta, K. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-03844-w · Cited by 5 · see citing works
Nakatsuka, K., Zanghi, B. M., & Hasegawa, D. (2023) · BMC Veterinary Research · doi:10.1186/s12917-023-03710-4 · Cited by 4 · see citing works
Yoshimura, Y., Nagano, F., Matsumoto, A., Shimazu, S., Shiraishi, A., Kido, Y., Bise, T., Hamada, T., & Yoneda, K. (2025) · Nutrients · doi:10.3390/nu17091599 · Cited by 4 · see citing works
Maiti, R., Mohanty, R. R., Dey, A., Maji, S., Padhan, M., & Mishra, A. (2023) · Journal of the American Nutrition Association · doi:10.1080/27697061.2023.2256816 · Cited by 4 · see citing works
Combating insulin resistance with the paleo diet
Olivieri, C. (2019) · The Nurse Practitioner · doi:10.1097/01.npr.0000552683.55684.f8 · Cited by 3 · see citing works
The effects of a unique medium chain triglyceride complex on migraine symptoms: A beta pilot study
Wolkodoff, N. E., Haase, G. M., & Firger, R. A. (2020) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2020.8.3.0479 · Cited by 3 · see citing works
Siri, M., Hosseini, E. M., Mazhari, S. A., Jalali, P., Soltaninejad, K., Raji, M. A., Yazdekhasti, N., Naseri, E., Mohammadi, A., & Maleki, M. H. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-01067-z · Cited by 2 · see citing works
Expanding endurance exercise physiology research: insights from animal migration
Parry, H. A., Yap, K. N., Mesquita, P. H. C., & Hood, W. R. (2026) · Journal of Experimental Biology · doi:10.1242/jeb.251152 · Cited by 2 · see citing works
Medium-Chain Triglycerides and Health
Volpe, S. L. (2019) · ACSMʼs Health & Fitness Journal · doi:10.1249/fit.0000000000000537 · Cited by 2 · see citing works
Intérêt du régime cétogène dans la prise en charge de la maladie d’Alzheimer
Charlot, A., Lernould, A., Plus, I., & Zoll, J. (2023) · Biologie Aujourd hui · doi:10.1051/jbio/2023031 · Cited by 2 · see citing works
Mutoh, T., Kataoka, H., Tatewaki, Y., & Taki, Y. (2025) · Nutrients · doi:10.3390/nu17101707 · Cited by 2 · see citing works
Korosteleva, M. M., Kobelkova, I. V., & Khanferyan, R. A. (2020) · Sports medicine research and practice · doi:10.47529/2223-2524.2020.3.18 · Cited by 2 · see citing works
Chen, M., Ling, C., Chen, Y., Wang, H.-P., Qin, Y., Xu, J.-Y., Chen, G.-C., Shi, B.-M., Qin, L.-Q., & Yang, J. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106114 · Cited by 2 · see citing works
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Wajs, J., & Brodziak, A. (2022) · Zywnosc-nauka Technologia Jakosc · doi:10.15193/zntj/2022/130/406 · Cited by 1 · see citing works
Pediatric Oral Systemic Health: From Fetus to Adolescence
Cannon, M. L. (2019) · Interventions in Pediatric Dentistry Open Access Journal · doi:10.32474/ipdoaj.2019.03.000158 · Cited by 1 · see citing works
Wolkodoff, N. E., Haase, G. M., & Kapteyn, R. W. (2022) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2022.13.1.0067 · Cited by 1 · see citing works
Dewi, N. P., Alaydrus, S., Nadila, N., Magfirah, M., Tandi, J., Anggi, V., & Polontalo, N. A. (2024) · Pharmaciana · doi:10.12928/pharmaciana.v14i1.27489 · Cited by 1 · see citing works
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Sari, N. P. W. P., & Artsanthia, J. (2019) · International Journal of Public Health Science (IJPHS) · doi:10.11591/ijphs.v8i4.20371 · Cited by 1 · see citing works
Sonnenburg, R. (2018) · UWSpace (University of Waterloo) · Cited by 1 · see citing works
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Moseley, M. C., Rawls, A., Sponsel, V. M., Berger, M. S., Abate, A. R., & Lin, C. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.01.466812
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Poff, A. M., Kesl, S., Koutnik, A. P., Moss, S. E., Rogers, C. Q., & D’Agostino, D. P. (2022) · doi:10.1093/med/9780197501207.003.0033
Noronha, C. M., Freitas, F. M. N. D. O., & Ferreira, J. C. D. S. (2022) · Research Society and Development · doi:10.33448/rsd-v11i5.28837
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Purnomo, H. D., Kusuma, R. A., Sianturi, E., Haroen, R. F., Solichin, M. R., Nissa, C., Pramono, A., Mahati, E., & Noer, E. R. (2023) · Journal of Nutrition and Metabolism · doi:10.1155/2023/2313503
Nakatsuka, K., Zanghi, B. M., & Hasegawa, D. (2023) · Figshare · doi:10.6084/m9.figshare.24098383
Wang, C., Qi, J.-Y., Li, H., Yokoi, K., Yanagimoto, K., Wang, X., Hou, S., & Fang, Z. (2025) · Research Square · doi:10.21203/rs.3.rs-7277115/v1
Nakatsuka, K., Zanghi, B. M., & Hasegawa, D. (2023) · Figshare · doi:10.6084/m9.figshare.24098386
Wichai, U., Keawsomnuk, P., Thongin, S., Mukthung, C., Boonthip, C., Pittayakhajonwut, P., Ketsawatsomkron, P., Bunyapraphatsara, N., & Muta, K. (2023) · Figshare · doi:10.6084/m9.figshare.22605848
Lipoeto, N. I., Sari, N. V., Febri, D. S., & Mirnawati, M. (2026) · Precision Nutrition · doi:10.1097/pn9.0000000000000139
- Authors
- Wang, Y., Liu, Z., Han, Y., Xu, J., Huang, W., & Li, Z.
- Affiliations
- Second Military Medical University (CN)
- Corresponding author
- Huang, Wen
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-02-08
- Volume
- 13
- Issue
- 2
- Pages
- e0191182
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5805166
- OpenAlex
- W2789789702
- Cited by
- 62
- References
- 35
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 14 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 4
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- medium-chain triglycerides, exercise endurance, mitochondrial biogenesis, mitochondrial metabolism, Akt signaling, AMPK signaling, TGF-beta signaling, dietary supplementation, heat stress
- MeSH terms
- Adenylate Kinase, Animals, Male, Mice, Inbred ICR, Mitochondria, Physical Conditioning, Animal, Physical Endurance, Triglycerides, Down-Regulation, Transforming Growth Factor beta, Proto-Oncogene Proteins c-akt, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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