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Choosing an appropriate probiotic product for your patient: An evidence-based practical guide
Open accessAbstract
INTRODUCTION: Clinicians and patients face a daunting task when choosing the most appropriate probiotic for their specific needs. Available preparations encompass a diverse and continuously expanding product base, with most available products lacking evidence-based trials that support their use. Even when evidence exists, not all probiotic products are equally effective for all disease prevention or treatment indications. At this point in time, drug regulatory agencies offer limited assistance with regard to guidance and oversight in most countries, including the U.S. METHODS: We reviewed the current medical literature and sources on the internet to survey the types of available probiotic products and to determine which probiotics had evidence-based efficacy data. Standard medical databases from inception to June 2018 were searched and discussions with experts in the field were conducted. We graded the strength of the evidence for probiotics having multiple, randomized controlled trials and developed a guide for the practical selection of current probiotic products for specific uses. RESULTS: We found the efficacy of probiotic products is both strain-specific and disease-specific. Important factors involved in choosing the appropriate probiotic include matching the strain(s) with the targeted disease or condition, type of formulation, dose used and the source (manufacturing quality control and shelf-life). While we found many probiotic products lacked confirmatory trials, we found sufficient evidence for 22 different types of probiotics from 249 trials to be included. For example, several types of probiotics had strong evidence for the prevention of antibiotic-associated diarrhea [Saccharomyces boulardii I-745, a three-strain mixture (Lactobacillus acidophilus CL1285, L. casei Lbc80r, L. rhamnosus CLR2) and L. casei DN114001]. Strong evidence was also found for four types of probiotics for the prevention of a variety of other diseases/conditions (enteral-feed associated diarrhea, travellers' diarrhea, necrotizing enterocolits and side-effects associated with H. pylori treatments. The evidence was most robust for the treatment of pediatric acute diarrhea based on 59 trials (7 types of probiotics have strong efficacy), while an eight-strain multi-strain mixture showed strong efficacy for inflammatory bowel disease and two types of probiotics had strong efficacy for irritable bowel disease. Of the 22 types of probiotics reviewed, 15 (68%) had strong-moderate evidence for efficacy for at least one type of disease. CONCLUSION: The choice of an appropriate probiotic is multi-factored, based on the mode and type of disease indication and the specific efficacy of probiotic strain(s), as well as product quality and formulation. TRIAL REGISTRATION: This review was registered with PROSPERO: CRD42018103979.
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“Our findings do not support recommendations for the use of specific probiotics for acute infectious diarrhoea in children (Floch 2015; Guarino 2018; Sniffen 2018).”
From Probiotics for treating acute infectious diarrhoea (2020) · cites this paper as Sniffen 2018
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“Also, the most suitable single-strain or probiotic mixture can then be selected based on knowledge and the summary of clinical studies reported in the literature [182].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [182]
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“Data from the literature indicates that the first aspect is related to the mode of therapy, prevention, or treatment, because different probiotics may be more suitable for each objective [182].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [182]
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“The second aspect refers to the fact that certain probiotics are more suitable for the pediatric population compared with the adult population.”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [182]
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PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592
Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. The Cochrane Collaboration
Higgins, J., Green, S. R., & Higgins, J. (2008) · Cited by 5,544
Multistate point-prevalence survey of health care-associated infections
Magill, S. S., Edwards, J. R., Bamberg, W., Beldavs, Z. G., Dumyati, G., Kainer, M. A., Lynfield, R., Maloney, M., McAllister-Hollod, L., Nadle, J., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1306801 · Cited by 3,931
Trends in the Use of Complementary Health Approaches Among Adults in the United States
Jackson, C. (2015) · Holistic Nursing Practice · doi:10.1097/hnp.0000000000000088 · Cited by 1,174
Doron, S., & Snydman, D. R. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ085 · Cited by 942
(2015) · PubMed · Cited by 926
McFarland, L. V. (1994) · JAMA · doi:10.1001/jama.1994.03510480037031 · Cited by 862
Self-citationMcFarland, L. V., Evans, C. T., & Goldstein, E. J. C. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00124 · Cited by 666
Self-citationProbiotics for the prevention of pediatric antibiotic-associated diarrhea
Goldenberg, J. Z., Lytvyn, L., Steurich, J., Parkin, P. C., Mahant, S., & Johnston, B. C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004827.pub4 · Cited by 635
Systematic review and meta-analysis ofSaccharomyces boulardiiin adult patients
McFarland, L. V. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i18.2202 · Cited by 611
Self-citationShane, A. L., Mody, R. K., Crump, J. A., Tarr, P. I., Steiner, T. S., Kotloff, K. L., Langley, J. M., WANKE, C. A., Warren, C. A., Cheng, A. C., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix959 · Cited by 541
Surawicz, C. M., McFarland, L. V., Greenberg, R. N., Rubin, M., Fekety, R., Mulligan, M. E., Garcia, R. J., Brandmarker, S. A., Bowen, K., Borjal, D., et al. (2000) · Clinical Infectious Diseases · doi:10.1086/318130 · Cited by 526
Self-citationSzajewska, H., & Mrukowicz, J. Z. (2001) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200110002-00004 · Cited by 509
World Gastroenterology Organisation Global Guidelines: Probiotics and Prebiotics October 2011
Guarner, F., Khan, A. G., Garisch, J., Eliakim, R., Gangl, A., Thomson, A., Krabshuis, J., Lemair, T., Kaufmann, P., de Paula, J. A., et al. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182549092 · Cited by 418
Meta-analysis of probiotics for the prevention of traveler's diarrhea
McFarland, L. V. (2005) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2005.10.003 · Cited by 412
Self-citationLactobacillus species: Taxonomic complexity and controversial susceptibilities
Goldstein, E. J. C., Tyrrell, K. L., & Citron, D. M. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ072 · Cited by 392
Self-citationProbiotics for Prevention and Treatment of Diarrhea
Guandalini, S. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182257e98 · Cited by 351
Gao, X. W., Mubasher, M., Fang, C. Y., Reifer, C., & Miller, L. E. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.11 · Cited by 318
Campana, R., van Hemert, S., & Baffone, W. (2017) · Gut Pathogens · doi:10.1186/s13099-017-0162-4 · Cited by 308
Probiotics for the Prevention of Antibiotic‐Associated Diarrhea in Children
Szajewska, H., Canani, R. B., Guarino, A., Hojsak, I., Indrio, F., Kolaček, S., Orel, R., Shamir, R., Vandenplas, Y., van Goudoever, J. B., et al. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001081 · Cited by 264
From yaks to yogurt: the history, development, and current use of probiotics
McFarland, L. V. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ054 · Cited by 248
Self-citationA review of dose-responses of probiotics in human studies
Ouwehand, A. C. (2016) · Beneficial Microbes · doi:10.3920/bm2016.0140 · Cited by 233
The effect of probiotics on clostridium difficile diarrhea
Pochapin, M. B. (2000) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(99)00809-6 · Cited by 227
Current Trends in the Epidemiology and Outcomes of Clostridium difficile Infection
Evans, C. T., & Safdar, N. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ140 · Cited by 226
Self-citationKolaček, S., Hojsak, I., Berni Canani, R., Guarino, A., Indrio, F., Orel, R., Pot, B., Shamir, R., Szajewska, H., Vandenplas, Y., et al. (2017) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001603 · Cited by 224
Probiotics for Prevention and Treatment of Diarrhea
Guarino, A., Guandalini, S., & Vecchio, A. L. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000349 · Cited by 217
Hungin, A. P. S., Mulligan, C., Pot, B., Whorwell, P., Agréus, L., Fracasso, P., Lionis, C., Mendive, J., Philippart de Foy, J.-M., Rubin, G., et al. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12460 · Cited by 212
Grandy, G., Medina, M., Soria, R., Terán, C. G., & Araya, M. (2010) · BMC Infectious Diseases · doi:10.1186/1471-2334-10-253 · Cited by 203
Urbancsek, H., Kazar, T., Mezes, I., & Neumann, K. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200104000-00015 · Cited by 166
Comparison of pediatric and adult antibiotic-associated diarrhea andClostridium difficileinfections
McFarland, L. V., Özen, M., Dinleyici, E. Ç., & Goh, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i11.3078 · Cited by 163
Self-citationMcFarland, L. V., Huang, Y., Wang, L., & Malfertheiner, P. (2015) · United European Gastroenterology Journal · doi:10.1177/2050640615617358 · Cited by 162
Self-citationBafeta, A., Koh, M., Riveros, C., & Ravaud, P. (2018) · Annals of Internal Medicine · doi:10.7326/m18-0343 · Cited by 162
Cruchet, S., Furnes, R., Saito, A. M., Eduardo Hebel, W., Palacios, J., Medina, F., Ramirez, N. E., Orsi, M., Rondon, L., Sdepanian, V. L., et al. (2015) · Pediatric Drugs · doi:10.1007/s40272-015-0124-6 · Cited by 128
Higashikawa, F., Noda, M., Awaya, T., Danshiitsoodol, N., Matoba, Y., Kumagai, T., & Sugiyama, M. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.17 · Cited by 123
Probiotics for the Prevention of Pediatric Antibiotic-Associated Diarrhea
Hayes, S. R., & Vargas, A. J. (2016) · EXPLORE · doi:10.1016/j.explore.2016.08.015 · Cited by 123
Is primary prevention of Clostridium difficile infection possible with specific probiotics?
Johnson, S., Maziade, P.-J., McFarland, L. V., Trick, W. E., Donskey, C. J., Currie, B. P., Low, D. E., & Goldstein, E. J. C. (2012) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2012.06.005 · Cited by 121
Self-citationManufacturing process influences properties of probiotic bacteria
Grześkowiak, Ł., Isolauri, E., Salminen, S., & Gueimonde, M. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510004496 · Cited by 120
Recommendations for Probiotic Use—2015 Update: Proceedings and Consensus Opinion
Floch, M. H., Walker, W. A., Sanders, M. E., Nieuwdorp, M., Kim, A. S., Brenner, D. A., Qamar, A. A., Miloh, T. A., Guarino, A., Guslandi, M., et al. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000420 · Cited by 119
Probiotics for recurrent Clostridium difficile disease
Lawrence, S. J., Korzenik, J. R., & Mundy, L. M. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46096-0 · Cited by 101
Efficacy and Safety of Saccharomyces boulardii for Acute Diarrhea
Feizizadeh, S., Salehi‐Abargouei, A., & Akbari, V. (2014) · PEDIATRICS · doi:10.1542/peds.2013-3950 · Cited by 95
Esaiassen, E., Cavanagh, J. P., Hjerde, E., Simonsen, G. S., Støen, R. Ø., & Klingenberg, C. (2016) · Emerging infectious diseases · doi:10.3201/eid2209.160033 · Cited by 95
Deshpande, G. C., Athalye‐Jape, G., Rao, S. C., & Patole, S. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-017638 · Cited by 90
Probiotic guidelines and physician practice: a cross-sectional survey and overview of the literature
Draper, K. V., Ley, C., & Parsonnet, J. (2017) · Beneficial Microbes · doi:10.3920/bm2016.0146 · Cited by 86
Effects of genetic, processing, or product formulation changes on efficacy and safety of probiotics
Sanders, M. E., Klaenhammer, T. R., Ouwehand, A. C., Pot, B., Johansen, E., Heimbach, J. T., Marco, M. L., Tennilä, J., Ross, R. P., Franz, C. M. A. P., et al. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12363 · Cited by 85
Zhao, M., Shen, C., & Ma, L. (2018) · International Journal of Dermatology · doi:10.1111/ijd.13873 · Cited by 76
Harms Reporting in Randomized Controlled Trials of Interventions Aimed at Modifying Microbiota
Bafeta, A., Koh, M., Riveros, C., & Ravaud, P. (2019) · Annals of Internal Medicine · doi:10.7326/l18-0562 · Cited by 76
Auclair, J., Frappier, M., & Millette, M. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ179 · Cited by 70
McFarland, L. V., Ship, N. J., Auclair, J., & Millette, M. (2018) · Journal of Hospital Infection · doi:10.1016/j.jhin.2018.04.017 · Cited by 69
Self-citationPhenotyping and genotyping are both essential to identify and classify a probiotic microorganism
Donelli, G., Vuotto, C., & Mastromarino, P. (2013) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v24i0.20105 · Cited by 67
Miquel, S., Beaumont, M., Martín, R., Langella, P., Braesco, V., & Thomas, M. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0229-1 · Cited by 62
Maziade, P.-J., Pereira, P., & Goldstein, E. J. C. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ178 · Cited by 60
Self-citationProbiotics for the Prevention of Nosocomial Diarrhea in Children
Hojsak, I., Szajewska, H., Canani, R. B., Guarino, A., Indrio, F., Kolaček, S., Orel, R., Shamir, R., Vandenplas, Y., van Goudoever, J. B., et al. (2017) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001637 · Cited by 58
Mercer, M., Brinich, M. A., Geller, G., Harrison, K. L., Highland, J., James, K. M., Marshall, P. A., McCormick, J. B., Tilburt, J. C., Achkar, J., et al. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318225f545 · Cited by 54
Prevalence of probiotic use among inpatients: A descriptive study of 145 U.S. hospitals
Yi, S. H., Jernigan, J. A., & McDonald, L. C. (2016) · American Journal of Infection Control · doi:10.1016/j.ajic.2015.12.001 · Cited by 52
Glanville, J., King, S., Guarner, F., Hill, C., & Sanders, M. E. (2015) · Nutrition Journal · doi:10.1186/s12937-015-0004-5 · Cited by 51
Yoghurt and probiotic bacteria in dietary guidelines of the member states of the European Union
Smug, L. N., Salminen, S., Sanders, M. E., & Ebner, S. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0050 · Cited by 48
META-ANALYSIS OF PROBIOTICS FOR THE PREVENTION AND TREATMENT OF ACUTE PEDIATRIC DIARRHEA
McFarland, L. V., Elmer, G. W., & Mcfarland, M. (2006) · Cited by 46
Self-citationSzajewska, H., Ruszczyński, M., & Kolaček, S. (2013) · Acta Paediatrica · doi:10.1111/apa.12487 · Cited by 45
Probiotics and prevention of Clostridium difficile infection
Goldstein, E. J. C., Johnson, S., Maziade, P.-J., Evans, C. T., Sniffen, J. C., Millette, M., & McFarland, L. V. (2016) · Anaerobe · doi:10.1016/j.anaerobe.2016.12.007 · Cited by 45
Self-citationGastrointestinal survival of bacteria in commercial probiotic products
Millette, M., Nguyen, A., Amine, K. M., & Lacroix, M. (2013) · Cited by 41
Microbiological quality and characteristics of probiotic products in China
Chen, T., Wu, Q., Li, S., Xiong, S., Jiang, S. S., Tan, Q., Zhang, Z., Zhu, D., & Wei, H. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6221 · Cited by 38
Microbiological and genetic identification of some probiotics proposed for medical use in 2011
Toscano, M., Vecchi, E. D., Rodighiero, V., & Drago, L. (2013) · Journal of Chemotherapy · doi:10.1179/1973947812y.0000000068 · Cited by 36
Quality control of fifteen probiotic products containing Saccharomyces boulardii
Vanhee, L. M. E., Goemé, F., Nelis, H. J., & Coenye, T. (2010) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2010.04805.x · Cited by 36
Patrone, V., Molinari, P., & Morelli, L. (2016) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2016.08.012 · Cited by 34
McFarland, L. V. (2013) · World Journal of Meta-Analysis · doi:10.13105/wjma.v1.i3.102 · Cited by 33
Self-citationSchultz, M., Baranchi, A., Thurston, L., Yu, Y. C., Wang, L., Chen, J., Sapsford, M., Chung, J., Binsadiq, M., Craig, L., et al. (2011) · PubMed · Cited by 32
Bacterial counts from five over-the-counter probiotics: Are you getting what you paid for?
Goldstein, E. J. C., Citron, D. M., Claros, M. C., & Tyrrell, K. L. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.10.005 · Cited by 31
Self-citationPooling data on different probiotics is not appropriate to assess the efficacy of probiotics
Szajewska, H. (2014) · European Journal of Pediatrics · doi:10.1007/s00431-014-2340-4 · Cited by 28
McFarland, L. V. (2015) · World Journal of Meta-Analysis · doi:10.13105/wjma.v3.i2.97 · Cited by 28
Self-citationProbiotic nomenclature matters
Hill, C., Scott, K. P., Klaenhammer, T. R., Quigley, E. M. M., & Sanders, M. E. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1127484 · Cited by 24
A survey of probiotic use practices among patients at a tertiary medical centre
Draper, K. V., Ley, C., & Parsonnet, J. (2017) · Beneficial Microbes · doi:10.3920/bm2016.0148 · Cited by 22
Trick, W. E., Sokalski, S. J., Johnson, S., Bunnell, K. L., Levato, J., Ray, M. J., & Weinstein, R. A. (2018) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2018.76 · Cited by 20
An analysis of online messages about probiotics
Brinich, M. A., Mercer, M. B., & Sharp, R. R. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-5 · Cited by 18
McFarland, L. V. (2016) · International Journal of General Medicine · doi:10.2147/ijgm.s119970 · Cited by 17
Self-citationPrimary prevention of Clostridium difficile infections – how difficult can it be?
McFarland, L. V. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1312343 · Cited by 11
Self-citationEpidemiology and healthcare factors associated with neonatal enterococcal infections
Wang, J. N., Kortsalioudaki, C., Heath, P. T., Buttery, J. P., Clarke, P., Gkentzi, D., Anthony, M., & Tan, K. (2018) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2018-315387 · Cited by 9
Probiotics Are Not a One‐Species‐Fits‐All Proposition
Tappenden, K. A. (2012) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607112458407 · Cited by 6
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(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Álvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., Cesare, A. D., Hilbert, F., et al. (2021) · EFSA Journal · doi:10.2903/j.efsa.2021.6377 · Cited by 446
Su, G. L., Ko, C. W., Bercik, P., Falck-Ytter, Y., Sultan, S., Weizman, A. V., & Morgan, R. L. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.059 · Cited by 421
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Metadata
- Authors
- Sniffen, J. C., McFarland, L. V., Evans, C. T., & Goldstein, E. J. C.
- Affiliations
- AdventHealth (US)
- University of Washington (US)
- Northwestern University (US)
- University of California, Los Angeles (US)
- Corresponding author
- McFarland, Lynne V.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-12-26
- Volume
- 13
- Issue
- 12
- Pages
- e0209205
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6306248
- OpenAlex
- W2905982611
- Cited by
- 265
- References
- 79
- Citations by year
- 2026: 18 · 2025: 35 · 2024: 39 · 2023: 36 · 2022: 44 · 2021: 40 · 2020: 35 · 2019: 16 · 2018: 1
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/publicdomain/zero/1.0/ (vor)
- Locations
- PLoS ONE (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Bio-K+ International
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, probiotic strain selection, antibiotic-associated diarrhea, Saccharomyces boulardii, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus, inflammatory bowel disease, irritable bowel disease, necrotizing enterocolitis, traveler's diarrhea, Helicobacter pylori treatment, probiotic regulation
- MeSH terms
- Humans, Randomized Controlled Trials as Topic, Evidence-Based Medicine, Probiotics
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