The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro
Open accessAbstract
Atmospheric particulate matter (PM) is a complex component of air pollution that is a composed of inorganic and organic constituents. The chemically-extracted organic fraction (OF) of PM excludes inorganics but retains most organic constituents like polycyclic aromatic hydrocarbons (PAHs). PAHs are ubiquitous environmental toxicants and known aryl hydrocarbon receptor (AHR) ligands. The AHR is a ligand activated transcription factor that responds to endogenous ligands and exogenous ligands including PAHs. Activation of the AHR leads to upregulation of cytochrome P450 (CYP) metabolizing enzymes which are important for the biotransformation of toxicants to less toxic, or in the case of PAHs, more toxic intermediates. Additionally, the AHR plays an important role in balancing regulatory and effector T cell responses. This study aimed to determine whether PAHs present in PM aggravate inflammation by driving inflammatory T cell and dendritic cell (DC) responses and their mechanism of action. This study tests the hypothesis that PAHs present in PM activate the AHR and alter the immune balance shifting from regulation to inflammation. To test this, the effects of SRM1649b OF on T cell differentiation and DC function were measured in vitro. SRM1649b OF enhanced Th17 differentiation in an AHR and CYP-dependent manner and increased the percent of IFNγ positive DCs in an AHR-dependent manner. SRM1649b PAH mixtures enhanced Th17 differentiation in an AHR-dependent but CYP-independent manner and increased the percent of IFNγ positive DCs. Cumulatively, these results suggest that PAHs present in PM are active components that contribute to immune responses in both T cells and BMDCs through the AHR and CYP metabolism. Understanding the role of AHR and CYP metabolism of PAHs in immune cells after PM exposure will shed light on new targets that will shift the immune balance from inflammation to regulation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PAHs can activate Toll-like receptors, activating intracellular pro-inflammatory pathways NF-κB and MAPK.
“For instance, PAHs can activate Toll-like receptors (TLRs), activating intracellular pro-inflammatory pathways (nuclear factor-kappa B [NF-κB] and mitogen-activated protein kinase [MAPK])52.”
From Air Pollution and Skin Diseases (2025) · cites this paper as [52]
The Discussion reports that PAHs in particulate matter promote proinflammatory T-cell and dendritic-cell responses through AHR-related pathways. Our copy does not establish the claimed Toll-like receptor activation or downstream NF-κB and MAPK signaling (searched: Toll-like receptor, TLR, NF-κB, MAPK). (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Zanger, U. M., & Schwab, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.007 · Cited by 4,169
ES&T Special Report: Priority pollutants: I-a perspective view
Keith, L., & Telliard, W. A. (1979) · Environmental Science & Technology · doi:10.1021/es60152a601 · Cited by 2,161
Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor
Quintana, F. J., Basso, A. S., Iglesias, A. H., Korn, T., Farez, M. F., Bettelli, E., Caccamo, M., Oukka, M., & Weiner, H. L. (2008) · Nature · doi:10.1038/nature06880 · Cited by 1,865
The Aryl Hydrocarbon Receptor Complex
Hankinson, O. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001515 · Cited by 1,649
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634
Kelly, F. J., & Fussell, J. C. (2012) · Atmospheric Environment · doi:10.1016/j.atmosenv.2012.06.039 · Cited by 1,351
Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C., & Bradfield, C. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6731 · Cited by 902
Self-citationAH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899
Self-citationShimada, T., & Fujii‐Kuriyama, Y. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03162.x · Cited by 805
The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor
Nguyen, L. P., & Bradfield, C. A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx7001965 · Cited by 718
Self-citationNguyen, N. T., Kimura, A., Nakahama, T., Chinen, I., Masuda, K., Nohara, K., Fujii‐Kuriyama, Y., & Kishimoto, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014465107 · Cited by 702
Shimada, T. (2006) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.21.257 · Cited by 606
Schwarze, P. E., Øvrevik, J., Låg, M., Refsnes, M., Nafstad, P. H. J., Hetland, R. B., & Dybing, E. (2006) · Human & Experimental Toxicology · doi:10.1177/096032706072520 · Cited by 527
Cassee, F. R., Héroux, M.-È., Gerlofs-Nijland, M. E., & Kelly, F. J. (2013) · Inhalation Toxicology · doi:10.3109/08958378.2013.850127 · Cited by 516
Carver, L. A., & Bradfield, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11452 · Cited by 428
Self-citationThe aryl hydrocarbon receptor: a perspective on potential roles in the immune system
Stevens, E. A., Mezrich, J. D., & Bradfield, C. A. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03054.x · Cited by 415
Self-citationMachala, M., Vondráček, J., Bláha, L., Cigánek, M., & Neča, J. (2001) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00240-6 · Cited by 335
Yeste, A., Nadeau, M., Burns, E. J., Weiner, H. L., & Quintana, F. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120611109 · Cited by 303
Shimada, T., & Guengerich, F. P. (2006) · Chemical Research in Toxicology · doi:10.1021/tx050291v · Cited by 197
Ehrlich, A. K., Pennington, J. M., Bisson, W. H., Kolluri, S. K., & Kerkvliet, N. I. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx215 · Cited by 145
van Voorhis, M., Knopp, S., Julliard, W., Fechner, J. H., Zhang, X., Schauer, J. J., & Mezrich, J. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082545 · Cited by 145
Self-citationThe AH Receptor in Biology and Toxicology
Pohjanvirta, R. (2011) · Wiley eBooks · doi:10.1002/9781118140574 · Cited by 141
Castañeda, A. R., Pinkerton, K. E., Bein, K. J., Magaña-Méndez, A., Yang, H. T., Ashwood, P., & Vogel, C. F. A. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.04.020 · Cited by 102
Andrysík, Z., Vondráček, J., Marvanová, S., Cigánek, M., Neča, J., Pěnčíková, K., Mahadevan, B., Topinka, J., Baird, W. M., Kozubı́k, A., et al. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.06.011 · Cited by 94
Vondráček, J., Pěnčíková, K., Neča, J., Cigánek, M., Grycová, A., Dvořák, Z., & Machala, M. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.09.064 · Cited by 83
Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease
O’Driscoll, C. A., Owens, L. A., Gallo, M. E., Hoffmann, E. J., Afrazi, A., Han, M., Fechner, J. H., Schauer, J. J., Bradfield, C. A., & Mezrich, J. D. (2018) · Particle and Fibre Toxicology · doi:10.1186/s12989-018-0271-3 · Cited by 58
Self-citationMohinta, S., Kannan, A., Gowda, K., Amin, S., Perdew, G. H., & August, A. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv046 · Cited by 57
Shimada, T., Murayama, N., Yamazaki, H., Tanaka, K., Takenaka, S., Komori, M., Kim, D., & Guengerich, F. P. (2013) · Chemical Research in Toxicology · doi:10.1021/tx3004906 · Cited by 55
“Gene‐Swap Knock‐in” Cassette in Mice to Study Allelic Differences in Human Genes
Nebert, D. W., Dalton, T. P., Stuart, G. W., & Carvan, M. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06876.x · Cited by 53
Líbalová, H., Krčková, S., Uhlířová, K., Milcová, A., Schmuczerová, J., Cigánek, M., Kléma, J., Machala, M., Šrám, R. J., & Topinka, J. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.01.028 · Cited by 46
AHR Ligands: Promiscuity in Binding and Diversity in Response
DeGroot, D., He, G., Fraccalvieri, D., Bonati, L., Pandini, A., & Denison, M. S. (2011) · The AH Receptor in Biology and Toxicology · doi:10.1002/9781118140574.ch4 · Cited by 43
Shimada, T., Murayama, N., Tanaka, K., Takenaka, S., Imai, Y., Hopkins, N. E., Foroozesh, M. K., Alworth, W. L., Yamazaki, H., Guengerich, F. P., et al. (2008) · Chemical Research in Toxicology · doi:10.1021/tx8002998 · Cited by 37
Ambient urban dust particulate matter reduces pathologic T cells in the CNS and severity of EAE
O’Driscoll, C. A., Owens, L. A., Hoffmann, E. J., Gallo, M. E., Afrazi, A., Han, M., Fechner, J. H., Schauer, J. J., Bradfield, C. A., & Mezrich, J. D. (2018) · Environmental Research · doi:10.1016/j.envres.2018.09.038 · Cited by 23
Self-citationCooney, D. (2008) · International Journal of Nanomedicine · doi:10.2147/ijn.s1193 · Cited by 13
Flagged first, then by citations
Cited by
Sorted by citations
Vogel, C. F. A., Winkle, L. S. V., Esser, C., & Haarmann‐Stemmann, T. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101530 · Cited by 535
Salminen, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101573 · Cited by 205
Pardo, M., Qiu, X., Zimmermann, R., & Rudich, Y. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00007 · Cited by 167
Oxidative stress in air pollution research
Mudway, I., Kelly, F. J., & Holgate, S. T. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.04.031 · Cited by 151
Sun, S., Shi, W. M., Tang, Y., Han, Y., Du, X., Zhou, W., Zhang, W., Sun, C., & Liu, G. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.147003 · Cited by 140
Grishanova, A. Y., & Perepechaeva, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126719 · Cited by 130
Tissue-specific immunity for a changing world
Weisberg, S. P., Ural, B. B., & Färber, D. L. (2021) · Cell · doi:10.1016/j.cell.2021.01.042 · Cited by 104
Toxicity of airborne nanoparticles: Facts and challenges
Portugal, J., Bedia, C., Amato, F., Juárez-Facio, A. T., Stamatiou, R., Lazou, A., Campiglio, C. E., Elihn, K., & Piña, B. (2024) · Environment International · doi:10.1016/j.envint.2024.108889 · Cited by 100
Ihantola, T., Bucchianico, S. D., Happo, M. S., Ihalainen, M., Uski, O., Bauer, S., Kuuspalo, K., Sippula, O., Tissari, J., Oeder, S., et al. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00355-1 · Cited by 74
Xu, C., Liu, Q., Liang, J., Weng, Z., Xu, J., Jiang, Z., & Gu, A. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116842 · Cited by 70
Sun, S., Shi, W. M., Tang, Y., Han, Y., Du, X., Zhou, W., Hu, Y., Zhou, C., & Liu, G. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138852 · Cited by 64
Natural and Synthetic Estrogens in Chronic Inflammation and Breast Cancer
Maharjan, C. K., Mo, J., Wang, L. A., Kim, M., Wang, S., Borcherding, N. C., Vikas, P., & Zhang, W. (2021) · Cancers · doi:10.3390/cancers14010206 · Cited by 63
Molot, J., Sears, M., Marshall, L. M., & Bray, R. I. (2021) · Reviews on Environmental Health · doi:10.1515/reveh-2021-0043 · Cited by 60
Hvidtfeldt, U. A., Chen, J., Andersen, Z. J., Atkinson, R. W., Bauwelinck, M., Bellander, T., Brandt, J. G., Brunekreef, B., Cesaroni, G., Concin, H., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110568 · Cited by 59
Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission
Beentjes, D., Shears, R. K., French, N., Neill, D. R., & Kadioglu, A. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202112-2668tr · Cited by 53
Chen, Y., Chuang, T.-Y., Liu, C., Liu, C.-W., Lai, T.-C., Lai, T.-C., & Chen, Y. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00373-z · Cited by 52
Pollution and endometriosis: A deep dive into the environmental impacts on women's health
Vallée, A., Ceccaldi, P., Carbonnel, M., Féki, A., & Ayoubi, J. (2023) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17687 · Cited by 51
Mimicking cigarette smoke exposure to assess cutaneous toxicity
Prieux, R., Eeman, M., Rothen‐Rutishauser, B., & Valacchi, G. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104664 · Cited by 44
Pompilio, A., & Bonaventura, G. D. (2020) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1816894 · Cited by 44
Xi, X., Ye, Q., Fan, D., Cao, X., Wang, Q., Wang, X., Zhang, M., Xu, Y., & Xiao, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.797815 · Cited by 38
Fang, L., Zhao, H., Chen, Y., Ma, Y., Xu, S., Xu, S., Pan, G., Cai, G., Shuai, Z., & Pan, F. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.137870 · Cited by 37
Ishihara, Y., Kado, S. Y., Bein, K. J., He, Y., Pouraryan, A. A., Urban, A., Haarmann‐Stemmann, T., Sweeney, C. A., & Vogel, C. F. A. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2021.787360 · Cited by 36
Lou, F., Okoye, C. O., Gao, L., Jiang, H., Wu, Y., Wang, Y., Li, X., & Jiang, J. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127410 · Cited by 34
Association between particulate matter containing EPFRs and neutrophilic asthma through AhR and Th17
Harding, J. N., Gross, M., Patel, V., Potter, S. S., & Cormier, S. A. (2021) · Respiratory Research · doi:10.1186/s12931-021-01867-w · Cited by 29
Air Pollution and Skin Diseases
Han, H. S., Seok, J., & Park, K. Y. (2025) · Annals of Dermatology · doi:10.5021/ad.24.159 · Cited by 28
“For instance, PAHs can activate Toll-like receptors (TLRs), activating intracellular pro-inflammatory pathways (nuclear factor-kappa B [NF-κ B] and mitogen-activated protein kinase [MAPK]) 52 .”
Khazaeel, K., Daaj, S. A. Z., Sadeghi, A., Tabandeh, M. R., & Basir, Z. (2022) · Reproductive Toxicology · doi:10.1016/j.reprotox.2022.08.001 · Cited by 22
The aryl hydrocarbon receptor: a new frontier in male reproductive system
Bustani, G. S., Alghetaa, H., Mohammed, A. K., Nagarkatti, M., & Nagarkatti, P. S. (2025) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-025-01401-3 · Cited by 20
Jiang, Q., Xu, X., Zhang, C., Luo, J., Lv, N., Shi, L., Ji, A., Gao, M. M., Chen, F., Cui, L., et al. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114718 · Cited by 20
Exhaled Volatile Organic Compounds for Identifying Patients With Chronic Pulmonary Aspergillosis
Li, Z., Zeng, P., Chen, Z., Guan, W., Wang, T., Lin, Y., Li, S., Zhang, Z., Zhan, Y., Wang, M.-D., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.720119 · Cited by 19
Morales-Rubio, R. A., Amador-Muñóz, O., Rosas‐Pérez, I., Sánchez-Pérez, Y., García-Cuellar, C. M., Segura-Medina, P., Osornio-Vargas, Á. R., & Vizcaya‐Ruíz, A. D. (2021) · Toxicology · doi:10.1016/j.tox.2021.153026 · Cited by 19
He, F., Wang, N., Yu, X., Zheng, Y., Liu, Q., Chen, Q., Pu, J., Li, N., Zou, W., Li, B., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129459 · Cited by 19
Rogers, K., WaMaina, E., Barber, A., Masood, S. S. M. E., Love, C. A., Kim, Y. H., Gilmour, M. I., & Jaspers, I. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae038 · Cited by 19
Tsai, C.-H., Lee, Y., Li, C.-H., Cheng, Y., & Kang, J. (2019) · Cell Biology and Toxicology · doi:10.1007/s10565-019-09499-z · Cited by 18
Efriza, E., Alshahrani, S. H., Zekiy, A. O., Al‐Awsi, G. R. L., Sharma, S. K., Ramírez‐Coronel, A. A., Shakeel, N., Riadi, Y., Aminov, Z., Zabibah, R. S., et al. (2023) · Air Quality Atmosphere & Health · doi:10.1007/s11869-023-01324-1 · Cited by 17
RetractedExogenous Estrogens as Breast Cancer Risk Factors: A Perspective
Malik, P., & Mukherjee, T. K. (2025) · Cancers · doi:10.3390/cancers17162680 · Cited by 15
Holme, J. A., Låg, M., Skuland, T., Pařenicová, M., Cigánek, M., Pěnčíková, K., Grytting, V. S., Neča, J., Øvrevik, J., Mariussen, E., et al. (2023) · Toxicology in Vitro · doi:10.1016/j.tiv.2023.105611 · Cited by 14
Sadeghi, A., Ghahari, L., Yousefpour, M., Khazaeel, K., & Zareian, P. (2023) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2023.102290 · Cited by 14
Huang, W., Huang, Y., Chen, Y., Tan, W., & Wu, K. (2023) · Discover Environment · doi:10.1007/s44274-023-00015-z · Cited by 13
Larsen, M. C., Almeldin, A., Tong, T., Rondelli, C. M., Maguire, M., Jaskula‐Sztul, R., & Jefcoate, C. R. E. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115111 · Cited by 13
Janpaijit, S., Sukprasansap, M., Tencomnao, T., & Prasansuklab, A. (2024) · Nutrients · doi:10.3390/nu16172882 · Cited by 11
Park, S., Siwakoti, R. C., Ferguson, K. K., Cathey, A. L., Hao, W., Cantonwine, D. E., Mukherjee, B., McElrath, T. F., & Meeker, J. D. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119205 · Cited by 11
The association of in-utero exposure to polycyclic aromatic hydrocarbons and umbilical liver enzymes
Li, W., Okromelidze, M. T., Ramírez‐Coronel, A. A., Zekiy, A. O., Obaid, R. F., Jawhar, Z. H., Gabr, G. A., Al‐Hamdani, M. M., Kadhim, S. I., Mustafa, Y. F., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164220 · Cited by 10
Журба, О. М., Merinov, A. V., Alekseenko, А. N., & Shayakhmetov, S. F. (2019) · Hygiene and Sanitation · doi:10.18821/0016-9900-2019-98-10-1037-1042 · Cited by 8
Gawron, I. M., Węgiel, M., Chrząszcz, R., Jach, R., & Maslanka, A. (2024) · Advances in Medical Sciences · doi:10.1016/j.advms.2024.07.002 · Cited by 7
Lin, J., Sun, W. D., Peng, S., Hu, Y., Zhang, G., Song, W., Jiang, B., Liao, Y., Pei, C., Zhang, J., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136583 · Cited by 7
Shi, W., Kaewsanmung, S., Kiratipaisarl, W., & Sapbamrer, R. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1721233 · Cited by 6
Kim, H., Kim, J.-H., Park, B.-J., & Park, H.-J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031105 · Cited by 6
Khazaeel, K., Hussein, H. A., Ranjbar, R., Tabandeh, M. R., & Alahmed, J. A. S. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108560 · Cited by 6
Shirkani, P., & Shirkani, A. (2024) · Медицинский журнал Западного Казахстана · doi:10.18502/wkmj.v66i3.15772 · Cited by 5
Sahoo, R., Pattnaik, S., Mohanty, B., Mir, S. A., & Behera, B. (2025) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2025.130805 · Cited by 5
Waye, A. A., Ticiani, E., & Veiga‐Lopez, A. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.116804 · Cited by 5
A prospective pilot study of the T‐lymphocyte response to fine particulate matter exposure
Zallouha, M. A., Landkocz, Y., Méausoone, C., Ledoux, F., Visade, F., Cazier, F., Martin, P. J., Borgie, M., Vitagliano, J., Trémolet, G., et al. (2020) · Journal of Applied Toxicology · doi:10.1002/jat.3932 · Cited by 5
Brocke, S. A., Smyth, T., Dang, H., Speen, A. M., Kim, Y. H., Christianson, C., Kovalcik, K. D., Pancras, J. P., Hays, M. D., An, Z., et al. (2025) · Particle and Fibre Toxicology · doi:10.1186/s12989-025-00643-8 · Cited by 4
Aryl hydrocarbon receptor–kynurenine axis promotes oncogenic activity in BCP-ALL
Wang, L., Liu, K.-Y., Wang, S., Lin, M., Liao, Y., Lin, P., Huang, S., Hsu, S., & Chiou, S. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-022-09734-0 · Cited by 4
Impact of Ambient Particulate Matter on the Skin’s Immune System
Rehman, A., & Koh, Y. (2022) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2022.52.3.083 · Cited by 4
Smoot, J., Padilla, S., Kim, Y. H., Hunter, D. L., Tennant, A. H., Hill, B. N., Lowery, M., Knapp, B. R., Oshiro, W. M., Hazari, M. S., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29675 · Cited by 4
Jia, W., Fu, Y., Zhang, N., Zhang, N., Wang, T., Wang, Z., Zhang, N., Xu, J., Yang, X., Zhang, Q., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169433 · Cited by 3
Aryl Hydrocarbon Receptor, a Critical Interface between Host Immunity and Microbiota
Rehman, A., & Koh, Y.-S. (2025) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2025.55.4.298 · Cited by 3
Hussein, H. A., Khazaeel, K., Ranjbar, R., Tabandeh, M. R., & Alahmed, J. A. S. (2023) · Birth Defects Research · doi:10.1002/bdr2.2240 · Cited by 3
Lin, F., Wang, H., Wang, X., & Fang, Y. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-29421-9 · Cited by 3
Huang, P., Pan, X., Chen, H., Lei, M., Ma, Y., Guo, X., Xie, J., Li, J., Sun, J., Hu, Y., et al. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1548038 · Cited by 2
Bao, C., Luo, J., & Miao, S. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42351 · Cited by 1
Frias, D. P., Vieira, G. L., Smelan, J., de Lacerda, J. P. A., da Silva, P. S. C., Sussa, F. V., Carvalho-Oliveira, R., Saldiva, P. H. N., Mauad, T., & Macchione, M. (2025) · Toxicology · doi:10.1016/j.tox.2025.154299 · Cited by 1
Effect of Environmental Factors on Bone Remodelling: A Narrative Review
Hama, B., Hama, S., Kashkosh, A., Jesry, F., Munir, I., Ejaz, M., & Kazemi, H. (2025) · Cureus · doi:10.7759/cureus.96490 · Cited by 1
Harding, J. N. (2020) · Louisiana State University · doi:10.31390/gradschool_dissertations.5362
Efeitos de hidrocarbonetos policíclicos aromáticos em mitocôndrias de células de mamíferos
Claudio, G. A. D. S. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.46.2023.tde-10042025-142911
Effects of policyclic aromatic hydrocarbons on mammalian mitochondria
Claudio, G. A. D. S. (2023) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Muhammad, A., Ibrahim, S. S., Irving, H., Al‐Yazeedi, T., Hearn, J., Paine, M. J. I., & Wondji, C. S. (2026) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2026.104661
Revisiting Quinone-Induced Oxidative Stress via Structure-Related Protein Alkylation
Yeung, K., Zhao, X., Hall, D. R., Han, J., & Peng, H. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c04463
Smyth, T., Brocke, S. A., Wu, W., An, Z., & Jaspers, I. (2026) · Toxicological Sciences · doi:10.1093/toxsci/kfag050
Lin, C.-H., Yen, C., Wu, Y., Chang, H., Ko, H., & Chen, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177573
The advent of molecular nanocarbon biology
Amaike, K., Ueda, A., & Itami, K. (2026) · Chemical Science · doi:10.1039/d6sc05731d
Lenich, A., Reindl, L.-M., & Ruez, S. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.116367
Online exposure systems for toxicological effects of combustion emissions and nanoparticles
Ihantola, T. (2021) · UEF eRepo (University of Eastern Finland)
Cao, Z., Zhou, C., Lu, J., Piao, X., Li, Z., Cao, S., Chang, Y., & Jin, H. (2026) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2026.109494
Chen, S., Liu, L., Zhao, C., Zeng, Y., Zhang, Y., Chen, Y., Lin, Z., Pang, T., Wu, J., Jin, H., et al. (2026) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2026.105207
Metadata
- Authors
- O’Driscoll, C. A., Gallo, M. E., Hoffmann, E. J., Fechner, J. H., Schauer, J. J., Bradfield, C. A., & Mezrich, J. D.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Mezrich, Joshua D.
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-12-21
- Volume
- 13
- Issue
- 12
- Pages
- e0209690
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6303068
- OpenAlex
- W2906492750
- Cited by
- 74
- References
- 34
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 10 · 2023: 13 · 2022: 9 · 2021: 8 · 2020: 12 · 2019: 3
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institute of Environmental Health Sciences (RO1 ES023842, R21 ES025304, T32 ES007015)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Keywords
- polycyclic aromatic hydrocarbons, aryl hydrocarbon receptor, atmospheric particulate matter, urban dust, Th17 cell differentiation, dendritic cells, interferon-gamma, cytochrome P450 metabolism, T cell differentiation, regulatory T cells, environmental toxins
- MeSH terms
- Animals, Bone Marrow Cells, Cell Differentiation, Cytochromes, Dendritic Cells, Dust, Gene Expression Regulation, Humans, Lymphocyte Activation, Polycyclic Aromatic Hydrocarbons, T-Lymphocytes, Urban Health, Receptors, Aryl Hydrocarbon, Mice, Knockout, Cytochrome P-450 CYP1A1, Mice, Particulate Matter, Th17 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
