Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism
Open accessAbstract
Phosphatidylinositol 4,5-bisphosphate (PIP 2 ) is an important cellular effector whose functions include the regulation of ion channels and membrane trafficking. Aberrant PIP 2 metabolism has also been implicated in a variety of human disease states, e.g., cancer and diabetes. Here we report that familial Alzheimer's disease (FAD)-associated presenilin mutations cause an imbalance in PIP 2 metabolism. We find that the transient receptor potential melastatin 7 (TRPM7)-associated Mg 2+ -inhibited cation (MIC) channel underlies ion channel dysfunction in presenilin FAD mutant cells, and the observed channel deficits are restored by the addition of PIP 2 , a known regulator of the MIC/TRPM7 channel. Lipid analyses show that PIP 2 turnover is selectively affected in FAD mutant presenilin cells. We also find that modulation of cellular PIP 2 closely correlates with 42-residue amyloid β-peptide (Aβ42) levels. Our data suggest that PIP 2 imbalance may contribute to Alzheimer's disease pathogenesis by affecting multiple cellular pathways, such as the generation of toxic Aβ42 as well as the activity of the MIC/TRPM7 channel, which has been linked to other neurodegenerative conditions. Thus, our study suggests that brain-specific modulation of PIP 2 may offer a therapeutic approach in Alzheimer's disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Familial AD PSEN1 mutations result in disrupted metabolism of PI(4,5)P2.
“Familial AD PSEN1 mutations result in disrupted metabolism of PI(4,5)P2 [95] and PI(4,5)P2 has been reported to be reduced in the AD brain [93].”
From Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease (2023) · cites this paper as [95]
Altered PI(4,5)P2 metabolism is linked to Aβ toxicity.
“Altered PI(4,5)P2 metabolism has been linked to Aβ toxicity [93–95].”
From Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease (2023) · cites this paper as [95]
The C-terminus of SHIP1 contains a NPxY motif that can bind proteins containing ITIM/ITAM, PTB or SH2 domains, and a proline-rich PxxP motif that contains SH3-binding domains.
“The C-terminus of SHIP1 contains a NPxY motif, which can bind to proteins containing immunoreceptor tyrosine inhibitory motifs (ITIM)/immunoreceptor tyrosine activating motifs (ITAM), phosphotyrosine-binding (PTB) or SH2 domains, as well as a proline-rich PxxP motif that contains SH3-binding domains [47, 93–98] (Fig. 2).”
From Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease (2023) · cites this paper as [95]
The Results and Discussion passages address presenilin mutations, PIP2 metabolism, and ion-channel activity, not SHIP1 structure. Searches for SHIP1, NPxY, PxxP, ITIM/ITAM, PTB, SH2, and SH3 found no passage in our copy addressing the claimed motifs or binding interactions. Page numbers were not available. (LLM, conf=0.78)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599 · see citing works
Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089 · see citing works
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849 · see citing works
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., & Van Leuven, F. (1998) · Nature · doi:10.1038/34910 · Cited by 1,818 · see citing works
Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., & Ihara, Y. (1994) · Neuron · doi:10.1016/0896-6273(94)90458-8 · Cited by 1,774 · see citing works
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
Schroeter, E. H., Kisslinger, J. A., & Kopan, R. (1998) · Nature · doi:10.1038/30756 · Cited by 1,624 · see citing works
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., et al. (2001) · Nature · doi:10.1038/35102591 · Cited by 1,388 · see citing works
Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
Li, Y.-M., Xu, M., Lai, M.-T., Huang, Q., Castro, J. L., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelil, J. G., et al. (2000) · Nature · doi:10.1038/35015085 · Cited by 866 · see citing works
A Key Role for TRPM7 Channels in Anoxic Neuronal Death
Aarts, M. M., Iihara, K., Wei, W.-L., Xiong, Z.-G., Arundine, M., Cerwinski, W., MacDonald, J. F., & Tymianski, M. (2003) · Cell · doi:10.1016/s0092-8674(03)01017-1 · Cited by 784 · see citing works
Regulation of Vertebrate Cellular Mg2+ Homeostasis by TRPM7
Schmitz, C., Perraud, A., Johnson, C. O., Inabe, K., Smith, M., Penner, R., Kurosaki, T., Fleig, A., & Scharenberg, A. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00556-7 · Cited by 726 · see citing works
A presynaptic inositol-5-phosphatase
McPherson, P. S., Garcia, E. P., Slepnev, V. I., David, C., Zhang, X., Grabs, D., Sossini, W. S., Bauerfeind, R., Nemoto, Y., & Camilli, P. V. D. (1996) · Nature · doi:10.1038/379353a0 · Cited by 585 · see citing works
Take five—BACE and the γ‐secretase quartet conduct Alzheimer's amyloid β‐peptide generation
Haass, C. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600061 · Cited by 547 · see citing works
The TRPM7 channel is inactivated by PIP2 hydrolysis
Runnels, L. W., Yue, L., & Clapham, D. E. (2002) · Nature Cell Biology · doi:10.1038/ncb781 · Cited by 516 · see citing works
Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells
Herreman, A., Serneels, L., Annaert, W. G., Collen, D., Schoonjans, L., & Strooper, B. D. (2000) · Nature Cell Biology · doi:10.1038/35017105 · Cited by 481 · see citing works
Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin
Grimm, M. O. W., Grimm, H. S., Pätzold, A. J., Zinser, E. G., Halonen, R., Duering, M., Tschäpe, J., Strooper, B. D., Müller, U., Shen, J., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1313 · Cited by 446 · see citing works
Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate
Suh, B., & Hille, B. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.005 · Cited by 436 · see citing works
Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes
Vetrivel, K. S., Cheng, H., Lin, W., Sakurai, T., Li, T., Nukina, N., Wong, P. C., Xu, H., & Thinakaran, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407986200 · Cited by 413 · see citing works
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
Bentahir, M., Nyabi, O., Verhamme, J., Tolia, A., Horré, K., Wiltfang, J., Esselmann, H., & Strooper, B. D. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03578.x · Cited by 412 · see citing works
The role of cerebral amyloid accumulation in common forms of Alzheimer disease
Gandy, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25100 · Cited by 394 · see citing works
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking
Paolo, G. D., Moskowitz, H. S., Gipson, K. E., Wenk, M. R., Voronov, S. V., Obayashi, M., Flavell, R. A., Fitzsimonds, R. M., Ryan, T. A., & Camilli, P. V. D. (2004) · Nature · doi:10.1038/nature02896 · Cited by 386 · see citing works
Self-citationEffects of PS1 Deficiency on Membrane Protein Trafficking in Neurons
Naruse, S., Thinakaran, G., Luo, J.-J., Kusiak, J. W., Tomita, T., Iwatsubo, T., Qian, X., Ginty, D. D., Price, D. L., Borchelt, D. R., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80637-6 · Cited by 355 · see citing works
Leissring, M. A., Akbari, Y., Fanger, C. M., Cahalan, M. D., Mattson, M. P., & LaFerla, F. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.4.793 · Cited by 325 · see citing works
Presenilin-Mediated Modulation of Capacitative Calcium Entry
Yoo, A. S. J., Cheng, I., Chung, S., Grenfell‐Lee, T. Z., Lee, H., Pack-Chung, E., Handler, M., Shen, J., Xia, W., Tesco, G., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00066-0 · Cited by 309 · see citing works
Self-citationPresenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors
Seiffert, D., Bradley, J. D., Rominger, C. M., Rominger, D. H., Yang, F., Meredith, J. E., Wang, Q., Roach, A., Thompson, L. A., Spitz, S. M., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005430200 · Cited by 301 · see citing works
Phospholipase C in Living Cells
Horowitz, L. F., Hirdes, W., Suh, B., Hilgemann, D. W., Mackie, K., & Hille, B. (2005) · The Journal of General Physiology · doi:10.1085/jgp.200509309 · Cited by 299 · see citing works
Baki, L., Shioi, J., Wen, P. H., Shao, Z., Schwarzman, A. L., Gama-Sosa, M. A., Neve, R. L., & Robakis, N. K. R. K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600251 · Cited by 289 · see citing works
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP
Leissring, M. A., Murphy, M. P., Mead, T. R., Akbari, Y., Sugarman, M. C., Jannatipour, M., Anliker, B., Müller, U., Säftig, P., Strooper, B. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072033799 · Cited by 273 · see citing works
Prakriya, M., & Lewis, R. S. (2002) · The Journal of General Physiology · doi:10.1085/jgp.20028551 · Cited by 270 · see citing works
Larner, A. J., & Doran, M. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0019-5 · Cited by 256 · see citing works
Presenilin Couples the Paired Phosphorylation of β-Catenin Independent of Axin
Kang, D. E., Soriano, S., Xia, X., Eberhart, C. G., Strooper, B. D., Zheng, H., & Koo, E. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00970-4 · Cited by 232 · see citing works
Purification and Characterization of the Human γ-Secretase Complex
Fraering, P. C., Ye, W., Strub, J., Dolios, G., LaVoie, M. J., Ostaszewski, B. L., DORSSELAER, A. V., Wang, R., Selkoe, D. J., & Wolfe, M. S. (2004) · Biochemistry · doi:10.1021/bi0494976 · Cited by 226 · see citing works
Georgakopoulos, A., Marambaud, P., Efthimiopoulos, S., Shioi, J., Cui, W., Li, H., Schütte, M., Gordon, R., Holstein, G. R., Martinelli, G. P., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80219-1 · Cited by 221 · see citing works
A novel presenilin 1 mutation associated with Pick's disease but not β‐amyloid plaques
Dermaut, B., Kumar‐Singh, S., Engelborghs, S., Theuns, J., Rademakers, R., Saerens, J., Pickut, B. A., Peeters, K., den Broeck, M. V., Vennekens, K., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20083 · Cited by 212 · see citing works
Hermosura, M. C., Nayakanti, H., Dorovkov, M. V., Calderon, F. R. O., Ryazanov, A. G., Haymer, D. S., & Garruto, R. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505149102 · Cited by 200 · see citing works
Distinct Properties of CRAC and MIC Channels in RBL Cells
Kozak, J. A., Kerschbaum, H., & Cahalan, M. D. (2002) · The Journal of General Physiology · doi:10.1085/jgp.20028601 · Cited by 181 · see citing works
Esselens, C. W., Oorschot, V. M. J., Baert, V., Raemaekers, T., Spittaels, K., Serneels, L., Zheng, H., Säftig, P., Strooper, B. D., Klumperman, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200406060 · Cited by 170 · see citing works
Identification of a Compound That Directly Stimulates Phospholipase C Activity
Bae, Y., Lee, T. G., Park, J. C., Hur, J. H., Kim, Y., Heo, K., Kwak, J.-Y., Suh, P., & Ryu, S. H. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.5.1043 · Cited by 152 · see citing works
Cai, D., Leem, J. Y., Greenfield, J. P., Wang, P., Kim, B. S., Wang, R., Radomski, K. L., Kim, S.-H., Zheng, H., Greengard, P., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209065200 · Cited by 132 · see citing works
Presenilin-1 uses phospholipase D1 as a negative regulator of β-amyloid formation
Cai, D., Netzer, W. J., Zhong, M., Lin, Y., Du, G., Frohman, M. A., Foster, D. A., Sisodia, S. S., Xu, H., Gorelick, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510708103 · Cited by 110 · see citing works
Herms, J. W., Schneider, I., Dewachter, I., Caluwaerts, N., Kretzschmar, H. A., & LEUVEN, F. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206769200 · Cited by 108 · see citing works
Kang, D. E., Yoon, I., Repetto, E., Busse, T., Yermian, N., Ie, L., & Koo, E. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500833200 · Cited by 107 · see citing works
Chen, F., Gu, Y., Hasegawa, H., Ruan, X., Arawaka, S., Fraser, P., Westaway, D. A., Mount, H. T. J., & George‐Hyslop, P. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205093200 · Cited by 105 · see citing works
Landman, N., & Kim, T. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.04.001 · Cited by 85 · see citing works
Self-citationPresenilin-Dependent γ-Secretase on Plasma Membrane and Endosomes Is Functionally Distinct
Fukumori, A., Okochi, M., Tagami, S., Jiang, J., Itoh, N., Nakayama, T., Yanagida, K., Ishizuka‐Katsura, Y., Morihara, T., Kamino, K., et al. (2006) · Biochemistry · doi:10.1021/bi052412w · Cited by 73 · see citing works
A Role for Presenilin 1 in Regulating the Delivery of Amyloid Precursor Protein to the Cell Surface
Leem, J. Y., Saura, C. A., Pietrzik, C. U., Christianson, J. C., Wanamaker, C., King, L. T., Veselits, M., Tomita, T., Gasparini, L., Iwatsubo, T., et al. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0546 · Cited by 72 · see citing works
Schwarzman, A. L., Singh, N., Tsiper, M. V., Gregori, L. L., Dranovsky, A., Vitek, M. P., Glabe, C. G., George‐Hyslop, P. S., & Goldgaber, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7932 · Cited by 64 · see citing works
Wrigley, J. D. J., Schurov, I., Nunn, E. J., Martin, A. C. L., Clarke, E. E., Ellis, S., Bonnert, T. P., Shearman, M. S., & Beher, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413086200 · Cited by 37 · see citing works
Regulation of magnesium-inhibited cation current by actin cytoskeleton rearrangement
Jeong, S. Y., Shin, S. Y., Kim, H., Bae, C., Uhm, D.-Y., Park, M.-K., & Chung, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.093 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Linking lipids to Alzheimer's disease: cholesterol and beyond
Di Paolo, G., & Kim, T.-W. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3012 · Cited by 972 · see citing works
Self-citationPresenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria
Área-Gómez, E., de Groof, A. J. C., Boldogh, I. R., Bird, T. D., Gibson, G. E., Koehler, C. M., Yu, W. H., Duff, K., Yaffe, M. P., Pon, L. A., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090219 · Cited by 397 · see citing works
Brain lipidomics: From functional landscape to clinical significance
Yoon, J. H., Seo, Y., Jo, Y. S., Lee, S., Cho, E., Cazenave-Gassiot, A., Shin, Y.-S., Moon, M. H., An, H. J., Wenk, M. R., et al. (2022) · Science Advances · doi:10.1126/sciadv.adc9317 · Cited by 324 · see citing works
Wunderlich, P., Glebov, K., Kemmerling, N., Tien, N. T., Neumann, H., & Walter, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.517540 · Cited by 296 · see citing works
Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids
Dickson, E. J., & Hille, B. (2019) · Biochemical Journal · doi:10.1042/bcj20180022 · Cited by 254 · see citing works
Morel, E., Chamoun, Z., Lasiecka, Z. M., Chan, R. B., Williamson, R. L., Vetanovetz, C., Dall’Armi, C., Simoes, S., Point Du Jour, K. S., McCabe, B. D., et al. (2013) · Nature Communications · doi:10.1038/ncomms3250 · Cited by 222 · see citing works
Li, R.-Y., Qin, Q., Yang, H.-C., Wang, Y.-Y., Mi, Y.-X., Yin, Y.-S., Wang, M., Yu, C.-J., & Tang, Y. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00542-y · Cited by 204 · see citing works
Calcium dysregulation in Alzheimer's disease
Bojarski, Ł., Herms, J. W., & Kuźnicki, J. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.10.002 · Cited by 202 · see citing works
Fukami, K., Inanobe, S., Kanemaru, K., & Nakamura, Y. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.06.001 · Cited by 197 · see citing works
Bourdenx, M., Koulakiotis, N. S., Sanoudou, D., Bézard, E., Dehay, B., & Tsarbopoulos, A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.07.003 · Cited by 189 · see citing works
Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism
Berman, D. E., Dall'Armi, C., Voronov, S. V., McIntire, L. B. J., Zhang, H., Moore, A. Z., Staniszewski, A., Arancio, O., Kim, T.-W., & Di Paolo, G. (2008) · Nature Neuroscience · doi:10.1038/nn.2100 · Cited by 199 · see citing works
Self-citationSantoni, G., Cardinali, C., Morelli, M. B., Santoni, M., Nabissi, M., & Amantini, C. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0239-2 · Cited by 176 · see citing works
Voronov, S. V., Frere, S. G., Giovedi, S., Pollina, E. A., Borel, C., Zhang, H., Schmidt, C., Akeson, E. C., Wenk, M. R., Cimasoni, L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803756105 · Cited by 174 · see citing works
Self-citationSphingolipids: Critical players in Alzheimer’s disease
van Echten‐Deckert, G., & Walter, J. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.07.001 · Cited by 172 · see citing works
Zhu, L., Zhong, M., Elder, G. A., Sano, M., Holtzman, D. M., Gandy, S., Cardozo, C., Haroutunian, V., Robakis, N. K., & Cai, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510011112 · Cited by 160 · see citing works
Nazıroğlu, M., Dikici, D. M., & Dursun, Ş. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0850-x · Cited by 141 · see citing works
Advances in the pathogenesis of Alzheimer’s disease: a re-evaluation of amyloid cascade hypothesis
Dong, S., Duan, Y., Hu, Y., & Zhao, Z. (2012) · Translational Neurodegeneration · doi:10.1186/2047-9158-1-18 · Cited by 139 · see citing works
X-ray Crystal Structure of a TRPM Assembly Domain Reveals an Antiparallel Four-stranded Coiled-coil
Fujiwara, Y., & Minor, D. L. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.08.059 · Cited by 122 · see citing works
Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene
Bagaria, J., Bagyinszky, E., & An, S. S. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810970 · Cited by 114 · see citing works
X-ray Crystal Structure Of A Trpm Assembly Domain Reveals An Antiparallel Four-stranded Coiled-coil
Fujiwara, Y., & Minor, D. L. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.12.2923 · Cited by 109 · see citing works
BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin
Finan, G. M., Okada, H., & Kim, T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.170217 · Cited by 108 · see citing works
Self-citationPhosphatidylinositol 4,5‐bisphosphate: Targeted production and signaling
Sun, Y., Thapa, N., Hedman, A. C., & Anderson, R. A. (2013) · BioEssays · doi:10.1002/bies.201200171 · Cited by 106 · see citing works
Proteomic identification of sorting nexin 6 as a negative regulator of BACE1‐mediated APP processing
Okada, H., Zhang, W., Peterhoff, C., Hwang, J. C., Nixon, R. A., Ryu, S. H., & Kim, T. (2010) · The FASEB Journal · doi:10.1096/fj.09-146357 · Cited by 102 · see citing works
Self-citationCossec, J., Lavaur, J., Berman, D. E., Rivals, I., Hoischen, A., Stora, S., Ripoll, C., Mircher, C., Grattau, Y., Olivo‐Marín, J., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds142 · Cited by 100 · see citing works
Phospholipase D in brain function and Alzheimer's disease
Oliveira, T. G., & Paolo, G. D. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.04.004 · Cited by 97 · see citing works
Terzioglu, G., & Young-Pearse, T. L. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00674-9 · Cited by 95 · see citing works
Dysregulation of Calcium Homeostasis in Alzheimer’s Disease
Small, D. H. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9960-5 · Cited by 94 · see citing works
TRPM7 and TRPM2—Candidate susceptibility genes for Western Pacific ALS and PD?
Hermosura, M. C., & Garruto, R. M. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.02.008 · Cited by 94 · see citing works
Phospholipase C families: Common themes and versatility in physiology and pathology
Katan, M., & Cockcroft, S. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101065 · Cited by 89 · see citing works
TRPM7: A unique channel involved in magnesium homeostasis
Paravicini, T. M., Chubanov, V., & Gudermann, T. W. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.05.010 · Cited by 86 · see citing works
Uddin, M. S., Kabir, M. T., Tewari, D., Mathew, B., & Aleya, L. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134836 · Cited by 83 · see citing works
Bennett, S. A. L., Valenzuela, N., Xu, H., Franko, B., Fai, S., & Figeys, D. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00168 · Cited by 86 · see citing works
TRPM7, the Mg2+ Inhibited Channel and Kinase
Bates-Withers, C., Sah, R., & Clapham, D. E. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-0265-3_9 · Cited by 83 · see citing works
Tseveleki, V., Rubio, R., Vamvakas, S. M., White, J., Taoufik, E., Petit, E., Quackenbush, J. F., & Probert, L. (2010) · Genomics · doi:10.1016/j.ygeno.2010.04.004 · Cited by 83 · see citing works
TRPM7 and its role in neurodegenerative diseases
Sun, Y., Sukumaran, P., Schaar, A., & Singh, B. B. (2015) · Channels · doi:10.1080/19336950.2015.1075675 · Cited by 82 · see citing works
Lipids as central modulators of sensory TRP channels
Ciardo, M. G., & Ferrer-Montiel, A. V. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.012 · Cited by 78 · see citing works
TRP Channels Role in Pain Associated With Neurodegenerative Diseases
Duitama, M., Vargas-López, V., Casas, Z., Albarracin, S., Sutachan, J., & Torres, Y. P. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00782 · Cited by 77 · see citing works
Cross-talk of membrane lipids and Alzheimer-related proteins
Walter, J., & van Echten‐Deckert, G. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-34 · Cited by 77 · see citing works
The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease
Small, D. H., Gasperini, R., Vincent, A. J., Hung, A. C., & Foa, L. C. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0951 · Cited by 75 · see citing works
McIntire, L. B., Berman, D. E., Myaeng, J., Staniszewski, A., Arancio, O., Paolo, G. D., & Kim, T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2034-12.2012 · Cited by 75 · see citing works
Self-citationFunction and regulation of the channel-kinase TRPM7 in health and disease
Visser, D., Middelbeek, J., van Leeuwen, F. N., & Jalink, K. (2014) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2014.07.001 · Cited by 75 · see citing works
PIP2 Improves Cerebral Blood Flow in a Mouse Model of Alzheimer’s Disease
Mughal, A., Harraz, O. F., Gonzales, A. L., Hill‐Eubanks, D. C., & Nelson, M. T. (2021) · Function · doi:10.1093/function/zqab010 · Cited by 71 · see citing works
Skwarek, L. C., & Boulianne, G. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2008.12.006 · Cited by 71 · see citing works
Zhu, L., Zhong, M., Zhao, J., Rhee, H., Caesar, I., Knight, E. M., Volpicelli-Daley, L., Bustos, V., Netzer, W., Liu, L., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.504365 · Cited by 70 · see citing works
Alzheimer’s Disease Risk Genes and Lipid Regulators
Gaamouch, F. E., Jing, P., Xia, J., & Cai, D. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160169 · Cited by 65 · see citing works
The Involvement of Lipids in Alzheimer's Disease
Lim, W. L. F., Martins, I. J., & Martins, R. N. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.04.003 · Cited by 64 · see citing works
Cao, Y., Zhao, L., Chen, Z., & Li, S. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1430465 · Cited by 64 · see citing works
Drouet, V., & Lesage, S. (2014) · BioMed Research International · doi:10.1155/2014/289728 · Cited by 61 · see citing works
Turlova, E., Wong, R., Xu, B., Li, F., Du, L., Habbous, S., Horgen, F. D., Fleig, A., Feng, Z., & Sun, H. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00810-3 · Cited by 61 · see citing works
Low hippocampal PI(4,5)P2 contributes to reduced cognition in old mice as a result of loss of MARCKS
Trovò, L., Ahmed, T., Callaerts‐Vegh, Z., Buzzi, A., Bagni, C., Chuah, M., VandenDriessche, T., D’Hooge, R., Balschun, D., & Dotti, C. G. (2013) · Nature Neuroscience · doi:10.1038/nn.3342 · Cited by 60 · see citing works
Discovery of Candidate Genes for Muscle Traits Based on GWAS Supported by eQTL-analysis
Ponsuksili, S., Muráni, E., Trakooljul, N., Schwerin, M., & Wimmers, K. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.8134 · Cited by 60 · see citing works
Lachén‐Montes, M., González-Morales, A., de Morentin, X. M., Pérez‐Valderrama, E., Ausín, K., Zelaya, M. V., Serna, A., Aso, E., Ferrer, I., Fernández‐Irigoyen, J., et al. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.07.032 · Cited by 61 · see citing works
Zeng, Z., Leng, T., Feng, X., Sun, H., Inoue, K., Zhu, L., & Xiong, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119912 · Cited by 58 · see citing works
Volpicelli-Daley, L. A., Lucast, L., Gong, L.-W., Liu, L., Sasaki, J., Sasaki, T., Abrams, C. S., Kanaho, Y., & De Camilli, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.132191 · Cited by 57 · see citing works
Waugh, M. G. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.02.002 · Cited by 57 · see citing works
Miranda, A. M., Herman, M., Cheng, R., Nahmani, E., Barrett, G., Micevska, E., Fontaine, G., Potier, M., Head, E., Schmitt, F. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.011 · Cited by 55 · see citing works
Li, J., Gao, Z., Zhao, D., Zhang, L., Qiao, X., Zhao, Y., Ding, H., Zhang, P., Lu, J., Liu, J., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0484 · Cited by 53 · see citing works
Cho, Y. Y., Kwon, O.-H., Park, M. K., Kim, T., & Chung, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210535 · Cited by 53 · see citing works
Self-citationPan, P., Sheehan, P., Wang, Q., Zhu, X., Zhang, Y., Choi, I., Li, X., Saenz, J., Zhu, J., Wang, J., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa080 · Cited by 52 · see citing works
Lipidomics of Alzheimer’s Disease
Touboul, D., & Gaudin, M. (2014) · Bioanalysis · doi:10.4155/bio.13.346 · Cited by 52 · see citing works
Kim, J., Kim, S. H., Lee, D.-S., Lee, D., Kim, S.-H., Chung, S., & Yang, H. O. (2013) · Journal of Ginseng Research · doi:10.5142/jgr.2013.37.100 · Cited by 52 · see citing works
Self-citationPlasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study
Chatterjee, P., Lim, W. L. F., Shui, G., Gupta, V. B., JAMES, I. R., Fagan, A. M., Xiong, C., Sohrabi, H. R., Taddei, K., Brown, B. M., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150948 · Cited by 52 · see citing works
Mendis, L. H. S., Grey, A. C., Faull, R. L. M., & Curtis, M. A. (2016) · Brain and Behavior · doi:10.1002/brb3.517 · Cited by 52 · see citing works
Role of Phosphoinositides at the Neuronal Synapse
Frère, S. G. A., Chang-Ileto, B., & Paolo, G. D. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-3015-1_5 · Cited by 48 · see citing works
Therapeutic potential of pharmacological agents targeting TRP channels in CNS disorders
Thapak, P., Vaidya, B., Joshi, H. C., Singh, J. N., & Sharma, S. S. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105026 · Cited by 46 · see citing works
Cholesterol modulates ion channels via down‐regulation of phosphatidylinositol 4,5‐bisphosphate
Chun, Y. S., Shin, S., Kim, Y., Cho, H., Park, M. K., Kim, T., Voronov, S. V., Paolo, G. D., Suh, B., & Chung, S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06545.x · Cited by 45 · see citing works
Self-citationPhosphoinositides Suppress γ-Secretase in Both the Detergent-soluble and -insoluble States
Osawa, S., Funamoto, S., Nobuhara, M., Wada‐Kakuda, S., Shimojo, M., Yagishita, S., & Ihara, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705954200 · Cited by 44 · see citing works
Kamermans, A., Planting, K. E., Jalink, K., van Horssen, J., & de Vries, H. E. (2018) · Glia · doi:10.1002/glia.23526 · Cited by 42 · see citing works
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterolPreprint
Wang, H., Kulas, J. A., Ferris, H. A., & Hansen, S. B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.18.159632 · Cited by 43 · see citing works
Kang, M. S., Baek, S., Chun, Y. S., Moore, A. Z., Landman, N., Berman, D. E., Yang, H. O., Morishima‐Kawashima, M., Osawa, S., Funamoto, S., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445734 · Cited by 37 · see citing works
Self-citationLiu, X., Du, Y., Trakooljul, N., Brand, B., Muráni, E., Krischek, C., Wicke, M., Schwerin, M., Wimmers, K., & Ponsuksili, S. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.13132 · Cited by 37 · see citing works
Role of the chanzyme TRPM7 in the nervous system in health and disease
Abumaria, N., Li, W., & Clarkson, A. N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03124-2 · Cited by 36 · see citing works
Kawade, N., & Yamanaka, K. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13661 · Cited by 32 · see citing works
Endocytosis and Alzheimer’s disease
Zadka, Ł., Sochocka, M., Hachiya, N., Chojdak-Łukasiewicz, J., Dzięgiel, P., Piasecki, E., & Leszek, J. (2023) · GeroScience · doi:10.1007/s11357-023-00923-1 · Cited by 32 · see citing works
Mandal, M., & Yan, Z. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058701 · Cited by 32 · see citing works
Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIγ in the mouse brain
Clarke, J. H., Emson, P. C., & Irvine, R. F. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22161 · Cited by 30 · see citing works
Presenilins and the γ-secretase: still a complex problem
Small, D. H., Klaver, D. W., & Foa, L. C. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-7 · Cited by 29 · see citing works
Defining the minimum substrate and charge recognition model of gamma-secretase
Yan, Y., Xu, T.-H., Melcher, K., & Xu, H. E. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.35 · Cited by 30 · see citing works
Gosney, R., Liau, W., & LaMunyon, C. W. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-44 · Cited by 29 · see citing works
Gandy, S., Zhang, Y., Ikin, A. F., Schmidt, S. D., Levy, E., Sheffield, R., Nixon, R. A., Liao, F., Mathews, P. M., Xu, H., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04587.x · Cited by 27 · see citing works
Su, R., Han, Z.-Y., Fan, J.-P., & Zhang, Y.-L. (2010) · Neuroscience Bulletin · doi:10.1007/s12264-010-0131-0 · Cited by 27 · see citing works
Oh, H. G., & Chung, S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.163 · Cited by 25 · see citing works
Self-citationMcKeever, P. M., Kim, T. P., Hesketh, A. R., MacNair, L., Miletic, D., Favrin, G., Oliver, S. G., Zhang, Z., George‐Hyslop, P. S., & Robertson, J. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.05.014 · Cited by 24 · see citing works
Self-citationMačianskienė, R., Gwanyanya, A., Vereecke, J., & Mubagwa, K. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000149788 · Cited by 23 · see citing works
Transient Receptor Potential (TRP) Channels in the Brain: the Good and the Ugly
Nilius, B. (2012) · European Review · doi:10.1017/s1062798711000597 · Cited by 23 · see citing works
Modulation of transient receptor potential melastatin related 7 channel by presenilins
Oh, H. G., Chun, Y. S., Kim, Y., Youn, S. H., Shin, S., Park, M. K., Kim, T., & Chung, S. (2011) · Developmental Neurobiology · doi:10.1002/dneu.22001 · Cited by 23 · see citing works
Self-citationWhat Do We Really Know and What Do We Need to Know: Some Controversies, Perspectives, and Surprises
Nilius, B., & Flockerzi, V. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-05161-1_20 · Cited by 22 · see citing works
Xing, J., & Strange, K. B. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00394.2009 · Cited by 21 · see citing works
Park, C. S., Lee, J. Y., Choi, H. Y., Ju, B. G., & Yune, T. Y. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2021.0338 · Cited by 20 · see citing works
Zhang, S., Cao, F., Li, W., & Abumaria, N. (2023) · Science Signaling · doi:10.1126/scisignal.ade6325 · Cited by 20 · see citing works
TRPM7 contributes to pyroptosis and its involvement in status epilepticus
Tong, X., Tong, Y., Zheng, J., Shi, R., Liang, H., Li, M., Meng, Y., Shi, J., Zhao, D., Seehus, C. R., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03292-4 · Cited by 19 · see citing works
Phosphoinositides in Neuroexocytosis and Neuronal Diseases
Wen, P. J., Osborne, S. L., & Meunier, F. A. (2012) · Current topics in microbiology and immunology · doi:10.1007/978-94-007-5025-8_4 · Cited by 19 · see citing works
PIP2: a new key player in Alzheimer's disease.
Arancio, O. (2008) · PubMed · Cited by 18 · see citing works
PIP 2 corrects an endothelial Piezo1 channelopathy
Hashad, A. M., Abd-Alhaseeb, M. M., Lim, X. R., Mathieu, N. M., & Harraz, O. F. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2522750122 · Cited by 14 · see citing works
Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism
Gutierrez, E., Lütjohann, D., Kerksiek, A., Fabiano, M., Oikawa, N., Kuerschner, L., Thiele, C., & Walter, J. (2020) · Life Science Alliance · doi:10.26508/lsa.201900521 · Cited by 14 · see citing works
Majid, H., Kohli, S., Islam, S. U., & Nidhi (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01597-6 · Cited by 13 · see citing works
Lee, S.-H., Lin, C., Chen, T., Chou, C. C. ‐., Chiu, M., Tee, B. L., Liang, H., & Cheng, T. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156456 · Cited by 13 · see citing works
Zhang, X., Wang, W.-A., Jiang, L.-X., Liu, H., Zhang, B., Lim, N. K.-H., Li, Q.-Y., & Huang, F.-D. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3567-16.2017 · Cited by 13 · see citing works
Altmann, S., Muráni, E., Metges, C. C., Schwerin, M., Wimmers, K., & Ponsuksili, S. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1541-z · Cited by 12 · see citing works
α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity
Horvath, J. D., Casas, M., Kutchukian, C., Sánchez, S. C., Pergande, M. R., Cologna, S. M., Simó, S., Dixon, R. E., & Dickson, E. J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113244 · Cited by 11 · see citing works
- Authors
- Landman, N., Jeong, S. Y., Shin, S. Y., Voronov, S. V., Serban, G., Kang, M. S., Park, M. K., Di Paolo, G., Chung, S., & Kim, T.-W.
- Affiliations
- Columbia University Irving Medical Center (US)
- Sungkyunkwan University (KR)
- Department of Pathology, and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-12-19
- Volume
- 103
- Issue
- 51
- Pages
- 19524-19529
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1748258
- OpenAlex
- W2047442659
- Cited by
- 149
- References
- 50
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 6 · 2021: 1 · 2020: 12 · 2019: 6 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 14 · 2012: 13
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ellison Medical Foundation
- National Institutes of Health
- Samsung
- National Institute of Neurological Disorders and Stroke (R01NS043467, F31NS051186, NS43467, NS51186)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD047733, R21HD047733)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- presenilin mutations, familial Alzheimer's disease, phosphatidylinositol 4,5-bisphosphate, TRPM7, ion channel dysfunction, amyloid-beta 42, lipid turnover, Alzheimer's disease pathogenesis, therapeutic target
- MeSH terms
- Alzheimer Disease, Cell Line, Electrophysiology, Humans, Mutation, Phosphorylation, Blotting, Western, Amyloid beta-Peptides, Protein Serine-Threonine Kinases, Phosphotransferases (Alcohol Group Acceptor), TRPM Cation Channels, Presenilins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
