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Cited by 27Seaweed-derived Bioactive CompoundsProbiotics and Fermented FoodsAlgal biology and biofuel production

Microalgae in Terms of Biomedical Technology: Probiotics, Prebiotics, and Metabiotics

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Oleskin, A. V., Boyang, Cao·2022·Applied Biochemistry and Microbiology
DOI 10.1134/s0003683822060126PMC PMC9734902
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Abstract

Green, red, brown, and diatomic algae, as well as cyanobacteria, have been in the focus of attention of scientists and technologists for over 5 decades. This is due to their importance as efficient and economical producers of food additives, cosmetics, pharmaceuticals, biofertilizers, biofuels, and wastewater bioremediation agents. Recently, the role of microalgae has increasingly been considered in terms of their probiotic function, i.e., of their ability to normalize the functioning of the microbiota of humans and agricultural animals and to produce biologically active substances, including hormones, neurotransmitters, and immunostimulators. A separate brief subsection of the review deals with the potential functions of microalgae with respect to the brain and psyche, i.e., as psychobiotics. Moreover, algal polysaccharides and some other compounds can be broken down to short fragments that will stimulate the development of useful intestinal microorganisms, i.e., function as efficient prebiotics. Finally, many components of microalgal cells and chemical agents produced by them can exert important health-promoting effects per se, which indicates that they are as potentially valuable metabiotics (the term preferred by late Prof. B.A. Shenderov), which are alternatively denoted as postbiotics in the literature.

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Crossref · 10.1134/s0003683822060126

Cites

87 of 87 references verified0 citation errors · 0 not checkable

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  • Microalgae contain non-digestible polysaccharides and fibres with prebiotic effects, including sulphated polysaccharides, β-glucans, and xylans/rhamnose-rich polysaccharides.

    “Microalgae contain various non-digestible polysaccharides and fibres with prebiotic effects, including sulphated polysaccharides (e.g., from Porphyridium), β-glucans (e.g., from Chlorella), and xylans and rhamnose-rich polysaccharides (e.g., from Spirulina).”

    From Microalgae Bioactives for Functional Food Innovation and Health Promotion (2025) · cites this paper as [60]

    The copy’s “Microalgae as prebiotics” passage (page not provided) says microalgal polysaccharides can yield prebiotic oligosaccharides and lists arabinoxylans and β-glucans. Other passages identify β-1,3-glucan in Chlorella and sulfated polysaccharides in Porphyridium, but describe the latter’s other biological effects, not prebiotic effects. The copy does not identify xylans or rhamnose-rich polysaccharides from Spirulina as prebiotics. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Microalgal polysaccharides selectively promote growth of beneficial gut microbes such as Lactobacillus, Bifidobacterium, and Faecalibacterium prausnitzii.

    “These compounds have been shown to selectively promote the growth of beneficial gut microbes such as Lactobacillus, Bifidobacterium, and Faecalibacterium prausnitzii, as supported by recent studies on microalgae-derived prebiotics [60,61].”

    From Microalgae Bioactives for Functional Food Innovation and Health Promotion (2025) · cites this paper as [60]

    In the section labeled Abstract (page not provided), the paper says that oligosaccharides derived from microalgal polysaccharides selectively stimulate lactobacilli and bifidobacteria, provided they reach the colon. It does not identify Faecalibacterium prausnitzii as a beneficiary, so the full list of microbes is not supported. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cites

1 retracted

Flagged first, then by citations

Research works printed but not linked: 10

  1. [4]Varfolomeev, S.D. and Vasserman, L.A., Biotekhnologiya, 2011, no. 2, pp. 9–33.
  2. [10]Didovich, S.V., Moskalenko, S.V., Temraleeva, A.D., and Khapchaeva, S.A., Vopr. Sovrem. Al’gol., 2017. vol. 2, no. 14. https://algology/ru/1170.
  3. [38]Shenderov B.A. The Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology 2016 Wiley
  4. [41]Ahn, N.L., Health-promoting microbes in traditional Vietnamese fermented foods: a review, Food Sci. Hum. Wellness, 2015. 10.1016/j.fshw.2015.08.009 · DOI
  5. [42]Boddu, R.S. and Divakar, K., in Microbial Biotechnology, vol. 2: Application in Food and Pharmacology, Patra, J.K., Das, G., and Shin, H.-S., Eds., Singapore: Springer Nature Singapore Pte, 2018, pp. 23–38.
  6. [43]Kerry, R.G., Pradhan, P., Samal, D., and Gouda, S., in Microbial Biotechnology, vol. 2: Application in Food and Pharmacology, Patra, J.K., Das, G., and Shin, H.-S., Eds., Singapore: Springer Nature Singapore Pte, 2018, pp. 141–152.
  7. [48]Shenderov, B.A., Meditsinskaya mikrobnaya ekologiya i funktsional’noe pitanie (Medical Microbial Ecology and Functional Nutrition), vol. 3: Probiotiki i funktsional’noe pitanie (Probiotics and Functional Nutrition), Moscow: Grant", 2001.
  8. [49]Shenderov, B.A., Metamorfozy, 2014, no. 5, pp. 72–80.
  9. [50]Shenderov, B.A., Golubev, V.L., Danilov, A.B., and Prishchepa, A.V., Nevrologiya, 2016, no. 1, pp. 7–13.
  10. [81]Jacob-Lopes E. Maroneze M.M. Deprá M.C. Sartori R.B. Dias R.R. Zepka L.Q. Curr. Opin. Food Sci 2018 25 1 7 10.3390/md17060312 · DOI · Paper page

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Authors
Oleskin, A. V., & Boyang, C.
Affiliations
  • Lomonosov Moscow State University (RU)
  • Shenzhen MSU-BIT University (CN)
Corresponding author
Oleskin, A. V.
ORCID
Oleskin, A. V.
Venue
Applied Biochemistry and Microbiology
Publisher
Pleiades Publishing Ltd
Published
2022-12
Volume
58
Issue
6
Pages
813-825
ISSN
  • 0003-6838 (ISSN-L)
  • 1608-3024
DOI
10.1134/s0003683822060126
PMC
PMC9734902
OpenAlex
W4311376293
Cited by
27
References
87
Citations by year
2026: 6 · 2025: 11 · 2024: 5 · 2023: 4 · 2022: 1
FWCI
3.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Applied Biochemistry and Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Lomonosov Moscow State University
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Keywords
microalgae, probiotics, prebiotics, metabiotics, postbiotics, psychobiotics, gut microbiota, algal polysaccharides, bioactive materials, immunostimulants, health-promoting properties, cyanobacteria

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