Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy.
Open accessAbstract
The evaluation of fat-free mass (FFM) in patients with Duchenne muscular dystrophy (DMD) is useful to investigate disease progression and therapeutic efficacy. This study aimed to validate the Bioelectrical impedance (BIA) method compared with the dual-energy X-ray absorptiometry (DXA) for estimating the %FFM in boys with DMD. This is a cross-sectional study performed with children and adolescents diagnosed with DMD. Resistance and reactance were measured with a BIA analyzer, from which eight predictive equations estimated the %FFM. The %FFM was also determined by DXA and its used as a reference method. Pearson correlation test, coefficient of determination, the root-mean-square error, the interclass correlation coefficient, and linear regression analysis were performed between %FFM values obtained by BIA and DXA. The agreement between these values was verified with the Bland-Altman plot analysis. Forty-six boys aged from 5 to 20 years were enrolled in the study. All the equations showed a correlation between the %FFM estimated by BIA and determined by DXA (p < 0.05). The Bland-Altman method indicated that two equations have a significant bias (p < 0.05) and six equations showed no significant bias of %FFM (p > 0.05). However, one of them has high variation and wide limits of agreement. Five of eight %FFM predictive equations tested in DMD were accurate when compared with the DXA. It can be concluded that BIA is a validity method to evaluate patients with DMD.
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BIA is one of the most convenient techniques for assessing body composition in a clinical setting and in epidemiological approaches, mainly because it is easy to apply, fast, and non-invasive, in addition to having a relatively low cost.
“The BIA is one of the most convenient techniques for assessing body composition in a clinical setting and in epidemiological approaches, mainly, because it is easy to apply, fast, and non-invasive, in addition to having a relatively low cost (5, 45, 46).”
From Development and Cross-Validation of a Predictive Equation for Fat-Free Mass in Brazilian Adolescents by Bioelectrical Impedance (2022) · cites this paper as [45]
The Introduction describes BIA as simple, practical, and low-cost for evaluating body composition in clinical practice; the Discussion calls it easy to apply and inexpensive compared with DXA. Our copy does not establish its use in epidemiological approaches or explicitly describe it as fast or non-invasive. (LLM, conf=0.84)
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“The BIA is one of the most convenient techniques for assessing body composition in a clinical setting and in epidemiological approaches, mainly, because it is easy to apply, fast, and noninvasive, in addition to having a relatively low cost (5, 45, 46).”
Method
- Authors
- Grilo, E. C., Cunha, T. A., Costa, Á. D. S., Araújo, B. G. M., Lopes, M. M. G. D., Maciel, B. L. L., Alves, C. X., Vermeulen-Serpa, K. M., Dourado-Júnior, M. E. T., Leite-Lais, L., Brandão-Neto, J., & Vale, S. H. L.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Corresponding author
- Grilo, Evellyn C.
- Cunha, Thais A.
- Costa, Ádila Danielly S.
- Araújo, Bárbara G. M.
- Lopes, Márcia Marília G. D.
- Maciel, Bruna L. L.
- Alves, Camila X.
- Vermeulen-Serpa, Karina M.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2020-11-20
- Volume
- 15
- Issue
- 11
- Pages
- e0241722
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC7679022
- OpenAlex
- W3103884425
- Cited by
- 13
- References
- 48
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (302298/2017-7, 422667/2016-1, 2017-7)
- Institute on the Environment, University of Minnesota
- Topics
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- Duchenne muscular dystrophy, bioelectrical impedance analysis, fat-free mass, dual-energy X-ray absorptiometry, prediction equations, method validation, children and adolescents, muscle mass assessment
- MeSH terms
- Adolescent, Algorithms, Body Composition, Body Weight, Child, Cross-Sectional Studies, Humans, Male, Absorptiometry, Photon, Body Mass Index, Linear Models, Electric Impedance, Muscular Dystrophy, Duchenne, Young Adult
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