Can ChatGPT assist authors with abstract writing in medical journals? Evaluating the quality of scientific abstracts generated by ChatGPT and original abstracts
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Introduction: ChatGPT, a sophisticated large language model (LLM), has garnered widespread attention for its ability to mimic human-like communication. As recent studies indicate a potential supportive role of ChatGPT in academic writing, we assessed the LLM’s capacity to generate accurate and comprehensive scientific abstracts from published Randomised Controlled Trial (RCT) data, focusing on the adherence to the Consolidated Standards of Reporting Trials for Abstracts (CONSORT-A) statement, in comparison to the original authors’ abstracts. Methodology: RCTs, identified in a PubMed/MEDLINE search post-September 2021 across various medical disciplines, were subjected to abstract generation via ChatGPT versions 3.5 and 4, following the guidelines of the respective journals. The overall quality score (OQS) of each abstract was determined by the total number of adequately reported components from the 18-item CONSORT-A checklist. Additional outcome measures included percent adherence to each CONOSORT-A item, readability, hallucination rate, and regression analysis of reporting quality determinants. Results: Original abstracts achieved a mean OQS of 11.89 (95% CI: 11.23–12.54), outperforming GPT 3.5 (7.89; 95% CI: 7.32–8.46) and GPT 4 (5.18; 95% CI: 4.64–5.71). Compared to GPT 3.5 and 4 outputs, original abstracts were more adherent with 10 and 14 CONSORT-A items, respectively. In blind assessments, GPT 3.5-generated abstracts were deemed most readable in 62.22% of cases which was significantly greater than the original (31.11%; P = 0.003) and GPT 4-generated (6.67%; P<0.001) abstracts. Moreover, ChatGPT 3.5 exhibited a hallucination rate of 0.03 items per abstract compared to 1.13 by GPT 4. No determinants for improved reporting quality were identified for GPT-generated abstracts. Conclusions: While ChatGPT could generate more readable abstracts, their overall quality was inferior to the original abstracts. Yet, its proficiency to concisely relay key information with minimal error holds promise for medical research and warrants further investigations to fully ascertain the LLM’s applicability in this domain.
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Prior studies have mostly discussed potential applications and ethical implications of LLMs for scientific writing in medicine overall and, when performance was measured, analyzed often only one (typically proprietary) LLM.
“Prior studies have mostly discussed potential applications and ethical implications of LLMs for scientific writing in medicine overall and – when performance was measured – analyzed often only one (typically proprietary) LLM.12–17”
From Open-source versus proprietary large language models for academic writing in medicine: A controlled evaluation of DeepSeek-R1 and ChatGPT-o1 in neuroradiology (2026) · cites this paper as [16]
The Introduction (page not available) discusses ChatGPT’s potential for scientific writing, and the Discussion addresses risks including bias, fabricated content and plagiarism. The paper also measures abstract-writing performance, but its Discussion explicitly says it evaluated both GPT 3.5 and GPT 4; it therefore does not support the suggestion that this study analyzed only one model. It does not establish what most prior studies did. (LLM, conf=0.84)
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- Authors
- Hwang, T., Aggarwal, N., Khan, P. Z., Roberts, T., Mahmood, A., Griffiths, M. M., Parsons, N., & Khan, S.
- Affiliations
- University Hospitals Coventry and Warwickshire NHS Trust (GB)
- University of Warwick (GB)
- Royal Devon and Exeter Hospital (GB)
- Corresponding author
- Hwang, Taesoon
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2024-02-14
- Volume
- 19
- Issue
- 2
- Pages
- e0297701
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC10866463
- OpenAlex
- W4391811744
- Cited by
- 59
- References
- 20
- Citations by year
- 2026: 22 · 2025: 22 · 2024: 15
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (publishedVersion)
- Warwick Research Archive Portal (University of Warwick) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Royal Devon and Exeter Research Repository (Royal Devon and Exeter) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Social Sciences › Library and Information Sciences › Academic Writing and Publishing
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Keywords
- ChatGPT, large language models, scientific abstracts, abstract writing, reporting quality, randomized controlled trials, hallucinations, readability, medical journal publishing, reporting guidelines adherence, publication ethics, plagiarism detection
- MeSH terms
- Hallucinations, Humans, Periodicals as Topic, Publications, Reference Standards, Writing
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