The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Origin, Spread and Demography of the Mycobacterium tuberculosis Complex
Open accessAbstract
The evolutionary timing and spread of the Mycobacterium tuberculosis complex (MTBC), one of the most successful groups of bacterial pathogens, remains largely unknown. Here, using mycobacterial tandem repeat sequences as genetic markers, we show that the MTBC consists of two independent clades, one composed exclusively of M. tuberculosis lineages from humans and the other composed of both animal and human isolates. The latter also likely derived from a human pathogenic lineage, supporting the hypothesis of an original human host. Using Bayesian statistics and experimental data on the variability of the mycobacterial markers in infected patients, we estimated the age of the MTBC at 40,000 years, coinciding with the expansion of "modern" human populations out of Africa. Furthermore, coalescence analysis revealed a strong and recent demographic expansion in almost all M. tuberculosis lineages, which coincides with the human population explosion over the last two centuries. These findings thus unveil the dynamic dimension of the association between human host and pathogen populations.
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Cites
Inference of Population Structure Using Multilocus Genotype Data
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Sex and virulence in Escherichia coli: an evolutionary perspective
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A new evolutionary scenario for the Mycobacterium tuberculosis complex
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Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
Bos, K. I., Harkins, K. M., Herbig, A., Coscolla, M., Weber, N., Comas, I., Forrest, S. A., Bryant, J. M., Harris, S. R., Schuenemann, V. J., et al. (2014) · Nature · doi:10.1038/nature13591 · Cited by 566
Self-citationEvolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
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Self-citationHershkovitz, I., Donoghue, H. D., Minnikin, D. E., Besra, G. S., Lee, O. Y.-C., Gernaey, A. M., Galili, E., Eshed, V., Greenblatt, C. L., Lemma, E., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003426 · Cited by 506
Consequences of genomic diversity in Mycobacterium tuberculosis
Coscolla, M., & Gagneux, S. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.09.012 · Cited by 451
Supply, P., Marceau, M., Mangenot, S., Roche, D., Rouanet, C., Khanna, V., Majlessi, L., Criscuolo, A., Tap, J., Pawlik, A., et al. (2013) · Nature Genetics · doi:10.1038/ng.2517 · Cited by 305
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Metadata
- Authors
- Wirth, T., Hildebrand, F., Allix-Béguec, C., Wölbeling, F., Kubica, T., Kremer, K., van Soolingen, D., Rüsch-Gerdes, S., Locht, C., Brisse, S., Meyer, A., Supply, P., & Niemann, S.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-09-26
- Volume
- 4
- Issue
- 9
- Pages
- e1000160
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2152363872
- Cited by
- 473
- References
- 51
- FWCI
- 19.66
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wirth, T., Hildebrand, F., Allix-Béguec, C., Wölbeling, F., Kubica, T., Kremer, K., van Soolingen, D., Rüsch-Gerdes, S., Locht, C., Brisse, S., Meyer, A., Supply, P., & Niemann, S. (2008). Origin, Spread and Demography of the Mycobacterium tuberculosis Complex. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1000160
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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