The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells
Open accessAbstract
Influenza A viruses (IAV) bind to sialic-acids at cellular surfaces and enter cells by using endocytotic routes. There is evidence that this process does not occur constitutively but requires induction of specific cellular signals, including activation of PI3K that promotes virus internalization. This implies engagement of cellular signaling receptors during viral entry. Here, we present first indications for an interplay of IAV with receptor tyrosine kinases (RTKs). As representative RTK family-members the epidermal growth factor receptor (EGFR) and the c-Met receptor were studied. Modulation of expression or activity of both RTKs resulted in altered uptake of IAV, showing that these receptors transmit entry relevant signals upon virus binding. More detailed studies on EGFR function revealed that virus binding lead to clustering of lipid-rafts, suggesting that multivalent binding of IAV to cells induces a signaling platform leading to activation of EGFR and other RTKs that in turn facilitates IAV uptake.
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Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES
Brown, D. A., & London, E. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.111 · Cited by 2,948
Human host factors required for influenza virus replication
König, R., Stertz, S., Zhou, Y., Inoue, A., Hoffmann, H. H., Bhattacharyya, S., Alamares, J. G., Tscherne, D. M., Ortigoza, M. B., Liang, Y., et al. (2010) · Nature · doi:10.1038/nature08699 · Cited by 813
The elderberry (Sambucus nigra L.) bark lectin recognizes the Neu5Ac(alpha 2-6)Gal/GalNAc sequence.
Shibuya, N., Goldstein, I. J., Broekaert, W. F., Nsimba-Lubaki, M., Peeters, B., & Peumans, W. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75677-4 · Cited by 784
Clathrin-independent endocytosis of ubiquitinated cargos
Sigismund, S., Woelk, T., Puri, C., Maspero, E., Tacchetti, C., Transidico, P., Di Fiore, P. P., & Polo, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409817102 · Cited by 739
Prenzel, N., Fischer, O. M., Streit, S., Hart, S., & Ullrich, A. (2001) · Endocrine-related cancer · doi:10.1677/erc.0.0080011 · Cited by 673
Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade
Pleschka, S., Wolff, T., Ehrhardt, C., Hobom, G., Planz, O., Rapp, U. R., & Ludwig, S. (2001) · Nature Cell Biology · doi:10.1038/35060098 · Cited by 526
Self-citationLakadamyali, M., Rust, M. J., & Zhuang, X. (2006) · Cell · doi:10.1016/j.cell.2005.12.038 · Cited by 508
The Ebola virus VP35 protein functions as a type I IFN antagonist
Basler, C. F., Wang, X., Mühlberger, E., Volchkov, V., Paragas, J., Klenk, H.-D., García-Sastre, A., & Palese, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220398297 · Cited by 478
Localization of Epidermal Growth Factor-stimulated Ras/Raf-1 Interaction to Caveolae Membrane
Mineo, C., James, G. L., Smart, E. J., & Anderson, R. G. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.11930 · Cited by 447
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Schelhaas, M., Shah, B., Holzer, M., Blattmann, P., Kühling, L., Day, P. M., Schiller, J. T., & Helenius, A. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002657 · Cited by 295
Stanley, S. A., Barczak, A. K., Silvis, M. R., Luo, S. S., Sogi, K., Vokes, M., Bray, M.-A., Carpenter, A. E., Moore, C. B., Siddiqi, N., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003946 · Cited by 251
Zhu, W., Phan, Q. T., Boontheung, P., Solis, N. V., Loo, J. A., & Filler, S. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117676109 · Cited by 180
Zheng, K., Xiang, Y., Wang, X., Wang, Q., Zhong, M., Wang, S., Wang, X., Fan, J., Kitazato, K., & Wang, Y. (2014) · mBio · doi:10.1128/mbio.00958-13 · Cited by 118
Metadata
- Authors
- Eierhoff, T., Hrincius, E. R., Rescher, U., Ludwig, S., & Ehrhardt, C.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-09-09
- Volume
- 6
- Issue
- 9
- Pages
- e1001099
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2088824199
- Cited by
- 340
- References
- 43
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- Eierhoff, T., Hrincius, E. R., Rescher, U., Ludwig, S., & Ehrhardt, C. (2010). The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1001099
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