The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Distinct Clones of Yersinia pestis Caused the Black Death
Open accessAbstract
From AD 1347 to AD 1353, the Black Death killed tens of millions of people in Europe, leaving misery and devastation in its wake, with successive epidemics ravaging the continent until the 18(th) century. The etiology of this disease has remained highly controversial, ranging from claims based on genetics and the historical descriptions of symptoms that it was caused by Yersinia pestis to conclusions that it must have been caused by other pathogens. It has also been disputed whether plague had the same etiology in northern and southern Europe. Here we identified DNA and protein signatures specific for Y. pestis in human skeletons from mass graves in northern, central and southern Europe that were associated archaeologically with the Black Death and subsequent resurgences. We confirm that Y. pestis caused the Black Death and later epidemics on the entire European continent over the course of four centuries. Furthermore, on the basis of 17 single nucleotide polymorphisms plus the absence of a deletion in glpD gene, our aDNA results identified two previously unknown but related clades of Y. pestis associated with distinct medieval mass graves. These findings suggest that plague was imported to Europe on two or more occasions, each following a distinct route. These two clades are ancestral to modern isolates of Y. pestis biovars Orientalis and Medievalis. Our results clarify the etiology of the Black Death and provide a paradigm for a detailed historical reconstruction of the infection routes followed by this disease.
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Cites
Yersinia pestis--etiologic agent of plague
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Yersinia pestis , the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
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Self-citationAncient DNA from the First European Farmers in 7500-Year-Old Neolithic Sites
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Self-citationThe Black Death, 1346-1353: the complete history
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Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
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Self-citationMicroevolution and history of the plague bacillus, Yersinia pestis
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Self-citationMolecular identification by “suicide PCR” of Yersinia pestis as the agent of Medieval Black Death
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Cited by
A draft genome of Yersinia pestis from victims of the Black Death
Bos, K. I., Schuenemann, V. J., Golding, G. B., Burbano, H. A., Waglechner, N., Coombes, B. K., McPhee, J. B., DeWitte, S. N., Meyer, M., Schmedes, S., et al. (2011) · Nature · doi:10.1038/nature10549 · Cited by 619
Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity
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Self-citationAncient pathogen genomics as an emerging tool for infectious disease research
Spyrou, M. A., Bos, K. I., Herbig, A., & Krause, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0119-1 · Cited by 285
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Metadata
- Authors
- Haensch, S., Bianucci, R., Signoli, M., Rajerison, M., Schultz, M., Kacki, S., Vermunt, M., Weston, D. A., Hurst, D., Achtman, M., Carniel, E., & Bramanti, B.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-10-07
- Volume
- 6
- Issue
- 10
- Pages
- e1001134
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W1968824590
- Cited by
- 379
- References
- 33
- FWCI
- 14.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- Haensch, S., Bianucci, R., Signoli, M., Rajerison, M., Schultz, M., Kacki, S., Vermunt, M., Weston, D. A., Hurst, D., Achtman, M., Carniel, E., & Bramanti, B. (2010). Distinct Clones of Yersinia pestis Caused the Black Death. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1001134
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