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Current Perspectives in Human T-Cell Leukemia Virus Type 1 Infection and Its Associated Diseases

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Epigenetic Modification of the FoxP3 TSDR in HAM/TSP Decreases the Functional Suppression of Tregs

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Correction: Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice

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Animal Models Utilized in HTLV-1 Research

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HTLV-1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signaling

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Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis

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Does HTLV-1 Infection Show Phenotypes Found in Sjögren’s Syndrome?

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Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia

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The role of viruses in cancer development versus cancer therapy: An oncological perspective

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The TP53-Induced Glycolysis and Apoptosis Regulator mediates cooperation between HTLV-1 p30II and the retroviral oncoproteins Tax and HBZ and is highly expressed in an in vivo xenograft model of HTLV-1-induced lymphoma

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Decoding pathogenesis factors involved in the progression of ATLL or HAM/TSP after infection by HTLV-1 through a systems virology study

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Expression of miR-34a in T-Cells Infected by Human T-Lymphotropic Virus 1

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Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP

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Current State of Therapeutics for HTLV-1

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IL-2/IL-2 Receptor Pathway Plays a Crucial Role in the Growth and Malignant Transformation of HTLV-1-Infected T Cells to Develop Adult T-Cell Leukemia

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HTLV-1 Replication and Adult T Cell Leukemia Development

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HTLV-1 bZIP Factor-Induced Reprogramming of Lactate Metabolism and Epigenetic Status Promote Leukemic Cell Expansion

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Does chronic infection in retroviruses have a sense?

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The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections

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Dual cytoplasmic and nuclear localization of HTLV-1-encoded HBZ protein is a unique feature of adult T-cell leukemia

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Portrait of the Intrinsically Disordered Side of the HTLV-1 Proteome

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Correction to: Human T-cell leukaemia virus type 1 associated pulmonary disease: clinical and pathological features of an under-recognised complication of HTLV-1 infection

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A transgenic mouse model of human T cell leukemia virus type 1-associated diseases

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HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors

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Role of the HTLV-1 viral factors in the induction of apoptosis

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Tumor necrosis factor alpha inhibitors have no effect on a human T-lymphotropic virus type-I (HTLV-I)-infected cell line from patients with HTLV-I-associated myelopathy

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HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice

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HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia

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Acetylation of the c-MYC oncoprotein is required for cooperation with the HTLV-1 p30II accessory protein and the induction of oncogenic cellular transformation by p30II/c-MYC

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HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia

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Lymphotropic Viruses: Chronic Inflammation and Induction of Cancers

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CRISPR Genome Editing Applied to the Pathogenic Retrovirus HTLV-1

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A role for an HTLV-1 vaccine?

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CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma

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Decreased RORC expression and downstream signaling in HTLV‐1‐associated adult T‐cell lymphoma/leukemia uncovers an antiproliferative IL17 link: A potential target for immunotherapy?

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Silencers of HTLV-1 and HTLV-2: the pX-encoded latency-maintenance factors

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The HIV-1 Antisense Gene ASP: The New Kid on the Block

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HTLV-1 persistence and leukemogenesis: A game of hide-and-seek with the host immune system

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HTLV-1 bZIP Factor–Specific CD4 T Cell Responses in Adult T Cell Leukemia/Lymphoma Patients after Allogeneic Hematopoietic Stem Cell Transplantation

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The sense behind retroviral anti-sense transcription

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Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia

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Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner

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Genomics of LGL leukemia and select other rare leukemia/lymphomas

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The bZIP Proteins of Oncogenic Viruses

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Human T-cell leukemia virus type 1 and Foxp3 expression: viral strategyin vivo

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Origin and functional role of antisense transcription in endogenous and exogenous retroviruses

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Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells

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From Immunodeficiency to Humanization: The Contribution of Mouse Models to Explore HTLV-1 Leukemogenesis

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Effect of HTLV-1 Infection on the Clinical Course of Patients with Rheumatoid Arthritis

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Nuclear Factor of Activated T Cells Signalling and Viral Pathogens: A Dynamic Cross‐Talk

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Stratagems of HTLV-1 for persistent infection and the resultant oncogenesis: Immune evasion and clonal expansion

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Time to Go Back to the Original Name

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Retrovirus insertion site analysis of LGL leukemia patient genomes

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Immunopathogenesis and Cellular Interactions in Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis

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The HTLV-1 HBZ protein inhibits cyclin D1 expression through interacting with the cellular transcription factor CREB

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Novel insights into human T‐lymphotropic virus type‐1 (HTLV‐1) pathogenesis‐host interactions in the manifestation of HTLV‐1‐associated myelopathy/tropical spastic paraparesis

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Early Effects of HTLV-1 Infection on the Activation, Exhaustion, and Differentiation of T-Cells in Humanized NSG Mice

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Tuning Rex rules HTLV-1 pathogenesis

Nakano, K., & Watanabe, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.959962 · Cited by 11

Novel interactions between the HTLV antisense proteins HBZ and APH-2 and the NFAR protein family: Implications for the HTLV lifecycles

Murphy, J. L., Hall, W. W., Ratner, L., & Sheehy, N. (2016) · Virology · doi:10.1016/j.virol.2016.04.012 · Cited by 13

Enhanced Stabilization of MCL1 by the Human T-Cell Leukemia Virus Type 1 bZIP Factor Is Modulated by Blocking the Recruitment of Cullin 1 to the SCF Complex

Mukai, R., & Ohshima, T. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00450-16 · Cited by 11

HLA-B*35 as a new marker for susceptibility to human T-cell lymphotropic virus type 1 (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina

Benencio, P., Gonzalez, S. A. F., Ducasa, N., Page, K. A., Berini, C. A., & Biglione, M. M. (2020) · Retrovirology · doi:10.1186/s12977-020-00536-y · Cited by 11

Comprehensive high-throughput meta-analysis of differentially expressed microRNAs in transcriptomic datasets reveals significant disruption of MAPK/JNK signal transduction pathway in Adult T-cell leukemia/lymphoma

Shadabi, S., Delrish, N., Norouzi, M., Ehteshami, M., Habibian-Sezavar, F., Pourrezaei, S., Madihi, M., Ostadali, M., Akhgar, F., Shayeghpour, A., et al. (2021) · Infectious Agents and Cancer · doi:10.1186/s13027-021-00390-3 · Cited by 11

Pentosan Polysulfate Demonstrates Anti-human T-Cell Leukemia Virus Type 1 ActivitiesIn VitroandIn Vivo

Ma, G., Yasunaga, J., Ohshima, K., Matsumoto, T., & Matsuoka, M. (2019) · Journal of Virology · doi:10.1128/jvi.00413-19 · Cited by 11

Immunological aspects of HTLV-1 persistence; for the prevention and treatment of Adult T-cell leukaemia-lymphoma (ATL)

Weterings, D. A., Rowan, A. G., & Cook, L. B. M. (2024) · Leukemia Research · doi:10.1016/j.leukres.2024.107635 · Cited by 10

HTLV-1 and ATLL: Epidemiology, Oncogenesis, and Opportunities for Community-Informed Research in the United States

Altieri, A. D., Reilly, S. P., Mansalay, A., Khoo, A. S. B., Johnson, N., Khan, Z. K., Leader, A. E., Jain, P., & Porcu, P. (2025) · Viruses · doi:10.3390/v17101333 · Cited by 10

Functional and Pathogenic Roles of Retroviral Antisense Transcripts

Toyoda, K., & Matsuoka, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.875211 · Cited by 10

HTLV-1 intragenic viral enhancer influences immortalization phenotype in vitro, but is dispensable for persistence and disease development in animal models

Maksimova, V. V., Smith, S. M., Seth, J., Phelps, C., Niewiesk, S., Satou, Y., Green, P. L., & Panfil, A. R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954077 · Cited by 10

T cell receptor repertoire analysis in HTLV-1-associated diseases

Clauze, A., Enose‐Akahata, Y., & Jacobson, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.984274 · Cited by 10

Mice transgenic for human CTLA4-CD28 fusion gene show proliferation and transformation of ATLL-like and AITL-like T cells

Lee, G. J., Jun, Y., Jeon, Y. K., Lee, D., Lee, S., & Kim, J. (2022) · OncoImmunology · doi:10.1080/2162402x.2021.2015170 · Cited by 10

Retroviral Antisense Transcripts and Genes: 33 Years after First Predicted, a Silent Retroviral Revolution?

Miller, R., Zimmer, A., Moutot, G., Mesnard, J.-M., & Chazal, N. (2021) · Viruses · doi:10.3390/v13112221 · Cited by 11

Conference Highlights of the 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses, 26–30 June 2013, Montreal, Canada

Barbeau, B., Hiscott, J. B., Bazarbachi, A. A., Carvalho, E. M., Jones, K. S., Martin, F., Matsuoka, M., Murphy, E. L., Ratner, L., Switzer, W. M., et al. (2014) · Retrovirology · doi:10.1186/1742-4690-11-19 · Cited by 9

Evidence for the antisense transcription in the proviral R29-127 strain of bovine immunodeficiency virus

Liu, B., Zhao, X., Shen, W., & Kong, X. (2015) · Virologica Sinica · doi:10.1007/s12250-015-3559-6 · Cited by 9

Mouse model recapitulates the phenotypic heterogeneity of human adult T-cell leukemia/lymphoma in bone

Kohart, N. A., Elshafae, S. M., Supsahvad, W., Demirer, A. A., Panfil, A. R., Xiang, J., Dirksen, W. P., Novack, D. V., Green, P. L., Weilbaecher, K. N., et al. (2019) · Journal of bone oncology · doi:10.1016/j.jbo.2019.100257 · Cited by 9

Pathogenesis of human T‐lymphotropic virus type 1‐associated myelopathy/tropical spastic paraparesis

Kubota, R. (2017) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12395 · Cited by 9

Causes and consequences of T cell DNA damage

Koufaris, C., Berger, M., & Aqeilan, R. I. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.04.006 · Cited by 8

How Does HTLV-1 Undergo Oncogene-Dependent Replication Despite a Strong Immune Response?

Gazon, H., Chauhan, P. S., Hamaïdia, M., Hoyos, C., Lin, L., Safari, R., & Willems, L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02684 · Cited by 9

Mouse Models That Enhanced Our Understanding of Adult T Cell Leukemia

Moodad, S., Akkouche, A., Hleihel, R., Darwiche, N., El-Sabban, M. E., Bazarbachi, A. A., & Hajj, H. E. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00558 · Cited by 8

A Preclinical Model for the ATLL Lymphoma Subtype With Insights Into the Role of Microenvironment in HTLV-1-Mediated Lymphomagenesis

Vicario, M., Mattiolo, A., Montini, B., Piano, M. A., Cavallari, I., Amadori, A., Chieco‐Bianchi, L., & Calabrò, M. L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01215 · Cited by 8

HTLV-1 as a Model for Virus and Host Coordinated Immunoediting

Mota, T. M., & Jones, R. B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02259 · Cited by 8

Current challenges facing the clinical treatment for HTLV-1 ocular manifestations

Kamoi, K. (2023) · Expert Review of Ophthalmology · doi:10.1080/17469899.2023.2281446 · Cited by 7

G106 Pathogenic roles of HTLV-1 bZIP factor gene

Matsuoka, M. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000429259.67597.b9

HTLV-1 bZIP Factor Induces Inflammation through Labile Foxp3 Expression

Yamamoto-Taguchi, N., Satou, Y., Miyazato, P., Ohshima, K., Nakagawa, M., Katagiri, K., Kinashi, T., & Matsuoka, M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003630 · Cited by 92

How human T-cell leukemia virus type 1 induces diseases

Matsuoka, M. (2013) · Retrovirology · doi:10.1186/1742-4690-10-s1-o15

Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice

Mitagami, Y., Yasunaga, J., Kinosada, H., Ohshima, K., & Matsuoka, M. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005120 · Cited by 42

HTLV-1 bZIP factor induces systemic inflammations in vivo

Taguchi, N., Satou, Y., Ohshima, K., & Matsuoka, M. (2011) · Retrovirology · doi:10.1186/1742-4690-8-s1-a8 · Cited by 2