The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo
Open accessAbstract
Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of a neoplastic disease of CD4+ T cells, adult T-cell leukemia (ATL), and inflammatory diseases including HTLV-1 associated myelopathy/tropical spastic paraparesis, dermatitis, and inflammatory lung diseases. ATL cells, which constitutively express CD25, resemble CD25+CD4+ regulatory T cells (T(reg)). Approximately 60% of ATL cases indeed harbor leukemic cells that express FoxP3, a key transcription factor for T(reg) cells. HTLV-1 encodes an antisense transcript, HTLV-1 bZIP factor (HBZ), which is expressed in all ATL cases. In this study, we show that transgenic expression of HBZ in CD4+ T cells induced T-cell lymphomas and systemic inflammation in mice, resembling diseases observed in HTLV-1 infected individuals. In HBZ-transgenic mice, CD4+Foxp3+ T(reg) cells and effector/memory CD4+ T cells increased in vivo. As a mechanism of increased T(reg) cells, HBZ expression directly induced Foxp3 gene transcription in T cells. The increased CD4+Foxp3+ T(reg) cells in HBZ transgenic mice were functionally impaired while their proliferation was enhanced. HBZ could physically interact with Foxp3 and NFAT, thereby impairing the suppressive function of T(reg) cells. Thus, the expression of HBZ in CD4+ T cells is a key mechanism of HTLV-1-induced neoplastic and inflammatory diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Transgenic expression of HBZ in CD4+ T cells induced leukaemia and lymphoma following a long latent period [145].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [145]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Self-citationFoxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Regulatory T Cells and Immune Tolerance
Sakaguchi, S., Yamaguchi, T., Nomura, T., & Ono, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.009 · Cited by 5,485
Self-citationThe Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., & Sakaguchi, S. (2008) · Science · doi:10.1126/science.1160062 · Cited by 2,956
Self-citationAn essential role for Scurfin in CD4+CD25+ T regulatory cells
Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860
ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS
Gessain, A., Vernant, J. C., Maurs, L., Barin, F., Gout, O., Calender, A., & de Thé, G. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92734-5 · Cited by 2,812
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
Self-citationHTLV-I ASSOCIATED MYELOPATHY, A NEW CLINICAL ENTITY
Osame, M., Usuku, K., Izumo, S., Ijichi, N., Amitani, H., Igata, A., Matsumoto, M., & Tara, M. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91298-5 · Cited by 2,381
A function for interleukin 2 in Foxp3-expressing regulatory T cells
Fontenot, J. D., Rasmussen, J. P., Gavin, M. A., & Rudensky, A. Y. (2005) · Nature Immunology · doi:10.1038/ni1263 · Cited by 1,819
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–315 of 315
Découverte et caractérisation de la protéine APH-2 codée par le brin antisens du HTLV-2
Douceron, E. (2011) · theses.fr (ABES) · doi:10.70675/ccbc3046zcdc4z4076za386zc9a56cedbf0a
Vernin, C. (2013) · theses.fr (ABES) · doi:10.70675/9b3a9ec7z08bdz4c34z9817z03eda7323cd4
La souris humanisée : modèle d'étude in vivo du processus leucémogène induit par HTLV-1
Pérès, É. (2017) · theses.fr (ABES) · doi:10.70675/4ad2e43dzbe11z425bz90ccz037c44667282
Nakajima, S., Hino, M., Takenouchi, N., Yamano, Y., Yamagishi, M., Odaka, T., Admadiani, F. R., Faye, C., Uchimaru, K., Fujisawa, J., et al. (2026) · Pathogens · doi:10.3390/pathogens15040450
The HTLV-1 HBZ Oncoprotein and Its Role in Adult T-Cell Leukemia/Lymphoma
Accolla, R. S., Shallak, M., & Forlani, G. (2026) · Cancers · doi:10.3390/cancers18132101
Immunological decoding of adult T cell leukemia – its cell of origin and oncogenesis
Hori, T. (2026) · Biomarker Research · doi:10.1186/s40364-026-00968-2
HTLV-1 HBZ inhibits DHX9 to reprogram circRNA biogenesis in ATLL
Ladet, J., Bazire, M., Fontrodona, N., den Broeke, A. V., Marçais, A., Shallak, M., Forlani, G., Accolla, R. S., Bourgeois, C. F., & Mortreux, F. (2026) · Tumour Virus Research · doi:10.1016/j.tvr.2026.200347
Immunophenotype and proviral landscape of HTLV-1c infection and pulmonary disease
Hirons, A., Jansz, N., Khoury, G., Ellenberg, P. C., Collins, S., Cooney, J. P., Zaunders, J., Williams, L., Nair, K. N., Yap, A. H. Y., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106403
Rewiring of the Apoptotic Rheostat in HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma
Darbandi, A., Raimondi, V., Ciccarese, F., D’Agostino, D. M., & Ciminale, V. (2026) · Cancers · doi:10.3390/cancers18152494
Metadata
- Authors
- Satou, Y., Yasunaga, J.-I., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., & Matsuoka, M.
- Affiliations
- Kyoto University (JP)
- Kurume University (JP)
- The Ohio State University (US)
- Corresponding author
- Matsuoka, Masao
- ORCID
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-02-10
- Volume
- 7
- Issue
- 2
- Pages
- e1001274
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC3037353
- OpenAlex
- W1966278500
- Cited by
- 319
- References
- 58
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 11 · 2023: 15 · 2022: 27 · 2021: 31 · 2020: 21 · 2019: 19 · 2018: 14 · 2017: 32 · 2016: 21 · 2015: 19 · 2014: 19 · 2013: 21 · 2012: 22
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion, cc-by)
- Funders
- Naito Foundation
- Sumitomo Foundation
- Uehara Memorial Foundation
- National Institutes of Health
- Japan Society for the Promotion of Science (22390193)
- National Cancer Institute (CA077556, R01CA077556)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- HTLV-1, bZIP transcription factors, HBZ, adult T-cell leukemia/lymphoma, T-cell lymphoma, regulatory T cells, Foxp3, NFAT, systemic inflammation, CD4+ T cells, transgenic mice, HTLV-1-associated myelopathy/tropical spastic paraparesis, transcriptional regulation
- MeSH terms
- Adult, Animals, Cell Transformation, Viral, Cells, Cultured, Gene Expression Regulation, Humans, Inflammation, Mice, Inbred C57BL, Mice, Transgenic, Human T-lymphotropic virus 1, HTLV-I Infections, CD4-Positive T-Lymphocytes, Lymphoma, T-Cell, Basic-Leucine Zipper Transcription Factors, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
