HacA-Independent Functions of the ER Stress Sensor IreA Synergize with the Canonical UPR to Influence Virulence Traits in Aspergillus fumigatus

Feng, Xizhi; Krishnan, Karthik; Richie, Daryl L.; Aimanianda, Vishukumar; Hartl, Lukas; Grahl, Nora; Powers-Fletcher, Margaret V.; Zhang, Minlu; Fuller, Kevin K.; Nierman, William C.; Lu, Long Jason; Latgé, Jean-Paul; Woollett, Laura; Newman, Simon L.; Cramer, Robert A.; Rhodes, Judith C.; Askew, David S.

doi:10.1371/journal.ppat.1002330

HacA-Independent Functions of the ER Stress Sensor IreA Synergize with the Canonical UPR to Influence Virulence Traits in Aspergillus fumigatus

Endoplasmic reticulum (ER) stress is a condition in which the protein folding capacity of the ER becomes overwhelmed by an increased demand for secretion or by exposure to compounds that disrupt ER homeostasis. In yeast and other fungi, the accumulation of unfolded proteins is detected by the ER-…