Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7
Open accessAbstract
The endogenous ligands for the LT, lipoxin (LX) and oxoeicosanoid receptors are bioactive products produced by the action of the lipoxygenase family of enzymes. The LT receptors BLT1 and BLT2, are activated by LTB4 and the CysLT1 and CysLT2 receptors are activated by the cysteinyl‐LTs, whereas oxoeicosanoids exert their action through the OXE receptor. In contrast to these pro‐inflammatory mediators,LX A 4 transduces responses associated with the resolution of inflammation through the receptor FPR 2/ALX(ALX/FPR 2). The aim of the present review is to give a state of the field on these receptors, with focus on recent important findings. For example,BLT1 receptor signalling in cancer and the dual role of the BLT2 receptor in pro‐ and anti‐inflammatory actions have added more complexity to lipid mediator signalling. Furthermore, a cross‐talk between the CysLT and P 2 Y receptor systems has been described, and also the presence of novel receptors for cysteinyl‐LTs, such as GPR 17 and GPR 99. Finally, lipoxygenase metabolites derived from ω‐3 essential polyunsaturated acids, the resolvins, activate the receptors GPR 32 and C hem R 23. In conclusion, the receptors for the lipoxygenase products make up a sophisticated and tightly controlled system of endogenous pro‐ and anti‐inflammatory signalling in physiology and pathology.
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ALX/FPR2 is activated by agonists with partly opposing effects: SPMs and annexin-derived peptides promote M2-like macrophage polarization and pro-resolving signalling, while acute phase, bacterial, or mitochondrial peptides elicit pro-inflammatory signalling.
“whereas SPMs and annexin-derived peptides promote M2-like macrophage polarization and pro-resolving signalling through ALX/FPR2, the same receptor elicits pro-inflammatory signalling when activated by acute phase, bacterial or mitochondrial peptides103.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [103]
ALX/FPR2 is the receptor for lipoxins, DHA-derived RvD1, and annexin A1, whereas EPA-derived resolvins signal through ChemR23.
“ALX/FPR2 is the receptor for lipoxins, the DHA-derived RvD1 and for annexin A1 and its derivatives, whereas the EPA-derived resolvins signal their pro-resolving effects through the ChemR23 receptor103.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [103]
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Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation
Samuelsson, B. O. (1983) · Science · doi:10.1126/science.6301011 · Cited by 2,858 · see citing works
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650 · see citing works
Self-citationSerhan, C. N. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141647 · Cited by 997 · see citing works
Self-citationA G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y., & Shimizu, T. (1997) · Nature · doi:10.1038/42506 · Cited by 971 · see citing works
Self-citationArita, M., Bianchini, F., Aliberti, J., Sher, A., Chiang, N., Hong, S., Yang, R., Petasis, N. A., & Serhan, C. N. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042031 · Cited by 926 · see citing works
Self-citationCitric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
He, W., Miao, F. J.-P., Lin, D. C.-H., Schwandner, R. T., Wang, Z., Gao, J., Chen, J.-L., Tian, H., & Ling, L. (2004) · Nature · doi:10.1038/nature02488 · Cited by 909 · cited 1× · see citing works
“, 2002), was initially recognized as an oxoglutarate receptor based on its binding of and activation by 2-oxoglutarate (α-ketoglutarate) with potency in the high micromolar range via a Gq-mediated pathway (He et al., 2004).”
BackgroundWittamer, V., Franssen, J.-D., Vulcano, M., Mirjolet, J.-F., Le Poul, E., Migeotte, I., Brézillon, S., Tyldesley, R., Blanpain, C., Detheux, M., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030382 · Cited by 888 · see citing works
Pawson, A. J., Sharman, J. L., Benson, H. E., Faccenda, E., Alexander, S. P. H., Buneman, O. P., Davenport, A. P., McGrath, J. C., Peters, J. A., Southan, C., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1143 · Cited by 845 · see citing works
Ye, R. D., Boulay, F., Wang, J. M., Dahlgren, C., Gerard, C. J., Parmentier, M., Serhan, C. N., & Murphy, P. M. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001578 · Cited by 767 · see citing works
Self-citationResolvin D1 binds human phagocytes with evidence for proresolving receptors
Krishnamoorthy, S., Recchiuti, A., Chiang, N., Yacoubian, S., Lee, C., Yang, R., Petasis, N. A., & Serhan, C. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907342107 · Cited by 738 · see citing works
Self-citationInfection regulates pro-resolving mediators that lower antibiotic requirements
Chiang, N., Fredman, G., Bäckhed, F., Oh, S. F., Vickery, T., Schmidt, B. A., & Serhan, C. N. (2012) · Nature · doi:10.1038/nature11042 · Cited by 664 · see citing works
Self-citationCharacterization of the Human Cysteinyl Leukotriene 2 Receptor
Heise, C. E., O’Dowd, B. F., Figueroa, D. J., Sawyer, N., Nguyen, T., Im, D., Stocco, R., Bellefeuille, J. N., Abramovitz, M., Cheng, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003490200 · Cited by 660 · see citing works
Self-citationArita, M., Ohira, T., Sun, Y., Elangovan, S., Chiang, N., & Serhan, C. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3912 · Cited by 636 · see citing works
Self-citationThe Concise Guide to PHARMACOLOGY 2013/14: G Protein‐Coupled Receptors
Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12445 · Cited by 555 · see citing works
A Second Leukotriene B4 Receptor, Blt2
Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., & Shimizu, T. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.421 · Cited by 540 · see citing works
Self-citationThe Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo
Chiang, N., Serhan, C. N., Dahlén, S., Drazen, J. M., Hay, D. W. P., Rovati, G. E., Shimizu, T., Yokomizo, T., & Brink, C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.4 · Cited by 464 · see citing works
Self-citationLipoxin A 4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma
Barnig, C., Cernadas, M., Dutile, S., Liu, X., Perrella, M. A., Kazani, S. D., Wechsler, M. E., Israel, E., & Levy, B. D. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004812 · Cited by 450 · see citing works
Ciana, P., Fumagalli, M., Trincavelli, M. L., Verderio, C., Rosa, P., Lecca, D., Ferrario, S., Parravicini, C., Capra, V., Gelosa, P., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601341 · Cited by 438 · see citing works
Self-citationThe Concise Guide to PHARMACOLOGY 2013/14: Enzymes
Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12451 · Cited by 423 · see citing works
Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors
Rivière, S., Challet, L., Fluegge, D., Spehr, M., & Rodríguez, I. (2009) · Nature · doi:10.1038/nature08029 · Cited by 383 · see citing works
Synthetic chemerin-derived peptides suppress inflammation through ChemR23
Cash, J. L., Hart, R., Russ, A., Dixon, J. P. C., Colledge, W. H., Doran, J., Hendrick, A. G., Carlton, M. B. L., & Greaves, D. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071601 · Cited by 372 · see citing works
Chou, R. C., Kim, N. D., Sadik, C. D., Seung, E., Lan, Y., Byrne, M. H., Haribabu, B., Iwakura, Y., & Luster, A. D. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.018 · Cited by 342 · see citing works
Davenport, A. P., Alexander, S. P. H., Sharman, J. L., Pawson, A. J., Benson, H. E., Monaghan, A. E., Liew, W. C., Mpamhanga, C. P., Bonner, T. I., Neubig, R. R., et al. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007179 · Cited by 327 · see citing works
Chauhan, B. F., & Ducharme, F. M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002314.pub3 · Cited by 306 · see citing works
Cooray, S. N., Gobbetti, T., Montero‐Melendez, T., McArthur, S., Thompson, D., Clark, A. J. L., Flower, R. J., & Perretti, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308253110 · Cited by 301 · see citing works
Dufton, N., Hannon, R., Brancaleone, V., Dalli, J., Patel, H., Gray, M., D’Acquisto, F., Buckingham, J. C., Perretti, M., & Flower, R. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903526 · Cited by 298 · see citing works
Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism
Bondue, B., Wittamer, V., & Parmentier, M. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.11.004 · Cited by 294 · see citing works
MicroRNAs in resolution of acute inflammation: identification of novel resolvin Dl‐miRNA circuits
Recchiuti, A., Krishnamoorthy, S., Fredman, G., Chiang, N., & Serhan, C. N. (2011) · The FASEB Journal · doi:10.1096/fj.10-169599 · Cited by 292 · see citing works
Self-citationInternational Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors
Brink, C., Dahlén, S., Drazen, J. M., Evans, J. F., Hay, D. W. P., NICOSIA, S., Serhan, C. N., Shimizu, T., & Yokomizo, T. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.8 · Cited by 287 · see citing works
Self-citationResolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs
Krishnamoorthy, S., Recchiuti, A., Chiang, N., Fredman, G., & Serhan, C. N. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.01.028 · Cited by 283 · see citing works
Self-citationResolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis
Ohira, T., Arita, M., Omori, K., Recchiuti, A., Van Dyke, T. E., & Serhan, C. N. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.044131 · Cited by 278 · see citing works
Self-citationKim, N. D., Chou, R. C., Seung, E., Tager, A. M., & Luster, A. D. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052349 · Cited by 272 · see citing works
Luangsay, S., Wittamer, V., Bondue, B., Henau, O. D., Rouger, L., Brait, M., Franssen, J.-D., de Nadaı̈, P., Huaux, F., & Parmentier, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901037 · Cited by 256 · see citing works
Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci
Norling, L. V., Dalli, J., Flower, R. J., Serhan, C. N., & Perretti, M. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.249508 · Cited by 252 · see citing works
Self-citationLeukotriene E4–induced pulmonary inflammation is mediated by the P2Y12 receptor
Paruchuri, S. M., Tashimo, H., Feng, C., Maekawa, A., Xing, W., Jiang, Y., Kanaoka, Y., Conley, P. B., & Boyce, J. A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091240 · Cited by 247 · see citing works
Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents
Dalli, J., Winkler, J. W., Colas, R. A., Arnardottir, H. H., Cheng, C.-Y. C., Chiang, N., Petasis, N. A., & Serhan, C. N. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.11.010 · Cited by 246 · see citing works
Self-citationBäck, M., Bu, D.-X., Bränström, R., Sheikine, Y., Yan, Z.-Q., & Hansson, G. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505845102 · Cited by 230 · see citing works
Self-citationDona, M., Fredman, G., Schwab, J. M., Chiang, N., Arita, M., Goodarzi, A., Cheng, G., von Andrian, U. H., & Serhan, C. N. (2008) · Blood · doi:10.1182/blood-2007-11-122598 · Cited by 228 · see citing works
Self-citationMontelukast for Children With Obstructive Sleep Apnea: A Double-blind, Placebo-Controlled Study
Goldbart, A. D., Greenberg‐Dotan, S., & Tal, A. (2012) · PEDIATRICS · doi:10.1542/peds.2012-0310 · Cited by 226 · see citing works
Chiang, N., Gronert, K., Clish, C. B., O’Brien, J. A., Freeman, M. W., & Serhan, C. N. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7016 · Cited by 217 · see citing works
Self-citationDectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes
Barrett, N. A., Rahman, O. M., Fernandez, J. M., Parsons, M. W., Xing, W., Austen, K. F., & Kanaoka, Y. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20100793 · Cited by 211 · see citing works
Wittamer, V., Grégoire, F., Robberecht, P., Vassart, G., Communi, D., & Parmentier, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313016200 · Cited by 206 · see citing works
Leukotriene B4-Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation
Oyoshi, M. K., He, R., Li, Y., Mondal, S., Yoon, J., Afshar, R., Chen, M., Lee, D. M., Luo, H. R., Luster, A. D., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.018 · Cited by 202 · see citing works
The resolution of inflammation: the devil in the flask and in the details
Serhan, C. N. (2011) · The FASEB Journal · doi:10.1096/fj.11-0502ufm · Cited by 195 · see citing works
Self-citationTager, A. M., Dufour, J. H., Goodarzi, K., Bercury, S. D., von Andrian, U. H., & Luster, A. D. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.439 · Cited by 195 · see citing works
12(S)-hydroxyheptadeca-5Z, 8E, 10E–trienoic acid is a natural ligand for leukotriene B4 receptor 2
Okuno, T., Iizuka, Y., Okazaki, H., Yokomizo, T., Taguchi, R., & Shimizu, T. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072329 · Cited by 194 · see citing works
Self-citationKanaoka, Y., Maekawa, A., & Austen, K. F. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.453704 · Cited by 186 · see citing works
MADERNA, P., Cottell, D. C., Toivonen, T., Dufton, N., Dalli, J., Perretti, M., & Godson, C. (2010) · The FASEB Journal · doi:10.1096/fj.10-159913 · Cited by 182 · see citing works
Southern, C., Cook, J. M., Neetoo‐Isseljee, Z., Taylor, D. L., Kettleborough, C. A., Merritt, A. T., Bassoni, D. L., Raab, W. J., Quinn, E. R., Wehrman, T. S., et al. (2013) · SLAS DISCOVERY · doi:10.1177/1087057113475480 · Cited by 181 · see citing works
Anti-inflammatory lipoxin A 4 is an endogenous allosteric enhancer of CB 1 cannabinoid receptor
Pamplona, F. A., Ferreira, J., de Lima, O. M., Duarte, F. S., Bento, A. F., Forner, S., Villarinho, J. G., Bellocchio, L., Wotjak, C. T., Lerner, R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202906109 · Cited by 178 · see citing works
Haribabu, B., Verghese, M. W., Steeber, D. A., Sellars, D. D., Bock, C. B., & D, R. S. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.433 · Cited by 175 · see citing works
Capra, V., Thompson, M. D., Sala, A., Cole, D. E. C., Folco, G., & Rovati, G. E. (2006) · Medicinal Research Reviews · doi:10.1002/med.20071 · Cited by 169 · see citing works
Self-citationTerawaki, K., Yokomizo, T., Nagase, T., Toda, A., Taniguchi, M., Hashizume, K., Yagi, T., & Shimizu, T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4217 · Cited by 167 · see citing works
Self-citationAn update on the role of leukotrienes in asthma
Hallstrand, T. S., & Henderson, W. R. (2010) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32833489c3 · Cited by 166 · see citing works
Bozinovski, S., Uddin, M., Vlahos, R., Thompson, M., McQualter, J. L., Merritt, A.-S., Wark, P. A. B., Hutchinson, A., Irving, L. B., Levy, B. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109382109 · Cited by 163 · see citing works
Powell, W. S., Gravelle, F., & Gravel, S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41766-8 · Cited by 160 · see citing works
Self-citation5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration.
Powell, W. S., Chung, D. H., & Gravel, S. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.8.4123 · Cited by 160 · see citing works
Self-citationIdentification of a Novel Human Eicosanoid Receptor Coupled to Gi/o
Hosoi, T., Koguchi, Y., Sugikawa, E., Chikada, A., Ogawa, K., Tsuda, N., Suto, N., Tsunoda, S., Taniguchi, T., & Ohnuki, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203194200 · Cited by 159 · see citing works
Bäck, M., Dahlén, S., Drazen, J. M., Evans, J. F., Serhan, C. N., Shimizu, T., Yokomizo, T., & Rovati, G. E. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.004184 · Cited by 151 · see citing works
Self-citationRecchiuti, A., & Serhan, C. N. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00298 · Cited by 151 · see citing works
Self-citationMontelukast for Children With Obstructive Sleep Apnea: A Double-blind, Placebo-Controlled Study
(2012) · PEDIATRICS · doi:10.1542/peds.2012-0310d · Cited by 149 · see citing works
Powell, W. S., Gravel, S., Macleod, J., Mills, E. L., & Hashefi, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98347-x · Cited by 139 · see citing works
Self-citationJiang, Y., Borrelli, L. A., Kanaoka, Y., Bacskai, B. J., & Boyce, J. A. (2007) · Blood · doi:10.1182/blood-2007-07-100453 · Cited by 137 · see citing works
Maekawa, A., Kanaoka, Y., Xing, W., & Austen, K. F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808993105 · Cited by 136 · see citing works
Lee, T. H., Austen, K. F., Corey, E. J., & Drazen, J. M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.15.4922 · Cited by 134 · see citing works
Self-citationNeutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling
Sadik, C. D., Kim, N. D., Iwakura, Y., & Luster, A. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213797109 · Cited by 130 · see citing works
Lipoxin A4 Regulates Bronchial Epithelial Cell Responses to Acid Injury
Bonnans, C., Fukunaga, K., Levy, M. A., & Levy, B. D. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051056 · Cited by 129 · see citing works
GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D 4
Maekawa, A., Balestrieri, B., Austen, K. F., & Kanaoka, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905364106 · Cited by 129 · see citing works
Tissue damage detection by osmotic surveillance
Enyedi, B., Kala, S., Nikolich‐Zugich, T., & Niethammer, P. (2013) · Nature Cell Biology · doi:10.1038/ncb2818 · Cited by 128 · see citing works
Resolvin E1 and Chemokine-like Receptor 1 Mediate Bone Preservation
Gao, L., Faibish, D., Fredman, G., Herrera, B. S., Chiang, N., Serhan, C. N., Dyke, T. E. V., & Gyurko, R. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103688 · Cited by 127 · see citing works
Self-citationSobrado, M., Pereira, M. P., Ballesteros, I., Hurtado, O., Fernández‐López, D., Pradillo, J. M., Caso, J. R., Vivancos, J., Nombela, F., Serena, J. L., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5529-08.2009 · Cited by 125 · see citing works
Pharmacological evidence for a distinct leukotriene C4 receptor in guinea-pig trachea.
Snyder, D. W., & Krell, R. D. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21729-3 · Cited by 124 · see citing works
Chen, K., Le, Y., Liu, Y., Gong, W., Ying, G., Huang, J., Yoshimura, T., Tessarollo, L., & Wang, J. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903022 · Cited by 117 · see citing works
Ingelsson, E., Yin, L., & Bäck, M. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.052 · Cited by 116 · see citing works
Self-citationEicosanoids and Their Drugs in Cardiovascular Diseases: Focus on Atherosclerosis and Stroke
Capra, V., Bäck, M., Barbieri, S. S., Camera, M., Tremoli, E., & Rovati, G. E. (2012) · Medicinal Research Reviews · doi:10.1002/med.21251 · Cited by 115 · see citing works
Self-citationNagy, E., Andersson, D. C., Caidahl, K., Eriksson, M. J., Eriksson, P. O., Franco‐Cereceda, A., Hansson, G. K., & Bäck, M. (2011) · Circulation · doi:10.1161/circulationaha.110.966846 · Cited by 112 · see citing works
Self-citationNielsen, C. K., Campbell-Tofte, J., Öhd, J., Mörgelin, M., Riesbeck, K., Landberg, G., & Sjölander, A. (2005) · Cancer Research · doi:10.1158/0008-5472.732.65.3 · Cited by 111 · see citing works
Lipoxin, leukotriene, and PDGF receptors cross‐talk to regulate mesangial cell proliferation
Mahon, B. M., Mitchell, D., Shattock, R., Martin, F., Brady, H. R., & Godson, C. (2002) · The FASEB Journal · doi:10.1096/fj.02-0416fje · Cited by 111 · see citing works
Nonaka, Y., Hiramoto, T., & Fujita, N. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.052 · Cited by 110 · see citing works
Requirement for Leukotriene B4 Receptor 1 in Allergen-induced Airway Hyperresponsiveness
Miyahara, N., Takeda, K., Miyahara, S., Matsubara, S., Koya, T., Joetham, A., Krishnan, E., Dakhama, A., Haribabu, B., & Gelfand, E. W. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200502-205oc · Cited by 109 · see citing works
Resolvin E1 Regulates Adenosine Diphosphate Activation of Human Platelets
Fredman, G., Dyke, T. E. V., & Serhan, C. N. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.209908 · Cited by 108 · see citing works
Self-citationHouard, X., Ollivier, V., Louedec, L., Michel, J., & Bäck, M. (2009) · The FASEB Journal · doi:10.1096/fj.08-116202 · Cited by 108 · see citing works
Self-citationJones, C. E., Holden, S., Tenaillon, L., Bhatia, U., Seuwen, K., TRANTER, P. R., Turner, J., Kettle, R., Bouhelal, R., Charlton, S. J., et al. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.3.471 · Cited by 108 · see citing works
Cysteinyl leukotriene receptors, old and new; implications for asthma
Laidlaw, T. M., & Boyce, J. A. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.03982.x · Cited by 108 · see citing works
Qu, X., Zhang, X., Yao, J., Song, J., Nikolic‐Paterson, D. J., & Li, J. (2012) · The Journal of Pathology · doi:10.1002/path.4050 · Cited by 107 · see citing works
Leukotriene receptors in atherosclerosis
Bäck, M., & Hansson, G. K. (2006) · Annals of Medicine · doi:10.1080/07853890600982737 · Cited by 107 · see citing works
Self-citation5-Oxo-ETE and the OXE receptor
Grant, G. E., Rokach, J., & Powell, W. S. (2009) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2009.05.002 · Cited by 107 · see citing works
Self-citationDalli, J., Consalvo, A. P., Ray, V., Filippo, C. D., D’Amico, M., Mehta, N., & Perretti, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203000 · Cited by 105 · see citing works
Chen, K., Liu, M., Liu, Y., Yoshimura, T., Shen, W., Le, Y., Durum, S. K., Gong, W., Wang, C., Gao, J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65569 · Cited by 103 · see citing works
Chauhan, B. F., & Ducharme, F. M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003137.pub5 · Cited by 100 · see citing works
Seo, J. M., Park, S., & Kim, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.317131 · Cited by 96 · see citing works
Brancaleone, V., Gobbetti, T., Cénac, N., Faouder, P. L., Colom, B., Flower, R. J., Vergnolle, N., Nourshargh, S., & Perretti, M. (2013) · Blood · doi:10.1182/blood-2013-04-496661 · Cited by 94 · see citing works
Protective role of the leukotriene B 4 receptor BLT2 in murine inflammatory colitis
Iizuka, Y., Okuno, T., Saeki, K., Uozaki, H., Okada, S., Misaka, T., Sato, T., Toh, H., Fukayama, M., Takeda, N., et al. (2010) · The FASEB Journal · doi:10.1096/fj.10-165050 · Cited by 94 · see citing works
Self-citation5-Oxo-eicosanoids Are Potent Eosinophil Chemotactic Factors.
Schwenk, U., & Schröder, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.25.15029 · Cited by 92 · see citing works
Bondue, B., Vosters, O., de Nadai, P., Glineur, S., De Henau, O., Luangsay, S., Van Gool, F., Communi, D., De Vuyst, P., Desmecht, D., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002358 · Cited by 92 · see citing works
Nonredundant Roles for Leukotriene B4 Receptors BLT1 and BLT2 in Inflammatory Arthritis
Mathis, S., Jala, V. R., Lee, D. M., & Haribabu, B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001031 · Cited by 90 · see citing works
Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer
Magnusson, C., Mezhybovska, M., Lörinc, E., Fernebro, E., Nilbert, M. C., & Sjölander, A. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2009.12.022 · Cited by 89 · see citing works
Distinct expression and ligand‐binding profiles of two constitutively active GPR17 splice variants
Benned‐Jensen, T., & ROSENKILDE, M. M. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00633.x · Cited by 83 · see citing works
CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors
Mamedova, L., Capra, V., Accomazzo, M. R., Gao, Z., Ferrario, S., Fumagalli, M., Abbracchio, M. P., Rovati, G. E., & Jacobson, K. A. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.10.003 · Cited by 82 · see citing works
Self-citationNakamura, M., & Shimizu, T. (2011) · Chemical Reviews · doi:10.1021/cr100392s · Cited by 82 · see citing works
Self-citationRavasi, S., Citro, S., Viviani, B., Capra, V., & Rovati, G. E. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-42 · Cited by 80 · see citing works
Self-citationO’Flaherty, J. T., Kuroki, M., Nixon, A. B., Wijkander, J., Yee, E., Lee, S. L., Smitherman, P. K., Wykle, R. L., & Daniel, L. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17821 · Cited by 80 · see citing works
Sozzani, S., Zhou, D., Locati, M., Bernasconi, S., Luini, W., Mantovani, A., & O’Flaherty, J. T. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.10.4664 · Cited by 79 · see citing works
Leukotriene B4 Receptor-1 Mediates Intermittent Hypoxia-induced Atherogenesis
Li, R. C., Haribabu, B., Mathis, S., Kim, J., & Gozal, D. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201012-2039oc · Cited by 79 · see citing works
5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes
O’Flaherty, J. T., Kuroki, M., Nixon, A. B., Wijkander, J., Yee, E., Lee, S., Smitherman, P. K., Wykle, R. L., & Daniel, L. W. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.1.336 · Cited by 77 · see citing works
Wunder, F., Tinel, H., Kast, R., Geerts, A., Becker, E., Kolkhof, P., Hütter, J. F., Ergüden, J., & Härter, M. W. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00730.x · Cited by 76 · see citing works
A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer
Blättermann, S., Peters, L., Ottersbach, P. A., Böck, A., Kónya, V., Weaver, C. D., González, Á., Schröder, R. J., Tyagi, R., Luschnig, P., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.962 · Cited by 76 · see citing works
Functional Characterization of Three Mouse Formyl Peptide Receptors
He, H.-Q., Liao, D., Wang, Z.-G., Wang, Z.-L., Zhou, H.-C., Wang, M.-W., & Ye, R. D. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.081315 · Cited by 76 · see citing works
Oyoshi, M. K., He, R., Kanaoka, Y., Elkhal, A., Kawamoto, S., Lewis, C. N., Austen, K. F., & Geha, R. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203127109 · Cited by 75 · see citing works
Antileukotriene Agents for the Treatment of Lung Disease
Scott, J. P., & Peters-Golden, M. L. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201301-0023pp · Cited by 74 · see citing works
5-Oxo-ETE analogs and the proliferation of cancer cells
O’Flaherty, J. T., Rogers, L. C., Paumi, C. M., Hantgan, R. R., Thomas, L. R., Clay, C. E., High, K. P., Chen, Y. Q., Willingham, M. C., Smitherman, P. K., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.08.009 · Cited by 72 · see citing works
GPR17 Regulates Immune Pulmonary Inflammation Induced by House Dust Mites
Maekawa, A., Xing, W., Austen, K. F., & Kanaoka, Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001131 · Cited by 72 · see citing works
Cysteinyl-Leukotriene Receptor Antagonists: Present Situation and Future Opportunities
Capra, V., Ambrosio, M., Riccioni, G., & Rovati, G. E. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706778742963 · Cited by 72 · see citing works
Self-citationInflammatory mediators in saliva associated with arterial stiffness and subclinical atherosclerosis
Labat, C., Temmar, M., Nagy, E., Bean, K., Brink, C., Bénétos, A., & Bäck, M. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328363dccc · Cited by 67 · see citing works
Self-citationQi, A. D., Harden, T. K., & Nicholas, R. A. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.207647 · Cited by 67 · see citing works
Kihara, Y., Yokomizo, T., Kunita, A., Morishita, Y., Fukayama, M., Ishii, S., & Shimizu, T. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.049 · Cited by 66 · see citing works
Self-citationThe Role of ChemR23 in the Induction and Resolution of Cigarette Smoke-Induced Inflammation
Demoor, T., Bracke, K. R., Dupont, L. L., Plantinga, M., Bondue, B., Roy, M., Lannoy, V. J., Lambrecht, B. N., Brusselle, G., & Joos, G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003862 · Cited by 66 · see citing works
Effect of montelukast for treatment of asthma in cigarette smokers
Price, D. B., Popov, T. A., Bjermer, L. H., Lu, S., Petrovic, R., Vandormael, K., Mehta, A., Strus, J., Polos, P. G., & Philip, G. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.673 · Cited by 65 · see citing works
Wang, L., Du, C., Lv, J., Wei, W., Cui, Y. B., & Xie, X. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100333 · Cited by 64 · see citing works
Capra, V., Ravasi, S., Accomazzo, M. R., Citro, S., Grimoldi, M., Abbracchio, M. P., & Rovati, G. E. (2005) · Journal of Cell Science · doi:10.1242/jcs.02668 · Cited by 64 · see citing works
Self-citationMetabolism and biologic effects of 5-oxoeicosanoids on human neutrophils
Powell, W. S., MacLeod, R., Gravel, S., Gravelle, F., & Bhakar, A. L. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.1.336 · Cited by 64 · see citing works
Self-citationLipoxin A4 Stimulates a Cytosolic Ca2+Increase in Human Bronchial Epithelium
Bonnans, C., Mainprice, B., Chanez, P., Bousquet, J., & Urbach, V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210294200 · Cited by 63 · see citing works
Magnusson, C., Liu, J., Ehrnström, R. A., Manjer, J., Jirström, K., Andersson, T., & Sjölander, A. (2010) · International Journal of Cancer · doi:10.1002/ijc.25648 · Cited by 61 · see citing works
Ni, N. C., Yan, D., Ballantyne, L. L., Barajas‐Espinosa, A. R., Amand, T. S., Pratt, D. A., & Funk, C. D. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.186031 · Cited by 61 · see citing works
Leukotriene B4 Mediates Neutrophil Migration Induced by Heme
Monteiro, A. P. T., Pinheiro, C. S., Luna-Gomes, T., Alves, L. R., Maya‐Monteiro, C. M., Porto, B. N., Barja‐Fidalgo, C., Benjamim, C. F., Peters-Golden, M. L., Bandeira‐Melo, C., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002400 · Cited by 61 · see citing works
5-Oxo-6,8,11,14-eicosatetraenoic acid induces the infiltration of granulocytes into human skin
Muro, S., Hamid, Q. A., Olivenstein, R., Taha, R. A., Rokach, J., & Powell, W. S. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(03)01888-8 · Cited by 60 · see citing works
Self-citationIncreased Synthesis of Leukotrienes in the Mouse Model of Diabetic Retinopathy
Talahalli, R. R., Zarini, S., Sheibani, N., Murphy, R. C., & Gubitosi‐Klug, R. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3557 · Cited by 59 · see citing works
Parmentier, C., Fuerst, E., McDonald, J., Bowen, H., Lee, T. H., Pease, J. E., Woszczek, G., & Cousins, D. J. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.01.057 · Cited by 59 · see citing works
Langlois, A., Chouinard, F., Flamand, N., Ferland, C., Rola‐Pleszczynski, M., & Laviolette, M. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0808492 · Cited by 59 · see citing works
Gaudreau, R., Gouill, C. L., Venne, M.-H., Staňková, J., & Rola‐Pleszczynski, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202723200 · Cited by 58 · see citing works
Hecht, I., Rong, J., Sampaio, A. L. F., Hermesh, C., Rutledge, C., Shemesh, R., Toporik, A., Beiman, M., Dassa, L., Niv, H., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.145821 · Cited by 58 · see citing works
Stanke‐Labesque, F., Bäck, M., Lefebvre, B., Tamisier, R., Baguet, J.-P., Arnol, N., Levy, P. A., & Pépin, J. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.033 · Cited by 57 · see citing works
Self-citationOkuno, T., Ago, H., Terawaki, K., Miyano, M., Shimizu, T., & Yokomizo, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307335200 · Cited by 56 · see citing works
Self-citationZhang, X.-Y., Wang, X., Xu, D., Yu, S.-Y., Shi, Q., Zhang, L., Chen, L., Fang, S., Lu, Y., Zhang, W., et al. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.203604 · Cited by 56 · see citing works
Qi, L., Fang, S., Shi, W., Huang, X., Zhang, X.-Y., Lu, Y., Zhang, W.-P., & Wei, E.-Q. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.10.025 · Cited by 54 · see citing works
Expression of 5-oxoETE receptor in prostate cancer cells: Critical role in survival
Sundaram, S., & Ghosh, J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.189 · Cited by 54 · see citing works
Waki, H., Hendy, E. B., Hindmarch, C. C. T., Gouraud, S. S., Toward, M. A., Kasparov, S., Murphy, D., & Paton, J. F. R. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.192252 · Cited by 53 · see citing works
Verrière, V., Higgins, G., Al‐Alawi, M., Costello, R. W., McNally, P., Chiron, R., Harvey, B. J., & Urbach, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037746 · Cited by 53 · see citing works
International Union of Pharmacology XLIV. Nomenclature for the Oxoeicosanoid Receptor
Brink, C., Dahlén, S., Drazen, J. M., Evans, J. F., Hay, D. W. P., Rovati, G. E., Serhan, C. N., Shimizu, T., & Yokomizo, T. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.1.4 · Cited by 53 · see citing works
Self-citationA distinctive role of the leukotriene B 4 receptor BLT1 in osteoclastic activity during bone loss
Hikiji, H., Ishii, S., Yokomizo, T., Takato, T., & Shimizu, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905209106 · Cited by 52 · see citing works
Self-citationDual role of lipoxin A4 in pneumosepsis pathogenesis
Sordi, R., Menezes‐de‐Lima, O., Horewicz, V. V., Scheschowitsch, K., Santos, L. F. D., & Assreuy, J. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.06.010 · Cited by 51 · see citing works
Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A4
Hanson, J., Ferreirós, N., Pirotte, B., Geißlinger, G., & Offermanns, S. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.04.019 · Cited by 51 · see citing works
5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent chemoattractant for human basophils
Sturm, G. J., Schuligoi, R., Sturm, E. M., Royer, J. F., Lang‐Loidolt, D., Stammberger, H., Amann, R., Peskar, B. A., & Heinemann, Á. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.08.001 · Cited by 51 · see citing works
Magnusson, C., Ehrnström, R. A., Olsen, J., & Sjölander, A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0771 · Cited by 50 · see citing works
Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism
Langlois, A., Ferland, C., Tremblay, G. M., & Laviolette, M. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.03.010 · Cited by 49 · see citing works
Leukotriene B 4 receptor BLT2 negatively regulates allergic airway eosinophilia
Matsunaga, Y., Fukuyama, S., Okuno, T., Sasaki, F., Matsunobu, T., Asai, Y., Matsumoto, K., Saeki, K., Oike, M., Sadamura, Y., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-217000 · Cited by 49 · see citing works
Self-citationBae, Y., Park, J. C., He, R. L., Ye, R. D., Kwak, J., Suh, P., & Ryu, S. H. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.3.721 · Cited by 49 · see citing works
Leukotriene Receptors: Crucial Components in Vascular Inflammation
Bäck, M. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.187 · Cited by 48 · see citing works
Self-citationWhat Formyl Peptide Receptors, if Any, Are Triggered by Compound 43 and Lipoxin A4?
Forsman, H. F., Önnheim, K., Andréasson, E., & Dahlgren, C. (2011) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2011.02570.x · Cited by 46 · see citing works
The Coupling of 5-Oxo-Eicosanoid Receptors to Heterotrimeric G Proteins
O’Flaherty, J. T., Taylor, J. S., & Kuroki, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3345 · Cited by 46 · see citing works
Zhao, C.-Z., Zhao, B., Zhang, X., Huang, X., Shi, W., Liu, H. L., Fang, S. H., Lu, Y.-P., Zhang, W. P., Tang, F. D., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.066 · Cited by 46 · see citing works
Endothelial cells modulate eosinophil surface markers and mediator release
Dallaire, M., Ferland, C., Pagé, N., Lavigne, S., Davoine, F., & Laviolette, M. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00102002 · Cited by 46 · see citing works
Walch, L., Norel, X., Bäck, M., Gascard, J., Dahlén, S., & Brink, C. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704991 · Cited by 45 · see citing works
Self-citationHosoi, T., Sugikawa, E., Chikada, A., Koguchi, Y., & Ohnuki, T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.191 · Cited by 45 · see citing works
Sharma, R. K., Chheda, Z. S., Jala, V. R., & Haribabu, B. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300967 · Cited by 45 · see citing works
Han, J., Jia, Y., Takeda, K., Shiraishi, Y., Okamoto, M., Dakhama, A., & Gelfand, E. W. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200912-1811oc · Cited by 43 · see citing works
Capra, V., NICOSIA, S., Ragnini, D., Mezzetti, M., KEPPLER, D. O. R., & Rovati, G. E. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.4.750 · Cited by 43 · see citing works
Self-citationShimbori, C., Shiota, N., & Okunishi, H. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.084 · Cited by 42 · see citing works
Wu, L., Liu, Z. J., Miao, S., Zou, L. B., Cai, L., Wu, P., Ye, D., Wu, Q., & Li, H. H. (2013) · Neurological Research · doi:10.1179/1743132813y.0000000242 · Cited by 41 · see citing works
Iikura, M., Suzukawa, M., Yamaguchi, M., Sekiya, T., Komiya, A., Yoshimura-Uchiyama, C., Nagase, H., Matsushima, K., Yamamoto, K., & Hirai, K. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.04.029 · Cited by 41 · see citing works
GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors
Wittenberger, T., Hellebrand, S., Munck, A., Kreienkamp, H., Schaller, H., & Hampe, W. (2002) · BMC Genomics · doi:10.1186/1471-2164-3-17 · Cited by 40 · see citing works
Czech, W., Barbisch, M., Tenscher, K., Schöpf, E., Schröder, J.-M., & Norgauer, J. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12285653 · Cited by 40 · see citing works
Leukotriene B4 pathway activation and atherosclerosis in obstructive sleep apnea
Stanke‐Labesque, F., Pépin, J., de Jouvencel, T., Arnaud, C., Baguet, J.-P., Petri, M. H., Tamisier, R., Jourdil, J., Levy, P. A., & Bäck, M. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p022814 · Cited by 40 · see citing works
Self-citationTsaoussoglou, M., Lianou, L., Maragozidis, P., Hatzinikolaou, S., Mavromati, M., Orologas‐Stavrou, N., Panaghiotopoulou‐Gartagani, P., Rassidakis, G. Z., Balatsos, N. A. A., Chrousos, G. P., et al. (2012) · Sleep Medicine · doi:10.1016/j.sleep.2012.03.010 · Cited by 40 · see citing works
Woszczek, G., Chen, L., Alsaaty, S., Nagineni, S., & Shelhamer, J. H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0900071 · Cited by 38 · see citing works
Shen, Y., Xu, Z., & Shen, K. (2011) · SLEEP · doi:10.5665/sleep.1178 · Cited by 38 · see citing works
Barrett, N. A., Fernandez, J., Maekawa, A., Xing, W., Li, L., Parsons, M. W., Austen, K. F., & Kanaoka, Y. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201865 · Cited by 37 · see citing works
Stamatiou, P. B., Chan, C., Monneret, G., Ethier, D., Rokach, J., & Powell, W. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401537200 · Cited by 36 · see citing works
Self-citationChemotactic 5‐Oxo‐Icosatetraenoic Acids Activate A Unique Pattern of Neutrophil Responses
Norgauer, J., Barbisch, M., Czech, W., Pareigis, J., Schwenk, U., & Schröder, J. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.01003.x · Cited by 35 · see citing works
Ravasi, S., Capra, V., Panigalli, T., Rovati, G. E., & NICOSIA, S. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)00889-4 · Cited by 35 · see citing works
Self-citationAntagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes
Bäck, M., Norel, X., Walch, L., Gascard, J., Mazmanian, G., Dahlén, S., & Brink, C. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00452-0 · Cited by 35 · see citing works
Self-citationShi, Q., Xiao, L., Zhao, B., Zhang, X.-Y., Wang, X., Xu, D., Yu, S.-Y., Fang, S., Lu, Y., Zhang, W., et al. (2012) · Brain Research · doi:10.1016/j.brainres.2012.09.020 · Cited by 35 · see citing works
Poulin, S., Thompson, C., Thivierge, M., Véronneau, S., McMahon, S., Dubois, C. M., Staňková, J., & Rola‐Pleszczynski, M. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03653.x · Cited by 34 · see citing works
Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells
Capra, V., Accomazzo, M. R., Ravasi, S., Parenti, M. D., Macchia, M., NICOSIA, S., & Rovati, G. E. (2003) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s1098-8823(03)00045-5 · Cited by 34 · see citing works
Self-citationCharacterisation of P2Y12 Receptor Responsiveness to Cysteinyl Leukotrienes
Foster, H. R., Fuerst, E., Lee, T. H., Cousins, D. J., & Woszczek, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058305 · Cited by 34 · see citing works
Jiang, Y., Borrelli, L. A., Bacskai, B. J., Kanaoka, Y., & Boyce, J. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.1129 · Cited by 33 · see citing works
Ravasi, S., Capra, V., Mezzetti, M., NICOSIA, S., & Rovati, G. E. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23228-4 · Cited by 33 · see citing works
Self-citationCapra, V., Ravasi, S., Accomazzo, M. R., Parenti, M. D., & Rovati, G. E. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.12.027 · Cited by 32 · see citing works
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Stanke‐Labesque, F., Pépin, J., Gautier‐Veyret, E., Levy, P. A., & Bäck, M. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt247 · Cited by 32 · see citing works
Self-citationCapra, V., & Rovati, G. E. (2013) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2013.06.005 · Cited by 32 · see citing works
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Li, Y., Wu, P., Zhou, X., Chen, J., Cai, L., Wang, F., Xu, L.-M., Zhang, X., Chen, Y., Liu, S.-J., et al. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.07.002 · Cited by 31 · see citing works
Effects and Zafirlukast on Capsular Contracture: Long-Term Results
Mazzocchi, M., Dessy, L. A., Alfano, C., & Scuderi, N. (2012) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201202500411 · Cited by 30 · see citing works
Addition of anti-leukotriene agents to inhaled corticosteroids in children with persistent asthma
Chauhan, B. F., Salah, R. B., & Ducharme, F. M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009585 · Cited by 30 · see citing works
Barajas‐Espinosa, A. R., Ochoa‐Cortés, F., Moos, M. P., Ramirez, F. D., Vanner, S. J., & Funk, C. D. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.02.041 · Cited by 29 · see citing works
Helix 8 of leukotriene B 4 receptor 1 inhibits ligand‐induced internalization
Aratake, Y., Okuno, T., Matsunobu, T., Saeki, K., Takayanagi, R., Furuya, S., & Yokomizo, T. (2012) · The FASEB Journal · doi:10.1096/fj.12-212050 · Cited by 29 · see citing works
Self-citationDrazen, J. M. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9194-2_1 · Cited by 28 · see citing works
Self-citationYokota, Y., Inoue, H., Matsumura, Y., Nabeta, H., Narusawa, M., Watanabe, A., Sakamoto, C., Hijikata, Y., Iga, M., Takayama, K., et al. (2012) · Blood · doi:10.1182/blood-2011-10-383240 · Cited by 28 · see citing works
Self-citationBarajas‐Espinosa, A. R., Ni, N. C., Yan, D., Zarini, S., Murphy, R. C., & Funk, C. D. (2011) · The FASEB Journal · doi:10.1096/fj.11-195792 · Cited by 28 · see citing works
Lee, J.-W., Kim, G.-Y., & Kim, J. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.012 · Cited by 27 · see citing works
Carnini, C., Accomazzo, M. R., Borroni, E., Vitellaro‐Zuccarello, L., Durand, T., Folco, G., Rovati, G. E., Capra, V., & Sala, A. (2011) · The FASEB Journal · doi:10.1096/fj.10-177030 · Cited by 27 · see citing works
Self-citationIdentification of a G Protein-Coupled Receptor for 5-oxo-Eicosatetraenoic Acid
Takeda, S., Yamamoto, A., & Haga, T. (2002) · Biomedical Research · doi:10.2220/biomedres.23.101 · Cited by 26 · see citing works
Eaton, A., Nagy, E., Pacault, M., Fauconnier, J., & Bäck, M. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0904-1 · Cited by 26 · see citing works
Self-citationCapra, V., Carnini, C., Accomazzo, M. R., Gennaro, A. D., Fiumicelli, M., Borroni, E., Brivio, I., Buccellati, C., Mangano, P., Carnevali, S., et al. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.03.007 · Cited by 24 · see citing works
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Poorter, C. D., Baertsoen, K., Lannoy, V. J., Parmentier, M., & Springael, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058075 · Cited by 24 · see citing works
Bengtsson, A. M., Jönsson, G., Magnusson, C., Salim, T., Axelsson, C., & Sjölander, A. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-336 · Cited by 24 · see citing works
Stanke‐Labesque, F., Molière, P., Bessard, J., Laville, M., Véricel, E., & Lagarde, M. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508923692 · Cited by 24 · see citing works
Provost, V., Langlois, A., Chouinard, F., Rola‐Pleszczynski, M., Chakir, J., Flamand, N., & Laviolette, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043544 · Cited by 23 · see citing works
Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells
Cooke, M., Cónsoli, H. D., Maloberti, P. M., & Maciel, F. C. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.11.003 · Cited by 23 · see citing works
Takahashi, M., Taniuchi, S., Soejima, K., Sudo, K., Hatano, Y., & Kaneko, K. (2014) · Allergy Asthma and Clinical Immunology · doi:10.1186/1710-1492-10-3 · Cited by 23 · see citing works
Planagumà, A., Domènech, T., Jover, I., Ramos, I., Sentellas, S., Malhotra, R., & Miralpeix, M. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12110 · Cited by 22 · see citing works
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Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Self-citationResolution of inflammation: a new therapeutic frontier
Fullerton, J. N., & Gilroy, D. W. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.39 · Cited by 937 · see citing works
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Yam, M. F., Loh, Y. C., Tan, C. S., Adam, S. K., Manan, N. A., & Basir, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082164 · Cited by 694 · see citing works
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Metzemaekers, M., Gouwy, M., & Proost, P. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0412-0 · Cited by 570 · see citing works
Anti-inflammatory therapies for atherosclerosis
Bäck, M., & Hansson, G. K. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.5 · Cited by 380 · see citing works
Self-citationPowell, W. S., & Rokach, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.008 · Cited by 322 · see citing works
Self-citationComplex Pharmacology of Free Fatty Acid Receptors
Milligan, G., Shimpukade, B., Ulven, T., & Hudson, B. D. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00056 · Cited by 267 · see citing works
Activation and resolution of periodontal inflammation and its systemic impact
Hastürk, H., & Kantarcı, A. (2015) · Periodontology 2000 · doi:10.1111/prd.12105 · Cited by 240 · see citing works
Smooth muscle cell and arterial aging: basic and clinical aspects
Lacolley, P. J., Regnault, V., & Avolio, A. P. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy009 · Cited by 222 · see citing works
Pawig, L., Klasen, C., Weber, C., Bernhagen, J., & Noels, H. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00429 · Cited by 207 · see citing works
Leukotriene receptors as potential therapeutic targets
Yokomizo, T., Nakamura, M., & Shimizu, T. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97946 · Cited by 179 · see citing works
Self-citationBadimón, L., Vilahur, G., Rocca, B., & Patrono, C. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab003 · Cited by 179 · see citing works
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Doran, A. C. (2022) · Circulation Research · doi:10.1161/circresaha.121.319822 · Cited by 177 · see citing works
Kennedy, A. J., & Davenport, A. P. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013177 · Cited by 175 · see citing works
Potential of anti-inflammatory agents for treatment of atherosclerosis
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Petri, M. H., Laguna-Fernández, A., Gonzalez-Diez, M., Paulsson-Berne, G., Hansson, G. K., & Bäck, M. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvu224 · Cited by 125 · see citing works
Self-citationPetri, M. H., Laguna‐Fernandez, A., Arnardottir, H., Wheelock, C. E., Perretti, M., Hansson, G. K., & Bäck, M. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13707 · Cited by 120 · see citing works
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Nielsen, M. M. B., Lambertsen, K. L., Clausen, B. H., Meyer, M., Bhandari, D. R., Larsen, S. T., Poulsen, S. S., Spengler, B., Janfelt, C., & Hansen, H. S. (2016) · Scientific Reports · doi:10.1038/srep39571 · Cited by 84 · see citing works
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Ghosh, A., Chen, F., Thakur, A., & Hong, H. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12596 · Cited by 78 · see citing works
Sala, A., Proschak, E., Steinhilber, D., & Rovati, G. E. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.10.007 · Cited by 77 · see citing works
Self-citationArnardottir, H. H., Pawelzik, S., Öhlund‐Wistbacka, U., Artiach, G., Hofmann, R., Reinholdsson, I., Braunschweig, F., Tornvall, P., Religa, D., & Bäck, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.624657 · Cited by 75 · see citing works
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Stalder, A. K., Lott, D., Strasser, D. S., Cruz, H. G., Krause, A., Groenen, P. M. A., & Dingemanse, J. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13149 · Cited by 70 · see citing works
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Self-citationSokołowska, M., Rovati, G. E., Diamant, Z., Untersmayr, E., Schwarze, J., Łukasik, Z. M., Sava, F., Angelina, A., Palomares, Ó., Akdiş, C. A., et al. (2020) · Allergy · doi:10.1111/all.14295 · Cited by 68 · see citing works
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Koeberle, A., & Werz, O. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.02.010 · Cited by 66 · see citing works
Petri, M. H., Laguna-Fernandez, A., Tseng, C.-N., Hedin, U., Perretti, M., & Bäck, M. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.11.010 · Cited by 60 · see citing works
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Petri, M. H., Thul, S., Andonova, T., Liljeqvist, M. L., Jin, H. H., Skenteris, N.-T., Arnardottir, H. H., Mäegdefessel, L., Caidahl, K., Perretti, M., et al. (2018) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2018.08.005 · Cited by 52 · see citing works
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Darios, E. S., Winner, B. M., Charvat, T. T., Krasinksi, A., Punna, S., & Watts, S. W. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00998.2015 · Cited by 49 · see citing works
Wang, Y., Yang, Y., Zhang, S., Li, C.-T., & Zhang, L. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.12.013 · Cited by 48 · see citing works
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Zong, L., Chen, K., Jiang, Z., Chen, X., Sun, L., Ma, J., Zhou, C., Xu, Q., Duan, W., Han, L., et al. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0655-5 · Cited by 46 · see citing works
Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2
Gaudin, A., Tolar, M., & Peters, O. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-27194-7 · Cited by 46 · see citing works
Cannflavins—From plant to patient: A scoping review
Erridge, S., Mangal, N., Salazar, O., Pacchetti, B., & Sodergren, M. H. (2020) · Fitoterapia · doi:10.1016/j.fitote.2020.104712 · Cited by 45 · see citing works
The G Protein‐Coupled Receptor GPR17: Overview and Update
Marucci, G., Ben, D. D., Lambertucci, C., Santinelli, C., Spinaci, A., Thomas, A., Volpini, R., & Buccioni, M. (2016) · ChemMedChem · doi:10.1002/cmdc.201600453 · Cited by 45 · see citing works
Carracedo, M., Artiach, G., Witasp, A., Clària, J., Carlström, M., Laguna-Fernández, A., Stenvinkel, P., & Bäck, M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy316 · Cited by 44 · see citing works
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Lee, M., Boyce, J. A., & Barrett, N. A. (2024) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-111523-023509 · Cited by 43 · see citing works
Gagliardo, R. P., Gras, D., Grutta, S. L., Chanez, P., Sano, C. D., Albano, G. D., Vachier, I., Montalbano, A. M., Anzalone, G., Bonanno, A., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.11.045 · Cited by 43 · see citing works
Trojan, E., Bryniarska, N., Leśkiewicz, M., Regulska, M., Chamera, K., Szuster-Głuszczak, M., Leopoldo, M., Lacivita, E., & Basta‐Kaim, A. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191019170244 · Cited by 42 · see citing works
Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents
Werz, O., Gerstmeier, J., & Garscha, U. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2017.1276568 · Cited by 40 · see citing works
The Leukotriene Receptor Antagonist Montelukast as a Potential COVID-19 Therapeutic
Aigner, L., Pietrantonio, F., de Sousa, D. M. B., Michael, J., Schuster, D., Reitsamer, H. A., Zerbe, H., & Studnicka, M. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.610132 · Cited by 40 · see citing works
Dahlgren, C., Lind, S., Mårtensson, J., Björkman, L. I., Wu, Y., Sundqvist, M., & Forsman, H. F. (2022) · Immunological Reviews · doi:10.1111/imr.13151 · Cited by 40 · see citing works
Impact of Androgens on Inflammation-Related Lipid Mediator Biosynthesis in Innate Immune Cells
Pace, S., & Werz, O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01356 · Cited by 39 · see citing works
Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
Henrique, T., Zanon, C. D. F., Girol, A. P., Stefanini, A. C. B., de Alcântara-Contessoto, N. S., da Silveira, N. J. F., Bezerra, D. P., Silveira, E. R., Barbosa‐Filho, J. M., Cornélio, M. L., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-78220-6 · Cited by 39 · see citing works
5-Lipoxygenase as an emerging target against age-related brain disorders
Yan, M., Zhang, S., Li, C.-T., Liu, Y., Zhao, J., Wang, Y., Yang, Y., & Zhang, L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101359 · Cited by 39 · see citing works
Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond
Sánchez‐García, S., Jaén, R. I., Fernández‐Velasco, M., Delgado, C., Boscá, L., & Prieto, P. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106982 · Cited by 39 · see citing works
Filosa, R., Peduto, A., Schaible, A. M., Krauth, V., Weinigel, C., Barz, D., Petronzi, C., Bruno, F., Roviezzo, F., Spaziano, G., et al. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.02.042 · Cited by 39 · see citing works
Omega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade Overreactions
Lands, B. (2015) · BioMed Research International · doi:10.1155/2015/285135 · Cited by 38 · see citing works
Reynolds, A., Álvarez, Y., Sasore, T., Waghorne, N., Butler, C. T., Kilty, C., Smith, A. J., McVicar, C., Wong, V. H. Y., Galvin, O., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.710665 · Cited by 38 · see citing works
Carracedo, M., Witasp, A., Qureshi, A. R., Laguna-Fernández, A., Brismar, T. B., Stenvinkel, P., & Bäck, M. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12940 · Cited by 38 · see citing works
Self-citationPathogenic mechanisms of lipid mediator lysophosphatidic acid in chronic pain
Ueda, H. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101079 · Cited by 38 · see citing works
Potential role of lipoxin in the management of COVID-19: a narrative review
Batiha, G. E., Al-Gareeb, A. I., Elekhnawy, E., & Al-Kuraishy, H. M. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01070-3 · Cited by 37 · see citing works
Molecular dynamics of inflammation resolution: therapeutic implications
Soliman, A. M., Soliman, M. M., Shah, S. S. H., Baig, H. A., Gouda, N. S., Alenezi, B. T., Alenezy, A. K., Hegazy, A. M. S., Jan, M., & Abdalla, E. H. E. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1600149 · Cited by 37 · see citing works
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology
Schierle, S., Flauaus, C., Heitel, P., Willems, S., Schmidt, J., Kaiser, A., Weizel, L., Goebel, T., Kahnt, A. S., Geißlinger, G., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00458 · Cited by 37 · see citing works
Self-citationGalvin, O., Srivastava, A., Carroll, O., Kulkarni, R. S., Dykes, S., Vickers, S. P., Dickinson, K., Reynolds, A., Kilty, C., Redmond, G., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.04.004 · Cited by 37 · see citing works
Schaible, A. M., Filosa, R., Krauth, V., Temml, V., Pace, S., Garscha, U., Liening, S., Weinigel, C., Rummler, S., Schieferdecker, S., et al. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.04.019 · Cited by 36 · see citing works
Bäck, M. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108439 · Cited by 34 · see citing works
Self-citationGreen, A. R., Freedman, C. J., Tena, J., Tourdot, B. E., Liu, B., Holinstat, M. A., & Holman, T. R. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00889 · Cited by 34 · see citing works
Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR
Sadybekov, A. A., Brouillette, R. L., Marin, E., Sadybekov, A., Luginina, A. P., Gusach, A., Mishin, A., Besserer‐Offroy, É., Longpré, J., Borshchevskiy, V. I., et al. (2020) · Biomolecules · doi:10.3390/biom10121634 · Cited by 32 · see citing works
Meesawatsom, P., Burston, J. J., Hathway, G. J., Bennett, A. J., & Chapman, V. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0676-6 · Cited by 32 · see citing works
Paula‐Silva, F. W. G., Ribeiro-Santos, F. R., Petean, I. B. F., Arnez, M. F. M., de Almeida‐Junior, L. A., de Carvalho, F. K., da Silva, L. A. B., & Faccioli, L. H. (2020) · Journal of Applied Oral Science · doi:10.1590/1678-7757-2019-0699 · Cited by 31 · see citing works
Druggable Lipid GPCRs: Past, Present, and Prospects
Mizuno, H., & Kihara, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-50621-6_10 · Cited by 31 · see citing works
The leukotriene B4 receptor (BLT) antagonist BIIL284 decreases atherosclerosis in ApoE−/− mice
Ketelhuth, D. F. J., Hermansson, A., Hlawaty, H., Letourneur, D., Yan, Z.-Q., & Bäck, M. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.05.007 · Cited by 30 · see citing works
Self-citationEicosanoid receptors as therapeutic targets for asthma
Powell, W. S. (2021) · Clinical Science · doi:10.1042/cs20190657 · Cited by 30 · see citing works
Self-citationNrf2 Activation by 5-lipoxygenase Metabolites in Human Umbilical Vascular Endothelial Cells
Nagahora, N., Yamada, H., Kikuchi, S., Hakozaki, M., & Yano, A. (2017) · Nutrients · doi:10.3390/nu9091001 · Cited by 29 · see citing works
Leukotrienes and kidney diseases
Rubinstein, M., & Dvash, E. (2017) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000381 · Cited by 29 · see citing works
Ammendola, R., Parisi, M., Esposito, G., & Cattaneo, F. (2021) · Antioxidants · doi:10.3390/antiox10010134 · Cited by 29 · see citing works
Wallin, J., & Svenningsson, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115606 · Cited by 29 · see citing works
Cristiano, C., Volpicelli, F., Crispino, M., Lacivita, E., Russo, R., Leopoldo, M., Calignano, A., & Perrone‐Capano, C. (2022) · Pharmaceuticals · doi:10.3390/ph15020161 · Cited by 29 · see citing works
Molecular Pharmacology of Inflammation Resolution in Atherosclerosis
Kotlyarov, S. N., & Котлярова, А. А. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094808 · Cited by 30 · see citing works
Zambalde, É. P., Teixeira, M. M., Favarin, D. C., de Oliveira, J. R., Magalhães, M. L., Cunha, M. M., Silva, W. C., Okuma, C. H., Rodrigues, V., Levy, B. D., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.03.014 · Cited by 29 · see citing works
Lyngstadaas, A. V., Olsen, M. V., Bair, J. A., Hodges, R. R., Utheim, T. P., Serhan, C. N., & Dartt, D. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.618653 · Cited by 28 · see citing works
Self-citationYun, B., Lee, H.-J., Jayaraja, S., Suram, S., Murphy, R. C., & Leslie, C. C. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.714873 · Cited by 28 · see citing works
Liotti, F., Marotta, M., Melillo, R. M., & Prevete, N. (2022) · Cancers · doi:10.3390/cancers14143333 · Cited by 26 · see citing works
- Authors
- Bäck, M., Powell, W. S., Dahlén, S., Drazen, J. M., Evans, J. F., Serhan, C. N., Shimizu, T., Yokomizo, T., & Rovati, G. E.
- Affiliations
- Karolinska University Hospital (SE)
- McGill University (CA)
- Brigham and Women's Hospital (US)
- Karolinska Institutet (SE)
- International Union of Basic and Clinical Pharmacology (US)
- National Center for Global Health and Medicine (JP)
- Juntendo University (JP)
- University of Milan (IT)
- Corresponding author
- Bäck, Magnus
- Rovati, G Enrico
- ORCID
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2014-07-12
- Volume
- 171
- Issue
- 15
- Pages
- 3551-3574
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC4128057
- OpenAlex
- W1564740964
- Cited by
- 217
- References
- 214
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 7 · 2023: 14 · 2022: 19 · 2021: 22 · 2020: 16 · 2019: 20 · 2018: 21 · 2017: 16 · 2016: 31 · 2015: 26 · 2014: 8
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (22116001, 22116002)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- leukotriene receptors, BLT1, BLT2, FPR2/ALX, lipoxygenase metabolites, cysteinyl leukotrienes, resolvins, GPR17, ChemR23, inflammation resolution, cancer, omega-3 polyunsaturated fatty acids
- MeSH terms
- Animals, Humans, Ligands, Signal Transduction, Receptors, Eicosanoid
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