The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity
Open accessAbstract
Dengue is one of the most important arboviral diseases caused by infection of four serotypes of dengue virus (DEN). We found that activation of interferon regulatory factor 3 (IRF3) triggered by viral infection and by foreign DNA and RNA stimulation was blocked by DEN-encoded NS2B3 through a protease-dependent mechanism. The key adaptor protein in type I interferon pathway, human mediator of IRF3 activation (MITA) but not the murine homologue MPYS, was cleaved in cells infected with DEN-1 or DEN-2 and with expression of the enzymatically active protease NS2B3. The cleavage site of MITA was mapped to LRR↓(96)G and the function of MITA was suppressed by dengue protease. DEN replication was reduced with overexpression of MPYS but not with MITA, while DEN replication was enhanced by MPYS knockdown, indicating an antiviral role of MITA/MPYS against DEN infection. The involvement of MITA in DEN-triggered innate immune response was evidenced by reduction of IRF3 activation and IFN induction in cells with MITA knockdown upon DEN-2 infection. NS2B3 physically interacted with MITA, and the interaction and cleavage of MITA could be further enhanced by poly(dA:dT) stimulation. Thus, we identified MITA as a novel host target of DEN protease and provide the molecular mechanism of how DEN subverts the host innate immunity.
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Cites
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“The conditioned Vero cells were infected with VSV (25 pfu/well) for 2 days, and adherent cells were stained by crystal violet.”
BackgroundInfluentialIPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
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Biochemistry and Molecular Biology of Flaviviruses
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Characterization of Lethal Zika Virus Infection in AG129 Mice
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Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation
Li, H., Saucedo-Cuevas, L., Regla-Nava, J. A., Chai, G., Sheets, N., Tang, W., Terskikh, A. V., Shresta, S., & Gleeson, J. G. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.08.005 · Cited by 293
Metadata
- Authors
- Yu, C.-Y., Chang, T.-H., Liang, J.-J., Chiang, R.-L., Lee, Y.-L., Liao, C.-L., & Lin, Y.-L.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-06-28
- Volume
- 8
- Issue
- 6
- Pages
- e1002780
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2038554008
- Cited by
- 259
- References
- 6
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yu, C.-Y., Chang, T.-H., Liang, J.-J., Chiang, R.-L., Lee, Y.-L., Liao, C.-L., & Lin, Y.-L. (2012). Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1002780
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