Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation
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Zika virus (ZIKV)-related neuropathology is an important global health concern. Several studies have shown that ZIKV can infect neural stem cells in the developing brain, but infection in the adult brain has not been examined. Two areas in the adult mouse brain contain neural stem cells: the subventricular zone of the anterior forebrain and the subgranular zone of the hippocampus. Here, using 6-week-old mice triply deficient in interferon regulatory factor (IRF) as a model, we show that blood-borne ZIKV administration can lead to pronounced evidence of ZIKV infection in these adult neural stem cells, leading to cell death and reduced proliferation. Our data therefore suggest that adult as well as fetal neural stem cells are vulnerable to ZIKV neuropathology. Thus, although ZIKV is considered a transient infection in adult humans without marked long-term effects, there may in fact be consequences of exposure in the adult brain.
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AG129 and Irf3/5/7 TKO mice are immunocompromised, permissive to different ZIKV strains, and vulnerable to ZIKV-related pathology and lethality.
“AG129 and Irf3/5/7 TKO mice are the immunocompromised mice which were permissive to different strain ZIKV infection and vulnerable to ZIKV-relative pathology and lethality [10, 21, 30, 31].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [31]
The passages labeled Abstract (page unavailable) describe Irf3/5/7 TKO mice as deficient in interferon signaling and report ZIKV infection, illness, and neural-cell pathology in those mice. The paper says it studied a single mouse strain and a single viral strain; it does not establish the claim about AG129 mice, different ZIKV strains, or lethality. (LLM, conf=0.88)
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Cites
Zika Virus Associated with Microcephaly
Mlakar, J., Korva, M., Tul, N., Popović, M., Poljšak-Prijatelj, M., Mraz, J., Kolenc, M., Resman Rus, K., Vesnaver Vipotnik, T., Fabjan Vodušek, V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1600651 · Cited by 2,884 · see citing works
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.032 · Cited by 2,127 · see citing works
Dynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841 · see citing works
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642 · see citing works
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works
The Brazilian Zika virus strain causes birth defects in experimental models
Cugola, F. R., Fernandes, I. R., Russo, F. B., Freitas, B. C., Dias, J. L. M., Guimarães, K. P., Benazzato, C., Almeida, N., Pignatari, G. C., Romero, S., et al. (2016) · Nature · doi:10.1038/nature18296 · Cited by 1,326 · see citing works
Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
Tang, H., Hammack, C., Ogden, S. C., Wen, Z., Qian, X., Li, Y., Yao, B., Shin, J., Zhang, F., Lee, E. M., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.02.016 · Cited by 1,292 · see citing works
Zika virus impairs growth in human neurospheres and brain organoids
Garcez, P. P., Loiola, E. C., Madeiro da Costa, R., Higa, L. M., Trindade, P., Delvecchio, R., Nascimento, J. M., Brindeiro, R., Tanuri, A., & Rehen, S. K. (2016) · Science · doi:10.1126/science.aaf6116 · Cited by 1,184 · see citing works
Calvet, G. A., Aguiar, R. S., Melo, A., Sampaio, S. A., de Filippis, I., Fabri, A. D. A., de Araújo, E. S. M., de Sequeira, P. C., de Mendonça, M. C. L., de Oliveira, L., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)00095-5 · Cited by 1,164 · see citing works
Zika Virus Outbreak, Bahia, Brazil
Campos, G. S., Bandeira, A. C., & Sardi, S. I. (2015) · Emerging infectious diseases · doi:10.3201/eid2110.150847 · Cited by 1,150 · see citing works
Saxe, M. D., Battaglia, F., Wang, J.-W., Malleret, G., David, D. J., Monckton, J. E., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., Santarelli, L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607207103 · Cited by 1,020 · see citing works
A Mouse Model of Zika Virus Pathogenesis
Lazear, H. M., Govero, J., Smith, A. M., Platt, D. J., Fernandez, E., Miner, J. J., & Diamond, M. S. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.03.010 · Cited by 909 · see citing works
Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise
Miner, J. J., Cao, B., Govero, J., Smith, A. M., Fernández, E., Cabrera, O. H., Garber, C., Elam-Noll, M., Klein, R. S., Noguchi, K. K., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.008 · Cited by 817 · see citing works
Dang, J., Tiwari, S. K., Lichinchi, G., Qin, Y., Patil, V. S., Eroshkin, A. M., & Rana, T. M. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.04.014 · Cited by 731 · see citing works
Inhibition of neurogenesis interferes with hippocampus‐dependent memory function
Winocur, G., Wojtowicz, J. M., Sekeres, M. J., Snyder, J. S., & Wang, S. Z. (2006) · Hippocampus · doi:10.1002/hipo.20163 · Cited by 580 · see citing works
Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells
Nowakowski, T. J., Pollen, A. A., Di Lullo, E., Sandoval-Espinosa, C., Bershteyn, M., & Kriegstein, A. R. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.03.012 · Cited by 529 · see citing works
DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING
Aguirre, S., Maestre, A. M., Pagni, S. E., Patel, J. R., Savage, T. J., Gutman, D. M., Maringer, K., Bernal‐Rubio, D., Shabman, R. S., Simon, V. R., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002934 · Cited by 525 · see citing works
Deng, W., Saxe, M. D., Gallina, I. S., & Gage, F. H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3362-09.2009 · Cited by 493 · see citing works
Zika Virus Associated with Meningoencephalitis
Carteaux, G., Maquart, M., Bedet, A., Contou, D., Brugières, P., Fourati, S., de Langavant, L. C., de Broucker, T., Brun‐Buisson, C., Leparc-Goffart, I., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmc1602964 · Cited by 477 · see citing works
Martines, R. B., Bhatnagar, J., Keating, M. K., Silva-Flannery, L. M., Muehlenbachs, A., Gary, J. M., Goldsmith, C. S., Hale, G., Ritter, J. M., Rollin, D., et al. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6506e1 · Cited by 416 · see citing works
Neurogenesis, inflammation and behavior
Kohman, R. A., & Rhodes, J. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.09.003 · Cited by 363 · see citing works
Demars, M., Hu, Y., Gadadhar, A., & Lazarov, O. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22387 · Cited by 326 · see citing works
Characterization of Lethal Zika Virus Infection in AG129 Mice
Aliota, M. T., Caine, E. A., Walker, E. C., Larkin, K. E., Camacho, E., & Osorio, J. E. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004682 · Cited by 322 · see citing works
Wu, K.-Y., Zuo, G.-L., Li, X.-F., Ye, Q., Deng, Y.-Q., Huang, X.-Y., Cao, W.-C., Qin, C.-F., & Luo, Z.-G. (2016) · Cell Research · doi:10.1038/cr.2016.58 · Cited by 283 · see citing works
Smithburn, K. C. (1952) · The Journal of Immunology · doi:10.4049/jimmunol.69.2.223 · Cited by 263 · see citing works
Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity
Yu, C.-Y., Chang, T.-H., Liang, J., Chiang, R.-L., Lee, Y.-L., Liao, C., & Lin, Y. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002780 · Cited by 257 · see citing works
Zika virus infection of the central nervous system of mice
Bell, T., Field, E. J., & Narang, H. K. (1971) · Archives of Virology · doi:10.1007/bf01249709 · Cited by 213 · see citing works
Mouse STAT2 Restricts Early Dengue Virus Replication
Ashour, J., Morrison, J. M., Laurent-Rolle, M., Belicha‐Villanueva, A., Plumlee, C. R., Bernal‐Rubio, D., Williams, K. L., Harris, E., Fernández-Sesma, A., Schindler, C., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.10.007 · Cited by 188 · see citing works
Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain
Pilaz, L., McMahon, J. J., Miller, E. E., Lennox, A. L., Suzuki, A., Salmon, E. D., & Silver, D. L. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.007 · Cited by 178 · see citing works
Kaneko, N., Kudo, K., Mabuchi, T., Takemoto, K., Fujimaki, K., Wati, H., Iguchi, H., Tezuka, H., & Kanba, S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301137 · Cited by 152 · see citing works
Mouse Models to Study Dengue Virus Immunology and Pathogenesis
Zellweger, R. L. M., & Shresta, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00151 · Cited by 116 · see citing works
Self-citationGuillain–Barré Syndrome (42 Cases) Occurring During a Zika Virus Outbreak in French Polynesia
Watrin, L., Ghawche, F., Larre, P., Neau, J., Mathis, S., & Fournier, E. (2016) · Medicine · doi:10.1097/md.0000000000003257 · Cited by 110 · see citing works
Rodriguez, J. J., Noristani, H. N., Olabarria, M., Fletcher, J. A., Somerville, T. D. D., Yeh, C., & Verkhratsky, A. (2011) · Current Alzheimer Research · doi:10.2174/156720511797633214 · Cited by 83 · see citing works
Zika Virus as an Emerging Global Pathogen
Beckham, J. D., Pastula, D. M., Massey, A. R., & Tyler, K. L. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.0800 · Cited by 71 · see citing works
Central nervous system involvement in dengue
Araújo, F. M. D. C., Araújo, M. S. S., Nogueira, R. M. R., Brilhante, R. S. N., Oliveira, D. N., Rocha, M. F. G., Cordeiro, R. D. A., Araújo, R. M. C., & Sidrim, J. J. C. (2012) · Neurology · doi:10.1212/wnl.0b013e31824b94e9 · Cited by 70 · see citing works
Understanding How Zika Virus Enters and Infects Neural Target Cells
Miner, J. J., & Diamond, M. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.04.009 · Cited by 65 · see citing works
Neurogenic niches in the brain: help and hindrance of the barrier systems
Stolp, H. B., & Molnár, Z. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00020 · Cited by 53 · see citing works
Patrício, P., Mateus‐Pinheiro, A., Sousa, N., & Pinto, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8422-x · Cited by 38 · see citing works
Luethy, L. N., Erickson, A. K., Jesudhasan, P. R. R., Ikizler, M. R., Dermody, T. S., & Pfeiffer, J. K. (2015) · Virology · doi:10.1016/j.virol.2015.09.019 · Cited by 31 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
An update on Zika virus infection
Baud, D., Gubler, D. J., Schaub, B., Lanteri, M. C., & Musso, D. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31450-2 · Cited by 634 · see citing works
Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses
Meertens, L., Labeau, A., Dejarnac, O., Cipriani, S., Sinigaglia, L., Bonnet-Madin, L., Le Charpentier, T., Hafirassou, M. L., Zamborlini, A., Cao-Lormeau, V.-M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.045 · Cited by 450 · see citing works
Zika Virus Pathogenesis and Tissue Tropism
Miner, J. J., & Diamond, M. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.01.004 · Cited by 423 · see citing works
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
Wu, X., Thi, V. L. D., Huang, Y., Billerbeck, E., Saha, D., Hoffmann, H.-H., Wang, Y., Silva, L. A. V., Sarbanes, S. L., Sun, T., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.018 · Cited by 385 · see citing works
Ultrastructural Characterization of Zika Virus Replication Factories
Cortese, M., Goellner, S., Acosta, E. G., Neufeldt, C. J., Oleksiuk, O., Lampe, M., Haselmann, U., Funaya, C., Schieber, N. L., Ronchi, P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.014 · Cited by 364 · see citing works
Gabriel, E., Ramani, A., Karow, U., Gottardo, M., Natarajan, K., Gooi, L. M., Goranci-Buzhala, G., Krut, O., Peters, F., Nikolić, M., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.12.005 · Cited by 292 · see citing works
Animal Models of Zika Virus Infection, Pathogenesis, and Immunity
Morrison, T. E., & Diamond, M. S. (2017) · Journal of Virology · doi:10.1128/jvi.00009-17 · Cited by 275 · see citing works
Immune Response to Dengue and Zika
Ngono, A. E., & Shresta, S. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053142 · Cited by 269 · see citing works
Self-citationZhou, T., Tan, L., Cederquist, G. Y., Fan, Y., Hartley, B. J., Mukherjee, S., Tomishima, M., Brennand, K. J., Zhang, Q., Schwartz, R. E., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.06.017 · Cited by 263 · see citing works
Liu, Y., Gordesky-Gold, B., Leney-Greene, M. A., Weinbren, N. L., Tudor, M., & Cherry, S. R. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.022 · Cited by 240 · see citing works
The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon Signaling
Best, S. M. (2016) · Journal of Virology · doi:10.1128/jvi.01970-16 · Cited by 244 · see citing works
An Immunocompetent Mouse Model of Zika Virus Infection
Gorman, M. J., Caine, E. A., Zaitsev, K., Begley, M., Weger‐Lucarelli, J., Uccellini, M. B., Tripathi, S., Morrison, J. M., Yount, B. L., Dinnon, K. H., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.04.003 · Cited by 240 · see citing works
Mapping and Role of the CD8 + T Cell Response During Primary Zika Virus Infection in Mice
Ngono, A. E., Vizcarra, E. A., Tang, W. W., Sheets, N., Joo, Y., Kim, K., Gorman, M. J., Diamond, M., & Shresta, S. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2016.12.010 · Cited by 237 · see citing works
Self-citationZika virus has oncolytic activity against glioblastoma stem cells
Zhu, Z., Gorman, M. J., McKenzie, L. D., Chai, J. N., Hubert, C. G., Prager, B. C., Fernández, E., Richner, J. M., Zhang, R., Shan, C., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171093 · Cited by 227 · see citing works
Tripathi, S., Balasubramaniam, V. R. M. T., Brown, J. A., Mena, I., Grant, A., Bardina, S. V., Maringer, K., Schwarz, M. C., Maestre, A. M., Sourisseau, M., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006258 · Cited by 230 · see citing works
Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
Figueiredo, C. P., Barros‐Aragão, F. G. Q., Neris, R. L. S., Frost, P. S., Soares, C., Souza, I. N. D. O., Zeidler, J. D., Zamberlan, D. C., de Sousa, V. L., de Souza, A. S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11866-7 · Cited by 211 · see citing works
The phenotypic spectrum of congenital Zika syndrome
Campo, M. D., Feitosa, I. M. L., Ribeiro, E. M., Horovitz, D. D. G., Pessoa, A. L. S., de França, G. V. A., Garcı́a-Alix, A., Doriqui, M. J. R., Wanderley, H. Y. C., Sanseverino, M. T. V., et al. (2017) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38170 · Cited by 215 · see citing works
Souza, B. S. D. F., Sampaio, G. L. D. A., Pereira, C. S., Campos, G. S., Sardi, S. I., de Freitas, L. A. R., Figueira, C. P., Paredes, B. D., Nonaka, C. K. V., Azevedo, C. M., et al. (2016) · Scientific Reports · doi:10.1038/srep39775 · Cited by 209 · see citing works
Flavivirus Receptors: Diversity, Identity, and Cell Entry
Lauréti, M., Narayanan, D., Rodriguez‐Andres, J., Fazakerley, J. K., & Kedzierski, Ł. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02180 · Cited by 178 · see citing works
Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication
Chavali, P. L., Stojic, L., Meredith, L. W., Joseph, N., Nahorski, M. S., Sanford, T. J., Sweeney, T. R., Krishna, B. A., Hosmillo, M. D. T., Firth, A. E., et al. (2017) · Science · doi:10.1126/science.aam9243 · Cited by 170 · see citing works
Wen, J., Tang, W. W., Sheets, N., Ellison, J., Sette, A., Kim, K., & Shresta, S. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.36 · Cited by 173 · see citing works
Self-citationAXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling
Chen, J., Yang, Y., Yang, Y. Z., Zou, P., Chen, J., He, Y., Shui, S., Cui, Y., Bai, R., Liang, Y., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-017-0092-4 · Cited by 168 · see citing works
Vermillion, M. S., Lei, J., Shabi, Y., Baxter, V. K., Crilly, N. P., McLane, M., Griffin, D. E., Pekosz, A. S., Klein, S. L., & Burd, I. D. (2017) · Nature Communications · doi:10.1038/ncomms14575 · Cited by 167 · see citing works
Manangeeswaran, M., Ireland, D. D. C., & Verthelyi, D. I. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1006004 · Cited by 164 · see citing works
Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells
Simonin, Y., Loustalot, F., Desmetz, C., Foulongne, V., Constant, O., Fournier‐Wirth, C., Léon, F., Molès, J., Goubaud, A., Lemaı̂tre, J.-M., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.09.020 · Cited by 161 · see citing works
Waldorf, K. M. A., Nelson, B. R., Stencel-Baerenwald, J., Studholme, C., Kapur, R. P., Armistead, B., Walker, C. L., Merillat, S. A., Vornhagen, J., Tisoncik-Go, J., et al. (2018) · Nature Medicine · doi:10.1038/nm.4485 · Cited by 147 · see citing works
Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response
Hou, S., Kumar, A., Xu, Z., Airo, A. M., Stryapunina, I., Wong, C. P., Branton, W. G., Tchesnokov, E. P., Götte, M., Power, C., et al. (2017) · Journal of Virology · doi:10.1128/jvi.00474-17 · Cited by 140 · see citing works
The evolution of Zika virus from Asia to the Americas
Liu, Z., Shi, W., & Qin, C. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0134-9 · Cited by 136 · see citing works
Zika virus causes testicular atrophy
Uraki, R., Hwang, J., Jurado, K. A., Householder, S., Yockey, L. J., Hastings, A. K., Homer, R., Iwasaki, A., & Fikrig, E. (2017) · Science Advances · doi:10.1126/sciadv.1602899 · Cited by 135 · see citing works
The Neurobiology of Zika Virus
Li, H., Saucedo-Cuevas, L. P., Shresta, S., & Gleeson, J. G. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.031 · Cited by 131 · see citing works
Self-citationAdvances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives
Munjal, A. K., Khandia, R., Dhama, K., Sachan, S., Karthik, K., Tiwari, R., Malik, Y. S., Kumar, D., Singh, R. K., Iqbal, H. M. N., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01469 · Cited by 130 · see citing works
Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons
Zhou, W., Woodson, M., Sherman, M. B., Neelakanta, G., & Sultana, H. (2019) · Emerging Microbes & Infections · doi:10.1080/22221751.2019.1578188 · Cited by 127 · see citing works
Shiryaev, S. A., Farhy, C., Pinto, A., Huang, C., Simonetti, N., Ngono, A. E., Dewing, A., Shresta, S., Pinkerton, A. B., Cieplak, P., et al. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.04.015 · Cited by 125 · see citing works
Self-citationMladinich, M. C., Schwedes, J. F., & Mackow, E. R. (2017) · mBio · doi:10.1128/mbio.00952-17 · Cited by 123 · see citing works
Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection
Nozaki, K., Li, L., & Miao, E. A. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-011235 · Cited by 119 · see citing works
Zika virus disrupts molecular fingerprinting of human neurospheres
Garcez, P. P., Nascimento, J. M., de Vasconcelos, J. M., da Costa, R. M., Delvecchio, R., Trindade, P., Loiola, E. C., Higa, L. M., Cassoli, J. S., Vitória, G., et al. (2017) · Scientific Reports · doi:10.1038/srep40780 · Cited by 119 · see citing works
Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities
Ming, G., Tang, H., & Song, H. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.11.014 · Cited by 116 · see citing works
Zika virus infection: an update
Ferraris, P., Yssel, H., & Missé, D. (2019) · Microbes and Infection · doi:10.1016/j.micinf.2019.04.005 · Cited by 120 · see citing works
Viperin is an important host restriction factor in control of Zika virus infection
der Hoek, K. H. V., Eyre, N. S., Shue, B., Khantisitthiporn, O., Glab-ampai, K., Carr, J. M., Gartner, M. J., Jolly, L. A., Thomas, P. Q., Adikusuma, F., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04138-1 · Cited by 108 · see citing works
Ayala‐Nunez, V., Follain, G., Delalande, F., Hirschler, A., Partiot, E., Hale, G., Bollweg, B. C., Roels, J. R. E., Chazal, M., Bakoa, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12408-x · Cited by 110 · see citing works
Zika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated and Defective in Neuroinvasion
Annamalai, A. S., Pattnaik, A., Sahoo, B. R., Muthukrishnan, E., Natarajan, S. K., Steffen, D. J., Vu, H. L. X., Delhon, G. A., Osorio, F. A., Petro, T. M., et al. (2017) · Journal of Virology · doi:10.1128/jvi.01348-17 · Cited by 104 · see citing works
Wang, S., Li, W., Wang, Z., Yang, W., Li, E., Xia, X., Yan, F., & Chiu, S. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01917-x · Cited by 117 · see citing works
Zika virus directly infects peripheral neurons and induces cell death
Oh, Y., Zhang, F., Wang, Y., Lee, E. M., Choi, I. Y., Lim, H., Mirakhori, F., Li, R., Huang, L., Xu, T., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4612 · Cited by 99 · see citing works
Huang, Y., Li, Y., Zhang, H., Zhao, R., Jing, R., Xu, Y., He, M., Peer, J., Kim, Y. C., Luo, J., et al. (2018) · Cell Discovery · doi:10.1038/s41421-018-0017-2 · Cited by 97 · see citing works
Zika infection and the development of neurological defects
Russo, F. B., Jungmann, P., & Beltrão-Braga, P. C. B. (2017) · Cellular Microbiology · doi:10.1111/cmi.12744 · Cited by 96 · see citing works
Male germ cells support long-term propagation of Zika virus
Robinson, C. L., Chong, A. C. N., Ashbrook, A. W., Jeng, G., Jin, J., Chen, H., Tang, E. I., Martin, L. A., Kim, R. S., Kenyon, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04444-w · Cited by 89 · see citing works
Zika virus crosses an in vitro human blood brain barrier model
Alimonti, J. B., Ribecco‐Lutkiewicz, M., Sodja, C., Jezierski, A., Stanimirovic, D. B., Liu, Q., Haqqani, A. S., Conlan, W. J., & Bani‐Yaghoub, M. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0100-y · Cited by 88 · see citing works
He, Z., An, S., Chen, J., Zhang, S., Tan, C., Yu, J., Ye, H., Wu, Y., Yuan, J. X., Wu, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007773117 · Cited by 88 · see citing works
AAV ablates neurogenesis in the adult murine hippocampus
Johnston, S., Parylak, S. L., Kim, S., Mac, N., Lim, C., Gallina, I., Bloyd, C., Newberry, A., Saavedra, C. D., Novak, O., et al. (2021) · eLife · doi:10.7554/elife.59291 · Cited by 87 · see citing works
Mavigner, M., Raper, J., Kovacs-Balint, Z., Gumber, S., O’Neal, J. T., Bhaumik, S. K., Zhang, X., Habib, J. G., Mattingly, C., McDonald, C. E., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao6975 · Cited by 87 · see citing works
Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade
Nair, S., Mazzoccoli, L., Jash, A., Govero, J., Bais, S. S., Hu, T., Fontes-Garfias, C. R., Shan, C., Okada, H., Shresta, S., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.144619 · Cited by 86 · see citing works
Self-citationThe Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein
Fontaine, K. A., Leon, K. E., Khalid, M. M., Tomar, S., Jimenez‐Morales, D., Dunlap, M., Kaye, J., Shah, P. S., Finkbeiner, S. M., Krogan, N. J., et al. (2018) · mBio · doi:10.1128/mbio.02126-18 · Cited by 85 · see citing works
Alzheimer’s disease as a viral disease: Revisiting the infectious hypothesis
Bruno, F., Abondio, P., Bruno, R., Ceraudo, L., Paparazzo, E., Citrigno, L., Luiselli, D., Bruni, A. C., Passarino, G., Colao, R., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102068 · Cited by 85 · see citing works
Zika Virus: Origins, Pathological Action, and Treatment Strategies
Gorshkov, K., Shiryaev, S. A., Fertel, S., Lin, Y.-W., Huang, C., Pinto, A., Farhy, C., Strongin, A. Y., Zheng, W., & Terskikh, A. V. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03252 · Cited by 82 · see citing works
Self-citationFerraris, P., Cochet, M., Hamel, R., Gladwyn-Ng, I. E., Alfano, C., Diop, F., Garcia, D., Talignani, L., Montero‐Menei, C. N., Nougaırède, A., et al. (2019) · Emerging Microbes & Infections · doi:10.1080/22221751.2019.1637283 · Cited by 80 · see citing works
Puma, D. D. L., Piacentini, R., Leone, L., Gironi, K., Marcocci, M. E., Chiara, G. D., Palamara, A. T., & Grassi, C. (2019) · Stem Cells · doi:10.1002/stem.3072 · Cited by 79 · see citing works
Zika Virus Fatally Infects Wild Type Neonatal Mice and Replicates in Central Nervous System
Li, S., Armstrong, N., Zhao, H., Hou, W., Liu, J., Chen, C.-Y., Wan, J., Wang, W., Zhong, C., Liu, C., et al. (2018) · Viruses · doi:10.3390/v10010049 · Cited by 74 · see citing works
Zika Virus Selectively Kills Aggressive Human Embryonal CNS Tumor Cells In Vitro and In Vivo
Kaid, C., Goulart, E., de Caires-Junior, L. C., Araújo, B. H. S., Schanoski, A. S., Bueno, H. M. S., Telles-Silva, K. A., Astray, R. M., Assoni, A. F., Júnior, A. F. R., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3201 · Cited by 74 · see citing works
Diagnostic Testing for Zika Virus: a Postoutbreak Update
Theel, E. S., & Hata, D. J. (2018) · Journal of Clinical Microbiology · doi:10.1128/jcm.01972-17 · Cited by 73 · see citing works
Zika virus induces inflammasome activation in the glial cell line U87-MG
Tricarico, P. M., Caracciolo, I., Crovella, S., & D’Agaro, P. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.158 · Cited by 69 · see citing works
Zika Virus Infection in the Central Nervous System and Female Genital Tract
Nicastri, E., Castilletti, C., Balestra, P., Galgani, S., & Ippolito, G. (2016) · Emerging infectious diseases · doi:10.3201/eid2212.161280 · Cited by 68 · see citing works
Zika virus: what we need to know?
Javed, F., Manzoor, K. N., Ali, M., Haq, I. U., Khan, A. A., Zaib, A., & Manzoor, S. (2017) · Journal of Basic Microbiology · doi:10.1002/jobm.201700398 · Cited by 68 · see citing works
Neurocognitive impacts of arbovirus infections
Clé, M., Eldin, P., Briant, L., Lannuzel, A., Simonin, Y., Van de Perre, P., Cabié, A., & Salinas, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01904-3 · Cited by 67 · see citing works
Visual and Motor Deficits in Grown-up Mice with Congenital Zika Virus Infection
Cui, L., Zou, P., Chen, E., Yao, H., Zheng, H., Wang, Q., Zhu, J., Jiang, S., Lu, L., & Zhang, J. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.029 · Cited by 63 · see citing works
Bat pluripotent stem cells reveal unusual entanglement between host and viruses
Déjosez, M., Marín, A., Hughes, G. M., Morales, A. E., Godoy-Parejo, C., Gray, J. L., Qin, Y., Singh, A. A., Xu, H., Javier Juste, B., et al. (2023) · Cell · doi:10.1016/j.cell.2023.01.011 · Cited by 62 · see citing works
Immune Regulation of Antibody Access to Neuronal Tissues
Iwasaki, A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.01.004 · Cited by 64 · see citing works
Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities
Leão, V. H. P., Aragão, M. D. M., Pinho, R., Hazin, A., Paciorkowski, A., de Oliveira, A. P., & Masruha, M. R. (2020) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-020-01072-0 · Cited by 63 · see citing works
Disruption of glial cell development by Zika virus contributes to severe microcephalic newborn mice
Li, C., Wang, Q., Jiang, Y., Ye, Q., Xu, D., Gao, F., Xu, J. W., Wang, R., Zhu, X., Shi, L., et al. (2018) · Cell Discovery · doi:10.1038/s41421-018-0042-1 · Cited by 61 · see citing works
Singh, P. K., Singh, S., Farr, D. A., & Kumar, A. (2019) · The Ocular Surface · doi:10.1016/j.jtos.2019.03.006 · Cited by 61 · see citing works
Zika virus pathogenesis and current therapeutic advances
Mwaliko, C., Nyaruaba, R., Zhao, L., Atoni, E., Karungu, S., Mwau, M., Lavillette, D., Xia, H., & Yuan, Z. (2020) · Pathogens and Global Health · doi:10.1080/20477724.2020.1845005 · Cited by 58 · see citing works
Dang, J. W., Tiwari, S. K., Qin, Y., & Rana, T. M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.059 · Cited by 56 · see citing works
Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
Sáiz, J., Martín-Acebes, M. A., Bueno‐Marí, R., Salomón, O. D., Jiménez, L. C. V., Heukelbach, J., Alencar, C. H., Armstrong, P., Ortiga-Carvalho, T. M., Méndez‐Otero, R., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01554 · Cited by 54 · see citing works
Zhang, F., Wang, H.-J., Wang, Q., Liu, Z., Yuan, L., Huang, X., Li, G., Ye, Q., Yang, H., Shi, L., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.10.019 · Cited by 55 · see citing works
In vitro and in vivo models for studying Zika virus biology
Pena, L., Guarines, K. M., Silva, A. J. D., Leal, L. R. S., Félix, D. M., Silva, A., de Oliveira, S. A., Ayres, C. F. J., Silva‐Júnior, A., & de Freitas, A. C. (2018) · Journal of General Virology · doi:10.1099/jgv.0.001153 · Cited by 55 · see citing works
Mouse vs man: Organoid models of brain development & disease
Marshall, J. J., & Mason, J. O. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146427 · Cited by 54 · see citing works
Advances in Zika Virus–Host Cell Interaction: Current Knowledge and Future Perspectives
Lee, J. K., & Shin, O. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051101 · Cited by 53 · see citing works
Potential mechanisms of Zika‐linked microcephaly
Merfeld, E., Ben‐Avi, L., Kennon, M., & Cerveny, K. L. (2017) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.273 · Cited by 48 · see citing works
Zika virus infection accelerates Alzheimer’s disease phenotypes in brain organoids
Lee, S., Choi, H., Shin, N., Kong, D., Kim, N. G., Kim, H.-Y., Kim, M., Choi, S. W., Kim, Y. B., & Kang, K. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00958-x · Cited by 48 · see citing works
Zika virus outbreak: a review of neurological complications, diagnosis, and treatment options
Koppolu, V., & Raju, T. S. (2018) · Journal of NeuroVirology · doi:10.1007/s13365-018-0614-8 · Cited by 52 · see citing works
Sahoo, B. R., Pattnaik, A., Annamalai, A. S., Franco, R., & Pattnaik, A. K. (2020) · Journal of Virology · doi:10.1128/jvi.01575-20 · Cited by 46 · see citing works
Dzieciolowska, S., Larroque, A., Kranjec, E.-A., Drapeau, P., & Samarut, É. (2017) · Scientific Reports · doi:10.1038/srep40067 · Cited by 47 · see citing works
Current Understanding of the Role of T Cells in Chikungunya, Dengue and Zika Infections
Mapalagamage, M., Weiskopf, D., Sette, A., & Silva, A. D. D. (2022) · Viruses · doi:10.3390/v14020242 · Cited by 46 · see citing works
Deleterious effect of Usutu virus on human neural cells
Salinas, S., Constant, O., Desmetz, C., Barthelemy, J., Lemaı̂tre, J.-M., Milhavet, O., Nagot, N., Foulongne, V., Perrin, F. E., Sáiz, J., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005913 · Cited by 46 · see citing works
Strain-Dependent Consequences of Zika Virus Infection and Differential Impact on Neural Development
Goodfellow, F. T., Willard, K. A., Wu, X. X., Scoville, S. L., Stice, S. L., & Brindley, M. A. (2018) · Viruses · doi:10.3390/v10100550 · Cited by 45 · see citing works
Replication of early and recent Zika virus isolates throughout mouse brain development
Rosenfeld, A. B., Doobin, D. J., Warren, A. L., Racaniello, V. R., & Vallee, R. B. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714624114 · Cited by 45 · see citing works
New advances in CNS immunity against viral infection
Manglani, M., & McGavern, D. B. (2017) · Current Opinion in Virology · doi:10.1016/j.coviro.2017.12.003 · Cited by 45 · see citing works
Nonhuman Primate Models of Zika Virus Infection, Immunity, and Therapeutic Development
Osuna, C. E., & Whitney, J. B. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix540 · Cited by 43 · see citing works
Multimerization of Zika Virus-NS5 Causes Ciliopathy and Forces Premature Neurogenesis
Saade, M., Ferrero, D. S., Blanco-Ameijeiras, J., Gonzalez-Gobartt, E., Flores‐Méndez, M., Ruiz-Arroyo, V. M., Martínez-Sáez, E. A., y Cajal, S. R., Akizu, N., Verdaguer, N., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.10.002 · Cited by 43 · see citing works
Alemán, T. S., Ventura, C. V. O. C., Cavalcanti, M. M., Serrano, L. W., Traband, A., Nti, A. A., Gois, A. L., Bravo-Filho, V., Martins, T. T. M. N., Nichols, C. W., et al. (2017) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2017.3292 · Cited by 42 · see citing works
Lang, J., Cheng, Y., Rolfe, A. J., Hammack, C., Vera, D. L., Kyle, K. E., Wang, J., Meissner, T. B., Ren, Y., Cowan, C. A., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.006 · Cited by 41 · see citing works
Bonenfant, G., Meng, R. C., Shotwell, C. R., Badu, P., Payne, A. F., Ciota, A. T., Sammons, M. A., Berglund, J. A., & Pager, C. T. (2020) · Viruses · doi:10.3390/v12050510 · Cited by 41 · see citing works
Kato, F., Tajima, S., Nakayama, E., Kawai, Y., Taniguchi, S., Shibasaki, K.-I., Taira, M., Maeki, T., Lim, C., Takasaki, T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-16475-2 · Cited by 40 · see citing works
Manet, C., Simon‐Lorière, E., Jouvion, G., Hardy, D., Prot, M., Conquet, L., Flamand, M., Panthier, J., Sakuntabhai, A., & Montagutelli, X. (2019) · Journal of Virology · doi:10.1128/jvi.01034-19 · Cited by 40 · see citing works
Ximenes, R. A. D. A., Miranda-Filho, D. D. B., Brickley, E. B., de Araújo, T. V. B., Montarroyos, U. R., Bernardino, M. R. A., Mussi‐Pinhata, M. M., Duarte, G. G., Coutinho, C. M., Negrini, S. F. B. D. M., et al. (2022) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2022.100395 · Cited by 40 · see citing works
Schilling, M., Bridgeman, A., Gray, N., Hertzog, J., Hublitz, P., Kohl, A., & Rehwinkel, J. (2020) · Cells · doi:10.3390/cells9061476 · Cited by 39 · see citing works
Paul, A. M., Acharya, D., Neupane, B., Thompson, E. A., Gonzalez-Fernandez, G., Copeland, K. M., Garrett, M., Liu, H., Lopez, M. E., de Cruz, M. A., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02028 · Cited by 38 · see citing works
Sahoo, B. R., Crook, A. A., Pattnaik, A., Torres-Gerena, A. D., Khalimonchuk, O., Powers, R., Franco, R., & Pattnaik, A. K. (2023) · Journal of Virology · doi:10.1128/jvi.01363-22 · Cited by 37 · see citing works
Bradley, M. P., & Nagamine, C. M. (2017) · Europe PMC (PubMed Central) · Cited by 36 · see citing works
Microencephaly in fetal piglets following in utero inoculation of Zika virus
Schreur, P. J. W., van Keulen, L. J. M., Anjema, D., Kant, J., & Kortekaas, J. (2018) · Emerging Microbes & Infections · doi:10.1038/s41426-018-0044-y · Cited by 37 · see citing works
Zika virus-induced hyper excitation precedes death of mouse primary neuron
Gaburro, J., Bhatti, A., Sundaramoorthy, V., Dearnley, M., Green, D., Nahavandi, S., Paradkar, P. N., & Duchemin, J. (2018) · Virology Journal · doi:10.1186/s12985-018-0989-4 · Cited by 37 · see citing works
- Authors
- Li, H., Saucedo-Cuevas, L., Regla-Nava, J. A., Chai, G., Sheets, N., Tang, W., Terskikh, A. V., Shresta, S., & Gleeson, J. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- La Jolla Institute for Immunology (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Shresta, Sujan
- Gleeson, Joseph G.
- ORCID
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 19
- Issue
- 5
- Pages
- 593-598
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC5097023
- OpenAlex
- W2517926000
- Cited by
- 293
- References
- 39
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 16 · 2023: 32 · 2022: 21 · 2021: 21 · 2020: 28 · 2019: 35 · 2018: 46 · 2017: 56 · 2016: 11
- FWCI
- 48.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases (R01AI116813)
- National Institute of Neurological Disorders and Stroke (R01NS041537, R01NS048453, R21NS100477, R01NS052455, P30NS047101)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD070494)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Zika virus, neural stem cells, adult brain, neural progenitor proliferation, subventricular zone, subgranular zone, hippocampus, bloodborne infections, cell death, neuropathology, mouse model
- MeSH terms
- Zika Virus Infection, Zika Virus, Aging, Animals, Brain, Cell Death, Cell Proliferation, Mice, Neural Stem Cells
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