The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Bifurcation of Arabidopsis NLR Immune Signaling via Ca2+-Dependent Protein Kinases
Open accessAbstract
Nucleotide-binding domain leucine-rich repeat (NLR) protein complexes sense infections and trigger robust immune responses in plants and humans. Activation of plant NLR resistance (R) proteins by pathogen effectors launches convergent immune responses, including programmed cell death (PCD), reactive oxygen species (ROS) production and transcriptional reprogramming with elusive mechanisms. Functional genomic and biochemical genetic screens identified six closely related Arabidopsis Ca²⁺-dependent protein kinases (CPKs) in mediating bifurcate immune responses activated by NLR proteins, RPS2 and RPM1. The dynamics of differential CPK1/2 activation by pathogen effectors controls the onset of cell death. Sustained CPK4/5/6/11 activation directly phosphorylates a specific subgroup of WRKY transcription factors, WRKY8/28/48, to synergistically regulate transcriptional reprogramming crucial for NLR-dependent restriction of pathogen growth, whereas CPK1/2/4/11 phosphorylate plasma membrane-resident NADPH oxidases for ROS production. Our studies delineate bifurcation of complex signaling mechanisms downstream of NLR immune sensors mediated by the myriad action of CPKs with distinct substrate specificity and subcellular dynamics.
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Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Host-Microbe Interactions: Shaping the Evolution of the Plant Immune Response
Chisholm, S. T., Coaker, G., Day, B., & Staskawicz, B. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.008 · Cited by 2,957
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
Davis, B. K., Wen, H., & Ting, J. P.-Y. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101405 · Cited by 1,618
Shen, Q.-H., Saijo, Y., Mauch, S., Biskup, C., Bieri, S., Keller, B., Seki, H., Ülker, B., Somssich, I. E., & Schulze-Lefert, P. (2007) · Science · doi:10.1126/science.1136372 · Cited by 751
Cited by
Effector-Triggered Immunity: From Pathogen Perception to Robust Defense
Cui, H., Tsuda, K., & Parker, J. E. (2015) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050213-040012 · Cited by 1,428
Pattern-recognition receptors are required for NLR-mediated plant immunity
Yuan, M., Jiang, Z., Bi, G., Nomura, K., Liu, M., Wang, Y., Cai, B., Zhou, J.-M., He, S. Y., & Xin, X.-F. (2021) · Nature · doi:10.1038/s41586-021-03316-6 · Cited by 1,257
Thirty years of resistance: Zig-zag through the plant immune system
Ngou, B. P. M., Ding, P., & Jones, J. D. G. (2022) · The Plant Cell · doi:10.1093/plcell/koac041 · Cited by 961
Li, L., Li, M., Yu, L., Zhou, Z., Liang, X., Liu, Z., Cai, G., Gao, L., Zhang, X., Wang, Y., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.009 · Cited by 845
Self-citationRegulation of the NADPH Oxidase RBOHD During Plant Immunity
Kadota, Y., Shirasu, K., & Zipfel, C. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcv063 · Cited by 641
Metadata
- Authors
- Gao, X., Chen, X., Lin, W., Chen, S., Lu, D., Niu, Y., Li, L., Cheng, C., McCormack, M., Sheen, J., Shan, L., & He, P.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-01-31
- Volume
- 9
- Issue
- 1
- Pages
- e1003127
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2030206081
- Cited by
- 331
- References
- 4
- FWCI
- 31.04
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gao, X., Chen, X., Lin, W., Chen, S., Lu, D., Niu, Y., Li, L., Cheng, C., McCormack, M., Sheen, J., Shan, L., & He, P. (2013). Bifurcation of Arabidopsis NLR Immune Signaling via Ca2+-Dependent Protein Kinases. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1003127
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