Cited by 578Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsAdipose Tissue and Metabolism

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans

Wang, Yu, Lam, Karen S L, Kraegen, Edward W, Sweeney, Gary, Zhang, Jialiang, Tso, Annette WK, Chow, Wing-Sun, Wat, Nelson MS, Xu, Jian Yu, Hoo, Ruby LC, Xu, Aimin·2007·Clinical Chemistry

DOI 10.1373/clinchem.2006.075614

Open this paper in CoChat — free account

Abstract

Background: Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for early detection of various renal injuries. Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies. Methods: We used real-time PCR and in-house immunoassays to quantify the mRNA and serum concentrations of lipocalin-2 in C57BL/KsJ db/db obese mice and their age- and sex-matched lean littermates. We analyzed the association between serum lipocalin-2 concentrations and various metabolic and inflammatory variables in 229 persons (121 men and 108 women) recruited from a previous cross-sectional study, and we evaluated the effect of the insulin-sensitizing drug rosiglitazone on serum lipocalin-2 concentrations in 32 diabetic patients (21 men and 11 women). Results: Compared with the lean littermates, lipocalin-2 mRNA expression in adipose tissue and liver and its circulating concentrations were significantly increased in db/db diabetic/obese mice (P <0.001). These changes were normalized after rosiglitazone treatment. In humans, circulating lipocalin-2 concentrations were positively correlated (P <0.005) with adiposity, hypertriglyceridemia, hyperglycemia, and the insulin resistance index, but negatively correlated (P = 0.002) with HDL cholesterol. There was also a strong positive association between lipocalin-2 concentrations and high sensitivity C-reactive protein (hs-CRP), independent of age, sex, and adiposity (P = 0.007). Furthermore, rosiglitazone-mediated decreases in lipocalin-2 concentrations correlated significantly with increases in insulin sensitivity (r = 0.527; P = 0.002) and decreases in hs-CRP concentrations (r = 0.509; P = 0.003). Conclusions: Lipocalin-2 is an inflammatory marker closely related to obesity and its metabolic complications. Measurement of serum lipocalin-2 might be useful for evaluating the outcomes of various clinical interventions for obesity-related metabolic and cardiovascular diseases.

Integrity signals

Registry

Crossref · 10.1373/clinchem.2006.075614

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
Retracted
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies
(2004) · The Lancet · doi:10.1016/s0140-6736(03)15268-3 · Cited by 12,717
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Adiponectin and Adiponectin Receptors
Kadowaki, T., & Yamauchi, T. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0005 · Cited by 2,634
Adipose tissue, adipokines, and inflammation
Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606

Flagged first, then by citations

Show all 42 references

Sorted by citations

Items 201–300 of 576

Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease
Wong, Y., Cheung, C. Y. Y., Tang, C. S.-M., Au, K., Hai, J. S. H., Lee, C., Lau, K. K., Cheung, B. M. Y., Sham, P. C., Xu, A., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311726 · Cited by 36
Self-citation
Mitochondrial disease, mitophagy, and cellular distress in methylmalonic acidemia
Luciani, A., Denley, M. C. S., Govers, L. P., Sorrentino, V., & Froese, D. S. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03934-3 · Cited by 41
Serum lipocalin-2, cathepsin S and chemerin levels and nonalcoholic fatty liver disease
Ye, Z., Wang, S., Yang, Z., He, M., Zhang, S., Zhang, W., Wen, J., Li, Q., Huang, Y., Wang, X., et al. (2014) · Molecular Biology Reports · doi:10.1007/s11033-013-2977-5 · Cited by 35
The response of circulating omentin-1 concentration to 16-week exercise training in male children with obesity
Zehsaz, F., Farhangi, N., & Ghahramani, M. (2016) · The Physician and Sportsmedicine · doi:10.1080/00913847.2016.1248223 · Cited by 35
Single-cell RNA-Seq analysis of diabetic wound macrophages in STZ-induced mice
Ma, J., Song, R., Liu, C., Cao, G., Zhang, G. K., Wu, Z., Zhang, H., Sun, R. X., Chen, A., Wang, Y., et al. (2022) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-022-00707-w · Cited by 34
Self-citation
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop
Wang, B., Liu, J., Wang, Q., Arhatte, M., Cheong, L. Y., Glogowska, E., Jiang, X., Chung, S. K., Jin, L., Hu, Q., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02455-w · Cited by 40
Self-citation
Clinical implication of plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations in patients with advanced carotid atherosclerosis
Giaginis, C., Zira, A. N., Katsargyris, Α., Klonaris, C. N., & Theocharis, S. E. (2010) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2010.211 · Cited by 34
Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity
Catalán, V., Gómez‐Ambrosi, J., Rodrı́guez, A., Ramírez, B., Rotellar, F., Valentí, V., Silva, C., Gil, M. J., Salvador, J., & Frühbeck, G. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0464-8 · Cited by 34
Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity
Barraco, G. M., Luciano, R., Semeraro, M., Prieto-Hontoria, P. L., & Manco, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151119760 · Cited by 33
Neutrophil Gelatinase Associated Lipocalin in Acute Kidney Injury
Peacock, W. F., Maisel, A. S., Kim, J., & Ronco, C. (2013) · Postgraduate Medicine · doi:10.3810/pgm.2013.11.2715 · Cited by 32
Weight loss in prepubertal obese children is associated with a decrease in adipocyte fatty-acid-binding protein without changes in lipocalin-2: a 2-year longitudinal study
Corripio, R., González-Clemente, J. M., Pérez, J., Näf, S., Gallart, L., Nosas, R., Vendrell, J. J., & Caixàs, A. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0408 · Cited by 34
CST, an Herbal Formula, Exerts Anti-Obesity Effects through Brain-Gut-Adipose Tissue Axis Modulation in High-Fat Diet Fed Mice
Ansari, A., Bose, S., Yadav, M., Wang, J., Song, Y.-K., Ko, S., & Kim, H. (2016) · Molecules · doi:10.3390/molecules21111522 · Cited by 36
Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner
Amersfoort, J., Schaftenaar, F. H., Douna, H., van Santbrink, P. J., Kröner, M. J., van Puijvelde, G. H. M., Quax, P. H. A., Kuiper, J., & Bot, I. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.06.015 · Cited by 34
Lipocalin-2 deficiency may predispose to the progression of spontaneous age-related adiposity in mice
Meyers, K. R., López, M., Ho, J., Wills, S., Rayalam, S., & Taval, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-71249-7 · Cited by 34
Satellite glia as a critical component of diabetic neuropathy: Role of lipocalin‐2 and pyruvate dehydrogenase kinase‐2 axis in the dorsal root ganglion
Bhusal, A., Rahman, M. H., Lee, W., Lee, I., & Suk, K. (2020) · Glia · doi:10.1002/glia.23942 · Cited by 34
Role of Mineralocorticoid Receptor in Adipogenesis and Obesity in Male Mice
Ferguson, D., Hutson, I., Tycksen, E., Pietka, T., Bauerle, K. T., & Harris, C. A. (2019) · Endocrinology · doi:10.1210/endocr/bqz010 · Cited by 35
Adipose tissue in older individuals: a contributing factor to sarcopenia
Wang, T., Zhou, D., & Hong, Z. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155998 · Cited by 37
Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling.
Yang, B., Fan, P., Xu, A., Lam, K. S., Berger, T., Mak, T. W., Tse, H., Yue, J. W., Song, E., Vanhoutte, P. M., et al. (2012) · Europe PMC (PubMed Central) · Cited by 32
Self-citation
Adipose proteome analysis: focus on mediators of insulin resistance
Chen, X., & Hess, S. Y. (2008) · Expert Review of Proteomics · doi:10.1586/14789450.5.6.827 · Cited by 33
Hippocampal Lipocalin 2 Is Associated With Neuroinflammation and Iron-Related Oxidative Stress in ob/ob Mice
Jin, Z. H., Kim, K. E., Shin, H. J., Jeong, E. A., Park, K.-A., Lee, J. Y., An, H. S., Choi, E. B., Jeong, J. H., Kwak, W., et al. (2020) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa017 · Cited by 34
Using lipocalin as a prognostic biomarker in acute kidney injury
Chen, J., Lee, T. H., Lee, C., & Chang, C. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.1917384 · Cited by 32
Omentin-1 plasma levels and omentin-1 expression are decreased in psoriatic lesions of psoriasis patients
Zhang, C., Zhu, K., Liu, J. L., Xu, G. X., Liu, W., Jiang, F., Zheng, H. F., & Quan, C. (2015) · Archives of Dermatological Research · doi:10.1007/s00403-015-1549-z · Cited by 32
Kidney Injury Biomarkers in Hypertensive, Diabetic, and Nephropathy Rat Models Treated with Contrast Media
Rouse, R. L., Stewart, S. R., Thompson, K. L., & Zhang, J. (2012) · Toxicologic Pathology · doi:10.1177/0192623312464122 · Cited by 32
Self-citation
Are there any new reliable markers to detect renal injury in obese children?
Gayret, Ö. B., Taşdemir, M. S., Erol, M., Nacaroğlu, H. T., Zengi, O., & Yiğit, Ö. (2018) · Renal Failure · doi:10.1080/0886022x.2018.1489284 · Cited by 32
High-intensity Interval Training Improves Lipocalin-2 and Omentin-1 Levels in Men with Obesity
Atashak, S., Stannard, S. R., Daraei, A., Soltani, M., Saeidi, A., Moradi, F., Laher, I., Hackney, A. C., & Zouhal, H. (2021) · International Journal of Sports Medicine · doi:10.1055/a-1560-5401 · Cited by 31
Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men
Luo, Y., Ma, X., Pan, X., Xu, Y., Xiong, Q., Xiao, Y., Bao, Y., & Jia, W. (2016) · Medicine · doi:10.1097/md.0000000000004039 · Cited by 30
The Role of Bone-Derived Hormones in Glucose Metabolism, Diabetic Kidney Disease, and Cardiovascular Disorders
Takashi, Y., & Kawanami, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042376 · Cited by 30
Expression and localisation of brain-type organic cation transporter (BOCT/24p3R/LCN2R) in the normal rat hippocampus and after kainate-induced excitotoxicity
Chia, W.-J., Tan, F. C. K., Ong, W., & Dawe, G. S. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.04.009 · Cited by 31
The changes of neutrophil gelatinase-associated lipocalin in plasma and its expression in adipose tissue in pregnant women with gestational diabetes
Lou, Y., Wu, C., Wu, M., Xie, C., & Ren, L. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.01.014 · Cited by 31
Omentin serum levels and omentin gene V al109 A sp polymorphism in patients with psoriasis
Turan, H., Yaykaşlı, K. O., Soğuktaş, H., Yaykaşlı, E., Aliağaoğlu, C., Erdem, T., Karkucak, M., Kaya, E., Uçgun, T., & Bahadır, A. (2013) · International Journal of Dermatology · doi:10.1111/ijd.12306 · Cited by 31
Neutrophil Gelatinase-Associated Lipocalin in Acute Kidney Injury
Makris, K., & Kafkas, N. V. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394383-5.00012-6 · Cited by 31
Inflammatory biomarkers associated with obesity and insulin resistance: a focus on lipocalin-2 and adipocyte fatty acid-binding protein
Hoo, R. L. C., Yeung, D. C. Y., Lam, K. S., & Xu, A. (2007) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.3.1.29 · Cited by 31
Self-citation
Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland
Wu, K., Joffre, C., Li, X., MacVeigh‐Aloni, M., Hom, M., Hwang, J., Ding, C., Gregoire, S., Brétillon, L., Zhong, J. F., et al. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.03.020 · Cited by 30
Obesity, inflammation, and insulin resistance
Martins, L. M., de Oliveira, A. R. S., Cruz, K. J. C., Torres‐Leal, F. L., & Marreiro, D. D. N. (2014) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s1984-82502014000400003 · Cited by 30
Newly Discovered Adipokines: Pathophysiological Link Between Obesity and Cardiometabolic Disorders
Kim, J. A., & Choi, K. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.568800 · Cited by 33
Serum neutrophil gelatinase-associated lipocalin levels are correlated with the complexity and the severity of atherosclerosis in acute coronary syndrome
Soylu, K., Aksan, G., Nar, G., Özdemir, M., Gülel, O., İnci, S., Aksakal, A., Soylu, A. İ., & Yılmaz, Ö. (2014) · The Anatolian Journal of Cardiology · doi:10.5152/akd.2014.5513 · Cited by 30
Obesity-promoting and anti-thermogenic effects of neutrophil gelatinase-associated lipocalin in mice
Ishii, A., Katsuura, G., Imamaki, H., Kimura, H., Mori, K. P., Kuwabara, T., Kasahara, M., Yokoi, H., Ohinata, K., Kawanishi, T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15825-4 · Cited by 30
Neutrophil gelatinase‐associated lipocalin in blood in children with inflammatory bowel disease
Janas, R. M., Ochocińska, A., Śnitko, R., Dudka, D., Kierkuś, J., Teisseyre, M., & Najberg, E. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12597 · Cited by 28
The endocrine role of bone: Novel functions of bone-derived cytokines
Wang, H., Zheng, X.-Q., Zhang, Y., Huang, J., Zhou, W., Li, X., Tian, H., Wang, B., Xing, D., Fu, W., et al. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114308 · Cited by 31
Genetic deficiency of apolipoprotein D in the mouse is associated with nonfasting hypertriglyceridemia and hyperinsulinemia
Jiménez-Palomares, M., Cózar‐Castellano, I., Ganfornina, M. D., Sánchez, D., & Perdomo, G. (2011) · Metabolism · doi:10.1016/j.metabol.2011.04.013 · Cited by 29
Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?
Grandone, A., Marzuillo, P., Perrone, L., & Giudice, E. D. (2015) · Nutrients · doi:10.3390/nu7115458 · Cited by 29
The role of bone in energy metabolism: A focus on osteocalcin
Smith, C., Lin, X., Parker, L., Yeap, B. B., Hayes, A., & Levinger, I. (2024) · Bone · doi:10.1016/j.bone.2024.117238 · Cited by 32
Role of human lipocalin proteins in abdominal obesity after acute pancreatitis
Singh, R. G., Pendharkar, S. A., Plank, L. D., & Petrov, M. S. (2017) · Peptides · doi:10.1016/j.peptides.2017.03.001 · Cited by 28
Lipocalin-2 expression and function in pancreatic diseases
Gumpper, K., Dangel, A. W., Pita-Grisanti, V., Krishna, S. G., Lara, L. F., Mace, T. A., Papachristou, G. I., Conwell, D. L., Hart, P. A., & Cruz‐Monserrate, Z. (2020) · Pancreatology · doi:10.1016/j.pan.2020.01.002 · Cited by 28
Association between Plasma Neutrophil Gelatinase Associated Lipocalin Level and Obstructive Sleep Apnea or Nocturnal Intermittent Hypoxia
Murase, K., Mori, K., Yoshimura, C., Aihara, K., Chihara, Y., Azuma, M., Harada, Y., Toyama, Y., Tanizawa, K., Handa, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054184 · Cited by 29
Weight loss significantly reduces serum lipocalin-2 levels in overweight and obese women with polycystic ovary syndrome
Koiou, E., Τζιόμαλος, Κ., Katsikis, I., Kandaraki, E., Kalaitzakis, E., Delkos, D., Vosnakis, C., & Panidis, D. (2011) · Gynecological Endocrinology · doi:10.3109/09513590.2011.588745 · Cited by 28
Association Between Plasma Neutrophil Gelatinase‐Associated Lipocalin and Cardiac Disease Hospitalizations and Deaths in Older Women
Chong, J. J. H., Prince, R. L., Thompson, P. L., Thavapalachandran, S., Ooi, E. M. M., Devine, A., Lim, E. E. M., Byrnes, E., Wong, G., Lim, W. H., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.011028 · Cited by 29
Crosstalk between intestinal flora and human iron metabolism: the role in metabolic syndrome-related comorbidities and its potential clinical application
Yan, Y., Zhang, W., Wang, Y., Yi, C., Yu, B., Pang, X., Li, K., Li, H., & Dai, Y. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127667 · Cited by 28
Self-citation
Progress in the Pathogenesis of Diabetic Encephalopathy: The Key Role of Neuroinflammation
Luo, Y., Zhu, J., Hu, Z., Luo, W., Du, X., Hu, H., & Peng, S. (2024) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3841 · Cited by 29
Levels of lipocalin‐2 in crevicular fluid and tear fluid in chronic periodontitis and obesity subjects
Pradeep, A. R., Nagpal, K., Karvekar, S., & Patnaik, K. (2015) · Journal of Investigative and Clinical Dentistry · doi:10.1111/jicd.12165 · Cited by 27
Clinical Relevance of NGAL/MMP-9 Pathway in Patients with Endometrial Cancer
Cymbaluk‐Płoska, A., Chudecka-Glaz, A. M., Pius‐Sadowska, E., Sompolska‐Rzechuła, A., Chudecka, K., Bulsa, M., Machaliński, B., & Menkiszak, J. (2017) · Disease Markers · doi:10.1155/2017/6589262 · Cited by 27
Adipose-Derived Lipid-Binding Proteins: The Good, the Bad and the Metabolic Diseases
Frances, L., Tavernier, G., & Viguerie, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910460 · Cited by 29
A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes
Díaz-Cañestro, C., Chen, J., Liu, Y., Han, H., Wang, Y., Honoré, É., Lee, C., Lam, K. S. L., Tse, M. A., & Xu, A. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.100944 · Cited by 29
Self-citation
Differential screening identifies transcripts with depot-dependent expression in white adipose tissues
Wu, Y., Kim, J. Y., Zhou, S., & Smas, C. M. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-397 · Cited by 27
Graphene-based immunoassay for human lipocalin-2
Vashist, S. K. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.10.022 · Cited by 26
Female obesity: Association with endocrine disruption and reproductive dysfunction
Baraskar, K., Thakur, P., Shrivastava, R., & Shrivastava, V. K. (2021) · Obesity Medicine · doi:10.1016/j.obmed.2021.100375 · Cited by 27
Escape from breast tumor dormancy: The convergence of obesity and menopause
Roy, R., Yang, J., Shimura, T., Merritt, L., Alluin, J., Man, E., Daisy, C. C., Aldakhlallah, R., Dillon, D. A. R., Pories, S. E., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204758119 · Cited by 25
First trimester serum neutrophil gelatinase‐associated lipocalin in gestational diabetes
D’Anna, R., Baviera, G., Corrado, F., Giordano, P., Recupero, S., & Benedetto, A. D. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02830.x · Cited by 26
Antimicrobial-Sensing Proteins in Obesity and Type 2 Diabetes
Moreno‐Navarrete, J. M., & Fernández‐Real, J. M. (2011) · Diabetes Care · doi:10.2337/dc11-s238 · Cited by 26
Intensive Cardiovascular Risk Reduction Induces Sustainable Changes in Expression of Genes and Pathways Important to Vascular Function
Ellsworth, D. L., Croft, D. T., Weyandt, J. D., Sturtz, L. A., Blackburn, H. L., Burke, A., Haberkorn, M. J., McDyer, F. A., Jellema, G. L., van Laar, R. K., et al. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.113.000121 · Cited by 26
Osteokines and the vasculature: a review of the in vitro effects of osteocalcin, fibroblast growth factor-23 and lipocalin-2
Millar, S., Anderson, S., & O’Sullivan, S. E. (2019) · PeerJ · doi:10.7717/peerj.7139 · Cited by 27
The Effect of Lactobacillus fermentum ME‐3 Treatment on Glycation and Diabetes Complications
Guilbaud, A., Howsam, M., Niquet‐Léridon, C., Delguste, F., Frémont, M., Lestavel, S., Maboudou, P., Garat, A., Schraen‐Maschke, S., Onraed, B., et al. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201901018 · Cited by 26
The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study
Panidis, D., Τζιόμαλος, Κ., Koiou, E., Kandaraki, E., Tsourdi, E. A., Delkos, D., Kalaitzakis, E., & Katsikis, I. (2010) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-8-151 · Cited by 26
Lipocalin-2 plasmatic levels are reduced in patients with long-term type 2 diabetes mellitus.
de la Chesnaye, E., Manuel‐Apolinar, L., Zárate, A., Damasio, L., Espino, N., Revilla-Monsalve, M. C., & Islas‐Andrade, S. (2015) · PubMed Central · Cited by 26
Waist circumference and Neutrophil Gelatinase-Associated Lipocalin in late-life depression
Marijnissen, R. M., Naudé, P. J. W., Comijs, H. C., Schoevers, R. A., & Oude Voshaar, R. C. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.12.021 · Cited by 22
Oxidative stress and insulin resistance in policemen working shifts
Demir, I., Toker, A., Zengin, S., Laloğlu, E., & Aksoy, H. (2015) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-015-1079-1 · Cited by 26
Circulating levels of lipocalin-2 are associated with fatty pancreas but not fatty liver
Singh, R. G., Nguyen, N. N., Cervantes, A., Kim, J. U., Stuart, C. E., & Petrov, M. S. (2019) · Peptides · doi:10.1016/j.peptides.2019.170117 · Cited by 25
Lipocalin 2 attenuates oligodendrocyte loss and immune cell infiltration in mouse models for multiple sclerosis
Gasterich, N., Bohn, A., Sesterhenn, A., Nebelo, F., Fein, L., Kaddatz, H., Nyamoya, S., Kant, S., Kipp, M., Weiskirchen, R., et al. (2022) · Glia · doi:10.1002/glia.24245 · Cited by 24
Eradicating hepatitis C virus ameliorates insulin resistance without change in adipose depots
Milner, K. ‐., Jenkins, A. B., Trenell, M. I., Tid-Ang, J. D., Samocha‐Bonet, D., Weltman, M., Xu, A., George, J., & Chisholm, D. J. (2013) · Journal of Viral Hepatitis · doi:10.1111/jvh.12143 · Cited by 24
Self-citation
Serum AFBP levels are elevated in patients with nonalcoholic fatty liver disease
Suh, J.-B., Kim, S. M., Cho, G.-J., & Choi, K. M. (2014) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.836754 · Cited by 24
Liver-Restricted Repin1 Deficiency Improves Whole-Body Insulin Sensitivity, Alters Lipid Metabolism, and Causes Secondary Changes in Adipose Tissue in Mice
Kern, M., Kosacka, J., Hesselbarth, N., Brückner, J., Heiker, J. T., Flehmig, G., Klöting, I., Kovacs, P. L., Matz‐Soja, M., Gebhardt, R., et al. (2014) · Diabetes · doi:10.2337/db13-0933 · Cited by 24
Early Hepatic Oxidative Stress and Mitochondrial Changes Following Western Diet in Middle Aged Rats
Mazzoli, A., Crescenzo, R., Cigliano, L., Spagnuolo, M. S., Cancelliere, R., Gatto, C., & Iossa, S. (2019) · Nutrients · doi:10.3390/nu11112670 · Cited by 23
Clinical significance of neutrophil gelatinase-associated lipocalin and sdLDL-C for coronary artery disease in patients with type 2 diabetes mellitus aged ≥ 65 years
Chen, Y., Fu, Y., Wang, S., Chen, P., Pei, Y., Zhang, J., Zhang, R., Niu, G., Gu, F., & Li, X. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01668-5 · Cited by 23
Self-citation
Effects of Resistance versus Endurance Training on Plasma Lipocalin-2 in Young Men.
Moghadasi, M., & Domieh, A. M. (2014) · Europe PMC (PubMed Central) · Cited by 23
Podwyższone stężenia lipokaliny-2 w surowicy krwi są związane ze wskaźnikami metabolizmu glukozy i metabolizmu kostnego w przebiegu cukrzycy typu 2
Wang, W., Ye, S., Qian, L., Xing, Y., An, R., Chen, C., Li, S., Xu, J., Liu, Q., Dong, L., et al. (2018) · Endokrynologia Polska · doi:10.5603/ep.a2018.0030 · Cited by 23
Self-citation
Plasmatic lipocalin‐2 levels in chronic low‐grade inflammation syndromes: Comparison between metabolic syndrome, total and partial adult growth hormone deficiency
Currò, D., Vergani, E., Bruno, C., Comi, S., d’Abate, C., & Mancini, A. (2020) · BioFactors · doi:10.1002/biof.1628 · Cited by 24
Plasma neutrophil gelatinase‐associated lipocalin levels are positively associated with diabetic retinopathy in patients with Type 2 diabetes
Chung, J. O., Park, S.-W., Cho, D. H., Chung, D. J., & Chung, M. Y. (2016) · Diabetic Medicine · doi:10.1111/dme.13141 · Cited by 23
Lipocalin 2—A bone‐derived anorexigenic and β‐cell promoting signal: From mice to humans
Yang, Y., Liu, J., & Kousteni, S. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13504 · Cited by 22
Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner
Watzenboeck, M. L., Drobits, B., Zahalka, S., Gorki, A.-D., Farhat, A., Quattrone, F., Hladik, A., Lakovits, K., Richard, G. M., Lederer, T., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009487 · Cited by 22
Mitochondrial Distress in Methylmalonic Acidemia: Novel Pathogenic Insights and Therapeutic Perspectives
Keller, S. A., & Luciani, A. (2022) · Cells · doi:10.3390/cells11193179 · Cited by 24
Gp130-Dependent Release of Acute Phase Proteins Is Linked to the Activation of Innate Immune Signaling Pathways
Luchtefeld, M., Preuss, C., Rühle, F., Bogalle, E. P., Sietmann, A., Figura, S., Müller, W., Grote, K., Schieffer, B., & Stoll, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019427 · Cited by 21
Estrogen interacts with glucocorticoids in the regulation of lipocalin 2 expression in human adipose tissue. Reciprocal roles of estrogen receptor α and β in insulin resistance?
Kamble, P. G., Pereira, M. J., Almby, K. E., & Eriksson, J. W. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.04.002 · Cited by 24
Recent advances in the crosstalk between adipose, muscle and bone tissues in fish
Hue, I., Capilla, E., Rosell-Moll, E., Balbuena-Pecino, S., Goffette, V., Gabillard, J., & Navarro, I. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1155202 · Cited by 23
Functional analysis of the mannose-binding lectin complement pathway in normal pregnancy and preeclampsia
Csuka, D., Molvarec, A., Derzsy, Z., Varga, L. Á., Füst, G., Rigó, J. J., & Prohászka, Z. (2010) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2010.07.004 · Cited by 21
Effect of NUCKS-1 Overexpression on Cytokine Profiling in Obese Women with Breast Cancer
Soliman, N. A., Zineldeen, D. H., & El-Khadrawy, O. H. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.2.837 · Cited by 21
Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels
Baran, A. M., Świderska, M., Myśliwiec, H., & Flisiak, I. (2016) · Journal of Dermatological Treatment · doi:10.1080/09546634.2016.1180340 · Cited by 21
Remodeling adipose tissue inflammasome for type 2 diabetes mellitus treatment: Current perspective and translational strategies
Banerjee, A., & Singh, J. (2019) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10150 · Cited by 20
Serum levels of the adipokine lipocalin-2 are increased in preeclampsia
Stepan, H., Philipp, A., Reiche, M., Klostermann, K., Schrey-Petersen, S., Reisenbüchler, C., Lössner, U., Kratzsch, J., Blüher, M., Stümvoll, M., et al. (2010) · Journal of Endocrinological Investigation · doi:10.1007/bf03346661 · Cited by 21
Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue
AlZaim, I., Al-Saidi, A., Hammoud, S. H., Darwiche, N., Al-Dhaheri, Y., Eid, A. H., & EL‐Yazbi, A. F. (2022) · Cancers · doi:10.3390/cancers14071679 · Cited by 23
Acute phase response, inflammation and metabolic syndrome biomarkers of Libby asbestos exposure
Shannahan, J. H., Álzate, Ó., Winnik, W., Andrews, D., Schladweiler, M. C. J., Ghio, A. J., Gavett, S. H., & Kodavanti, U. P. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.02.006 · Cited by 19
Lipocalin-2 in Fructose-Induced Fatty Liver Disease
Lambertz, J., Berger, T., Mak, T. W., van Helden, J., & Weiskirchen, R. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00964 · Cited by 19
Lipocalin 2 as a clinical significance in rheumatoid arthritis
Gülkesen, A., Akgöl, G., Poyraz, A. K., Aydın, S., Denk, A., Yıldırım, T., & Kaya, A. (2017) · Central European Journal of Immunology · doi:10.5114/ceji.2017.70969 · Cited by 20
Neutrophil Gelatinase-Associated Lipocalin (NGAL) Is Related with the Proteinuria Degree and the Microscopic Kidney Findings in Leishmania-Infected Dogs
Peris, M. P., Morales, M., Ares-Gómez, S., Esteban-Gil, A., Gómez-Ochoa, P., Gascón, M., Moreno, B., & Castillo, J. A. (2020) · Microorganisms · doi:10.3390/microorganisms8121966 · Cited by 19
Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ
Zhang, Y., Bobe, G., Miranda, C. L., Lowry, M. B., Hsu, V. L., Löhr, C. V., Wong, C. P., Jump, D. Β., Robinson, M. M., Sharpton, T. J., et al. (2021) · eLife · doi:10.7554/elife.66398 · Cited by 18
The role of novel adipokines and adipose-derived extracellular vesicles (ADEVs): Connections and interactions in liver diseases
Xie, L., Wang, H., Hu, J., Liu, Z., & Hu, F. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116104 · Cited by 19
Characterizing 3T3-L1 MBX Adipocyte Cell Differentiation Maintained with Fatty Acids as an In Vitro Model to Study the Effects of Obesity
Mubtasim, N., & Gollahon, L. (2023) · Life · doi:10.3390/life13081712 · Cited by 20
Enhancing intestinal absorption of a macromolecule through engineered probiotic yeast in the murine gastrointestinal tract
Gelli, H. P., Hedin, K. A., Laursen, M. F., Vazquez-Uribe, R., & Sommer, M. O. A. (2024) · Trends in biotechnology · doi:10.1016/j.tibtech.2024.10.019 · Cited by 17
Bone Regulation of Insulin Secretion and Glucose Homeostasis
Ducy, P. F. (2020) · Endocrinology · doi:10.1210/endocr/bqaa149 · Cited by 18
Maternal serum adipokines and inflammatory markers at late gestation and newborn weight in mothers with and without gestational diabetes mellitus
Saucedo, R., Valencia‐Ortega, J., Moreno-González, L. E., Peña-Cano, M. I., Aranda-Martínez, A., García, Y., Díaz-Velázquez, M. F., & Hernández-Valencia, M. (2021) · Ginekologia Polska · doi:10.5603/gp.a2021.0083 · Cited by 18
The Potential Role of Chemerin, Lipocalin 2, and Apelin in the Diagnosis and Pathophysiology of Gestational Diabetes Mellitus
Mierzyński, R., Poniedziałek‐Czajkowska, E., Dłuski, D. F., Kamiński, M., Mierzyńska, A., & Leszczyńska‐Gorzelak, B. (2021) · Journal of Diabetes Research · doi:10.1155/2021/5547228 · Cited by 18

Authors: Wang, Y., Lam, K. S. L., Kraegen, E. W., Sweeney, G., Zhang, J., Tso, A. W., Chow, W.-S., Wat, N. M., Xu, J. Y., Hoo, R. L., & Xu, A.
Affiliations: Genome Research Center and Department of Biochemistry,
University of Hong Kong (HK)
Garvan Institute of Medical Research (AU)
York University (CA)
Research Center of Heart, Brain, Hormone and Healthy Aging, and
Corresponding author: Xu, Aimin
ORCID: Wang, Yu
Lam, Karen S L
Sweeney, Gary
Zhang, Jialiang
Hoo, Ruby LC
Xu, Aimin
Venue: Clinical Chemistry
Publisher: Oxford University Press (OUP)
Published: 2007-01-01
Volume: 53
Issue: 1
Pages: 34-41
ISSN: 0009-9147 (ISSN-L)
1530-8561
DOI: 10.1373/clinchem.2006.075614
OpenAlex: W2123416046
Cited by: 578
References: 42
Citations by year: 2026: 18 · 2025: 29 · 2024: 31 · 2023: 28 · 2022: 45 · 2021: 36 · 2020: 28 · 2019: 39 · 2018: 31 · 2017: 33 · 2016: 20 · 2015: 31 · 2014: 43 · 2013: 35 · 2012: 34
FWCI: 12.45
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical Chemistry (publishedVersion)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: neutrophil gelatinase-associated lipocalin, obesity, insulin resistance, hyperglycemia, inflammation, C-reactive protein, adipose tissue, liver, rosiglitazone, type 2 diabetes, hypertriglyceridemia, HDL cholesterol, db/db mice, biomarkers
MeSH terms: Lipocalin-2, Rosiglitazone, Acute-Phase Proteins, Adult, Age Factors, Aged, Animals, C-Reactive Protein, Diabetes Mellitus, Type 2, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hyperglycemia, Inflammation, Insulin Resistance, Male, Mice, Inbred C57BL, Mice, Obese, Middle Aged, Obesity, Proto-Oncogene Proteins, Sex Factors, Biomarkers, Oncogene Proteins, Body Mass Index, Polymerase Chain Reaction, Thiazolidinediones, PPAR gamma, Mice, Lipocalins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks