Cited by 326Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsCholesterol and Lipid Metabolism

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Apolipoprotein B and Cardiovascular Disease Risk: Position Statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices

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Contois, John H, McConnell, Joseph P, Sethi, Amar A, Csako, Gyorgy, Devaraj, Sridevi, Hoefner, Daniel M, Warnick, G Russell·2009·Clinical Chemistry

DOI 10.1373/clinchem.2008.118356

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Abstract

Background: Low-density lipoprotein cholesterol (LDL-C) has been the cornerstone measurement for assessing cardiovascular risk for nearly 20 years. Content: Recent data demonstrate that apolipoprotein B (apo B) is a better measure of circulating LDL particle number (LDL-P) concentration and is a more reliable indicator of risk than LDL-C, and there is growing support for the idea that addition of apo B measurement to the routine lipid panel for assessing and monitoring patients at risk for cardiovascular disease (CVD) would enhance patient management. In this report, we review the studies of apo B and LDL-P reported to date, discuss potential advantages of their measurement over that of LDL-C, and present information related to standardization. Conclusions: In line with recently adopted Canadian guidelines, the addition of apo B represents a logical next step to National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII) and other guidelines in the US. Considering that it has taken years to educate physicians and patients regarding the use of LDL-C, changing perceptions and practices will not be easy. Thus, it appears prudent to consider using apo B along with LDL-C to assess LDL-related risk for an interim period until the superiority of apo B is generally recognized.

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Authors: Contois, J. H., McConnell, J. P., Sethi, A. A., Csako, G., Devaraj, S., Hoefner, D. M., & Warnick, G. R.
Affiliations: Maine Standards Company, Windham, ME
Mayo Clinic (US)
National Institutes of Health (US)
National Institutes of Health, Bethesda, MD
University of California Davis Medical Center (US)
Marshfield Clinic (US)
Berkeley HeartLab Inc, Alameda, CA
Corresponding author: Contois, John H
ORCID: Contois, John H
Devaraj, Sridevi
Hoefner, Daniel M
Warnick, G Russell
Venue: Clinical Chemistry
Publisher: Oxford University Press (OUP)
Published: 2009-03-01
Volume: 55
Issue: 3
Pages: 407-419
ISSN: 0009-9147 (ISSN-L)
1530-8561
DOI: 10.1373/clinchem.2008.118356
OpenAlex: W2107424758
Cited by: 326
References: 97
Citations by year: 2026: 6 · 2025: 8 · 2024: 7 · 2023: 16 · 2022: 12 · 2021: 24 · 2020: 25 · 2019: 16 · 2018: 22 · 2017: 17 · 2016: 14 · 2015: 16 · 2014: 28 · 2013: 25 · 2012: 24
FWCI: 29.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical Chemistry (publishedVersion)
PubMed (publishedVersion)
Funders: NIH
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: apolipoprotein B, LDL particle number, LDL cholesterol, cardiovascular risk, lipid profile, Canadian guidelines, cardiovascular risk assessment
MeSH terms: Apolipoproteins B, Cardiovascular Diseases, Humans, Risk Factors, Clinical Chemistry Tests

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Apolipoprotein B and Cardiovascular Disease Risk: Position Statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices

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