The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
A New Season for Cardiac Troponin Assays: It’s Time to Keep a Scorecard
Abstract
Advancements in cardiac troponin (cTn)1 assay technology have created a conundrum for clinicians and laboratory scientists, who must determine which assays are best for optimal patient care. Unfortunately, few resources are available to guide the medical and scientific communities in this regard. International guidelines (1)(2)(3) have defined an increased cTn above the 99th percentile limit as an abnormal result; what is lacking, unfortunately, is an approach to define this limit across the heterogeneity of the assays. In spite of the evidence-based literature demonstrating that cTn concentrations tend to increase in individuals >60 years old (4), 99th percentile reference limits are often determined across wide age ranges using subjects as old as 70 years (convenience samples). Further frustrating the problem of selecting relevant reference subjects, in clinically defined “normal” individuals without known cardiovascular disease, increased cTn concentrations are indicative of a significantly higher risk of death (4)(5). The occurrence of such individuals in reference populations may reflect inadequate screening for comorbidities at the time of sample acquisition. Given such problems, a majority of laboratories either accept the manufacturer’s reference limit from the US Food and Drug Administration (FDA)-cleared package insert, perform an underpowered normal range study to establish a reference limit, or accept a reference limit published in the literature. To validate cTn assays, however—to level the playing field for all users—is necessary for the best patient care.
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Thygesen, K. A. (2007) · Circulation · Cited by 3,126
Task Force Members, Thygesen, K., Alpert, J. S., White, H. D., Biomarker Group, Jaffe, A. S., Apple, F. S., Galvani, M., Katus, H. A., Newby, L. K., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm355 · Cited by 2,541
Self-citationNACB WRITING GROUP MEMBERS, Morrow, D. A., Cannon, C. P., Jesse, R. L., Newby, L. K., Ravkilde, J., Storrow, A. B., Wu, A. H. B., & Christenson, R. H. (2007) · Circulation · doi:10.1161/circulationaha.107.182882 · Cited by 610
NACB WRITING GROUP MEMBERS, Morrow, D. A., Cannon, C. P., Jesse, R. L., Newby, L. K., Ravkilde, J., Storrow, A. B., Wu, A. H. B., Christenson, R. H., NACB COMMITTEE MEMBERS, et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.084194 · Cited by 474
Self-citationApple, F. S., Quist, H. E., Doyle, P. J., Otto, A. P., & Murakami, M. M. (2003) · Clinical Chemistry · doi:10.1373/49.8.1331 · Cited by 322
Self-citationNACB Writing Group Members, Apple, F. S., Jesse, R. L., Newby, L. K., Wu, A. H. B., & Christenson, R. H. (2007) · Circulation · doi:10.1161/circulationaha.107.182881 · Cited by 300
Self-citationZethelius, B., Johnston, N., & Venge, P. (2006) · Circulation · doi:10.1161/circulationaha.105.570762 · Cited by 280
Sabatine, M. S., Morrow, D. A., de Lemos, J. A., Jarolim, P., & Braunwald, E. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn504 · Cited by 277
NACB WRITING GROUP MEMBERS, Apple, F. S., Jesse, R. L., Newby, L. K., Wu, A. H. B., Christenson, R. H., NACB COMMITTEE MEMBERS, Christenson, R. H., Apple, F. S., Cannon, C. P., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.084715 · Cited by 258
Self-citationApple, F. S., Pearce, L. A., Smith, S. W., Kaczmarek, J. M., & Murakami, M. M. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.114728 · Cited by 212
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Cited by
Roffi, M., Patrono, C., Collet, J.-P., Mueller, C., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv320 · Cited by 8,261
Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays
Apple, F. S., Collinson, P. O., & for the IFCC Task Force on Clinical Applications of Cardiac Biomarkers (2012) · Clinical Chemistry · doi:10.1373/clinchem.2011.165795 · Cited by 861
Self-citationChow, S. L., Maisel, A. S., Anand, I., Bozkurt, B., de Boer, R. A., Felker, G. M., Fonarow, G. C., Greenberg, B., Januzzi, J. L., Kiernan, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000490 · Cited by 601
Apple, F. S., Sandoval, Y., Jaffe, A. S., & Ordonez-Llanos, J. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2016.255109 · Cited by 408
Self-citationEvaluation of Biomarkers and Surrogate Endpoints in Chronic Disease
(2010) · National Academies Press eBooks · doi:10.17226/12869 · Cited by 276
Metadata
- Authors
- Apple, F. S.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-07-01
- Volume
- 55
- Issue
- 7
- Pages
- 1303-1306
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2098617627
- Cited by
- 438
- References
- 18
- FWCI
- 24.12
- Type
- journal article
- Language
- en
- Open access
- closed
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