The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Association between Functional Small Airway Disease and FEV 1 Decline in Chronic Obstructive Pulmonary Disease
Open accessAbstract
RATIONALE: The small conducting airways are the major site of airflow obstruction in chronic obstructive pulmonary disease and may precede emphysema development. OBJECTIVES: We hypothesized a novel computed tomography (CT) biomarker of small airway disease predicts FEV1 decline. METHODS: We analyzed 1,508 current and former smokers from COPDGene with linear regression to assess predictors of change in FEV1 (ml/yr) over 5 years. Separate models for subjects without and with airflow obstruction were generated using baseline clinical and physiologic predictors in addition to two novel CT metrics created by parametric response mapping (PRM), a technique pairing inspiratory and expiratory CT images to define emphysema (PRM(emph)) and functional small airways disease (PRM(fSAD)), a measure of nonemphysematous air trapping. MEASUREMENTS AND MAIN RESULTS: Mean (SD) rate of FEV1 decline in ml/yr for GOLD (Global Initiative for Chronic Obstructive Lung Disease) 0-4 was as follows: 41.8 (47.7), 53.8 (57.1), 45.6 (61.1), 31.6 (43.6), and 5.1 (35.8), respectively (trend test for grades 1-4; P < 0.001). In multivariable linear regression, for participants without airflow obstruction, PRM(fSAD) but not PRM(emph) was associated with FEV1 decline (P < 0.001). In GOLD 1-4 participants, both PRM(fSAD) and PRM(emph) were associated with FEV1 decline (P < 0.001 and P = 0.001, respectively). Based on the model, the proportional contribution of the two CT metrics to FEV1 decline, relative to each other, was 87% versus 13% and 68% versus 32% for PRM(fSAD) and PRM(emph) in GOLD 1/2 and 3/4, respectively. CONCLUSIONS: CT-assessed functional small airway disease and emphysema are associated with FEV1 decline, but the association with functional small airway disease has greatest importance in mild-to-moderate stage chronic obstructive pulmonary disease where the rate of FEV1 decline is the greatest. Clinical trial registered with www.clinicaltrials.gov (NCT 00608764).
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Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Self-citationMiller, M. R., Hankinson, J., Brusasco, V., Burgos, F., Casaburi, R., Coates, A., Crapo, R., Enright, P., van der Grinten, C. P. M., Gustafsson, P., et al. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00034805 · Cited by 15,627
Self-citationJones, P. W., Quirk, F. H., Baveystock, C. M., & Littlejohns, P. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.6.1321 · Cited by 3,035
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Fletcher, C., & Peto, R. (1977) · BMJ · doi:10.1136/bmj.1.6077.1645 · Cited by 2,370
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Self-citationLung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease
Lange, P., Celli, B., Agustí, A., Boje Jensen, G., Divo, M., Faner, R., Guerra, S., Marott, J. L., Martinez, F. D., Martinez-Camblor, P., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411532 · Cited by 1,284
Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
McDonough, J. E., Yuan, R., Suzuki, M., Seyednejad, N., Elliott, W. M., Sanchez, P. G., Wright, A. C., Gefter, W. B., Litzky, L., Coxson, H. O., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1106955 · Cited by 1,207
Self-citationSite and Nature of Airway Obstruction in Chronic Obstructive Lung Disease
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Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary
Agustí, A., Celli, B. R., Criner, G. J., Halpin, D., Anzueto, A., Barnes, P., Bourbeau, J., Han, M. K., Martinez, F. J., Montes de Oca, M., et al. (2023) · European Respiratory Journal · doi:10.1183/13993003.00239-2023 · Cited by 1,303
Self-citationHan, M. K., Quibrera, P. M., Carretta, E. E., Barr, R. G., Bleecker, E. R., Bowler, R. P., Cooper, C. B., Comellas, A., Couper, D. J., Curtis, J. L., et al. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30207-2 · Cited by 319
Self-citationTiotropium in Early-Stage Chronic Obstructive Pulmonary Disease
Zhou, Y., Zhong, N.-S., Li, X., Chen, S., Zheng, J., Zhao, D., Yao, W., Zhi, R., Wei, L., He, B., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1700228 · Cited by 282
At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease
Martinez, F. J., Han, M. K., Allinson, J. P., Barr, R. G., Boucher, R. C., Calverley, P. M. A., Celli, B. R., Christenson, S. A., Crystal, R. G., Fagerås, M., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201710-2028pp · Cited by 282
Self-citationLung imaging in COPD and asthma
Tanabe, N., Nakagawa, H., Sakao, S., Ohno, Y., Shimizu, K., Nakamura, H., Hanaoka, M., Nakano, Y., & Hirai, T. (2024) · Respiratory Investigation · doi:10.1016/j.resinv.2024.08.014 · Cited by 21
Metadata
- Authors
- Bhatt, S. P., Soler, X., Wang, X., Murray, S., Anzueto, A. R., Beaty, T. H., Boriek, A. M., Casaburi, R., Criner, G. J., Diaz, A. A., Dransfield, M. T., Curran-Everett, D., Galbán, C. J., Hoffman, E. A., Hogg, J. C., Kazerooni, E. A., Kim, V., Kinney, G. L., Lagstein, A., Lynch, D. A., Make, B. J., Martinez, F. J., Ramsdell, J. W., Reddy, R., Ross, B. D., Rossiter, H. B., Steiner, R. M., Strand, M. J., van Beek, E. J. R., Wan, E. S., Washko, G. R., Wells, J. M., Wendt, C. H., Wise, R. A., Silverman, E. K., Crapo, J. D., Bowler, R. P., & Han, M. K.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-07-15
- Volume
- 194
- Issue
- 2
- Pages
- 178-184
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2257628484
- Cited by
- 386
- References
- 20
- FWCI
- 33.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Bhatt, S. P., Soler, X., Wang, X., Murray, S., Anzueto, A. R., Beaty, T. H., Boriek, A. M., Casaburi, R., Criner, G. J., Diaz, A. A., Dransfield, M. T., Curran-Everett, D., Galbán, C. J., Hoffman, E. A., Hogg, J. C., Kazerooni, E. A., Kim, V., Kinney, G. L., Lagstein, A., . . . Han, M. K. (2016). Association between Functional Small Airway Disease and FEV 1 Decline in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201511-2219oc
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