JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

Solinas, Giovanni; Karin, Michael

doi:10.1096/fj.09-151340

Cited by 348Adipokines, Inflammation, and Metabolic DiseasesNF-κB Signaling PathwaysDiet, Metabolism, and Disease

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

Solinas, Giovanni, Karin, Michael·2010·The FASEB Journal

DOI 10.1096/fj.09-151340

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Abstract

Inflammation is thought to underlie the pathogenesis of many chronic diseases. It is now established that obesity results in a state of chronic low‐grade inflammation thought to contribute to several metabolic disorders' including insulin resistance and pancreatic islet dysfunction. The protein kinases JNK1 and IKKβ have been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. The precise mechanisms of these linkages are still being investigated. However, as we discuss here, JNK1 and IKKβ are activated by almost all forms of metabolic stress that have been implicated in insulin resistance or islet dysfunction. Furthermore, both JNK1 and IKKβ are critically involved in the promotion of diet‐induced obesity, metabolic inflammation, insulin resistance, and β‐cell dysfunction. Understanding the molecular mechanisms by which JNK1 and IKKβ mediate obesity‐induced metabolic stress is likely to be of importance for the development of new treatments for a variety of obesity‐associated diseases.—Solinas, G., Karin, M. JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction. FASEB J . 24, 2596–2611 (2010). www.fasebj.org

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During a pathophysiological state, a large and sustained increase in ROS impairs insulin action, through the activation of stress signaling pathways (i.e., MAPK and JNK), contributing to the pathogenesis of diet-induced insulin resistance.
“On the other hand, during a pathophysiological state, abundant evidence indicates that a large and sustained increase in ROS impairs insulin action, through the activation of stress signaling pathways (*i.e.,* MAPK and JNK) ([85](#B85), [154](#B154)), contributing to the pathogenesis of diet-induced insulin resistance ([67](#B67)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [154]

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c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade
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JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes
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Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activationPreprint
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Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults
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Involvement of c-Jun N-terminal Kinase in Oxidative Stress-mediated Suppression of Insulin Gene Expression
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Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
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Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress
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JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
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High Glucose–Induced Apoptosis in Human Endothelial Cells Is Mediated by Sequential Activations of c-Jun NH 2 -Terminal Kinase and Caspase-3
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Interleukin-6 depletion selectively improves hepatic insulin action in obesity.
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Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents
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A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity
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Salicylic Acid Reverses Phorbol 12-Myristate-13-Acetate (PMA)- and Tumor Necrosis Factor α (TNFα)-induced Insulin Receptor Substrate 1 (IRS1) Serine 307 Phosphorylation and Insulin Resistance in Human Embryonic Kidney 293 (HEK293) Cells
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c-Jun amino terminal kinase 1 deficient mice are protected from streptozotocin-induced islet injury
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Interleukin-1α inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes
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Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
Type 2 diabetes as an inflammatory disease
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Inflammatory links between obesity and metabolic disease
Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319 · see citing works
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.
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“Solinas G, Karin M. JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction.”
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New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis
Yuan, T., Yang, T., Chen, H., Fu, D., Hu, Y., Wang, J., Yuan, Q., Yu, H., Xu, W., & Xie, X. (2018) · Redox Biology · doi:10.1016/j.redox.2018.09.025 · Cited by 749 · see citing works
Macrophages, Immunity, and Metabolic Disease
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Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance
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Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
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Obesity, inflammation, and liver cancer
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Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation
Rodríguez-Hernández, H., Simental‐Mendía, L. E., Ramírez, G. R., & Reyes-Romero, M. A. (2013) · International Journal of Endocrinology · doi:10.1155/2013/678159 · Cited by 484 · see citing works
The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation
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JNK at the crossroad of obesity, insulin resistance, and cell stress response
Solinas, G., & Becattini, B. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.12.001 · Cited by 431 · see citing works
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Obesity and cancer: inflammation bridges the two
Kolb, R. H., Sutterwala, F. S., & Zhang, W. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.07.005 · Cited by 411 · see citing works
Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus
Akash, M. S. H., Rehman, K., & Chen, S. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24402 · Cited by 410 · see citing works
Inflammation as a Link between Obesity and Metabolic Syndrome
Faloia, E., Grazia, M., Robertis, M. D., Luconi, M. P., Furlani, G., & Boscaro, M. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/476380 · Cited by 358 · see citing works
Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?
Asrih, M., & Jornayvaz, F. R. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.02.018 · Cited by 331 · see citing works
Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis
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Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review
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Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives
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Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function
Kitada, M., Ogura, Y., Monno, I., & Koya, D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00187 · Cited by 289 · see citing works
Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels
Ilich, J. Z., Kelly, O. J., Inglis, J. E., Panton, L. B., Duque, G., & Ormsbee, M. J. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.02.007 · Cited by 282 · see citing works
Berberine and Its Role in Chronic Disease
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Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man
Jaïs, A., Einwallner, E., Sharif, O., Gossens, K., Lu, T. T.-H., Soyal, S. M., Medgyesi, D., Neureiter, D., Paier-Pourani, J., Dalgaard, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.043 · Cited by 270 · see citing works
Body composition phenotypes in pathways to obesity and the metabolic syndrome
Dulloo, A. G., Jacquet, J., Solinas, G., Montani, J.-P., & Schutz, Y. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.234 · Cited by 268 · see citing works
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Adipocyte-Macrophage Cross-Talk in Obesity
Engin, A. B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_14 · Cited by 269 · see citing works
Polycystic ovary syndrome and mitochondrial dysfunction
Zhang, J., Bao, Y.-G., Zhou, X., & Zheng, L. (2019) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-019-0509-4 · Cited by 259 · see citing works
Mitochondrial fatty acid oxidation in obesity
Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246 · see citing works
Implication of inflammatory signaling pathways in obesity-induced insulin resistance
Tanti, J., Ceppo, F., Jager, J., & Berthou, F. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00181 · Cited by 241 · see citing works
Leptin, resistin and visfatin: the missing link between endocrine metabolic disorders and immunity
Al-Suhaimi, E. A., & Shehzad, A. (2013) · European journal of medical research · doi:10.1186/2047-783x-18-12 · Cited by 228 · see citing works
p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis
Lee, J., Sun, C., Zhou, Y., Lee, J., Gökalp, D., Herrema, H., Park, S. W., Davis, R. J., & Özcan, U. (2011) · Nature Medicine · doi:10.1038/nm.2449 · Cited by 208 · see citing works
Evaluation of the association of chronic inflammation and cancer: Insights and implications
Nigam, M., Mishra, A. P., Deb, V. K., Dimri, D. B., Tiwari, V., BUNGAU, S. G., Bungău, A. F., & Radu, A.-F. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115015 · Cited by 215 · see citing works
OxInflammation: From Subclinical Condition to Pathological Biomarker
Valacchi, G., Virgili, F., Cervellati, C., & Pecorelli, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00858 · Cited by 206 · see citing works
The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders
Szymczak-Pajor, I., Drzewoski, J., & Śliwińska, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186644 · Cited by 204 · see citing works
Emerging Role of Nitric Oxide and Heat Shock Proteins in Insulin Resistance
Molina, M. N., Ferder, L., & Manucha, W. A. (2015) · Current Hypertension Reports · doi:10.1007/s11906-015-0615-4 · Cited by 199 · see citing works
De novo lipogenesis in metabolic homeostasis: More friend than foe?
Solinas, G., Borén, J., & Dulloo, A. G. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.004 · Cited by 197 · see citing works
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Role of ceramide in diabetes mellitus: evidence and mechanisms
Galadari, S., Rahman, A. U., Pallichankandy, S., Galadari, A., & Thayyullathil, F. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-98 · Cited by 196 · see citing works
The Role of the Immune System in Obesity and Insulin Resistance
Patel, P., Buras, E. D., & Balasubramanyam, A. (2013) · Journal of Obesity · doi:10.1155/2013/616193 · Cited by 193 · see citing works
Metabolic inflammation: Connecting obesity and insulin resistance
Dali‐Youcef, N., Mecili, M., Ricci, R., & Andrès, E. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.705015 · Cited by 193 · see citing works
Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration
Spielman, L. J., Little, J. P., & Klegeris, A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.06.004 · Cited by 182 · see citing works
Metabolic adaptations of tissue-resident immune cells
Caputa, G., Castoldi, Â., & Pearce, E. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0407-0 · Cited by 176 · see citing works
Phytochemicals and their impact on adipose tissue inflammation and diabetes
Leiherer, A., Muendlein, A., & Drexel, H. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.09.002 · Cited by 169 · see citing works
Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism
Liang, G., Song, L., Chen, Z., Qian, Y., Xie, J.-J., Zhao, L., Lin, Q., Zhu, G., Tan, Y., Li, X., et al. (2017) · Kidney International · doi:10.1016/j.kint.2017.05.013 · Cited by 161 · see citing works
Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance
Wang, X.-A., Zhang, R., She, Z., Zhang, X., Jiang, D.-S., Wang, T., Gao, L., Deng, W., Zhang, S., Zhu, L., et al. (2013) · Hepatology · doi:10.1002/hep.26751 · Cited by 160 · see citing works
Redox changes in obesity, metabolic syndrome, and diabetes
Korać, B., Kalezic, A., Pekovic‐Vaughan, V., Korać, A., & Janković, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101887 · Cited by 162 · see citing works
Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 Diabetes
Lee, J. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0023-8 · Cited by 157 · see citing works
TGR5 and Immunometabolism: Insights from Physiology and Pharmacology.
Perino, A., & Schoonjans, K. (2015) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.002 · Cited by 141 · see citing works
Hypothalamic dysfunction in obesity
Williams, L. M. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s002966511200078x · Cited by 145 · see citing works
Hepatocellular Carcinoma in Obesity, Type 2 Diabetes, and NAFLD
Reeves, H. L., Zaki, M. Y. W., & Day, C. P. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4085-6 · Cited by 147 · see citing works
Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
Jurczak, M. J., Lee, A., Jornayvaz, F. R., Lee, H., Birkenfeld, A. L., Guigni, B. A., Kahn, M., Samuel, V. T., Glimcher, L. H., & Shulman, G. I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.316760 · Cited by 142 · see citing works
Evidence for the effects of yogurt on gut health and obesity
Pei, R., Martin, D., DiMarco, D. M., & Bolling, B. W. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.883356 · Cited by 144 · see citing works
Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study
Fryk, E., Olausson, J., Mossberg, K., Strindberg, L., Schmelz, M., Brogren, H., Gan, L., Piazza, S., Provenzani, A., Becattini, B., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103264 · Cited by 139 · see citing works
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Oxidative stress: The nexus of obesity and cognitive dysfunction in diabetes
Li, H., Ren, J. L., Li, Y., Wu, Q., & Wei, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1134025 · Cited by 148 · see citing works
Nature or nurture: Let food be your epigenetic medicine in chronic inflammatory disorders
Szic, K. S. V., Ndlovu, ’. N., Haegeman, G., & Berghe, W. V. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.07.029 · Cited by 138 · see citing works
Adipose tissue in obesity and obstructive sleep apnoea
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MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue
Sun, X., Lin, J., Zhang, Y., Kang, S., Belkin, N., Wara, A. K., Icli, B., Hamburg, N. M., Li, D., & Feinberg, M. W. (2016) · Circulation Research · doi:10.1161/circresaha.115.308166 · Cited by 133 · see citing works
Staphylococcal Superantigens: Pyrogenic Toxins Induce Toxic Shock
Krakauer, T. (2019) · Toxins · doi:10.3390/toxins11030178 · Cited by 123 · see citing works
ATP-Induced Inflammation Drives Tissue-Resident Th17 Cells in Metabolically Unhealthy Obesity
Pandolfi, J., Ferraro, A., Sananez, I., Gancedo, M. C., Baz, P., Billordo, L. A., Fainboim, L., & Arruvito, L. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502506 · Cited by 113 · see citing works
Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats
Naidu, P. B., Uddandrao, V. V. S., Naik, R. R., Suresh, P., Meriga, B., Begum, M. S., Pandiyan, R., & Saravanan, G. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.007 · Cited by 114 · see citing works
High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression
Wu, K.-M., Hsu, Y., Ying, M.-C., Tsai, F., Tsai, C., Chung, J., Yang, J., Tang, C., Cheng, L.-Y., Su, P.-H., et al. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0356-5 · Cited by 113 · see citing works
Tributyltin chloride leads to adiposity and impairs metabolic functions in the rat liver and pancreas
Bertuloso, B. D., Podratz, P. L., Merlo, E., de Araújo, J. F. P., Freitas‐Lima, L. C., Miguel, E. C., de Souza, L. N., Gava, A. L., de Oliveira, M., Miranda‐Alves, L., et al. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.03.009 · Cited by 112 · see citing works
Redox Balance, Antioxidant Defense, and Oxidative Damage in the Hypothalamus and Cerebral Cortex of Rats with High Fat Diet‐Induced Insulin Resistance
Maciejczyk, M., Żebrowska, E., Zalewska, A., & Chabowski, A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6940515 · Cited by 110 · see citing works
Inhibiting Ceramide Synthesis Attenuates Hepatic Steatosis and Fibrosis in Rats With Non-alcoholic Fatty Liver Disease
Jiang, M., Li, C., Liu, Q., Wang, A., & Lei, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00665 · Cited by 110 · see citing works
Role of Gut Microbiota in Obesity, Type 2 Diabetes and Alzheimer’s Disease
Naseer, M. I., Bibi, F., Al-Qahtani, M. H., Chaudhary, A., Azhar, E. I., Kamal, M. A., & Yasir, M. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660147 · Cited by 109 · see citing works
A review on the molecular mechanisms involved in insulin resistance induced by organophosphorus pesticides
Lasram, M. M., Dhouib, I. B., Annabi, A. B., Fazâa, S. E., & Gharbi, N. (2014) · Toxicology · doi:10.1016/j.tox.2014.04.009 · Cited by 108 · see citing works
Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer’s disease risk
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The Role of the Dysregulated JNK Signaling Pathway in the Pathogenesis of Human Diseases and Its Potential Therapeutic Strategies: A Comprehensive Review
Yan, H., He, L., Lv, D., Yang, J., & Yuan, Z. (2024) · Biomolecules · doi:10.3390/biom14020243 · Cited by 112 · see citing works
The Role of Hepatocyte Growth Factor (HGF) in Insulin Resistance and Diabetes
Oliveira, A. G., Araújo, T. G., Carvalho, B. D. M., Rocha, G. Z., Santos, A., & Saad, M. J. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00503 · Cited by 103 · see citing works
High glucose induces inflammatory responses in HepG2 cells via the oxidative stress-mediated activation of NF-κB, and MAPK pathways in HepG2 cells
Panahi, G., Pasalar, P., Zare, M., Rizzuto, R., & Meshkani, R. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1427764 · Cited by 100 · see citing works
Type 2 diabetes – An autoinflammatory disease driven by metabolic stress
Gonzalez, L. L., Garrie, K., & Turner, M. D. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.034 · Cited by 98 · see citing works
The effect of a short-term low-carbohydrate, high-fat diet with or without postmeal walks on glycemic control and inflammation in type 2 diabetes: a randomized trial
Myette‐Côté, É., Durrer, C. G., Neudorf, H., Bammert, T. D., Botezelli, J. D., Johnson, J. D., DeSouza, C. A., & Little, J. P. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00240.2018 · Cited by 100 · see citing works
Obesity promotes the expansion of metastasis-initiating cells in breast cancer
Bousquenaud, M., Fico, F., Solinas, G., Rüegg, C., & Santamaria‐Martínez, A. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-1029-4 · Cited by 91 · see citing works
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Interferon Regulatory Factor 9 Protects Against Hepatic Insulin Resistance and Steatosis in Male Mice
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Authors: Solinas, G., & Karin, M.
Affiliations: University of Fribourg (CH)
University of California San Diego (US)
Corresponding author: Solinas, Giovanni
ORCID: Solinas, Giovanni
Karin, Michael
Venue: The FASEB Journal
Publisher: Wiley
Published: 2010-04-06
Volume: 24
Issue: 8
Pages: 2596-2611
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.09-151340
OpenAlex: W2127873334
Cited by: 347
References: 179
Citations by year: 2026: 8 · 2025: 12 · 2024: 13 · 2023: 15 · 2022: 18 · 2021: 20 · 2020: 15 · 2019: 28 · 2018: 28 · 2017: 27 · 2016: 29 · 2015: 31 · 2014: 23 · 2013: 32 · 2012: 28
FWCI: 2.91
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
reroDoc Digital Library (submittedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF31003A‐118172)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: JNK1, IKKβ, obesity, metabolic inflammation, insulin resistance, beta-cell dysfunction, pancreatic islets, glucose homeostasis, metabolic stress, diet-induced obesity, low-grade inflammation
MeSH terms: Humans, Inflammation, Metabolic Diseases, Obesity, Mitogen-Activated Protein Kinase 8, I-kappa B Kinase

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JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

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