The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Cytogenetic Characterization of Tumor Cell Lines
Abstract
The total number of human tumor cell lines is probably too great to count accurately, but given the established sum from hematopoietic tumors alone, over 1000 known samples ( 1 ), the grand total may well exceed 10,000. Because only a minority of these cell lines are in regular use, individuals describing new cell lines should justify their establishment during characterization. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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In lymphoblastoid cell lines, tetraploidy is common but rarely produces genetic imbalances.
“This is an unusual finding for lymphoblastoid cell lines, where tetraploidy is common, but rarely produces genetic imbalances.51”
From Authentication of M14 melanoma cell line proves misidentification of MDA‐MB‐435 breast cancer cell line (2018) · cites this paper as [51]
Citations
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Self-citationCell contamination leads to inaccurate data: we must take action now
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Self-citationMulticolor FISHing: what's the catch?
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False leukemia–lymphoma cell lines: an update on over 500 cell lines
Drexler, H. G., Dirks, W. G., Matsuo, Y., & MacLeod, R. A. F. (2003) · Leukemia · doi:10.1038/sj.leu.2402799 · Cited by 202
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Self-citationNagel, S., Scherr, M., Kel, A. E., Hornischer, K., Crawford, G. E., Kaufmann, M., Meyer, C., Drexler, H. G., & MacLeod, R. A. F. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2615 · Cited by 81
Self-citationNagel, S., Burek, C., Venturini, L., Scherr, M., Quentmeier, H., Meyer, C., Rosenwald, A., Drexler, H. G., & MacLeod, R. A. F. (2006) · Blood · doi:10.1182/blood-2006-08-044347 · Cited by 73
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“This is an unusual finding for lymphoblastoid cell lines, where tetraploidy is common, but rarely produces genetic imbalances.(51) Although lymphoblastoid cell lines from normal patients typically have stable karyotypes, chromosomal abnormalities have been documented in association with immortalization.”
BackgroundNagel, S., Kaufmann, M., Scherr, M., Drexler, H. G., & MacLeod, R. A. F. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20113 · Cited by 28
Self-citationMalignant hematopoietic cell lines: in vitro models for the study of anaplastic large-cell lymphoma
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Self-citationvan Zutven, L. J. C. M., Velthuizen, S. C. J. M., Wolvers-Tettero, I. L. M., van Dongen, J. J. M., Poulsen, T. S., MacLeod, R. A. F., Beverloo, H. B., & Langerak, A. W. (2004) · PubMed · Cited by 16
Self-citationMalignant hematopoietic cell lines: in vitro models for the study of mast cell leukemia
Drexler, H. G., & MacLeod, R. A. F. (2003) · Leukemia Research · doi:10.1016/s0145-2126(03)00007-9 · Cited by 15
Self-citationRagusa, D., Makarov, E. M., Britten, O., Moralli, D., Green, C., & Tosi, S. (2019) · Cancer Reports · doi:10.1002/cnr2.1207 · Cited by 8
Hu, Z., Quentmeier, H., Meyer, C., Kaufmann, M., MacLeod, R. A. F., & Drexler, H. G. (2003) · Leukemia Research · doi:10.1016/j.leukres.2003.09.013 · Cited by 5
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Metadata
- Authors
- MacLeod, R. A. F., & Drexler, H. G.
- Affiliations
- Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures (DE)
- Venue
- Cancer Cell Culture
- Publisher
- Humana Press
- Published
- 2003-11-15
- Volume
- 88
- Pages
- 57-76
- OpenAlex
- W2409566463
- Cited by
- 11
- References
- 25
- Citations by year
- 2019: 1 · 2017: 1
- FWCI
- 5.32
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Humana Press eBooks (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- cancer cell lines, cytogenetic characterization, karyotype, hematopoietic tumors, cell line establishment, karyology
- MeSH terms
- Chromosome Aberrations, Chromosome Banding, Cytogenetics, DNA, Neoplasm, Humans, Karyotyping, Metaphase, Neoplasms, In Situ Hybridization, Fluorescence, Cell Line, Tumor
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