Cited by 58Muscle Physiology and DisordersHormonal and reproductive studiesSperm and Testicular Function

Androgen Receptor Regulates Expression of Skeletal Muscle–Specific Proteins and Muscle Cell Types

Altuwaijri, Saleh, Lee, Dong Kun, Chuang, Kuang-Hsiang, Ting, Huei-Ju, Yang, Zhiming, Xu, Qingquan, Tsai, Meng-Yin, Yeh, Shuyuan +3 more·2004·Endocrine

Abstract

C2C12 myoblasts expressing the androgen receptor (AR) were used to analyze the role of androgen-AR signaling pathway in skeletal muscle development. Marked up-regulation of AR expression was observed in differentiated myotubes. A nuclear run-on transcription assay demonstrated that transcription of the AR gene is increased during skeletal muscle cell differentiation. Regulation of skeletal muscle-specific protein expression by the androgen-AR signaling pathway was further analyzed using quadriceps skeletal muscle from wild-type (WT) and AR knock-out (ARKO) male mice. A histological analysis of quadriceps skeletal muscle indicates no morphological differences between ARKO and WT mice. However, the androgen-AR signaling pathway increases expression of slow-twitch-specific skeletal muscle proteins and downregulates fast-twitch-specific skeletal muscle proteins, resulting in an increase of slow-twitch muscle fiber type cells in quadriceps muscle.

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Crossref · 10.1385/endo:25:1:27

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Authors
Altuwaijri, S., Lee, D. K., Chuang, K.-H., Ting, H.-J., Yang, Z., Xu, Q., Tsai, M.-Y., Yeh, S., Hanchett, L. A., Chang, H.-C., & Chang, C.
Affiliations
  • University of Rochester Medicine (US)
  • Chang Gung University (TW)
  • National Taiwan University (TW)
Corresponding author
Chang, Chawnshang
Venue
Endocrine
Published
2004
Volume
25
Issue
1
Pages
27-32
ISSN
0969-711X (ISSN-L)
OpenAlex
W2056602633
Cited by
58
References
25
Citations by year
2025: 2 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
0.36
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK 60948, R01DK060948)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
androgen receptor, androgen signaling, skeletal muscle development, muscle fiber type, slow-twitch muscle, fast-twitch muscle, myogenesis, C2C12 myoblasts, quadriceps
MeSH terms
Animals, Cell Differentiation, Cell Line, Hindlimb, Male, Mice, Inbred Strains, Muscle Proteins, Receptors, Androgen, Signal Transduction, Down-Regulation, Up-Regulation, Mice, Knockout, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Myoblasts, Mice

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