Disruptions to the limb muscle core molecular clock coincide with changes in mitochondrial quality control following androgen depletion
Abstract
Androgen depletion in humans leads to significant atrophy of the limb muscles. However, the pathways by which androgens regulate limb muscle mass are unclear. Our laboratory previously showed that mitochondrial degradation was related to the induction of autophagy and the degree of muscle atrophy following androgen depletion, implying that decreased mitochondrial quality contributes to muscle atrophy. To increase our understanding of androgen-sensitive pathways regulating decreased mitochondrial quality, total RNA from the tibialis anterior of sham and castrated mice was subjected to microarray analysis. Using this unbiased approach, we identified significant changes in the expression of genes that compose the core molecular clock. To assess the extent to which androgen depletion altered the limb muscle clock, the tibialis anterior muscles from sham and castrated mice were harvested every 4 h throughout a diurnal cycle. The circadian expression patterns of various core clock genes and known clock-controlled genes were disrupted by castration, with most genes exhibiting an overall reduction in phase amplitude. Given that the core clock regulates mitochondrial quality, disruption of the clock coincided with changes in the expression of genes involved with mitochondrial quality control, suggesting a novel mechanism by which androgens may regulate mitochondrial quality. These events coincided with an overall increase in mitochondrial degradation in the muscle of castrated mice and an increase in markers of global autophagy-mediated protein breakdown. In all, these data are consistent with a novel conceptual model linking androgen depletion-induced limb muscle atrophy to reduced mitochondrial quality control via disruption of the molecular clock.
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Knockout of AR results in the down-regulation of PGC-1α and TFAM in the muscle of castrated rats and mice, while the administration of exogenous androgen reversed these effects.
“It has been reported that knockout of AR results in the down-regulation of PGC-1α and TFAM in the muscle of castrated rats and mice, while the administration of exogenous androgen reversed these effects (144, 145).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [145]
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Tice, A. L., Laudato, J. A., Fadool, D. A., Gordon, B. S., & Steiner, J. L. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00026.2022 · Cited by 19 · see citing works
Self-citationNicotinamide: Oversight of Metabolic Dysfunction Through SIRT1, mTOR, and Clock Genes
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Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids
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Self-citationChronic Alcohol Consumption Disrupts the Skeletal Muscle Circadian Clock in Female Mice
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Self-citationMaiese, K. (2024) · World Journal of Diabetes · doi:10.4239/wjd.v16.i1.98948 · Cited by 15 · see citing works
Rossetti, M. L., Tomko, R. J., & Gordon, B. S. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03963-9 · Cited by 13 · see citing works
Self-citationFan, Y., Ren, Y., Deng, L., Lv, D., Chen, J., Ling, Y., Tu, J., Xu, X., Wang, D., & Cai, Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113641 · Cited by 11 · see citing works
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Dunlap, K. R., Laskin, G. R., Waddell, D. S., Black, A. J., Steiner, J. L., Vied, C., & Gordon, B. S. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111652 · Cited by 7 · see citing works
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Self-citationRodolphi, M. S., Strogulski, N. R., Kopczynski, A., Sartor, M., Soares, G., de Oliveira, V. G., Vinadé, L., Belo, C. A. D., Portela, J. V., Geller, C. A., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04488-8 · Cited by 6 · see citing works
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Rossetti, M. L., Dunlap, K. R., Salazar, G., Hickner, R. C., Kim, J., Chase, P. B., Miller, B. F., & Gordon, B. S. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111391 · Cited by 6 · see citing works
Self-citationGordon, B. S., Burns, P. K., Laskin, G. R., Dunlap, K. R., Boykin, J. R., Rossetti, M. L., Fukuda, D. H., & Steiner, J. L. (2023) · The Journal of Physiology · doi:10.1113/jp284869 · Cited by 5 · see citing works
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Mealtime alcohol consumption suppresses skeletal muscle mTORC1 signaling in female mice
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Self-citationNovel Insights to Mitochondrial Impact in Aging Skeletal Muscle
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Self-citationAyers-Creech, W. A., Steiner, J. L., Laskin, G. R., & Gordon, B. S. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112704 · Cited by 2 · see citing works
Self-citationCircadian Rhythm, Clock Genes, and Stroke
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Understanding the role of sirtuin 1 in muscle physiology during androgen deprivation
Joaquim, V. H. A., da Silva, J. G., & Jannig, P. R. (2023) · The Journal of Physiology · doi:10.1113/jp285588 · Cited by 1 · see citing works
Laskin, G. R., Steiner, J. L., Berryman, C. E., & Gordon, B. S. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.10.005 · Cited by 1 · see citing works
Self-citationOtsuka, T., Onishi, H., Suzuki, M., & Marusawa, M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.13.495888 · Cited by 1 · see citing works
Androgen-mediated Regulation of Skeletal Muscle Mass: A Ticking Clock
Hughes, D. C., Hettinger, Z. R., & Deane, C. S. (2025) · Function · doi:10.1093/function/zqaf040
Restoration of circadian rhythm as novel targets against sarcopenia
Wang, T., & Hong, Z. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004087
Emerging evidence suggests that circadian disruption and muscle wasting form a self-reinforcing loop
Li, F., & Liu, C. (2026) · Chronobiology International · doi:10.1080/07420528.2026.2743668
- Authors
- Rossetti, M. L., Esser, K. A., Lee, C., Tomko, R. J., Eroshkin, A. M., & Gordon, B. S.
- Affiliations
- Florida State University (US)
- University of Florida (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Gordon, Bradley S.
- ORCID
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2019-10-01
- Volume
- 317
- Issue
- 4
- Pages
- E631-E645
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2966233099
- Cited by
- 37
- References
- 80
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 1 · 2018: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institute for Successful Longevity
- HHS | National Institutes of Health (R01AR066082, NS-099813)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- castration, circadian clock, core clock genes, mitochondrial quality control, mitochondrial degradation, autophagy, tibialis anterior, clock-controlled genes, diurnal gene expression
- MeSH terms
- Androgens, Animals, Atrophy, Autophagy, Body Weight, Extremities, Male, Mice, Inbred C57BL, Mitochondria, Muscle, Orchiectomy, Testosterone, Tibia, Muscle, Skeletal, Mice, Circadian Rhythm Signaling Peptides and Proteins, Mitophagy
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