Muscle metabolism and atrophy: let’s talk about sex

Rosa-Caldwell, Megan E.; Greene, Nicholas P.

doi:10.1186/s13293-019-0257-3

Cited by 204Muscle Physiology and DisordersNutrition and Health in AgingMuscle metabolism and nutrition

Muscle metabolism and atrophy: let’s talk about sex

Open access

Rosa-Caldwell, Megan E., Greene, Nicholas P.·2019·Biology of Sex Differences

DOI 10.1186/s13293-019-0257-3PMC PMC6714453

Open this paper in CoChat — free account Open PDF

Abstract

Skeletal muscle health is a strong predictor of overall health and longevity. Pathologies affecting skeletal muscle such as cancer cachexia, intensive care unit treatment, muscular dystrophies, and others are associated with decreased quality of life and increased mortality. Recent research has begun to determine that these muscular pathologies appear to present and develop differently between males and females. However, to our knowledge, there has yet to be a comprehensive review on musculoskeletal differences between males and females and how these differences may contribute to sex differences in muscle pathologies. Herein, we present a review of the current literature on muscle phenotype and physiology between males and females and how these differences may contribute to differential responses to atrophic stimuli. In general, females appear to be more susceptible to disuse induced muscle wasting, yet protected from inflammation induced (such as cancer cachexia) muscle wasting compared to males. These differences may be due in part to differences in muscle protein turnover, satellite cell content and proliferation, hormonal interactions, and mitochondrial differences between males and females. However, more works specifically examining muscle pathologies in females are necessary to more fully understand the inherent sex-based differences in muscle pathologies between the sexes and how they may correspond to different clinical treatments.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/s13293-019-0257-3

Cites

198 of 198 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Muscle protein synthesis rates are greater in older women at rest.
“Although muscle protein synthesis rates are greater in older women at rest [245]”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [245]
The Hormonal interactions section (page unavailable) reports greater fractional protein synthesis rates in older women than in younger women. It does not establish that older women have greater rates than older men at rest. The Muscle phenotypes section describes a female–male difference after whey ingestion, not at rest. (LLM, conf=0.83)
Experimental — accuracy not yet measured
Both an upregulation of stimulatory and inhibitory muscle growth regulatory genes in postmenopausal women compared with premenopausal women have been reported.
“Both an upregulation of stimulatory and inhibitory muscle growth regulatory genes in postmenopausal women compared with premenopausal women have also been reported [245].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [245]
The Background’s Hormonal interactions section says postmenopausal women generally have smaller muscles than controls, but it does not report upregulation of muscle-growth regulatory genes. Searches for postmenopausal and premenopausal comparisons found no passage reporting increased expression of both stimulatory and inhibitory genes; page numbers are unavailable in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
Epidemiology of women and depression
Kessler, R. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00426-3 · Cited by 2,006 · see citing works
Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
Naugler, W. E., Sakurai, T., Kim, S., Maeda, S., Kim, K., Elsharkawy, A. M., & Karin, M. (2007) · Science · doi:10.1126/science.1140485 · Cited by 1,955 · see citing works
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
Gomes, M. D., Lecker, S. H., Jagoe, R. T., Navon, A., & Goldberg, A. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251541198 · Cited by 1,774 · see citing works
Estimation of clinical trial success rates and related parameters
Wong, C. H., Siah, K. W., & Lo, A. W. (2019) · Biostatistics · doi:10.1093/biostatistics/kxx069 · Cited by 1,585 · see citing works
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539 · see citing works
Paresis Acquired in the Intensive Care Unit A Prospective Multicenter Study
Jonghe, B. D. (2002) · JAMA · doi:10.1001/jama.288.22.2859 · Cited by 1,518 · see citing works
Adverse Events Associated with Testosterone Administration
Basaria, S., Coviello, A. D., Travison, T. G., Storer, T. W., Farwell, W. R., Jette, A. M., Eder, R., Tennstedt, S., Ulloor, J., Zhang, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000485 · Cited by 1,494 · see citing works
Mechanisms regulating skeletal muscle growth and atrophy
Schiaffino, S., Dyar, K. A., Ciciliot, S., Blaauw, B., & Sandri, M. (2013) · The FEBS Journal · doi:10.1111/febs.12253 · Cited by 1,492 · see citing works
Plasma Concentration of LH, FSH, Prolactin, Progesterone and Estradiol-17β Throughout the 4-Day Estrous Cycle of the Rat
Butcher, R. L., COLLINS, W. E., & FUGO, N. W. (1974) · Endocrinology · doi:10.1210/endo-94-6-1704 · Cited by 1,313 · see citing works
The Control of Progesterone Secretion During the Estrous Cycle and Early Pseudopregnancy in the Rat: Prolactin, Gonadotropin and Steroid Levels Associated with Rescue of the Corpus Luteum of Pseudopregnancy 1 2
Smith, M. S., Freeman, M. E., & Neill, J. D. (1975) · Endocrinology · doi:10.1210/endo-96-1-219 · Cited by 1,286 · see citing works
The sexual dimorphism of obesity
Palmer, B. F., & Clegg, D. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.029 · Cited by 919 · see citing works
Acquired Weakness, Handgrip Strength, and Mortality in Critically Ill Patients
Ali, N. A., O’Brien, J. M., Hoffmann, S. P., Phillips, G. S., Garland, A., Finley, J. C. W., Almoosa, K. F., Hejal, R. B., Wolf, K. M., Lemeshow, S. A., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200712-1829oc · Cited by 778 · see citing works
Gender differences in depression in 23 European countries. Cross-national variation in the gender gap in depression.
de Velde, S. V. V., Bracke, P., & Levecque, K. (2010) · Social Science & Medicine (1967) · doi:10.1016/j.socscimed.2010.03.035 · Cited by 765 · see citing works
Skeletal muscle loss: cachexia, sarcopenia, and inactivity
Evans, W. J. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28608a · Cited by 724 · see citing works
Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome
Sandri, M. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.04.023 · Cited by 689 · see citing works
Sex differences in metabolic homeostasis, diabetes, and obesity
Mauvais-Jarvis, F. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0033-y · Cited by 626 · see citing works
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle
McCarthy, J. J., Mula, J., Miyazaki, M., Erfani, R., Garrison, K., Farooqui, A. B., Srikuea, R., Lawson, B. A., Grimes, B., Keller, C., et al. (2011) · Development · doi:10.1242/dev.068858 · Cited by 616 · see citing works
Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases
Sacheck, J. M., Hyatt, J. K., Raffaello, A., Thomas Jagoe, R., Roy, R. R., Reggie Edgerton, V., Lecker, S. H., & Goldberg, A. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-6604com · Cited by 585 · see citing works
Testosterone Replacement Increases Fat-Free Mass and Muscle Size in Hypogonadal Men 1
Bhasin, S., Storer, T. W., Berman, N., Yarasheski, K. E., Clevenger, B., Phillips, J., Lee, W. P., Bunnell, T. J., & Casaburi, R. H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3733 · Cited by 540 · see citing works
Acute Outcomes and 1-Year Mortality of Intensive Care Unit–acquired Weakness. A Cohort Study and Propensity-matched Analysis
Hermans, G., Mechelen, H. V., Clerckx, B., Vanhullebusch, T., Mesotten, D., Wilmer, A. P., Casaer, M. P., Meersseman, P., Debaveye, Y. A., Cromphaut, S. J. V., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201312-2257oc · Cited by 536 · see citing works
Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition
Haizlip, K. M., Harrison, B. C., & Leinwand, L. A. (2015) · Physiology · doi:10.1152/physiol.00024.2014 · Cited by 521 · see citing works
Mitochondrial localization of estrogen receptor β
Yang, S.-H., Liu, R., Perez, E., Wen, Y., Stevens, S. M., Valencia, T. G., Brun‐Zinkernagel, A., Prókai, L., Will, Y., Dykens, J. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306948101 · Cited by 501 · see citing works
Body composition in patients with non−small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis
Baracos, V. E., Reiman, T., Mourtzakis, M., Gioulbasanis, I., & Antoun, S. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28608c · Cited by 496 · see citing works
Skeletal muscle fiber type: using insights from muscle developmental biology to dissect targets for susceptibility and resistance to muscle disease
Talbot, J. C., & Maves, L. (2016) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.230 · Cited by 439 · see citing works
Mechanisms for fiber-type specificity of skeletal muscle atrophy
Wang, Y., & Pessin, J. E. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328360272d · Cited by 416 · see citing works
Disuse atrophy and exercise rehabilitation in humans profoundly affects the expression of genes associated with the regulation of skeletal muscle mass
Jones, S. W., Hill, R. J. W., Krasney, P. A., O'Conner, B., Peirce, N. S., & Greenhaff, P. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-1228fje · Cited by 404 · see citing works
Skeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia
Wall, B. T., Dirks, M. L., & van Loon, L. J. C. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.07.003 · Cited by 400 · see citing works
Trends and Patterns of Disparities in Cancer Mortality Among US Counties, 1980-2014
Mokdad, A. H., Dwyer‐Lindgren, L., Fitzmaurice, C., Stubbs, R. W., Bertozzi-Villa, A., Morozoff, C., Charara, R. N., Allen, C., Naghavi, M., & Murray, C. J. L. (2017) · JAMA · doi:10.1001/jama.2016.20324 · Cited by 399 · see citing works
Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle
Lawler, J. M. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00186-2 · Cited by 370 · see citing works
Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise
Goncalves, R. L. S., Quinlan, C. L., Perevoshchikova, I. V., Hey-Mogensen, M., & Brand, M. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.619072 · Cited by 329 · cited 1× · see citing works
“complex III within the mitochondria [182], and some”
Background
Independent effects of physical activity in patients with nonalcoholic fatty liver disease #
St. George, A., Bauman, A., Johnston, A., Farrell, G., Chey, T., & George, J. (2009) · Hepatology · doi:10.1002/hep.22940 · Cited by 318 · see citing works
Testosterone Replacement Increases Fat-Free Mass and Muscle Size in Hypogonadal Men
Bhasin, S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.2.407 · Cited by 318 · see citing works
An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy
Lach-Trifilieff, E., Minetti, G. C., Sheppard, K., Ibebunjo, C., Feige, J. N., Hartmann, S., Brachat, S., Rivet, H., Koelbing, C., Morvan, F., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01307-13 · Cited by 306 · see citing works
Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice
Brown, J. L., Rosa‐Caldwell, M. E., Lee, D. E., Blackwell, T. A., Brown, L. A., Perry, R. A., Haynie, W. S., Hardee, J. P., Carson, J. A., Wiggs, M. P., et al. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12232 · Cited by 288 · see citing works
Self-citation
Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
Choi, C. S., Befroy, D. E., Codella, R., Kim, S., Reznick, R. M., Hwang, Y.-J., Liu, Z.-X., Lee, H.-Y., Distefano, A., Samuel, V. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810339105 · Cited by 279 · see citing works
Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures
Gao, Y., Arfat, Y., Wang, H., & Goswami, N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00235 · Cited by 275 · see citing works
Stereospecific binding of estrogens in the rat uterus
Noteboom, W. D., & Gorski, J. (1965) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(65)90235-3 · Cited by 272 · see citing works
Mitochondrial localization of ERα and ERβ in human MCF7 cells
Chen, J. Q., Delannoy, M., Cooke, C., & Yager, J. D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00508.2003 · Cited by 272 · see citing works
Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle
Stevenson, E. J., Giresi, P. G., Koncarevic, A., & Kandarian, S. C. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00033.x · Cited by 270 · see citing works
Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality*
Sharshar, T., Bastuji‐Garin, S., Stevens, R. D., Durand, M., Malissin, I., Rodríguez, P., Cerf, C., Outin, H., & Jonghe, B. D. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b027e9 · Cited by 268 · see citing works
Mechanical Ventilation–induced Diaphragm Disuse in Humans Triggers Autophagy
Hussain, S. N. A., Mofarrahi, M., Sigala, I., Kim, H. C., Vassilakopoulos, T., Maltais, F., Bellenis, I. P., Chaturvedi, R. K., Gottfried, S. B., Metrakos, P. P., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201002-0234oc · Cited by 264 · see citing works
Gender-based differences in mechanisms of protection in myocardial ischemia–reperfusion injury
Murphy, E., & Steenbergen, C. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.025 · Cited by 253 · see citing works
Food intake and the menstrual cycle: a retrospective analysis, with implications for appetite research
BUFFENSTEIN, R. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)02003-9 · Cited by 252 · see citing works
Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men
Alibegovic, A. C., Sonne, M. P., Højbjerre, L., Bork-Jensen, J., Jacobsen, S., Nilsson, E., Færch, K., Hiscock, N., Mortensen, B., Friedrichsen, M., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00590.2009 · Cited by 247 · see citing works
Colorectal Cancer Mortality Rates in Adults Aged 20 to 54 Years in the United States, 1970-2014
Siegel, R. L., Miller, K. D., & Jemal, A. (2017) · JAMA · doi:10.1001/jama.2017.7630 · Cited by 242 · see citing works
24-hour energy expenditure and the menstrual cycle
Webb, P. (1986) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/44.5.614 · Cited by 237 · see citing works
Autophagy signal transduction by ATG proteins: from hierarchies to networks
Wesselborg, S., & Stork, B. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2034-8 · Cited by 231 · see citing works
Time course of soleus muscle myosin expression during hindlimb suspension and recovery
Thomason, D. B., Herrick, R. E., Surdyka, D., & Baldwin, K. M. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.1.130 · Cited by 229 · see citing works
Myostatin, insulin‐like growth factor‐1, and leukemia inhibitory factor mRNAs are upregulated in chronic human disuse muscle atrophy
Reardon, K. A., Davis, J. A., Kapsa, R. M. I., Choong, P., & Byrne, E. (2001) · Muscle & Nerve · doi:10.1002/mus.1086 · Cited by 227 · see citing works
Sex Differences in Muscle Wasting
Anderson, L. J., Liu, H. M., & Garcia, J. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_9 · Cited by 222 · see citing works
PGC1‐α over‐expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice
Cannavino, J., Brocca, L., Sandri, M., Bottinelli, R., & Pellegrino, M. A. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.275545 · Cited by 220 · see citing works
Endurance exercise training attenuates leucine oxidation and BCOAD activation during exercise in humans
McKenzie, S., Phillips, S. M., Carter, S. L., Lowther, S., Gibala, M. J., & Tarnopolsky, M. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.4.e580 · Cited by 219 · see citing works
Constitutive activities of estrogen-related receptors: Transcriptional regulation of metabolism by the ERR pathways in health and disease
Huss, J. M., Garbacz, W. G., & Xie, W. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.06.016 · Cited by 217 · see citing works
Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy
Brault, J. J., Jespersen, J. G., & Goldberg, A. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.113092 · Cited by 217 · see citing works
Cancer Causes Cardiac Atrophy and Autophagy in a Sexually Dimorphic Manner
Cosper, P. F., & Leinwand, L. A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-3145 · Cited by 214 · see citing works
Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle
Stevenson, E. J., Giresi, P. G., Koncarevic, A., et al. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.044701 · Cited by 212 · see citing works
Gender Disparities in Metastatic Colorectal Cancer Survival
Hendifar, A. E., Yang, D., Lenz, F., Lurje, G., Pohl, A., Lenz, C., Ning, Y., Zhang, W., & Lenz, H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0877 · Cited by 206 · see citing works
Estrogen receptors α and β (ERα and ERβ) and androgen receptor (AR) in human sperm: localization of ERβ and AR in mitochondria of the midpiece
Solakidi, S., Psarra, A. G., Nikolaropoulos, S., & Sekeris, C. E. (2005) · Human Reproduction · doi:10.1093/humrep/dei267 · Cited by 205 · see citing works
Can Sarcopenia Quantified by Ultrasound of the Rectus Femoris Muscle Predict Adverse Outcome of Surgical Intensive Care Unit Patients as well as Frailty? A Prospective, Observational Cohort Study
Mueller, N., Murthy, S., Tainter, C. “., Lee, J., Riddell, K., Fintelmann, F. J., Grabitz, S. D., Timm, F. P., Levi, B., Kurth, T., et al. (2015) · Annals of Surgery · doi:10.1097/sla.0000000000001546 · Cited by 204 · see citing works
Satellite cell depletion prevents fiber hypertrophy in skeletal muscle
Egner, I. M., Bruusgaard, J. C., & Gundersen, K. (2016) · Development · doi:10.1242/dev.134411 · Cited by 203 · see citing works
Menstrual cycle phase and sex influence muscle glycogen utilization and glucose turnover during moderate-intensity endurance exercise.
Devries, M. C., Hamadeh, M. J., Phillips, S. M., & Tarnopolsky, M. A. (2006) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00700.2005 · Cited by 202 · cited 1× · see citing works
“Each of these phases affects energy utilization and bioenergetics [133].”
Background
Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways
Brooks, N. E., & Myburgh, K. H. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00099 · Cited by 194 · see citing works
The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms
Brocca, L., Cannavino, J., Coletto, L., Biolo, G., Sandri, M., Bottinelli, R., & Pellegrino, M. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.240267 · Cited by 190 · see citing works
Muscular and Systemic Correlates of Resistance Training-Induced Muscle Hypertrophy
Mitchell, C. J., Churchward‐Venne, T. A., Bellamy, L. M., Parise, G., Baker, S. K., & Phillips, S. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078636 · Cited by 182 · see citing works
Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease
Carson, J. A., & Manolagas, S. C. (2015) · Bone · doi:10.1016/j.bone.2015.04.015 · Cited by 171 · see citing works
Prevention of unloading-induced atrophy by vitamin E supplementation: Links between oxidative stress and soleus muscle proteolysis?
Servais, S., Letexier, D., Favier, R. J. M., Duchamp, C., & Dominique Desplanches, C. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.001 · Cited by 170 · see citing works
Greater muscle protein synthesis and mitochondrial biogenesis in males compared with females during sprint interval training
Scalzo, R. L., Peltonen, G. L., Binns, S. E., Shankaran, M., Giordano, G. R., Hartley, D. A., Klochak, A. L., Lonac, M. C., Paris, H. L. R., Szallar, S. E., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-246595 · Cited by 167 · see citing works
Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway
Lee, S., Huynh, T. V., Lee, Y., Sebald, S. M., Wilcox‐Adelman, S. A., Iwamori, N., Lepper, C., Matzuk, M. M., & Fan, C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206410109 · Cited by 167 · see citing works
Temporal Interrelationships Among Circulating Levels of Estradiol, Progesterone and LH During the Rat Estrous Cycle: Effects of Exogenous Progesterone1
Kalra, S. P., & Kalra, P. S. (1974) · Endocrinology · doi:10.1210/endo-95-6-1711 · Cited by 163 · see citing works
A cellular memory mechanism aids overload hypertrophy in muscle long after an episodic exposure to anabolic steroids
Egner, I. M., Bruusgaard, J. C., Eftestøl, E., & Gundersen, K. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.264457 · Cited by 159 · see citing works
Mechanism of oxidative stress in skeletal muscle atrophied by immobilization
Kondo, H., Nakagaki, I., Sasaki, S., Hori, S., & Itokawa, Y. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.6.e839 · Cited by 158 · see citing works
Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse
Levine, S., Biswas, C., Dierov, J. K., Barsotti, R., Shrager, J. B., Nguyen, T., Sonnad, S. S., Kucharchzuk, J. C., Kaiser, L. R., Singhal, S. K., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200910-1487oc · Cited by 157 · see citing works
Associations of exercise-induced hormone profiles and gains in strength and hypertrophy in a large cohort after weight training
West, D. W. D., & Phillips, S. M. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2246-z · Cited by 152 · see citing works
Estrogen status and skeletal muscle recovery from disuse atrophy
McClung, J. M., Davis, J. M., Wilson, M. A., Goldsmith, E. C., & Carson, J. A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01583.2005 · Cited by 147 · see citing works
Testosterone Signals through mTOR and Androgen Receptor to Induce Muscle Hypertrophy
Basualto-Alarcón, C., Jorquera, G., Altamirano, F. J., Jaimovich, E., & Estrada, M. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31828cf5f3 · Cited by 147 · see citing works
Sex differences in the pharmacokinetics and pharmacodynamics of antidepressants: An updated review
Bigos, K. L., Pollock, B. G., Stankevich, B. A., & Bies, R. R. (2009) · Gender Medicine · doi:10.1016/j.genm.2009.12.004 · Cited by 146 · see citing works
Overexpression of peroxisome proliferator-activated receptor γ coactivator-1α down-regulates GLUT4 mRNA in skeletal muscles.
Miura, S., Kai, Y., Ono, M., & Ezaki, O. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304312200 · Cited by 146 · see citing works
Alterations in intrinsic mitochondrial function with aging are fiber type‐specific and do not explain differential atrophy between muscles
Picard, M. A., Ritchie, D., Thomas, M. M., Wright, K. J., & Hepple, R. T. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00745.x · Cited by 145 · see citing works
Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state
West, D. W. D., Burd, N. A., Churchward-Venne, T. A., Camera, D. M., Mitchell, C. J., Baker, S. K., Hawley, J. A., Coffey, V. G., & Phillips, S. M. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00170.2012 · Cited by 143 · see citing works
Resistance exercise increases leg muscle protein synthesis and mTOR signalling independent of sex
Dreyer, H. C., Fujita, S., Glynn, E. L., Drummond, M. J., Volpi, E., & Rasmussen, B. B. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02074.x · Cited by 140 · see citing works
Immobilization-induced activation of key proteolytic systems in skeletal muscles is prevented by a mitochondria-targeted antioxidant
Talbert, E. E., Smuder, A. J., Min, K., Kwon, O. S., Szeto, H. H., & Powers, S. K. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00471.2013 · Cited by 138 · see citing works
Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation
Murach, K. A., Fry, C. S., Kirby, T. J., Jackson, J. R., Lee, J. D., White, S. H., Dupont-Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2018) · Physiology · doi:10.1152/physiol.00019.2017 · Cited by 137 · see citing works
Gender dimorphism in rat liver mitochondrial oxidative metabolism and biogenesis
Justo, R., Boada, J., Frontera, M., Oliver, J., Bermúdez, J., & Gianotti, M. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00035.2005 · Cited by 133 · see citing works
Testosterone and Progesterone, But Not Estradiol, Stimulate Muscle Protein Synthesis in Postmenopausal Women
Smith, G. I., Yoshino, J., Reeds, D. N., Bradley, D., Burrows, R. E., Heisey, H. D., Moseley, A. C., & Mittendorfer, B. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2835 · Cited by 124 · see citing works
A satellite cell‐specific knockout of the androgen receptor reveals myostatin as a direct androgen target in skeletal muscle
Dubois, V., Laurent, M. R., Sinnesael, M., Cielen, N., Helsen, C., Clinckemalie, L., Spans, L., Gayan‐Ramirez, G., Deldicque, L., Hespel, P., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-249748 · Cited by 124 · see citing works
Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17beta-oestradiol
Toda, K., Takeda, K., Okada, T., Akira, S., Saibara, T., Kaname, T., Yamamura, K., Onishi, S., & Shizuta, Y. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1700099 · Cited by 124 · see citing works
Supplementation of Vitamin E May Attenuate Skeletal Muscle Immobilization Atrophy
Duarte, J. A., & Soares, J. M. C. (1997) · International Journal of Sports Medicine · doi:10.1055/s-2007-972612 · Cited by 122 · see citing works
Low Testosterone Levels and Increased Inflammatory Markers in Patients with Cancer and Relationship with Cachexia
Burney, B. O., Hayes, T. G., Smiechowska, J., Cardwell, G., Papusha, V. Z., Bhargava, P., Konda, B., Auchus, R. J., & Garcia, J. M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2387 · Cited by 119 · see citing works
Subcellular distribution of native estrogen receptor α and β isoforms in rabbit uterus and ovary
Monje, P. V., & Boland, R. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1182 · Cited by 114 · see citing works
Transcriptome Characterization of Estrogen-Treated Human Myocardium Identifies Myosin Regulatory Light Chain Interacting Protein as a Sex-Specific Element Influencing Contractile Function
Kararigas, G., Bito, V., Tinel, H., Becher, E., Baczkó, I., Knosalla, C., Albrecht-Küpper, B. E., Sipido, K. R., & Regitz‐Zagrosek, V. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.09.054 · Cited by 114 · see citing works
The Anticancer Drug Tamoxifen Counteracts the Pathology in a Mouse Model of Duchenne Muscular Dystrophy
Dorchies, O. M., Reutenauer, J., Dahmane, E., Ismail, H. M., Petermann, O., Patthey-Vuadens, O., Comyn, S. A., Gayi, E., Piacenza, T., Handa, R. J., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.10.018 · Cited by 107 · see citing works
Estrogen receptor beta is involved in skeletal muscle hypertrophy induced by the phytoecdysteroid ecdysterone.
Parr, M. K., Zhao, P., Haupt, O., Ngueu, S. T., Hengevoss, J., Fritzemeier, K. H., Piechotta, M., Schlörer, N., Muhn, P., Zheng, W., et al. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300806 · Cited by 106 · cited 1× · see citing works
“Estrogen overall appears to exert a hypertrophic effect [134], which is at least partially mediated by increased sensitivity of IGF-1 in satellite cells [135].”
Background
Sexual dimorphism of substrate utilization: Differences in skeletal muscle mitochondrial volume density and function
Montero, D., Madsen, K., Meinild‐Lundby, A., Edin, F., & Lundby, C. (2018) · Experimental Physiology · doi:10.1113/ep087007 · Cited by 105 · see citing works
A Potential Role for Estrogen in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
OFFNER, H., & POLANCZYK, M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1386.021 · Cited by 102 · see citing works
The Satellite Cell in Male and Female, Developing and Adult Mouse Muscle: Distinct Stem Cells for Growth and Regeneration
Neal, A., Boldrin, L., & Morgan, J. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037950 · Cited by 99 · see citing works
Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions
Valle, A., Guevara, R., García-Palmer, F., Roca, P., & Oliver, J. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00203.2007 · Cited by 96 · see citing works
Mitochondrial and sex steroid hormone crosstalk during aging
Velarde, M. C. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-2 · Cited by 96 · see citing works
Myonuclear Domain Flexibility Challenges Rigid Assumptions on Satellite Cell Contribution to Skeletal Muscle Fiber Hypertrophy
Murach, K. A., Englund, D. A., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00635 · Cited by 96 · see citing works
Gender difference in the activity but not expression of estrogen receptors α and β in human lung adenocarcinoma cells
Dougherty, S. M., Mazhawidza, W., Bohn, A. R., Robinson, K. A., Mattingly, K. A., Blankenship, K. A., Huff, M. O., McGregor, W. G., & Klinge, C. M. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01118 · Cited by 95 · see citing works
Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer
Dalton, J. T., Taylor, R. P., Mohler, M. L., & Steiner, M. S. (2013) · Current Opinion in Supportive & Palliative Care · doi:10.1097/spc.0000000000000015 · Cited by 91 · see citing works
Skeletal muscle of female rats exhibit higher mitochondrial mass and oxidative-phosphorylative capacities compared to males
Colom, B., Alcolea, M., Valle, A., Oliver, J., Roca, P., & García-Palmer, F. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000099208 · Cited by 89 · see citing works
Age-related structural alterations in human skeletal muscle fibers and mitochondria are sex specific: relationship to single-fiber function
Callahan, D. M., Bedrin, N. G., Subramanian, M., Berking, J., Ades, P. A., Toth, M. J., & Miller, M. S. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01362.2013 · Cited by 89 · see citing works
A randomized trial of adjunct testosterone for cancer‐related muscle loss in men and women
Wright, T. J., Dillon, E. L., Durham, W. J., Chamberlain, A., Randolph, K. M., Danesi, C. P., Horstman, A. M. H., Gilkison, C. R., Willis, M., Richardson, G., et al. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12295 · Cited by 89 · see citing works
Basal muscle intracellular amino acid kinetics in women and men
Fujita, S., Rasmussen, B. B., Bell, J. A., Cadenas, J. G., & Volpi, E. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00173.2006 · Cited by 88 · see citing works
Branched-Chain Amino Acids Reduce Hindlimb Suspension-Induced Muscle Atrophy and Protein Levels of Atrogin-1 and MuRF1 in Rats
Maki, T., Yamamoto, D., Nakanishi, S., Iida, K., Iguchi, G., Takahashi, Y., Kaji, H., Chihara, K., & Okimura, Y. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.07.005 · Cited by 85 · see citing works
Modeling human cancer cachexia in colon 26 tumor‐bearing adult mice
Talbert, E. E., Metzger, G. A., He, W., & D, D. C. G. (2014) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-014-0141-2 · Cited by 84 · see citing works
Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise
MANKOWSKI, R. T., ANTON, S. D., BUFORD, T. W., & LEEUWENBURGH, C. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000620 · Cited by 83 · see citing works
Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice
Mukai, R., Horikawa, H., Fujikura, Y., Kawamura, T., Nemoto, H., Nikawa, T., & Terao, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045048 · Cited by 83 · see citing works
Pgc-1α overexpression Via local transfection attenuates mitophagy pathway in muscle disuse atrophy
Kang, C., & Ji, L. L. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.032 · Cited by 83 · see citing works
Subcellular distribution of native estrogen receptor α and β subtypes in cultured human lens epithelial cells
Cammarata, P. R., Chu, S., Moor, A. N., Wang, Z., Yang, S., & Simpkins, J. W. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2003.09.027 · Cited by 82 · see citing works
Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb‐unloaded mice
Brocca, L., Pellegrino, M. A., Desaphy, J., Pierno, S., Camerino, D. C., & Bottinelli, R. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.050245 · Cited by 82 · see citing works
Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activity
Teveroni, E., Pellegrino, M., Sacconi, S., Calandra, P., Cascino, I., Vecchioli, S. F., Puma, A. R., Garibaldi, M., Roberta Morosetti, A., Tasca, G. A., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89401 · Cited by 82 · see citing works
Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: Therapeutic implications for multiple sclerosis
Offner, H. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20330 · Cited by 80 · see citing works
Testosterone protects against dexamethasone-induced muscle atrophy, protein degradation and MAFbx upregulation.
Zhao, W., Pan, J.-P., Zhao, Z., Wu, Y., Bauman, W., & Cardozo, C. (2008) · Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.024 · Cited by 80 · see citing works
Testosterone Treatment Results in Quiescent Satellite Cells Being Activated and Recruited into Cell Cycle in Rat Levator Ani Muscle
Joubert, Y., & Tobin, C. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1144 · Cited by 79 · see citing works
No major sex differences in muscle protein synthesis rates in the postabsorptive state and during hyperinsulinemia-hyperaminoacidemia in middle-aged adults
Smith, G. I., Atherton, P. J., Reeds, D. N., Mohammed, B. S., Jaffery, H., Rankin, D., Rennie, M. J., & Mittendorfer, B. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00348.2009 · Cited by 78 · see citing works
Loss of muscle mass in the end of life in patients with advanced cancer
Wallengren, O., Iresjö, B., Lundholm, K., & Bosaeus, I. G. (2014) · Supportive Care in Cancer · doi:10.1007/s00520-014-2332-y · Cited by 77 · see citing works
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy via the Mas receptor
Morales, M. G., Abrigo, J., Acuña, M. J., Santos, R. A., Bader, M., Brandan, E., Simon, F., Olguin, H., Cabrera, D., & Cabello-Verrugio, C. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.023390 · Cited by 77 · see citing works
Role of iron in oxidative stress in skeletal muscle atrophied by immobilization
Kondo, H., Miura, M., Kodama, J., Ahmed, S. M., & Itokawa, Y. (1992) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00374844 · Cited by 76 · see citing works
Actions of Steroids in Mitochondria
Gavrilova-Jordan, L. P., & Price, T. M. (2007) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-973428 · Cited by 74 · see citing works
The Effects of Cycling Levels of 17β-Estradiol and Progesterone on the Magnitude of Temporomandibular Joint-Induced Nociception
Kramer, P. R., & Bellinger, L. L. (2009) · Endocrinology · doi:10.1210/en.2008-1707 · Cited by 72 · see citing works
Behavioral and biochemical sensitivity to low doses of ketamine: Influence of estrous cycle in C57BL/6 mice
Dossat, A. M., Wright, K. N., Strong, C. E., & Kabbaj, M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.022 · Cited by 72 · see citing works
Muscle ERRγ mitigates Duchenne muscular dystrophy via metabolic and angiogenic reprogramming
Matsakas, A., Yadav, V., Lorca, S., & Narkar, V. A. (2013) · The FASEB Journal · doi:10.1096/fj.13-228296 · Cited by 71 · see citing works
Muscle disuse alters skeletal muscle contractile function at the molecular and cellular levels in older adult humans in a sex‐specific manner
Callahan, D. M., Miller, M. S., Sweeny, A. P., Tourville, T. W., Slauterbeck, J. R., Savage, P. D., Maugan, D. W., Ades, P. A., Beynnon, B. D., & Toth, M. J. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.279034 · Cited by 68 · see citing works
Gene expression phenotypes for lipid metabolism and intramuscular fat in skeletal muscle of cattle1
de Jager, N., Hudson, N. J., Reverter, A., Barnard, R. T., Cafe, L. M., Greenwood, P. L., & Dalrymple, B. P. (2013) · Journal of Animal Science · doi:10.2527/jas.2012-5409 · Cited by 67 · see citing works
Sex differences in mitochondrial biogenesis determine neuronal death and survival in response to oxygen glucose deprivation and reoxygenation
Sharma, J., Johnston, M. V., & Hossain, M. A. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-9 · Cited by 67 · see citing works
Hindlimb skeletal muscle function in myostatin‐deficient mice
Gentry, B. A., Ferreira, J. A., Phillips, C. L., & Brown, M. (2010) · Muscle & Nerve · doi:10.1002/mus.21796 · Cited by 66 · see citing works
Antioxidant enzyme systems in skeletal muscle atrophied by immobilization
Kondo, H., Miura, M., & Itokawa, Y. (1993) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00374299 · Cited by 63 · see citing works
Skeletal Muscle Mass as a Mortality Predictor among Nonagenarians and Centenarians: A Prospective Cohort Study
Wang, H., Hai, S., Liu, Y., Liu, Y., & Dong, B. (2019) · Scientific Reports · doi:10.1038/s41598-019-38893-0 · Cited by 63 · see citing works
Effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury.
White, J., Baltgalvis, K. A., Sato, S., Wilson, L., & Carson, J. A. (2009) · Journal of applied physiology · doi:10.1152/japplphysiol.00668.2009 · Cited by 62 · see citing works
A Small-Scale Clinical Trial to Determine the Safety and Efficacy of Testosterone Replacement Therapy in Hypogonadal Men with Spinal Cord Injury
Bauman, W. A., Cirnigliaro, C. M., Fountaine, M. F. L., Jensen, A. M., Wecht, J. M., Kirshblum, S. C., & Spungen, A. M. (2011) · Hormone and Metabolic Research · doi:10.1055/s-0031-1280797 · Cited by 62 · see citing works
Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model
Sinha, I., Sinha‐Hikim, A. P., Wagers, A. J., & Sinha‐Hikim, I. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1900-2 · Cited by 60 · see citing works
Progesterone stimulates cardiac muscle protein synthesis via receptor-dependent pathway
Goldstein, J. S., Sites, C. K., & Toth, M. J. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.03.018 · Cited by 58 · see citing works
Regulation of Physiological and Metabolic Function of Muscle by Female Sex Steroids
Spangenburg, E. E., Geiger, P. C., Leinwand, L. A., & Lowe, D. A. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31825871fa · Cited by 58 · see citing works
Androgen Receptor Regulates Expression of Skeletal Muscle–Specific Proteins and Muscle Cell Types
Altuwaijri, S., Lee, D. K., Chuang, K.-H., Ting, H.-J., Yang, Z., Xu, Q., Tsai, M.-Y., Yeh, S., Hanchett, L. A., Chang, H.-C., et al. (2004) · Endocrine · doi:10.1385/endo:25:1:27 · Cited by 58 · see citing works
Distinct protein degradation profiles are induced by different disuse models of skeletal muscle atrophy
Bialek, P., Morris, C., Parkington, J., St. Andre, M., Owens, J., Yaworsky, P., Seeherman, H., & Jelinsky, S. A. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00247.2010 · Cited by 57 · see citing works
Sex Differences in Estrogen Receptor Subcellular Location and Activity in Lung Adenocarcinoma Cells
Ivanova, M. M., Mazhawidza, W., Dougherty, S. M., & Klinge, C. M. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0059oc · Cited by 55 · see citing works
Sex Differences in Constitutive Autophagy
Oliván, S., Calvo, A. C., Manzano, R., Zaragoza, P., & Osta, R. (2014) · BioMed Research International · doi:10.1155/2014/652817 · Cited by 55 · see citing works
Transcriptomic and epigenetic regulation of disuse atrophy and the return to activity in skeletal muscle
Fisher, A. G., Seaborne, R. A., Hughes, T. M., Gutteridge, A., Stewart, C., Coulson, J., Sharples, A., & Jarvis, J. (2017) · The FASEB Journal · doi:10.1096/fj.201700089rr · Cited by 54 · see citing works
White adipose tissue cells and the progression of cachexia: inflammatory pathways
das Neves, R. X., Neto, J. C. R., Yamashita, A. S., de Matos‐Neto, E. M., Riccardi, D. M. R., Lira, F. S., Júnior, M. L. B., & Seelaender, M. C. L. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12041 · Cited by 53 · see citing works
Testosterone mediates satellite cell activation in denervated rat levator ani muscle
Nnodim, J. O. (2001) · The Anatomical Record · doi:10.1002/ar.1072 · Cited by 53 · see citing works
Gender Differences in Basal Protein Kinetics in Young Adults
Volpi, E., Lucidi, P., Bolli, G. B., Santeusanio, F., & Feo, P. D. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.12.5330 · Cited by 53 · see citing works
Antioxidant supplementation accelerates cachexia development by promoting tumor growth in C26 tumor-bearing mice
Assi, M., Derbré, F., Lefeuvre‐Orfila, L., & Rébillard, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.019 · Cited by 53 · see citing works
Sex, fiber-type, and age dependent in vitro proliferation of mouse muscle satellite cells
Manzano, R., Toivonen, J. M., Calvo, A. C., Mena, F. J. M., Zaragoza, P., Muñoz, M. J., Montarras, D., & Osta, R. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23197 · Cited by 51 · see citing works
Reactive Oxygen Species/Nitric Oxide Mediated Inter-Organ Communication in Skeletal Muscle Wasting Diseases
Leitner, L. M., Wilson, R. J., Yan, Z., & Gödecke, A. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6942 · Cited by 51 · see citing works
The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control
Hodson, N. W., & Philp, A. (2018) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000173 · Cited by 50 · see citing works
Chronic disuse and skeletal muscle structure in older adults: sex-specific differences and relationships to contractile function
Callahan, D. M., Tourville, T. W., Miller, M. S., Hackett, S. B., Sharma, H., Cruickshank, N. C., Slauterbeck, J. R., Savage, P. D., Ades, P. A., Maughan, D. W., et al. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00014.2015 · Cited by 49 · see citing works
Molecular Plasticity of Male and Female Murine Gonadotropes Revealed by mRNA Sequencing
Qiao, S., Nordström, K. J. V., Muijs, L., Gasparoni, G., Tierling, S., Krause, E., Walter, J., & Boehm, U. (2015) · Endocrinology · doi:10.1210/en.2015-1836 · Cited by 49 · see citing works
Methodological issues limit interpretation of negative effects of satellite cell depletion on adult muscle hypertrophy
McCarthy, J. J., Dupont‐Versteegden, E. E., Fry, C. S., Murach, K. A., & Peterson, C. A. (2017) · Development · doi:10.1242/dev.145797 · Cited by 49 · see citing works
A Truncated Progesterone Receptor (PR-M) Localizes to the Mitochondrion and Controls Cellular Respiration
Dai, Q., Shah, A. A., Garde, R. V., Yonish, B. A., Zhang, L., Medvitz, N. A., Miller, S., Hansen, E. L., Dunn, C. N., & Price, T. M. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1292 · Cited by 48 · see citing works
Characterization of the male ApcMin/+ mouse as a hypogonadism model related to cancer cachexia
White, J. P., Puppa, M. J., Narsale, A. A., & Carson, J. (2013) · Biology Open · doi:10.1242/bio.20136544 · Cited by 48 · see citing works
Pleiotropic actions of estrogen: a mitochondrial matter
Velarde, M. C. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00155.2012 · Cited by 47 · see citing works
Developmental abnormalities in multiple proliferative tissues of ApcMin/+ mice
You, S., Ohmori, M., Peña, M. M. O., Nassri, B., Quiton, J. D., Al-Assaad, Z., Liu, L., Wood, P. A., Berger, S. H., Liu, Z., et al. (2006) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2006.00477.x · Cited by 47 · see citing works
Prevention of muscle disuse atrophy by MG132 proteasome inhibitor
Jamart, C., Raymackers, J., An, G.-L., Deldicque, L., & Francaux, M. (2011) · Muscle & Nerve · doi:10.1002/mus.21949 · Cited by 46 · see citing works
Tissue and sex specificities in Ca2+ handling by isolated mitochondria in conditions avoiding the permeability transition
Chweih, H., Castilho, R. F., & Figueira, T. R. (2015) · Experimental Physiology · doi:10.1113/ep085248 · Cited by 45 · see citing works
Estrogen administration attenuates immobilization-induced skeletal muscle atrophy in male rats.
Sugiura, T., Ito, N., Goto, K., Naito, H., Yoshioka, T., & Powers, S. (2006) · Journal of Physiological Sciences · doi:10.2170/physiolsci.rp006906 · Cited by 45 · see citing works
Reduced resting metabolic rate in athletes with menstrual disorders
Lebenstedt, M., Platte, P., & Pirke, K. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199909000-00004 · Cited by 45 · see citing works
Rapid Uptake and Binding of Estradiol-17β-6-(O-carboxymethyl)oxime:125I-labeled Bsa by Female Rat Liver1
Moats, R. K., & Ramirez, V. D. (1998) · Biology of Reproduction · doi:10.1095/biolreprod58.2.531 · Cited by 44 · see citing works
Proliferation of Skeletal Muscle Satellite Cells after Castration and Administration of Testosterone Propionate
Mulvaney, D. R., Marple, D. N., & Merkel, R. A. (1988) · Experimental Biology and Medicine · doi:10.3181/00379727-188-42704 · Cited by 43 · see citing works
Progesterone signalling in broiler skeletal muscle is associated with divergent feed efficiency
Bottje, W. G., Kong, B. C., Reverter, A., Waardenberg, A. J., Lassiter, K., & Hudson, N. J. (2017) · BMC Systems Biology · doi:10.1186/s12918-017-0396-2 · Cited by 41 · see citing works
Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice
Ogawa, M., Kitano, T., 夏初, 河., Sugihira, T., Kitakaze, T., Harada, N., & Yamaji, R. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.07.017 · Cited by 41 · see citing works
Female-specific regulation of skeletal muscle mass by USP19 in young mice
Ogawa, M., Kitakaze, T., Harada, N., & Yamaji, R. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0128 · Cited by 38 · see citing works
Progesterone increases skeletal muscle mitochondrial H2O2emission in nonmenopausal women
Kane, D. A., Lin, C., Anderson, E. J., Kwak, H., Cox, J. H., Brophy, P. M., Hickner, R. C., Neufer, P. D., & Cortright, R. N. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00389.2010 · Cited by 37 · see citing works
Ovarian function's role during cancer cachexia progression in the female mouse.
Hetzler, K. L., Hardee, J., LaVoie, H. A., Murphy, E. A., & Carson, J. (2017) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00294.2016 · Cited by 35 · see citing works
The Role of a Mitochondrial Progesterone Receptor (PR-M) in Progesterone Action
Dai, Q., & Price, T. M. (2015) · Seminars in Reproductive Medicine · doi:10.1055/s-0035-1552583 · Cited by 33 · see citing works
Increased fat deposition in injured skeletal muscle is regulated by sex-specific hormones
McHale, M. J., Sarwar, Z. U., Cardenas, D., Porter, L., Salinas, A. S., Michalek, J. E., McManus, L. M., & Shireman, P. K. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00427.2011 · Cited by 31 · see citing works
Sex differences in forkhead box O3a signaling response to hindlimb unloading in rat soleus muscle
Yoshihara, T., Natsume, T., Tsuzuki, T., Chang, S.-W., Kakigi, R., Sugiura, T., & Naıto, H. (2018) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-0640-6 · Cited by 30 · see citing works
Tissue Distribution, Gender- and Genotype-Dependent Expression of Autophagy-Related Genes in Avian Species
Piekarski, A., Khaldi, S., Greene, E., Lassiter, K., Mason, J. G., Anthony, N. B., Bottje, W. G., & Dridi, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112449 · Cited by 29 · see citing works
Muscle fatigue, nNOS and muscle fiber atrophy in limb girdle muscular dystrophy.
Angelini, C. I., Tasca, E., Nascimbeni, A. C., & Fanin, M. (2014) · PubMed Central · Cited by 28 · see citing works
Gastrocnemius mitochondrial respiration: are there any differences between men and women?
Thompson, J. R., Swanson, S. A., Casale, G. P., Johanning, J. M., Papoutsi, E., Koutakis, P., Miserlis, D., Zhu, Z. H., & Pipinos, I. I. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.05.054 · Cited by 26 · see citing works
Immunocytochemical Localization of the [3H]Estradiol-Binding Protein in Rat Pancreatic Acinar Cells
Grossman, A., Oppenheim, J. D., Grondin, G., St-Jean, P., & Beaudoin, A. R. (1989) · Endocrinology · doi:10.1210/endo-124-6-2857 · Cited by 26 · see citing works
Sex and Mortality of Hospitalized Adults After Admission to an Intensive Care Unit
Lipes, J., Mardini, L., & Jayaraman, D. (2013) · American Journal of Critical Care · doi:10.4037/ajcc2013225 · Cited by 26 · see citing works
Effects of gender-specific adult bovine serum on myogenic satellite cell proliferation, differentiation and lipid accumulation
Lee, D., Bajracharya, P., Lee, E. J., Kim, J.-E., Lee, H.-J., Chun, T., Kim, J., Cho, K. H., Chang, J., Hong, S., et al. (2011) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-011-9427-2 · Cited by 25 · see citing works
Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and satellite cell number in rodent muscle
Dalbo, V. J., Roberts, M. D., Mobley, C. B., Ballmann, C. G., Kephart, W. C., Fox, C. D., Santucci, V. A., Conover, C. F., Beggs, L. A., Balaez, A., et al. (2016) · Andrologia · doi:10.1111/and.12622 · Cited by 24 · see citing works
Sexual Dimorphism in the Alterations of Cardiac Muscle Mitochondrial Bioenergetics Associated to the Ageing Process
Colom, B., Oliver, J., & García-Palmer, F. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu014 · Cited by 23 · see citing works
Dystrophin Involved in the Susceptibility of Slow Muscles to Hindlimb Unloading via Concomitant Activation of TGF-β1/Smad3 Signaling and Ubiquitin–Proteasome Degradation in Mice
Zhang, P., Li, W., Liu, H., Li, J., Wang, J., Li, Y., Chen, X., Yang, Z., & Fan, M. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0023-4 · Cited by 22 · see citing works
Plasma Concentrations of Estradiol Produced with Two Delivery Systems in Ovariectomized Rats
Butcher, R. L., Inskeep, E. K., & Pope, R. S. (1978) · Experimental Biology and Medicine · doi:10.3181/00379727-158-40229 · Cited by 22 · see citing works
l -Carnitine supplement reduces skeletal muscle atrophy induced by prolonged hindlimb suspension in rats
Jang, J., Park, J., Chang, H., & Lim, K. (2016) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2016-0094 · Cited by 22 · see citing works
8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice
Mukai, R., Horikawa, H., Lin, P.-Y., Tsukumo, N., Nikawa, T., Kawamura, T., Nemoto, H., & Terao, J. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00521.2015 · Cited by 21 · see citing works
Role of estrogen receptor-α (ESR1) and the type 1 insulin-like growth factor receptor (IGFR1) in estradiol-stimulated proliferation of cultured bovine satellite cells
Kamanga‐Sollo, E., White, M. E., Weber, W. J., & Dayton, W. R. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2012.08.002 · Cited by 20 · see citing works
The Muscle Protein Synthetic Response to Whey Protein Ingestion Is Greater in Middle-Aged Women Compared With Men
Horstman, A. M. H., Kouw, I. W. K., van Dijk, J., Hamer, H. M., Groen, B. B. L., van Kranenburg, J. M. X., Gorissen, S. H. M., & van Loon, L. J. C. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01734 · Cited by 20 · see citing works
Integrated analysis of mRNA and miRNA expression profiles reveals muscle growth differences between adult female and male Chinese concave-eared frogs (Odorrana tormota)
Shu, Y., Xia, J., Yu, Q., Wang, G., Zhang, J., He, J., Wang, H., Zhang, L., & Wu, H. (2018) · Gene · doi:10.1016/j.gene.2018.08.007 · Cited by 19 · see citing works
Mitochondria can orchestrate sex differences in cell fate of vascular smooth muscle cells from rats
Straface, E., Vona, R., Campesi, I., & Franconi, F. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0051-9 · Cited by 18 · see citing works
White adipose tissue IFN-γ expression and signalling along the progression of rodent cancer cachexia
Yamashita, A. S., das Neves, R. X., Neto, J. C. R., Lira, F. S., Júnior, M. L. B., de Alcântara, P. S. M., Otoch, J. P., & Seelaender, M. C. L. (2016) · Cytokine · doi:10.1016/j.cyto.2016.02.015 · Cited by 18 · see citing works
Autophagy activation, not peroxisome proliferator‐activated receptor γ coactivator 1α, may mediate exercise‐induced improvements in glucose handling during diet‐induced obesity
Rosa‐Caldwell, M. E., Brown, J. L., Lee, D. E., Blackwell, T. A., Turner, K. W., Brown, L. A., Perry, R. A., Haynie, W. S., Washington, T. A., & Greene, N. P. (2017) · Experimental Physiology · doi:10.1113/ep086406 · Cited by 16 · see citing works
Self-citation
Repurposing the Selective Oestrogen Receptor Modulator Tamoxifen for the Treatment of Duchenne Muscular Dystrophy
Gayi, E., Neff, L. A., Ismail, H. M., Rüegg, U. T., Scapozza, L., & Dorchies, O. M. (2018) · CHIMIA International Journal for Chemistry · doi:10.2533/chimia.2018.238 · Cited by 15 · see citing works
Androgen receptor expression in satellite cells of the neonatal levator ani of the rat
Swift‐Gallant, A., & Monks, D. A. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22066 · Cited by 14 · see citing works
Growth and sex effects on the expression of syndecan-4 and glypican-1 in turkey myogenic satellite cell populations
Song, Y. Y., McFarland, D. C., & Velleman, S. G. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1594-x · Cited by 13 · see citing works
Myosin heavy chain mRNA and protein distribution in immobilized rat skeletal muscle are not affected by testosterone status
Harjola, Jänkälä, & Härkönen (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00739.x · Cited by 13 · see citing works
Skeletal muscle antioxidant enzyme levels in rats after simulated weightlessness, exercise and dobutamine.
Girten, B. E., Oloff, C. M., Plato, P. A., Eveland, E. S., MEROLA, A. J., & Kazarian, L. (1989) · PubMed · Cited by 13 · see citing works
Estrogen: A Mitochrondrial Energizer That Keeps on Going
Burris, T. P., & Krishnan, V. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.017335 · Cited by 12 · see citing works
Neuromuscular electrical stimulation and testosterone did not influence heterotopic ossification size after spinal cord injury: A case series
Moore, P. D., Gorgey, A. S., Wade, R. C., Khalil, R. E., Lavis, T. D., Khan, R., & Adler, R. A. (2016) · World Journal of Clinical Cases · doi:10.12998/wjcc.v4.i7.172 · Cited by 11 · see citing works
Changes in calcium, PTH and 1,25(OH)2 vitamin D3 during tail-suspension in ovariectomized rats: effects of estrogen administration.
Ohmori, S., Kanda, K., Kawano, S., Kambe, F., & Seo, H. (2000) · PubMed · Cited by 9 · see citing works
Effect of estrogen on the development of disuse atrophy of bone and muscle induced by tail-supension in rats.
Kawano, S., Kanda, K., Ohmori, S., Izumi, R., Yasukawa, K., Murata, Y., & Seo, H. (1997) · PubMed · Cited by 8 · see citing works
Over-Expression of Porcine Myostatin Missense Mutant Leads to A Gender Difference in Skeletal Muscle Growth between Transgenic Male and Female Mice
Ma, D., Gao, P., Qian, L., Wang, Q., Cai, C., Jiang, S., Xiao, G., & Cui, W. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160820020 · Cited by 7 · see citing works
Effects of tail suspension on serum testosterone and molecular targets regulating muscle mass
Naeyer, H. D., Lamon, S., Russell, A. P., Everaert, I., Spaey, A. D., Jamart, C., Vanheel, B., Taes, Y., & Derave, W. (2014) · Muscle & Nerve · doi:10.1002/mus.24542 · Cited by 6 · see citing works

Flagged first, then by citations

1 of the 199 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

[34]Mauvais-Jarvis F. Sex differences in metabolic homeostasis, diabetes, and obesity. Biol Sex Differ. 2015;6. PMC4559072 26339468
[178]Kang C, Ji LL. PGC-1α overexpression via local transfection attenuates mitophagy pathway in muscle disuse atrophy. Free Radic Biol Med. 2015. 26746585

Sorted by citations

How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation
Harper, J., O'Donnell, E., Sorouri Khorashad, B., McDermott, H., & Witcomb, G. L. (2021) · British Journal of Sports Medicine · doi:10.1136/bjsports-2020-103106 · Cited by 167 · see citing works
Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease
Gaitán, J. M., Moon, H. Y., Stremlau, M., Dubal, D. B., Cook, D. B., Okonkwo, O. C., & van Praag, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.660181 · Cited by 160 · see citing works
Sarcopenic obesity research perspectives outlined by the sarcopenic obesity global leadership initiative (SOGLI)—Proceedings from the SOGLI consortium meeting in rome November 2022
Gortan Cappellari, G., Guillet, C., Poggiogalle, E., Ballesteros Pomar, M. D., Batsis, J. A., Boirie, Y., Breton, I., Frara, S., Genton, L., Gepner, Y., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.02.018 · Cited by 113 · see citing works
Sex Differences in Inflammation and Muscle Wasting in Aging and Disease
Peruta, C. D., Lozanoska‐Ochser, B., Renzini, A., Moresi, V., Riera, C. S., Bouché, M., & Coletti, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054651 · Cited by 108 · see citing works
Myonuclear Domain Flexibility Challenges Rigid Assumptions on Satellite Cell Contribution to Skeletal Muscle Fiber Hypertrophy
Murach, K. A., Englund, D. A., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00635 · Cited by 96 · see citing works
International society of sports nutrition position stand: nutritional concerns of the female athlete
Sims, S. T., Kerksick, C. M., Smith-Ryan, A. E., Janse de Jonge, X. A. K., Hirsch, K. R., Arent, S. M., Hewlings, S. J., Kleiner, S. M., Bustillo, E., Tartar, J. L., et al. (2023) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2023.2204066 · Cited by 91 · see citing works
“synthesis rate in postmenopausal women, which is counteracted by an upregulation of protein breakdown [246].”
Background
Antioxidant Apigenin Relieves Age-Related Muscle Atrophy by Inhibiting Oxidative Stress and Hyperactive Mitophagy and Apoptosis in Skeletal Muscle of Mice
Wang, D., Yang, Y., Zou, X., Zhang, J., Zheng, Z., & Wang, Z. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa214 · Cited by 87 · see citing works
Muscle unloading: A comparison between spaceflight and ground‐based models
Qaisar, R., Karim, A., & Elmoselhi, A. B. (2019) · Acta Physiologica · doi:10.1111/apha.13431 · Cited by 86 · see citing works
Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control
Peris-Moreno, D., Cussonneau, L., Combaret, L., Polge, C., & Taillandier, D. (2021) · Molecules · doi:10.3390/molecules26020407 · Cited by 87 · see citing works
Sex and population-specific cutoff values of muscle quality index: Results from NHANES 2011–2014
Lopes, L. C. C., Vaz-Gonçalves, L., Schincaglia, R. M., González, M. C., Prado, C. M. M., de Oliveira, E. P., & Mota, J. F. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.04.026 · Cited by 83 · see citing works
Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease
Thome, T., Kumar, R. A., Burke, S., Khattri, R. B., Salyers, Z. R., Kelley, R. C., Coleman, M. D., Christou, D. D., Hepple, R. T., Scali, S. T., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.139826 · Cited by 77 · see citing works
Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation
Shi, W., Sheng, X., Dorr, K. M., Hutton, J. E., Emerson, J. I., Davies, H. A., Andrade, T. D., Wasson, L. K., Greco, T. M., Hashimoto, Y., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.09.022 · Cited by 75 · see citing works
Impact of biological sex and sex hormones on molecular signatures of skeletal muscle at rest and in response to distinct exercise training modes
Pataky, M. W., Dasari, S., Michie, K. L., Sevits, K. J., Kumar, A., Klaus, K. A., Heppelmann, C. J. H., Robinson, M. M., Carter, R. E., Lanza, I. R., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.10.010 · Cited by 69 · see citing works
Sleep Duration and Sarcopenia: An Updated Systematic Review and Meta-Analysis
Li, X., He, J., & Sun, Q. (2023) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2023.04.032 · Cited by 63 · see citing works
Development and progression of cancer cachexia: Perspectives from bench to bedside
Lim, S., Brown, J. L., Washington, T. A., & Greene, N. P. (2020) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2020.10.003 · Cited by 60 · see citing works
Self-citation
Automated Muscle Measurement on Chest CT Predicts All-Cause Mortality in Older Adults From the National Lung Screening Trial
Lenchik, L., Barnard, R., Boutin, R. D., Kritchevsky, S. B., Chen, H., Tan, J., Cawthon, P. M., Weaver, A. A., & Hsu, F. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa141 · Cited by 56 · see citing works
Biomarkers for Cancer Cachexia: A Mini Review
Cao, Z., Zhao, K., Jose, I., Hoogenraad, N. J., & Osellame, L. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094501 · Cited by 55 · see citing works
Imaging modalities for diagnosis and monitoring of cancer cachexia
Han, J., Harrison, L., Patzelt, L., Wu, M., Junker, D., Herzig, S., Díaz, M. B., & Karampinos, D. C. (2021) · EJNMMI Research · doi:10.1186/s13550-021-00834-2 · Cited by 55 · see citing works
Targeting Mitochondria by SS-31 Ameliorates the Whole Body Energy Status in Cancer- and Chemotherapy-Induced Cachexia
Ballarò, R., Lopalco, P., Audrito, V., Beltrà, M., Pin, F., Angelini, R., Costelli, P., Corcelli, A., Bonetto, A., Szeto, H. H., et al. (2021) · Cancers · doi:10.3390/cancers13040850 · Cited by 53 · see citing works
Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
Rosa‐Caldwell, M. E., Lim, S., Haynie, W. A., Brown, J. L., Deaver, J. W., da Silva, F. M., Jansen, L. T., Lee, D. E., Wiggs, M. P., Washington, T. A., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12693 · Cited by 45 · see citing works
Self-citation
Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes
Singh, N. N., Hoffman, S., Reddi, P. P., & Singh, R. N. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.166063 · Cited by 47 · see citing works
Weight stability masks changes in body composition in colorectal cancer: a retrospective cohort study
Brown, J. C., Caan, B. J., Feliciano, E. M. C., Xiao, J., Weltzien, E. K., Prado, C. M. M., Kroenke, C. H., Castillo, A., Kwan, M. L., & Meyerhardt, J. A. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa440 · Cited by 46 · see citing works
Skeletal muscle wasting: the estrogen side of sexual dimorphism
McMillin, S. L., Minchew, E. C., Lowe, D. A., & Spangenburg, E. E. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00333.2021 · Cited by 42 · see citing works
A critical discussion on the relationship between E3 ubiquitin ligases, protein degradation, and skeletal muscle wasting: it’s not that simple
Hughes, D. C., Goodman, C. A., Baehr, L. M., Gregorevic, P., & Bodine, S. C. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00457.2023 · Cited by 42 · see citing works
Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
Lim, S., Deaver, J. W., Rosa‐Caldwell, M. E., Haynie, W. S., da Silva, F. M., Cabrera, A. R., Schrems, E. R., Saling, L. W., Jansen, L. T., Dunlap, K. R., et al. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2021 · Cited by 36 · see citing works
Self-citation
Muscle wasting in cancer: opportunities and challenges for exercise in clinical cancer trials
Fairman, C. M., Lønbro, S., Cardaci, T. D., VanderVeen, B. N., Nilsen, T. S., & Murphy, A. E. (2021) · JCSM Rapid Communications · doi:10.1002/rco2.56 · Cited by 36 · see citing works
Exercise Counteracts the Deleterious Effects of Cancer Cachexia
Tsitkanou, S., Murach, K. A., Washington, T. A., & Greene, N. (2022) · Cancers · doi:10.3390/cancers14102512 · Cited by 33 · see citing works
Self-citation
Risk Factors for Muscle Loss in Hemodialysis Patients with High Comorbidity
Visser, W. J., Egmond, A. M. E. D. M.-V., Timman, R., Severs, D., & Hoorn, E. J. (2020) · Nutrients · doi:10.3390/nu12092494 · Cited by 34 · see citing works
Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice
Rosa‐Caldwell, M. E., Lim, S., Haynie, W. S., Brown, J. L., Lee, D. E., Dunlap, K. R., Jansen, L. T., Washington, T. A., Wiggs, M. P., & Greene, N. P. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12809 · Cited by 32 · see citing works
Self-citation
Hindlimb suspension in Wistar rats: Sex‐based differences in muscle response
Mortreux, M., Rosa‐Caldwell, M. E., Stiehl, I. D., Sung, D., Thomas, N. T., Fry, C. S., & Rutkove, S. B. (2021) · Physiological Reports · doi:10.14814/phy2.15042 · Cited by 34 · see citing works
Self-citation
Sex Difference in Spinal Muscular Atrophy Patients – are Males More Vulnerable?
Sun, J., Harrington, M. A., Porter, B., & on behalf of the TREAT-NMD Global Registry Network for SMA (2023) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-230011 · Cited by 31 · see citing works
The time-course of cancer cachexia onset reveals biphasic transcriptional disruptions in female skeletal muscle distinct from males
da Silva, F. M., Lim, S., Cabrera, A. R., Schrems, E. R., Jones, R. G., Rosa‐Caldwell, M. E., Washington, T. A., Murach, K. A., & Greene, N. P. (2023) · BMC Genomics · doi:10.1186/s12864-023-09462-7 · Cited by 32 · see citing works
Self-citation
AnthropoAge, a novel approach to integrate body composition into the estimation of biological age
Fermín‐Martínez, C. A., Márquez‐Salinas, A., Guerra, E. C., Zavala‐Romero, L., Antonio‐Villa, N. E., Fernández‐Chirino, L., Sandoval-Colin, D. E., Barquera‐Guevara, D. A., Muñoz, A. C., Vargas‐Vázquez, A., et al. (2022) · Aging Cell · doi:10.1111/acel.13756 · Cited by 30 · see citing works
Sex differences in forkhead box O3a signaling response to hindlimb unloading in rat soleus muscle
Yoshihara, T., Natsume, T., Tsuzuki, T., Chang, S.-W., Kakigi, R., Sugiura, T., & Naıto, H. (2018) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-0640-6 · Cited by 30 · see citing works
An Inverse Relation between Hyperglycemia and Skeletal Muscle Mass Predicted by Using a Machine Learning Approach in Middle-Aged and Older Adults in Large Cohorts
Wu, X., & Park, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102133 · Cited by 29 · see citing works
PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia
Huot, J. R., Pin, F., Chatterjee, R., & Bonetto, A. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13035 · Cited by 29 · see citing works
Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
Cabrera, A. R., Deaver, J. W., Lim, S., da Silva, F. M., Schrems, E. R., Saling, L. W., Tsitkanou, S., Rosa‐Caldwell, M. E., Wiggs, M. P., Washington, T. A., et al. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00196.2023 · Cited by 29 · see citing works
Self-citation
Sex differences in systemic bone and muscle loss following femur fracture in mice
Osipov, B., Paralkar, M. P., Emami, A. J., Cunningham, H. C., Tjandra, P. M., Pathak, S. J., Langer, H. T., Baar, K., & Christiansen, B. (2021) · Journal of Orthopaedic Research® · doi:10.1002/jor.25116 · Cited by 28 · see citing works
Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness
Engelhardt, L. J., Grunow, J. J., Wollersheim, T., Carbon, N. M., Balzer, F., Spranger, J., & Weber‐Carstens, S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030846 · Cited by 28 · see citing works
Altering aspects of mitochondrial quality to improve musculoskeletal outcomes in disuse atrophy
Rosa‐Caldwell, M. E., Lim, S., Haynie, W. S., Jansen, L. T., Westervelt, L. C., Amos, M. G., Washington, T. A., & Greene, N. P. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00407.2020 · Cited by 28 · see citing works
Self-citation
Skeletal muscle properties show collagen organization and immune cell content are associated with resistance exercise response heterogeneity in older persons
Long, D. E., Peck, B. D., Lavin, K. M., Dungan, C. M., Kosmac, K., Tuggle, S. C., Bamman, M. M., Kern, P. A., & Peterson, C. A. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00025.2022 · Cited by 25 · see citing works
Investigating the rate of skeletal muscle atrophy in men and women in the intensive care unit: a prospective observational study
Wu, R.-Y., Sung, W. H., Cheng, H., & Yeh, H.-J. (2022) · Scientific Reports · doi:10.1038/s41598-022-21052-3 · Cited by 26 · see citing works
Considerations for Sex-Cognizant Research in Exercise Biology and Medicine
O’Bryan, S. M., Connor, K. R., Drummer, D. J., Lavin, K. M., & Bamman, M. M. (2022) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2022.903992 · Cited by 24 · see citing works
Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle
Christianto, A., Baba, T., Takahashi, F., Inui, K., Inoue, M., Suyama, M., Ono, Y., Ohkawa, Y., & Morohashi, K.-I. (2021) · Communications Biology · doi:10.1038/s42003-021-02790-y · Cited by 26 · see citing works
Females have a different metabolic response to critical illness, measured by comprehensive amino acid flux analysis
Deutz, N. E. P., Singer, P., Wierzchowska-McNew, R. A., Viana, M. V., Bendavid, I., Pantet, O., Thaden, J. J., Have, G. A. M. T., ENGELEN, M. P. K. J., & Berger, M. M. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155400 · Cited by 23 · see citing works
Sex related differences in muscle health and metabolism in chronic obstructive pulmonary disease
ENGELEN, M. P. K. J., Kirschner, S. K., Coyle, K. S., Argyelan, D., Neal, G., Dasarathy, S., & Deutz, N. E. P. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.031 · Cited by 22 · see citing works
Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction
Espino-González, E., Tickle, P. G., Altara, R., Gallagher, H., Cheng, C. W., Engman, V., Wood, N., da Silva, G. J. J., Scalabrin, M., Yu, X., et al. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.09.014 · Cited by 21 · see citing works
Sexual dimorphisms in skeletal muscle: current concepts and research horizons
Emmert, M. E., Emmert, A. S., Goh, Q., & Cornwall, R. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00529.2023 · Cited by 22 · see citing works
Imoxin prevents dexamethasone-induced promotion of muscle-specific E3 ubiquitin ligases and stimulates anabolic signaling in C2C12 myotubes
Eo, H., Reed, C. H., & Valentine, R. J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110238 · Cited by 20 · see citing works
Muscle distribution in relation to all-cause and cause-specific mortality in young and middle-aged adults
Liu, C., Liu, T., Ge, Y., Song, M., Ruan, G., Lin, S., Xie, H., Shi, J., Zheng, X., Chen, Y., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04008-7 · Cited by 20 · see citing works
Effects of Different Conditioning Activities on the Sprint Performance of Elite Sprinters: A Systematic Review With Meta-Analysis
Loturco, I., Pereira, L. A., Moura, T. B. M. A., McGuigan, M. R., & Boullosa, D. A. (2024) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2024-0005 · Cited by 19 · see citing works
Associations of skeletal muscle mass with atherosclerosis and inflammatory markers in Korean adults
Yoon, S.-K., Kim, H., & Song, S.-W. (2020) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2020.104163 · Cited by 19 · see citing works
Gender-specific analysis for the association between trunk muscle mass and spinal pathologies
Hori, Y., Hoshino, M., Inage, K., Miyagi, M., Takahashi, S., Ohyama, S., Suzuki, A., Tsujio, T., Terai, H., Dohzono, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-87334-4 · Cited by 19 · see citing works
Lean mass sparing in resistance-trained athletes during caloric restriction: the role of resistance training volume
Roth, C., Schoenfeld, B. J., & Behringer, M. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-04896-5 · Cited by 19 · see citing works
A Ketogenic Diet in Combination with Gemcitabine Mitigates Pancreatic Cancer-Associated Cachexia in Male and Female KPC Mice
Cortez, N. E., Pathak, S. J., Lanzi, C. R., Hong, B. V., Sule, R. O., Crone, R., Wang, F., Chen, S., Gomes, A. V., Baar, K., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310753 · Cited by 19 · see citing works
Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice
Jia, W., Wang, N., Yin, L., Chen, X., Hou, B., Wang, J., Qiang, G., Chan, C. B., Yang, X., & Du, G. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00287-7 · Cited by 18 · see citing works
Effect of administration of β-hydroxy-β-methyl butyrate–enriched formula after liver transplantation: A pilot randomized controlled trial
Kamo, N., Kaido, T., Uozumi, R., Ito, T., Yagi, S., Hata, K., Taura, K., & Üemoto, S. (2020) · Nutrition · doi:10.1016/j.nut.2020.110871 · Cited by 18 · see citing works
Tenotomy-induced muscle atrophy is sex-specific and independent of NFκB
Meyer, G. A., Thomopoulos, S., Abu‐Amer, Y., & Shen, K. C. (2022) · eLife · doi:10.7554/elife.82016 · Cited by 18 · see citing works
Pathophysiological mechanisms of reduced physical activity: Insights from the human step reduction model and animal analogues
Sarto, F., Bottinelli, R., Franchi, M. V., Porcelli, S., Šimunič, B., Pišot, R., & Narici, M. V. (2023) · Acta Physiologica · doi:10.1111/apha.13986 · Cited by 18 · see citing works
Skeletal muscle atrophy in clinical and preclinical models of chronic kidney disease: A systematic review and meta‐analysis
Troutman, A. D., Arroyo, E., Sheridan, E. M., D'Amico, D. J., Brandt, P., Hinrichs, R., Chen, X., Lim, K. J., & Avin, K. G. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13400 · Cited by 18 · see citing works
Cancer cachexia: biomarkers and the influence of age
Geppert, J., & Rohm, M. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13590 · Cited by 21 · see citing works
The psoas muscle density as a predictor of postoperative complications and 30-day mortality for acute mesenteric ischemia patients
Miao, S., Ye, X.-N., Lin, T., Qiu, Y., Huang, J., Zheng, X., & Chen, F. (2020) · Abdominal Radiology · doi:10.1007/s00261-020-02714-0 · Cited by 17 · see citing works
Cardiovasomobility: an integrative understanding of how disuse impacts cardiovascular and skeletal muscle health
Trinity, J. D., Drummond, M. J., Fermoyle, C. C., McKenzie, A. I., Supiano, M. A., & Richardson, R. S. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00607.2021 · Cited by 18 · see citing works
Secondary sarcopenia assessed by computed tomography can predict hospitalization for heart failure in adults with Fontan circulation
Shiina, Y., Nagao, M., Shimomiya, Y., & Inai, K. (2020) · Journal of Cardiology · doi:10.1016/j.jjcc.2020.06.009 · Cited by 17 · see citing works
Withaferin A and Ovarian Cancer Antagonistically Regulate Skeletal Muscle Mass
Straughn, A. R., Kelm, N., & Kakar, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.636498 · Cited by 15 · see citing works
Optimal Skeletal Muscle Mass Index Cut-Off Values for Presarcopenia Evaluated by Computed Tomography against Dual-Energy X-ray Absorptiometry in Patients with Chronic Liver Disease
Ohashi, K., Ishikawa, T., Hoshii, A., Hokari, T., Noguchi, H., Suzuki, M., Hirosawa, H., Imai, M., Mitobe, Y., & Yoshida, T. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071419 · Cited by 15 · see citing works
Muscle miRNAs are influenced by sex at baseline and in response to exercise
Hiam, D., Landen, S., Jacques, M., Voisin, S. A. C., Lamon, S., & Eynon, N. (2023) · BMC Biology · doi:10.1186/s12915-023-01755-3 · Cited by 17 · see citing works
Longitudinal Changes in CT Body Composition in Patients Undergoing Surgery for Colorectal Cancer and Associations With Peri-Operative Clinicopathological Characteristics
Dolan, R. D., Abbass, T., Sim, W. M. J., Almasaudi, A. S., Dieu, L. B., Horgan, P. G., McSorley, S. T., & McMillan, D. C. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.678410 · Cited by 15 · see citing works
Musclin Counteracts Skeletal Muscle Dysfunction and Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
Saw, E. L., Werner, L. D., Cooper, H. L., Pimental, D. R., Zamani, P. L., Chirinos, J. A., Valero‐Muñoz, M., & Sam, F. (2025) · Circulation Heart Failure · doi:10.1161/circheartfailure.124.012350 · Cited by 15 · see citing works
Reduced CT-derived erector spinae muscle area: a poor prognostic factor for short- and long-term outcomes in idiopathic pulmonary fibrosis patients
Çinkooğlu, A., Bayraktaroğlu, S., Ufuk, F., Unat, Ö. S., Köse, T., Savaş, R., & Moğulkoç, N. (2023) · Clinical Radiology · doi:10.1016/j.crad.2023.08.011 · Cited by 14 · see citing works
Androgens as the “old age stick” in skeletal muscle
Gentile, G., Stefano, F. D., Sorrentino, C., D’Angiolo, R., Lauretta, C., Giovannelli, P., Migliaccio, A., Castoria, G., & Donato, M. D. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02163-6 · Cited by 14 · see citing works
The combination of a male donor’s high muscle mass and quality is an independent protective factor for graft loss after living donor liver transplantation
Miyachi, Y., Kaido, T., Hirata, M., Iwamura, S., Yao, S., Shirai, H., Kamo, N., Uozumi, R., Yagi, S., & Üemoto, S. (2020) · American Journal of Transplantation · doi:10.1111/ajt.15884 · Cited by 14 · see citing works
Approaching Gravity as a Continuum Using the Rat Partial Weight-Bearing Model
Mortreux, M., & Rosa‐Caldwell, M. E. (2020) · Life · doi:10.3390/life10100235 · Cited by 14 · see citing works
Self-citation
Development of skeletal muscle fibrosis in a rodent model of cancer cachexia
Washington, T. A., Schrems, E. R., Haynie, W. S., Rosa‐Caldwell, M. E., Brown, J. L., Saling, L. W., Lim, S., Perry, R. A., Brown, L. A., Lee, D. E., et al. (2023) · Cell Biochemistry and Function · doi:10.1002/cbf.3797 · Cited by 14 · see citing works
Self-citation
Hallmarks of Cancer Cachexia: Sexual Dimorphism in Related Pathways
Satari, S., Mota, I. N. R., Silva, A. C. L., Brito, H. O., Oliveira, P. A., da Costa, R. M. G., & Medeiros, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26093952 · Cited by 13 · see citing works
Loss of 4E-BPs prevents the hindlimb immobilization-induced decrease in protein synthesis in skeletal muscle
Kincheloe, G. N., Roberson, P. A., Toro, A. L., Stanley, B. A., Stanley, A. E., Jefferson, L. S., Dennis, M. D., & Kimball, S. R. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00563.2022 · Cited by 13 · see citing works
Sex differences in cachexia and branched‐chain amino acid metabolism following chemotherapy in mice
Mora, S., Mann, G., & Adegoke, O. A. J. (2024) · Physiological Reports · doi:10.14814/phy2.16003 · Cited by 13 · see citing works
Rat Model of Quadriceps Contracture by Joint Immobilization
Suwankanit, K., & Shimizu, M. (2022) · Biology · doi:10.3390/biology11121781 · Cited by 13 · see citing works
The oestrous cycle and skeletal muscle atrophy: Investigations in rodent models of muscle loss
Rosa‐Caldwell, M. E., Mortreux, M., Kaiser, U. B., Sung, D., Bouxsein, M., Dunlap, K. R., Greene, N. P., & Rutkove, S. B. (2021) · Experimental Physiology · doi:10.1113/ep089962 · Cited by 13 · see citing works
Self-citation
Fibroblast growth factor–inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair
da Silva, M. T., Joshi, A. S., & Kumar, A. (2025) · JCI Insight · doi:10.1172/jci.insight.187825 · Cited by 12 · see citing works
Sex Differences in Quadriceps Atrophy After Anterior Cruciate Ligament Tear
Owen, M. K., Casadonte, K. R., Thomas, N. T., Latham, C. M., Brightwell, C. R., Thompson, K. L., Hawk, G. S., Jacobs, C. A., Johnson, D. L., Fry, C. S., et al. (2024) · Sports Health A Multidisciplinary Approach · doi:10.1177/19417381241230612 · Cited by 12 · see citing works
Association between sarcopenia and cardiovascular disease according to menopausal status: findings from the China Health and Retirement Longitudinal Study (CHARLS)
Dai, X., He, S., Wu, Y., Zhuang, J., & Xu, G. (2025) · BMC Public Health · doi:10.1186/s12889-025-21933-y · Cited by 12 · see citing works
Secreted Protein Acidic and Rich in Cysteine as an Exercise-Induced Gene: Towards Novel Molecular Therapies for Immobilization-Related Muscle Atrophy in Elderly Patients
Ghanemi, A., Yoshioka, M., & St‐Amand, J. (2022) · Genes · doi:10.3390/genes13061014 · Cited by 12 · see citing works
Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years
de Jong, J. C. B. C., Verschuren, L., Caspers, M. P. M., van der Hoek, M. D., van der Leij, F. R., Kleemann, R., van den Hoek, A. M., Nieuwenhuizen, A. G., & Keijer, J. (2023) · Biology of Sex Differences · doi:10.1186/s13293-023-00531-w · Cited by 12 · see citing works
Long-Lasting Impairments in Quadriceps Mitochondrial Health, Muscle Size, and Phenotypic Composition Are Present After Non-invasive Anterior Cruciate Ligament Injury
Davi, S. M., Ahn, A., White, M. S., Butterfield, T. A., Kosmac, K., Kwon, O. S., & Lepley, L. K. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.805213 · Cited by 11 · see citing works
Preoperative Lower-Limb Muscle Predictors for Gait Speed Improvement after Total Hip Arthroplasty for Patients with Osteoarthritis
Yasuda, T., Ota, S., Mitsuzawa, S., Yamashita, S., Tsukamoto, Y., Takeuchi, H., & Onishi, E. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13081279 · Cited by 11 · see citing works
Possible Mechanisms Linking Obesity, Steroidogenesis, and Skeletal Muscle Dysfunction
Sheptulina, A. F., Antyukh, K. Y., Kiselev, A. R., Mitkovskaya, N. P., & Drapkina, O. M. (2023) · Life · doi:10.3390/life13061415 · Cited by 11 · see citing works
Partial Weight-Bearing in Female Rats: Proof of Concept in a Martian-Gravity Analog
Semple, C., Riveros, D., Nagy, J. A., Rutkove, S. B., & Mortreux, M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00302 · Cited by 11 · see citing works
Sex Differences in the Skeletal Muscle Response to a High Fat, High Sucrose Diet in Rats
Hulett, N. A., Knaub, L. A., Hull, S., Pott, G. B., Peelor, R., Miller, B. F., Shankar, K., Rudolph, M. C., Reusch, J. E. B., & Scalzo, R. L. (2023) · Nutrients · doi:10.3390/nu15204438 · Cited by 10 · see citing works
Protein turnover in pigs: A review of interacting factors.
Sarri, L., Balcells, J., Seradj, A. R., & de la Fuente, G. (2023) · Journal of animal physiology and animal nutrition · doi:10.1111/jpn.13906 · Cited by 10 · see citing works
Differential Autophagy Response in Men and Women After Muscle Damage
Luk, H., Appell, C. R., Levitt, D. E., Jiwan, N. C., & Vingren, J. L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.752347 · Cited by 10 · see citing works
Skeletal muscle mitochondrial function and whole-body metabolic energetics in the +/G610C mouse model of osteogenesis imperfecta
Gremminger, V. L., Omosule, C. L., Crawford, T. K., Cunningham, R. P., Rector, R. S., & Phillips, C. L. (2022) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2022.06.004 · Cited by 9 · see citing works
The importance of biological sex in cardiac cachexia
Holder, E. R., Alibhai, F. J., Caudle, S. L., McDermott, J. C., & Tobin, S. W. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00187.2022 · Cited by 9 · see citing works
Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats
Rosa‐Caldwell, M. E., Mortreux, M., Wadhwa, A., Kaiser, U. B., Sung, D., Bouxsein, M., & Rutkove, S. B. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00023.2023 · Cited by 9 · see citing works
Self-citation
Leucine Supplementation Exacerbates Morbidity in Male but Not Female Mice with Colorectal Cancer-Induced Cachexia
Schrems, E. R., Haynie, W. S., Perry, R. A., da Silva, F. M., Cabrera, A. R., Rosa‐Caldwell, M. E., Greene, N. P., & Washington, T. A. (2023) · Nutrients · doi:10.3390/nu15214570 · Cited by 9 · see citing works
Self-citation
Exposure to Doxorubicin Modulates the Cardiac Response to Isoproterenol in Male and Female Mice
Agostinucci, K. J., Grant, M. K. O., Melaku, W., Nair, C., & Zordoky, B. N. M. (2023) · Pharmaceuticals · doi:10.3390/ph16030391 · Cited by 9 · see citing works
Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
Tsitkanou, S., da Silva, F. M., Cabrera, A. R., Schrems, E. R., Murach, K. A., Washington, T. A., Rosa‐Caldwell, M. E., & Greene, N. P. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00352.2023 · Cited by 8 · see citing works
Self-citation
Muscle Insulin Resistance Elicits Muscle Atrophy in Obesity
Razi, O., Zamani, N., Saeidi, A., Hadjicharalambous, M., Ayed, K., Hackney, A. C., Coso, J. D., Laher, I., Muscogiuri, G., & Zouhal, H. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00672-6 · Cited by 11 · see citing works
Amino acid kinetics in the critically ill
Deutz, N. E. P., Haines, K., Wischmeier, P. E., & ENGELEN, M. P. K. J. (2023) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000995 · Cited by 8 · see citing works
Sex differences in anaerobic performance in CrossFit® athletes: a comparison of three different all-out tests
Ponce-García, T., García-Romero, J., Carrasco-Fernández, L., Castillo-Domínguez, A., & Benítez‐Porres, J. (2025) · PeerJ · doi:10.7717/peerj.18930 · Cited by 8 · see citing works

Sex Differences in Inflammation and Muscle Wasting in Aging and Disease
Peruta, C. D., Lozanoska‐Ochser, B., Renzini, A., Moresi, V., Riera, C. S., Bouché, M., & Coletti, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054651 · Cited by 108 · see citing works
Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia
Cabrera, A. R., Deaver, J. W., Lim, S., da Silva, F. M., Schrems, E. R., Saling, L. W., Tsitkanou, S., Rosa‐Caldwell, M. E., Wiggs, M. P., Washington, T. A., et al. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00196.2023 · Cited by 29 · see citing works
Self-citation
Sex Differences in Cancer Cachexia
Zhong, X.-L., & Zimmers, T. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00628-w · Cited by 98 · see citing works
Sex Differences in Muscle Wasting
Anderson, L. J., Liu, H. M., & Garcia, J. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_9 · Cited by 222 · see citing works
Role of Biological Sex in the Onset of Muscle Atrophy
ASIAN SOCIETY OF KINESIOLOGY, & Greene, N. P. G. N. P. (2024) · doi:10.63020/pa.2024.2.2.16
Self-citation

Authors: Rosa-Caldwell, M. E., & Greene, N. P.
Affiliations: University of Arkansas at Fayetteville (US)
Corresponding author: Greene, Nicholas P.
ORCID: Greene, Nicholas P.
Venue: Biology of Sex Differences
Publisher: Springer Science and Business Media LLC
Published: 2019-08-28
Volume: 10
Issue: 1
Pages: 43-43
ISSN: 2042-6410 (ISSN-L)
DOI: 10.1186/s13293-019-0257-3
PMC: PMC6714453
OpenAlex: W2971287565
Cited by: 202
References: 199
Citations by year: 2026: 18 · 2025: 26 · 2024: 23 · 2023: 49 · 2022: 32 · 2021: 32 · 2020: 18 · 2019: 2 · 2018: 2
FWCI: 1.85
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biology of Sex Differences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (R15 AR069913/AR/NIAMS)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: sex differences, skeletal muscle metabolism, muscle atrophy, cancer cachexia, muscle protein turnover, satellite cells, hormonal differences
MeSH terms: Energy Metabolism, Female, Humans, Male, Muscular Atrophy, Risk Factors, Sex Characteristics, Muscle, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Muscle metabolism and atrophy: let’s talk about sex

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks