Cell signaling in trophoblast-uterine communication
Open accessAbstract
Intricate and precise communication between the blastocyst and the uterus orchestrates embryo implantation. However, many questions remain unanswered regarding the molecular complexities of implantation. On-time implantation requires a receptive uterus and a mature blastocyst with trophoblast cells capable of adhering to and invading the endometrium. Defects in uterine receptivity or embryo/uterine signaling can cause implantation failure or early pregnancy loss, whereas deficient trophoblast differentiation can generate placental abnormalities that produce adverse pregnancy outcomes. This review will discuss several examples of signaling pathways that regulate trophoblast and uterine development during this period. Leukemia inhibitory factor is involved in uterine priming for implantation. The epidermal growth factor signaling system contributes to trophoblast-uterine communication, as well as trophoblast adhesion and invasion. Indian hedgehog signaling synchronizes tissue compartments within the uterus, and WNT signaling mediates numerous interactions within the implantation site and developing placenta. The autocrine, paracrine and juxtacrine interactions mediated by these signaling pathways contribute significantly to the establishment of pregnancy, although there are many other known and yet to be discovered factors that synchronize the maternal and embryonic developmental programs.
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Trophoblast implantation defects can cause early pregnancy loss.
“Trophoblast implantation defects (TID) can cause an early pregnancy loss.”
From Retrospective Analysis of 1168 Cases of Ovular Decidual Tissue from First-Trimester Abortions: Proposal for a Histopathological Diagnostic Framework (2026) · cites this paper as [22]
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Mutations affecting segment number and polarity in Drosophila
Nüsslein‐Volhard, C., & Wieschaus, E. F. (1980) · Nature · doi:10.1038/287795a0 · Cited by 4,370 · see citing works
Hedgehog signaling in animal development: paradigms and principlesPreprint
Ingham, P. W., & McMahon, A. P. (2001) · Genes & Development · doi:10.1101/gad.938601 · Cited by 2,987 · see citing works
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912 · see citing works
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154 · see citing works
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130 · see citing works
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
Liu, C., Li, Y., Semënov, M. V., Han, C., Baeg, G., Tan, Y., Zhang, Z., Lin, X., & He, X. (2002) · Cell · doi:10.1016/s0092-8674(02)00685-2 · Cited by 2,066 · see citing works
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
Stewart, C. L., Kašpar, P., Brunet, L. J., Bhatt, H., Gadi, I. K., Köntgen, F., & Abbondanzo, S. J. (1992) · Nature · doi:10.1038/359076a0 · Cited by 2,033 · see citing works
Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype
Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U. F., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., et al. (1995) · Science · doi:10.1126/science.7618084 · Cited by 1,460 · see citing works
Implantation and the Survival of Early Pregnancy
Norwitz, E. R., Schust, D. J., & Fisher, S. J. (2001) · New England Journal of Medicine · doi:10.1056/nejmra000763 · Cited by 1,267 · see citing works
Neuregulins: functions, forms, and signaling strategies
Falls, D. L. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00102-7 · Cited by 1,071 · see citing works
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
Miettinen, P. J., Berger, J. E., Meneses, J. J., Phung, Y. T., Pedersen, R. A., Werb, Z., & Derynck, R. (1995) · Nature · doi:10.1038/376337a0 · Cited by 1,038 · see citing works
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
Sibilia, M., & Wagner, E. F. (1995) · Science · doi:10.1126/science.7618085 · Cited by 1,002 · see citing works
Regulation of Human Placental Development by Oxygen Tension
Genbačev, O., Zhou, Y., Ludlow, J. W., & Fisher, S. J. (1997) · Science · doi:10.1126/science.277.5332.1669 · Cited by 914 · see citing works
The role of the spiral arteries in the pathogenesis of pre-eclampsia.
Brosens, I. A., Robertson, W. B., & Dixon, H. G. (1970) · PubMed · Cited by 894 · see citing works
Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy.
Rodesch, F., Simon, P., Donner, C., & Jauniaux, E. R. M. (1992) · PubMed · Cited by 753 · see citing works
92-kD type IV collagenase mediates invasion of human cytotrophoblasts.
Librach, C. L., Werb, Z., Fitzgerald, M. L., Chiu, K., Corwin, N., Esteves, R. A., Grobelny, D. W., Galardy, R. E., Damsky, C. H., & Fisher, S. J. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.2.437 · Cited by 718 · see citing works
Ion exchange resins in the treatment and prophylaxis of pre-eclampsia.
Brosens, I. A., Wb, R., & Dixon, H. (1953) · PubMed · Cited by 706 · see citing works
Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos
Rappolee, D. A., Brenner, C. A., Schultz, R. M., Mark, D., & Werb, Z. (1988) · Science · doi:10.1126/science.3175624 · Cited by 678 · see citing works
Placental oxidative stress: from miscarriage to preeclampsia
Burton, G. J., & Jauniaux, E. (2004) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2004.03.003 · Cited by 673 · see citing works
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
Luetteke, N., Qiu, T. H., Peiffer, R. L., Oliver, P. M., Smithies, O., & Lee, D. C. (1993) · Cell · doi:10.1016/0092-8674(93)90228-i · Cited by 658 · see citing works
ErbB Receptors: Directing Key Signaling Networks Throughout Life
Holbro, T., & Hynes, N. E. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121440 · Cited by 642 · see citing works
Physiological and molecular determinants of embryo implantation
Zhang, S., Lin, H., Kong, S., Wang, S., Wang, H., Wang, H., & Armant, D. R. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.011 · Cited by 592 · see citing works
Talbi, S., Hamilton, A. E., Vo, K. C., Tulac, S., Overgaard, M. T., Dosiou, C., Le Shay, N., Nezhat, C. N., Kempson, R., Lessey, B. A., et al. (2006) · Endocrinology · doi:10.1210/en.2005-1076 · Cited by 589 · see citing works
Integrin switching regulates normal trophoblast invasion
Damsky, C. H., Librach, C. L., Lim, K.-H., Fitzgerald, M. L., McMaster, M., Janatpour, M. J., Zhou, Y., Logan, S. K., & Fisher, S. J. (1994) · Development · doi:10.1242/dev.120.12.3657 · Cited by 587 · see citing works
Ware, C. B., Horowitz, M. C., Renshaw, B. R., Hunt, J. S., Liggitt, D., Koblar, S. A., Gliniak, B., McKenna, H. J., Papayannopoulou, T., Thoma, B., et al. (1995) · Development · doi:10.1242/dev.121.5.1283 · Cited by 586 · see citing works
Mann, G. B., Fowler, K. J., Gabriel, A., Nice, E. C., Williams, R. L., & Dunn, A. R. (1993) · Cell · doi:10.1016/0092-8674(93)90227-h · Cited by 583 · see citing works
Genbačev, O., Joslin, R. J., Damsky, C. H., Polliotti, B., & Fisher, S. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118447 · Cited by 573 · see citing works
Das, S., Wang, X., Paria, B. C., Damm, D. L., Abraham, J. A., Klagsbrun, M., Andrews, G. K., & Dey, S. K. (1994) · Development · doi:10.1242/dev.120.5.1071 · Cited by 568 · see citing works
Luetteke, N., Qiu, T. H., Fenton, S. E., Troyer, K. L., Riedel, R. F., Chang, A. Y., & Lee, D. C. (1999) · Development · doi:10.1242/dev.126.12.2739 · Cited by 568 · see citing works
Assisted Reproductive Technology Surveillance — United States, 2013
Sunderam, S., Kissin, D. M., Crawford, S. B., Folger, S. G., Jamieson, D. J., Warner, L., & Barfield, W. D. (2015) · MMWR Surveillance Summaries · doi:10.15585/mmwr.ss6411a1 · Cited by 521 · see citing works
Neuregulins and Their Receptors: A Versatile Signaling Module in Organogenesis and Oncogenesis
Burden, S. J., & Yarden, Y. (1997) · Neuron · doi:10.1016/s0896-6273(00)80324-4 · Cited by 479 · see citing works
Burton, G. J., Jauniaux, E. R. M., & Watson, A. L. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70518-1 · Cited by 453 · see citing works
Carson, D. D. (2002) · Molecular Human Reproduction · doi:10.1093/molehr/8.9.871 · Cited by 437 · see citing works
Lysophosphatidic Acid Receptors
Contos, J. J. A., Ishii, I., & Chun, J. J. M. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.6.1188 · Cited by 398 · see citing works
Isoform-specific expression and function of neuregulin
Meyer, D., Yamaai, T., Garratt, A. N., Sonnenberg-Riethmacher, E., Kane, D. J., Theill, L. E., & Birchmeier, C. (1997) · Development · doi:10.1242/dev.124.18.3575 · Cited by 395 · see citing works
A new nomenclature for int-1 and related genes: The Wnt gene family
Nusse, R., Brown, A. M. C., Papkoff, J. S., Scambler, P. J., Shackleford, G. M., McMahon, A., Moon, R. T., & VARMUS, H. E. (1991) · Cell · doi:10.1016/0092-8674(91)90633-a · Cited by 368 · see citing works
Targeted disruption of the Wnt2 gene results in placentation defects
Monkley, S. J., Delaney, S. J., Pennisi, D. J., Christiansen, J. H., & Wainwright, B. J. (1996) · Development · doi:10.1242/dev.122.11.3343 · Cited by 357 · see citing works
Paria, B. C., Ma, W., Tan, J., Raja, S., Das, S. K., Dey, S. K., & Hogan, B. L. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1047 · Cited by 352 · see citing works
SnapShot: Noncanonical Wnt Signaling Pathways
Semënov, M. V., Habas, R., MacDonald, B. T., & He, X. (2007) · Cell · doi:10.1016/j.cell.2007.12.011 · Cited by 349 · see citing works
DiFederico, E., Genbacev, O., & Fisher, S. J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65123-1 · Cited by 348 · see citing works
Jauniaux, E. R. M., Watson, A. L., & Burton, G. J. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.111935 · Cited by 316 · see citing works
Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis
Ishikawa, T., Tamai, Y., Zorn, A. M., Yoshida, H., Seldin, M. F., Nishikawa, S.-I., & Taketo, M. M. (2001) · Development · doi:10.1242/dev.128.1.25 · Cited by 311 · see citing works
Jones, D. S., Sharkey, A., Fenwick, P., & Smith, S. K. (1994) · Reproduction · doi:10.1530/jrf.0.1010421 · Cited by 294 · see citing works
Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus
Lee, K. C., Jeong, J., Kwak, I., Yu, C., Lanske, B., Soegiarto, D. W., Toftgård, R., Tsai, M., Tsai, S. Y., Lydon, J. P., et al. (2006) · Nature Genetics · doi:10.1038/ng1874 · Cited by 288 · see citing works
Wnt Signalling in Implantation, Decidualisation and Placental Differentiation – Review
Sonderegger, S., Pollheimer, J., & Knöfler, M. (2010) · Placenta · doi:10.1016/j.placenta.2010.07.011 · Cited by 265 · see citing works
Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus
Das, S. K., Chakraborty, I., Paria, B. C., Wang, X. N., Plowman, G. D., & Dey, S. K. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.6.8592515 · Cited by 263 · see citing works
Hamatani, T., Daikoku, T., Wang, H., Matsumoto, H., Carter, M. G., Ko, M. S. H., & Dey, S. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402597101 · Cited by 254 · see citing works
Song, H., Lim, H. J., Das, S., Paria, B. C., & Dey, S. K. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.8.0498 · Cited by 250 · see citing works
Arici, A. M., Engin, O., Attar, E., & Olive, D. L. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.6.7775640 · Cited by 247 · see citing works
Assisted reproductive technology surveillance--United States, 2009.
Sunderam, S., Kissin, D. M., Flowers, L. M., Anderson, J. E., Folger, S. G., Jamieson, D. J., & Barfield, W. D. (2012) · PubMed · Cited by 242 · see citing works
Bass, K. E., Morrish, D. W., Roth, I., Bhardwaj, D., Taylor, R. N., Zhou, Y., & Fisher, S. J. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1223 · Cited by 242 · see citing works
Assisted Reproductive Technology Surveillance - United States, 2001
Wright, V. C., Schieve, L. A., Reynolds, M. A., Jeng, G. T., & Kissin, D. (2004) · PsycEXTRA Dataset · doi:10.1037/e566402006-001 · Cited by 226 · see citing works
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development
van Amerongen, R., Fuerer, C., Mizutani, M., & Nusse, R. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.06.020 · Cited by 224 · see citing works
Uterine Wnt/β-catenin signaling is required for implantation
Mohamed, O. A., Jonnaert, M., Labelle‐Dumais, C., Kuroda, K., Clarke, H. J., & Dufort, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500612102 · Cited by 221 · see citing works
Hambartsoumian, E. (1998) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1998.tb00345.x · Cited by 220 · see citing works
Tulac, S., Nayak, N. R., Kao, L. C., Waes, M. V., Huang, J. A., Lobo, S. C., Germeyer, A., Lessey, B. A., Taylor, R. N., Suchanek, E., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030494 · Cited by 217 · see citing works
COUP-TFII Mediates Progesterone Regulation of Uterine Implantation by Controlling ER Activity
Kurihara, I., Lee, D.-K., Petit, F. G., Jeong, J., Lee, K., Lydon, J. P., DeMayo, F. J., Tsai, M., & Tsai, S. Y. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030102 · Cited by 202 · see citing works
Raab, G., Kover, K. L., Paria, B. C., Dey, S. K., Ezzell, R. M., & Klagsbrun, M. (1996) · Development · doi:10.1242/dev.122.2.637 · Cited by 196 · see citing works
Pollheimer, J., Loregger, T., Sonderegger, S., Saleh, L., Bauer, S., Bilban, M., Czerwenka, K. F., Husslein, P. W., & Knöfler, M. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050686 · Cited by 192 · see citing works
Martin, K. L., Barlow, D. H., & Sargent, I. L. (1998) · Human Reproduction · doi:10.1093/humrep/13.6.1645 · Cited by 190 · see citing works
Matsumoto, H., Zhao, X., Das, S. K., Hogan, B. L. M., & Dey, S. K. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0645 · Cited by 188 · see citing works
Paria, B. C., Das, S., Andrews, G. K., & Dey, S. K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.55 · Cited by 186 · see citing works
Mechanisms of endometrial progesterone resistance
Al-Sabbagh, M., Lam, E. W.-F., & Brosens, J. J. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.035 · Cited by 183 · see citing works
Inhibition of GSK3 by Wnt signalling – two contrasting models
Metcalfe, C., & Bienz, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.091991 · Cited by 181 · see citing works
Leukemia Inhibitory Factor and Human Embryo Implantation
Aghajanova, L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1335.020 · Cited by 180 · see citing works
Inactivation of nuclear Wnt-β-catenin signaling limits blastocyst competency for implantation
Xie, H., Tranguch, S. L., Jia, X.-X., Zhang, H., Das, S. K., Dey, S. K., Kuo, C. J., & Wang, H. (2008) · Development · doi:10.1242/dev.015339 · Cited by 179 · see citing works
Identification of Indian Hedgehog as a Progesterone-Responsive Gene in the Murine Uterus
Takamoto, N., Zhao, B., Tsai, S. Y., & DeMayo, F. J. (2002) · Molecular Endocrinology · doi:10.1210/me.2001-0154 · Cited by 172 · see citing works
Expression of Leukemia Inhibitory Factor in Human Endometrium and Placenta1
Kojima, K., Kanzaki, H., Iwai, M., Hatayama, H., Fujimoto, M., Inoue, T. K., Horie, K., Nakayama, H., Fujita, J., & Mori, T. (1994) · Biology of Reproduction · doi:10.1095/biolreprod50.4.882 · Cited by 161 · see citing works
R-spondin3 is required for mouse placental development
Aoki, M., Mieda, M., Ikeda, T., Hamada, Y., Nakamura, H., & Okamoto, H. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.018 · Cited by 158 · see citing works
Wnt7b Regulates Placental Development in Mice
Parr, B. A., Cornish, V., Cybulsky, M. I., & McMahon, A. P. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0373 · Cited by 151 · see citing works
Preimplantation development of the mammalian embryo and its regulation by growth factors
Stewart, C. L., & Cullinan, E. B. (1997) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1997)21:1 · Cited by 136 · see citing works
Wnt Genes in the Mouse Uterus: Potential Regulation of Implantation1
Hayashi, K., Erikson, D. W., Tilford, S., Bany, B. M., MacLean, J. A., Rucker, E. B., Johnson, G. A., & Spencer, T. E. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.075416 · Cited by 136 · see citing works
Leach, R. E., Khalifa, R., Ramirez, N. D., Das, S., Wang, J., Dey, S. K., Romero, R. J., & Armant, D. R. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.9.5980 · Cited by 135 · see citing works
Paria, B. C., Elenius, K., Klagsbrun, M., & Dey, S. K. (1999) · Development · doi:10.1242/dev.126.9.1997 · Cited by 135 · see citing works
Reduced expression of biomarkers associated with the implantation window in women with endometriosis
Wei, Q., Clair, J. B. S., Fu, T., Stratton, P., & Nieman, L. K. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.02.121 · Cited by 133 · see citing works
Catalano, R. D., Johnson, M. H., Campbell, E. A., Jones, D. S., Smith, S. K., & Sharkey, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502343102 · Cited by 133 · see citing works
Localization of Leukemia Inhibitory Factor and Its Receptor in Human Placenta Throughout Pregnancy1
Sharkey, A., King, A., Clark, D. E., Burrows, T. D., Jokhi, P., Jones, D. S., Loke, Y. W., & Smith, S. K. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.2.355 · Cited by 131 · see citing works
Maternal heparin-binding-EGF deficiency limits pregnancy success in mice
Xie, H., Wang, H., Tranguch, S. L., Iwamoto, R., Mekada, E., DeMayo, F. J., Lydon, J. P., Das, S. K., & Dey, S. K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707909104 · Cited by 129 · see citing works
Lessey, B. A., Gui, Y., Apparao, K. B. C., Young, S. L., & Mulholland, J. (2002) · Molecular Reproduction and Development · doi:10.1002/mrd.10129 · Cited by 129 · see citing works
Local regulation of implantation at the human fetal-maternal interface
Dimitriadis, E., Nie, G., Hannan, N. J., Paiva, P., & Salamonsen, L. A. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082772ed · Cited by 125 · see citing works
Das, S. K., Das, N., Wang, J., Lim, H. J., Schryver, B. B., Plowman, G. D., & Dey, S. K. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8694 · Cited by 122 · see citing works
Leach, R. E., Kilburn, B. A., Wang, J., Liu, Z., Romero, R. J., & Armant, D. R. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.09.026 · Cited by 119 · see citing works
Sonderegger, S., Husslein, H., Leisser, C., & Knöfler, M. (2007) · Placenta · doi:10.1016/j.placenta.2006.11.003 · Cited by 118 · see citing works
Matsuzaki, S., Darcha, C., Maleysson, E., Canis, M. J., & Mage, G. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2713 · Cited by 116 · see citing works
Tamada, H., Das, S., Andrews, G. K., & Dey, S. K. (1991) · Biology of Reproduction · doi:10.1095/biolreprod45.2.365 · Cited by 111 · see citing works
Umata, T., Hirata, M., Takahashi, T., Ryu, F., Shida, S., Takahashi, Y., Tsuneoka, M., Miura, Y., Masuda, M., Horiguchi, Y., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103673200 · Cited by 107 · see citing works
Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium
Catalano, R. D., Critchley, H., Heikinheimo, O., Baird, D. T., Hapangama, D. K., Sherwin, J. R. A., Jones, D. S., Smith, S. K., & Sharkey, A. (2007) · Molecular Human Reproduction · doi:10.1093/molehr/gam021 · Cited by 107 · see citing works
Leukemia inhibitory factor in human reproduction
Lass, A., Weiser, W. Y., Munafo, A., & Loumaye, E. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02878-3 · Cited by 106 · see citing works
Wang, J., Mayernik, L., Schultz, J. F., & Armant, D. R. (2000) · Development · doi:10.1242/dev.127.1.33 · Cited by 106 · see citing works
Chobotova, K., Spyropoulou, I., Carver, J. G., Manek, S., Heath, J. K., Gullick, W. J., Barlow, D. H., Sargent, I. L., & Mardon, H. J. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00342-8 · Cited by 104 · see citing works
HB-EGF: A unique mediator of embryo-uterine interactions during implantation
Lim, H. J., & Dey, S. K. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.07.025 · Cited by 103 · see citing works
Pre-eclampsia and expression of heparin-binding EGF-like growth factor
Leach, R. E., Romero, R. J., Kim, Y. M., Chaiworapongsa, T., Kilburn, B. A., Das, S., Dey, S. K., Johnson, A., Qureshi, F., Jacques, S. M., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11283-9 · Cited by 103 · see citing works
Leach, R. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.9.3355 · Cited by 103 · see citing works
The ins and outs of virulence gene expression: Mg2 as a regulatory signal
Groisman, E. A. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199801)20:1 · Cited by 100 · see citing works
Leukaemia inhibitory factor gene mutations in infertile women
Giess, R. (1999) · Molecular Human Reproduction · doi:10.1093/molehr/5.6.581 · Cited by 97 · see citing works
Aghajanova, L., Horcajadas, J. A., Weeks, J. L., Esteban, F. J., NEZHAT, C. R., Conti, M., & Giudice, L. C. (2010) · Endocrinology · doi:10.1210/en.2009-0923 · Cited by 94 · see citing works
Chobotova, K., Karpovich, N., Carver, J. G., Manek, S., Gullick, W. J., Barlow, D. H., & Mardon, H. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0476 · Cited by 93 · see citing works
Novakovic, B., Rakyan, V. K., Ng, H., Manuelpillai, U., Dewi, C., Wong, N. C., Morley, R., Down, T. A., Beck, S., Craig, J. M., et al. (2008) · Molecular Human Reproduction · doi:10.1093/molehr/gan046 · Cited by 93 · see citing works
Leukaemia inhibitory factor expression in human follicular fluid and ovarian cells
Arici, A. M., Oral, E., Bahtiyar, M. O., Engin, O., Seli, E. U., & Jones, E. E. (1997) · Human Reproduction · doi:10.1093/humrep/12.6.1233 · Cited by 91 · see citing works
Mohamed, O. A., Dufort, D., & Clarke, H. J. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.025692 · Cited by 87 · see citing works
Kimber, S. J., Sneddon, S., Bloor, D., El-Bareg, A. M., Hawkhead, J. A., Metcalfe, A. D., Houghton, F. D., Leese, H. J., Rutherford, A. J., Lieberman, B. A., et al. (2008) · Reproduction · doi:10.1530/rep-07-0359 · Cited by 85 · see citing works
Danielsson, K. G., Swahn, M. L., & Bygdeman, M. (1997) · Human Reproduction · doi:10.1093/humrep/12.6.1293 · Cited by 83 · see citing works
Haimovici, F., & Anderson, D. J. (1993) · Biology of Reproduction · doi:10.1095/biolreprod49.1.124 · Cited by 79 · see citing works
Diverse functions of HBEGF during pregnancy
Jessmon, P., Leach, R. E., & Armant, D. R. (2009) · Molecular Reproduction and Development · doi:10.1002/mrd.21066 · Cited by 76 · see citing works
Expression of Trophinin, Tastin, and Bystin by Trophoblast and Endometrial Cells in Human Placenta1
Suzuki, N., Nakayama, J., Shih, I., Aoki, D., Nozawa, S., & Fukuda, M. N. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.3.621 · Cited by 74 · see citing works
Liu, Z., & Armant, D. R. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.02.006 · Cited by 73 · see citing works
Dong, J., & Wiley, H. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.557 · Cited by 72 · see citing works
Wong, N. C., Novakovic, B., Weinrich, B., Dewi, C., Andronikos, R. H., Sibson, M., Macrae, F., Morley, R., Pertile, M. D., Craig, J. M., et al. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.033 · Cited by 71 · see citing works
Armant, D. R., Kilburn, B. A., Petkova, A. P., Edwin, S. S., Duniec‐Dmuchowski, Z., Edwards, H. J., Romero, R. J., & Leach, R. E. (2006) · Development · doi:10.1242/dev.02237 · Cited by 69 · see citing works
HOFMANN, G. E., Drews, M. R., Scott, R. T., Navot, D., Heller, D. S., & Deligdisch, L. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.5.1569175 · Cited by 63 · see citing works
Neu Differentiation Factors: A Family of Alternatively Spliced Neuronal and Mesenchymal Factors
Ben-Baruch, N. E., & Yarden, Y. (1994) · Experimental Biology and Medicine · doi:10.3181/00379727-206-43746 · Cited by 61 · see citing works
Serafini, P. C., da Silva, I. D. C. G., Smith, G. D., Motta, E. L. A., da Rocha, A. M., & Baracat, E. C. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-30 · Cited by 57 · see citing works
Wu, M., Yin, Y., Zhao, M., Hu, L., & Chen, Q. (2013) · Cytokine · doi:10.1016/j.cyto.2013.03.002 · Cited by 57 · see citing works
Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation
Sugihara, K., Sugiyama, D., Byrne, J., Wolf, D. P., Lowitz, K., Kobayashi, Y., Kabir‐Salmani, M., Nadano, D., Aoki, D., Nozawa, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611516104 · Cited by 57 · see citing works
Keltz, M. D., Attar, E., Buradagunta, S., Olive, D. L., Kliman, H. J., & Arici, A. M. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70114-x · Cited by 55 · see citing works
Rout, U. K., Wang, J., Paria, B. C., & Armant, D. R. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.12.010 · Cited by 55 · see citing works
Zhang, Z., Li, H., Zhang, L., Jia, L., & Wang, P. (2013) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-11-17 · Cited by 47 · see citing works
Chobotova, K., Muchmore, M.-E. A., Carver, J. G., Yoo, H. J., Manek, S., Gullick, W. J., Barlow, D. H., & Mardon, H. J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020069 · Cited by 47 · see citing works
Wei, Q., Levens, E. D., Stefansson, L., & Nieman, L. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0637 · Cited by 46 · see citing works
Wang, J., Mayernik, L., & Armant, D. R. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.09.015 · Cited by 44 · see citing works
Leach, R. E., Jessmon, P., Coutifaris, C., Kruger, M. L., Myers, E. R., Ali‐Fehmi, R., Carson, S. A., Legro, R. S., Schlaff, W. D., Carr, B. R., et al. (2012) · Human Reproduction · doi:10.1093/humrep/der436 · Cited by 43 · see citing works
Assisted reproductive technology surveillance -- United States, 2010.
Sunderam, S., Kissin, D. M., Crawford, S. B., Anderson, J. E., Folger, S. G., Jamieson, D. J., & Barfield, W. D. (2013) · PubMed · Cited by 42 · see citing works
Peng, S., Miao, C., Li, J., Fan, X., Cao, Y., & Duan, E. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.087 · Cited by 40 · see citing works
The use of recombinant growth factors to promote human embryo development in serum-free medium
Sargent, I. L., Martin, K. L., & Barlow, D. H. (1998) · Human Reproduction · doi:10.1093/humrep/13.suppl_4.239 · Cited by 39 · see citing works
Wang, X., Wang, H., Matsumoto, H., Roy, S. K., Das, S. K., & Paria, B. C. (2002) · Development · doi:10.1242/dev.129.17.4125 · Cited by 39 · see citing works
Shalhoub, V., Aslam, F., Breen, E. C., van Wijnen, A. J., Bortell, R., Stein, G. S., Stein, J. L., & Lian, J. B. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19980501)69:2 · Cited by 36 · see citing works
Increased Dickkopf-1 expression in patients with unexplained recurrent spontaneous miscarriage
Bao, S., Shuai, W., Tong, J., Wang, L., Chen, P., & Duan, T. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12066 · Cited by 35 · see citing works
Brown, N., Deb, K. D., Paria, B. C., Das, S., & Reese, J. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.031864 · Cited by 35 · see citing works
Stachecki, J. J., & Armant, D. R. (1996) · Biology of Reproduction · doi:10.1095/biolreprod55.6.1292 · Cited by 35 · see citing works
Tamura, N., Sugihara, K., Akama, T. O., & Fukuda, M. N. (2011) · Cell Cycle · doi:10.4161/cc.10.1.14448 · Cited by 29 · see citing works
Imudia, A. N., Kilburn, B. A., Petkova, A. P., Edwin, S. S., Romero, R. J., & Armant, D. R. (2008) · Placenta · doi:10.1016/j.placenta.2008.06.013 · Cited by 29 · see citing works
Li, M., & Jin, L. (2013) · Europe PMC (PubMed Central) · Cited by 24 · see citing works
Expression of neu Differentiation Factor during the Periimplantation Period in the Mouse Uterus1
Reese, J., Brown, N., Das, S. K., & Dey, S. K. (1998) · Biology of Reproduction · doi:10.1095/biolreprod58.3.719 · Cited by 23 · see citing works
Machida, T., Taga, M., & MINAGUCHI, H. (1995) · European Journal of Endocrinology · doi:10.1530/eje.0.1330741 · Cited by 22 · see citing works
Aghajanova, L., Bjuresten, K., Altmäe, S., Landgren, B.-M., & Stavreus-Evers, A. C. (2008) · Reproductive Sciences · doi:10.1177/1933719108314624 · Cited by 21 · see citing works
Evidence for the involvement of transforming growth factor-α in implantation in the rat
Tamada, H., Sakamoto, M., Sakaguchi, H., Inaba, T., & Sawada, T. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00103-3 · Cited by 17 · see citing works
Endometrial Indian hedgehog expression is decreased in women with endometriosis
Smith, K., Alnifaidy, R., Wei, Q., & Nieman, L. K. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.018 · Cited by 16 · see citing works
Tanimura, K., Nakago, S., Murakoshi, H., Takekida, S., Moriyama, T., Matsuo, H., Hashimoto, K., & Maruo, T. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510093 · Cited by 12 · see citing works
Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis
Ishikawa, T., Tamai, Y., Am, Z., Yoshida, H., Seldin, M., Nishikawa, S., & Taketo, M. (2001) · HighWire Press Open Archive · Cited by 12 · see citing works
Lee, D., Ueta, Y. Y., & Suzuki, H. (2006) · Journal of Reproduction and Development · doi:10.1262/jrd.18034 · Cited by 10 · see citing works
LIU, Z. (2004) · Experimental Cell Research · doi:10.1016/s0014-4827(04)00078-3 · Cited by 2 · see citing works
Endometrial Indian hedgehog expression is decreased in women with endometriosis
Smith, K. M., Alnifaidy, R., Wei, Q., & Neiman, L. K. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.07.775 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 143 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- BROSENS IA, ROBERTSON WB and DIXON HG. (1972). The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu 1: 177– 191. 4669123
- DETHLEFSEN SM, RAAB G, MOSES MA, ADAM RM, KLAGSBRUN M and FREEMAN MR. (1998). Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C. J Cell Biochem 69: 143– 153. 9548562
- RIESE DJ and STERN DF. (1998). Specificity within the EGF family/ErbB receptor family signaling network. Bioessays 20: 41– 48. 9504046
- YOO HJ, BARLOW DH and MARDON HJ. (1997). Temporal and spatial regulation of expression of heparin-binding epidermal growth factor-like growth factor in the human endometrium: a possible role in blastocyst implantation. Dev Genet 21: 102– 108. 9291586
Cited by
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Sharma, S., Godbole, G., & Modi, D. N. (2016) · American Journal of Reproductive Immunology · doi:10.1111/aji.12466 · Cited by 277 · see citing works
Epithelial-mesenchymal transition during extravillous trophoblast differentiation
Davies, J. E., Pollheimer, J., Yong, H. E. J., Kokkinos, M. I., Kalionis, B., Knöfler, M., & Murthi, P. (2016) · Cell Adhesion & Migration · doi:10.1080/19336918.2016.1170258 · Cited by 271 · see citing works
Embryos, DOHaD and David Barker
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Ojosnegros, S., Seriola, A., Godeau, A. L., & Veiga, A. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa054 · Cited by 107 · see citing works
The placenta as a model for understanding the origin and evolution of vertebrate organs
Griffith, O. W., & Wagner, G. P. (2017) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0072 · Cited by 91 · see citing works
Matsumoto, H. (2017) · Journal of Reproduction and Development · doi:10.1262/jrd.2017-047 · Cited by 68 · see citing works
Liu, X., Shi, W., & Shi, J. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.11.023 · Cited by 64 · see citing works
Fritz, R., Jindal, S., Feil, H., & Büyük, E. (2017) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-017-1016-1 · Cited by 58 · see citing works
Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer
Cong, G., Zhu, X., Chen, X., Chen, H., & Chong, W. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02327-w · Cited by 55 · see citing works
Bielfeld, A. P., Pour, S. J., Poschmann, G., Stühler, K., Krüssel, J.-S., & Baston-Büst, D. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020425 · Cited by 54 · see citing works
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Wang, C., Tsai, H., Syu, J., Chen, T., & Su, M. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25649 · Cited by 52 · see citing works
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Böddeker, S., & Hess, A. P. (2015) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2015.02.002 · Cited by 52 · see citing works
Zhang, Y.-M., Zhang, Y.-Y., Ahmmed, B., Shan, X., Wang, X.-Q., & Yan, Q. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.04.011 · Cited by 45 · see citing works
Berkhout, R. P., Keijser, R., Repping, S., Lambalk, C. B., Afink, G., Mastenbroek, S., & Hamer, G. (2020) · Human Reproduction · doi:10.1093/humrep/deaa149 · Cited by 43 · see citing works
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MacDougall, M. S., Clarke, R., & Merrill, B. J. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.04.015 · Cited by 39 · see citing works
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Yu, M., Cui, X., Wang, H., Liu, J., Qin, H., Liu, S., & Yan, Q. (2018) · Placenta · doi:10.1016/j.placenta.2018.11.005 · Cited by 38 · see citing works
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Chatterjee, S., & Sil, P. C. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.889719 · Cited by 37 · see citing works
Gusella, A., Martignoni, G., & Giacometti, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147886 · Cited by 41 · see citing works
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Leese, H. J. (2015) · Reproduction Fertility and Development · doi:10.1071/rd14278 · Cited by 38 · see citing works
Chen, S., Mukherjee, N., Janjanam, V. D., Arshad, S. H., Kurukulaaratchy, R. J., Holloway, J. W., Zhang, H., & Karmaus, W. (2017) · Genetics & Epigenetics · doi:10.1177/1179237x17721540 · Cited by 35 · see citing works
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Dimova, T., Alexandrova, M., Vangelov, I., You, Y., & Mor, G. (2024) · Human Reproduction Update · doi:10.1093/humupd/dmae033 · Cited by 36 · see citing works
Sánchez, J. M., Passaro, C., Forde, N., Browne, J. A., Behura, S. K., Fernández-Fuertes, B., Mathew, D. J., Kelly, A. K., Butler, S. T., Spencer, T. E., et al. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy185 · Cited by 30 · see citing works
Ogoyama, M., Ohkuchi, A., Takahashi, H., Zhao, D., Matsubara, S., & Takizawa, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031237 · Cited by 29 · see citing works
MSX2 Induces Trophoblast Invasion in Human Placenta
Liang, H., Zhang, Q., Lu, J., Yang, G., Tian, N., Wang, X., Tan, Y., & Tan, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153656 · Cited by 28 · see citing works
Progesterone regulates inflammation and receptivity of cells via the NF-κB and LIF/STAT3 pathways
Feng, R., Qin, X., Li, Q., Adeniran, S. O., Huang, F., Li, Y., Zhao, Q., & Zheng, P. (2022) · Theriogenology · doi:10.1016/j.theriogenology.2022.04.005 · Cited by 28 · see citing works
Soszyńska, A., Klimczewska, K., & Suwińska, A. (2019) · The International Journal of Developmental Biology · doi:10.1387/ijdb.180408as · Cited by 26 · see citing works
Cui, X., Wang, H., Li, Y., Chen, T., Liu, S., & Yan, Q. (2019) · Cell Proliferation · doi:10.1111/cpr.12745 · Cited by 23 · see citing works
Zhou, R.-Y., Zhang, X., Huang, L., Zhu, X., Dong, M., Liu, W., Wang, S., & Liu, F. (2021) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.16777 · Cited by 23 · see citing works
Jain, C. V., Jessmon, P., Barrak, C. T., Bolnick, A. D., Kilburn, B. A., Hertz, M., & Armant, D. R. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.104 · Cited by 23 · see citing works
Tríbulo, P., Rabaglino, M. B., Bo, M. B., Carvalheira, L. D. R., Bishop, J. V., Hansen, T. R., & Hansen, P. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-48374-z · Cited by 22 · see citing works
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Poh, Q. H., Rai, A., Salamonsen, L. A., & Greening, D. W. (2023) · PROTEOMICS · doi:10.1002/pmic.202200107 · Cited by 22 · see citing works
Vagnini, L. D., Nascimento, A. M., Canas, M. D. C. T., Renzi, A., Oliveira‐Pelegrin, G. R., Petersen, C. G., Mauri, A. L., Oliveira, J. B. A., Baruffi, R. L. R., Cavagna, M., et al. (2015) · Medical Principles and Practice · doi:10.1159/000437370 · Cited by 21 · see citing works
Takeuchi, M., Seki, M., Furukawa, E., Takahashi, A., Saito, K., Kobayashi, M., Ezoe, K., Fukui, E., Yoshizawa, M., & Matsumoto, H. (2017) · Molecular Human Reproduction · doi:10.1093/molehr/gax035 · Cited by 21 · see citing works
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Baston-Büst, D. M., Altergot-Ahmad, O., Pour, S. J., Krüssel, J.-S., Markert, U. R., Fehm, T. N., & Bielfeld, A. P. (2017) · Mediators of Inflammation · doi:10.1155/2017/8379256 · Cited by 21 · see citing works
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Gui, J., Xu, W., Yang, J., Feng, L., & Jia, J. (2018) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.13854 · Cited by 16 · see citing works
Godeau, A. L., Seriola, A., Tchaicheeyan, O., Casals, M., Denkova, D., Aroca, E., Massafret, O., Parra, A., Demestre, M., Ferrer‐Vaquer, A., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr5199 · Cited by 13 · see citing works
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Gao, D.-D., Li, L., Zhang, Y., Wang, X.-X., Song, J., & Sun, Z. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.691428 · Cited by 14 · see citing works
Muhandiram, S., Dissanayake, K., Orro, T., Godakumara, K., Kodithuwakku, S. P., & Fazeli, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511924 · Cited by 14 · see citing works
Impaired female fertility in tubulointerstitial antigen-like 1-deficient mice
Takahashi, A., Ajalli, R., TAKEUCHI, M., Fukui, E., Yoshizawa, M., Mukai, K., Suematsu, M., Hasuwa, H., Okabe, M., & Matsumoto, H. (2015) · Journal of Reproduction and Development · doi:10.1262/jrd.2015-109 · Cited by 14 · see citing works
Cytokines hold promise for human embryo culture in vitro: results of a randomized clinical trial
Fawzy, M. M., Emad, M., Elsuity, M. A., Mahran, A. M., Abdel-Rahman, M., Fetih, A. N., Abdelghafar, H., Sabry, M., Nour, M., & Rasheed, S. M. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.07.012 · Cited by 14 · see citing works
Suzuki, D., Okura, K., Nagakura, S., & Ogawa, H. (2022) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12446 · Cited by 14 · see citing works
WINGLESS (WNT) signaling is a progesterone target for rat uterine stromal cell proliferation
Rider, V., Talbott, A., Bhusri, A., Krumsick, Z., Foster, S., Wormington, J., & Kimler, B. F. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0523 · Cited by 13 · see citing works
Oliveira, J. B. A., Vagnini, L. D., Petersen, C. G., Renzi, A., Oliveira‐Pelegrin, G. R., Mauri, A. L., Ricci, J., Massaro, F. C., Dieamant, F., Cavagna, M., et al. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.09.018 · Cited by 12 · see citing works
Stamenov, G., Parvanov, D. A., & Chaushev, T. A. (2018) · Case Reports in Obstetrics and Gynecology · doi:10.1155/2018/1687583 · Cited by 12 · see citing works
Meza-Herrera, C. A., Santamaría-Estrada, C. E., Flores-Hernández, A., Cano-Villegas, O., la Peña, C. G.-D., Macías‐Cruz, U., Calderón-Leyva, G., Ángel-García, Ó., Mellado, M., Carrillo-Moreno, D. I., et al. (2019) · Livestock Science · doi:10.1016/j.livsci.2019.09.002 · Cited by 10 · see citing works
Li, Q., Chen, Y., Adeniran, S. O., Qiu, Z., Zhao, Q., & Zheng, P. (2023) · Theriogenology · doi:10.1016/j.theriogenology.2023.07.013 · Cited by 9 · see citing works
Biase, F. H., Moorey, S. E., Schnuelle, J. G., Rodning, S. P. P., Ortega, M. S., & Spencer, T. E. (2023) · PNAS Nexus · doi:10.1093/pnasnexus/pgad284 · Cited by 9 · see citing works
MIF is among the proinflammatory cytokines increased by LPS in the human trophoblast line
Krivokuća, M. J., Stefanoska, I., Rabi, A., Vilotić, A., Petronijevic, M. A., Vrzić-Petronijević, S., Radojčić, L., & Vićovac, L. (2016) · Archives of Biological Sciences · doi:10.2298/abs151123012j · Cited by 8 · see citing works
PAR 1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors
Grisaru‐Granovsky, S., Nag, J. K., Zakar, L., Rudina, T., Gupta, C. L., Maoz, M., Kozlova, D., & Bar‐Shavit, R. (2020) · The FASEB Journal · doi:10.1096/fj.202000306r · Cited by 6 · see citing works
From Germ Cells to Implantation: The Role of Extracellular Vesicles
Fazzio, A., Caponnetto, A., Ferrara, C., Purrello, M., Pietro, C. D., & Battaglia, R. (2024) · Journal of Developmental Biology · doi:10.3390/jdb12030022 · Cited by 5 · see citing works
Morales-Hernández, F. V., Bautista-Bautista, G., Acuña‐González, R. J., Vázquez-Cárdenas, P., López‐Canales, J. S., Lozano‐Cuenca, J., Osorio‐Caballero, M., & Flores‐Herrera, H. (2022) · Acta Biochimica Polonica · doi:10.18388/abp.2020_6406 · Cited by 5 · see citing works
Meza-Herrera, C. A., Machado-Ramos, M. G., Santiago-Miramontes, A. D., Mellado, M., Navarrete-Molina, C., Sariñana-Navarrete, M. D. L. Á., Arévalo, J. R., Ángel-García, Ó., Alvarado-Espino, A. S., & Rodríguez-Venegas, R. (2023) · Agriculture · doi:10.3390/agriculture13112079 · Cited by 4 · see citing works
Penugurti, V., Dey, O., Kalali, S., Kashyap, D., Khumukcham, S. S., Kizhuvedath, A., Satpathy, S., Kiran, M., Row, A. T., Surapaneni, T., et al. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111633 · Cited by 4 · see citing works
Kuwabara, Y., Shiraishi, T., Kato, R., Matsuda, S., Sakata, A., Kubota, Y., Yokote, R., Nakao, K., Yonezawa, M., Ichikawa, T., et al. (2025) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12668 · Cited by 4 · see citing works
Progesterone signaling during pregnancy in the lab opossum, Monodelphis domestica
Yoshida, K., Line, J. E. K., Griffith, K., Wooldredge, A., & Cruz, Y. P. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.06.026 · Cited by 4 · see citing works
lncRNA CLRN1-AS1 reduces adhesion ability of human trophoblasts via CXCL10/CXCL11
Zhang, Y., Chen, Y., Zhang, L., Wu, Y., Feng, Y., & Ma, F. (2023) · Placenta · doi:10.1016/j.placenta.2023.07.003 · Cited by 4 · see citing works
Hirbo, J. B., Eidem, H. R., Rokas, A., & Abbot, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144155 · Cited by 4 · see citing works
Sakurai, J., Oka, S., Higuchi, Y., Ohsawa, S., & Fujimori, T. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1421222 · Cited by 3 · see citing works
[A second trimester ovarian ectopic pregnancy: A case report].
Ávila-Vergara, M. A., Ayón, A. R. P., Guzmán-Gutiérrez, L. E., Valenzuela-Verduzco, J. E., Caballero-Rodríguez, C. B., & Vadillo‐Ortega, F. (2015) · PubMed · Cited by 3 · see citing works
Downing, P., Howe, M., Sacco, M., Santos, L. L., Menkhorst, E. M., Teh, W. T., Lucky, T. T. A., Zhou, W., & Dimitriadis, E. (2024) · Molecular Human Reproduction · doi:10.1093/molehr/gaae039 · Cited by 2 · see citing works
Liu, C., Fukui, E., & Matsumoto, H. (2025) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12633 · Cited by 2 · see citing works
Pyneandee, E. M., Bakos, H. W., Iuliis, G. N. D., & Aitken, R. J. (2026) · Antioxidants · doi:10.3390/antiox15060674 · Cited by 2 · see citing works
Nakazato, M., Matsuzaki, M., Okai, D., Takeuchi, E., Seki, M., Takeuchi, M., Fukui, E., & Matsumoto, H. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae114 · Cited by 2 · see citing works
Ughade, P. A., & Shrivastava, D. (2024) · Cureus · doi:10.7759/cureus.54782 · Cited by 2 · see citing works
Duan, H., Zhang, J., Jiang, Z., Jia, J., Li, J., & Du, J. (2025) · The FASEB Journal · doi:10.1096/fj.202501656r · Cited by 1 · see citing works
Shumovskaya, V. V., Putilova, N. V., Tretyakova, T. B., & Pestryaeva, L. A. (2019) · Russian Bulletin of Obstetrician-Gynecologist · doi:10.17116/rosakush20191901160 · Cited by 1 · see citing works
In-vitro investigation of calcitonin associated effects on the trophoblastic cells
Ozdemir, B., Özkan, S., Güzel, E., & Koyutürk, M. (2020) · Acta Histochemica · doi:10.1016/j.acthis.2020.151510 · Cited by 1 · see citing works
Fritz, R. (2015) · Human Biology · Cited by 1 · see citing works
Jain, C. V. (2016) · Human Biology · Cited by 1 · see citing works
Olvera-Valencia, M., Acuña‐González, R. J., Iyune‐Cojab, E., Vázquez-Cárdenas, P., López‐Canales, J. S., Lozano-Cuenca, J., Osorio‐Caballero, M., & Flores‐Herrera, H. (2021) · Research Square · doi:10.21203/rs.3.rs-435065/v1 · Cited by 1 · see citing works
Nardi, E., & Arena, V. (2026) · Diagnostics · doi:10.3390/diagnostics16081128
105.心拍数・主観的運動強度(RPE)・万歩計からみた大学正課体育授業の運動の「量」と「質」についての検討 :運動生理学的研究II : 第34回日本体力医学会大会
鬼頭, 伸., 長沢, 弘., 天野, 義., 竹本, 洋., 米田, 吉., 吉田, 正., 合屋, 十., 星川, 保., 豊島, 進., & 島岡, 清. (1979) · 体力科學
Bulmer, J. N. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726282584.793561745
"In Vitro 3d Model of Female Reproductive Tract: An Overview and Future Aspect"
Capuzzo, A. M. (2022) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2022.46.007417
"Lynch Syndrome: Current Status of Crc in Biotechnological and Biomedical Fields"
Capuzzo, A. M. (2022) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2022.46.007418
Endometrial receptivity: The journey so far
Osazee, K., & Omorogiuw, A. (2019) · Ibom Medical Journal · doi:10.61386/imj.v12i1.214
Dönmez, H. G., & Beksaç, M. S. (2025) · Gazi Üniversitesi Fen Fakültesi Dergisi · doi:10.63716/guffd.1617231
Vahdani, S., Mashayekhi, F., Bahadori, M. H., & Salehi, Z. (2025) · Middle East Fertility Society Journal · doi:10.1186/s43043-025-00252-7
Aggarwal, K., Khurana, S., Sharma, U., Choudhury, J., Dhole, B., Jala, M. A., Sharma, A., Chaturvedi, P. K., & Gupta, S. (2025) · Placenta · doi:10.1016/j.placenta.2025.11.015
Risk Factors of Subchorionic Hematoma Under Assisted Reproductive Technology
Yi, X., Zhaxicuo, & Tian, D. (2025) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.70142
Tu, J., Wangchen, M., Liu, J., Zhou, J., & Gong, F. (2026) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-026-08929-1
Asano, H., Nakazato, M., Fukui, E., & Matsumoto, H. (2026) · F&S Science · doi:10.1016/j.xfss.2026.07.002
- Authors
- Fritz, R., Jain, C., & Armant, D. R.
- Affiliations
- Wayne State University (US)
- United States Department of Health and Human Services (US)
- Corresponding author
- Armant, D. Randall
- Venue
- The International Journal of Developmental Biology
- Publisher
- EHU Press
- Published
- 2014
- Volume
- 58
- Issue
- 2-3-4
- Pages
- 261-271
- ISSN
- 0214-6282 (ISSN-L)
- PMC
- PMC10411524
- OpenAlex
- W2008135772
- Cited by
- 86
- References
- 143
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 11 · 2018: 4 · 2017: 7 · 2016: 8 · 2015: 11
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- W.K. Kellogg Foundation
- National Institutes of Health (HD071408)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD071408, R21HD071408)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- embryo implantation, endometrial receptivity, leukemia inhibitory factor, EGF signaling, Indian hedgehog signaling, Wnt signaling, trophoblast invasion, trophoblast adhesion, placental development, implantation failure, miscarriage
- MeSH terms
- Animals, Cell Communication, Female, Humans, Trophoblasts, Uterus, Signal Transduction
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