Cited by 86Reproductive System and PregnancyPregnancy and preeclampsia studiesReproductive Biology and Fertility

Cell signaling in trophoblast-uterine communication

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Fritz, Rani, Jain, Chandni, Armant, D. Randall·2014·The International Journal of Developmental Biology

Abstract

Intricate and precise communication between the blastocyst and the uterus orchestrates embryo implantation. However, many questions remain unanswered regarding the molecular complexities of implantation. On-time implantation requires a receptive uterus and a mature blastocyst with trophoblast cells capable of adhering to and invading the endometrium. Defects in uterine receptivity or embryo/uterine signaling can cause implantation failure or early pregnancy loss, whereas deficient trophoblast differentiation can generate placental abnormalities that produce adverse pregnancy outcomes. This review will discuss several examples of signaling pathways that regulate trophoblast and uterine development during this period. Leukemia inhibitory factor is involved in uterine priming for implantation. The epidermal growth factor signaling system contributes to trophoblast-uterine communication, as well as trophoblast adhesion and invasion. Indian hedgehog signaling synchronizes tissue compartments within the uterus, and WNT signaling mediates numerous interactions within the implantation site and developing placenta. The autocrine, paracrine and juxtacrine interactions mediated by these signaling pathways contribute significantly to the establishment of pregnancy, although there are many other known and yet to be discovered factors that synchronize the maternal and embryonic developmental programs.

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  1. BROSENS IA, ROBERTSON WB and DIXON HG. (1972). The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu 1: 177– 191. 4669123
  2. DETHLEFSEN SM, RAAB G, MOSES MA, ADAM RM, KLAGSBRUN M and FREEMAN MR. (1998). Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C. J Cell Biochem 69: 143– 153. 9548562
  3. RIESE DJ and STERN DF. (1998). Specificity within the EGF family/ErbB receptor family signaling network. Bioessays 20: 41– 48. 9504046
  4. YOO HJ, BARLOW DH and MARDON HJ. (1997). Temporal and spatial regulation of expression of heparin-binding epidermal growth factor-like growth factor in the human endometrium: a possible role in blastocyst implantation. Dev Genet 21: 102– 108. 9291586

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Authors
Fritz, R., Jain, C., & Armant, D. R.
Affiliations
  • Wayne State University (US)
  • United States Department of Health and Human Services (US)
Corresponding author
Armant, D. Randall
Venue
The International Journal of Developmental Biology
Publisher
EHU Press
Published
2014
Volume
58
Issue
2-3-4
Pages
261-271
ISSN
0214-6282 (ISSN-L)
OpenAlex
W2008135772
Cited by
86
References
143
Citations by year
2026: 4 · 2025: 11 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 11 · 2018: 4 · 2017: 7 · 2016: 8 · 2015: 11
FWCI
0.85
Type
journal article
Language
en
Open access
Locations
  • The International Journal of Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • W.K. Kellogg Foundation
  • National Institutes of Health (HD071408)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD071408, R21HD071408)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
embryo implantation, endometrial receptivity, leukemia inhibitory factor, EGF signaling, Indian hedgehog signaling, Wnt signaling, trophoblast invasion, trophoblast adhesion, placental development, implantation failure, miscarriage
MeSH terms
Animals, Cell Communication, Female, Humans, Trophoblasts, Uterus, Signal Transduction

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