The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
Abstract
Idiosyncratic drug-induced liver injury (DILI) is common in gastroenterology and hepatology practices, and it can have multiple presentations, ranging from asymptomatic elevations in liver biochemistries to hepatocellular or cholestatic jaundice, liver failure, or chronic hepatitis. Antimicrobials, herbal and dietary supplements, and anticancer therapeutics (e.g., tyrosine kinase inhibitors or immune-checkpoint inhibitors) are the most common classes of agents to cause DILI in the Western world. DILI is a diagnosis of exclusion, and thus, careful assessment for other etiologies of liver disease should be undertaken before establishing a diagnosis of DILI. Model for end-stage liver disease score and comorbidity burden are important determinants of mortality in patients presenting with suspected DILI. DILI carries a mortality rate up to 10% when hepatocellular jaundice is present. Patients with DILI who develop progressive jaundice with or without coagulopathy should be referred to a tertiary care center for specialized care, including consideration for potential liver transplantation. The role of systemic corticosteroids is controversial, but they may be administered when a liver injury event cannot be distinguished between autoimmune hepatitis or DILI or when a DILI event presents with prominent autoimmune hepatitis features.
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In the citing paper
“It is the most widely used and accepted DILI diagnostic tool.2, 3”
From A revised electronic version of RUCAM for the diagnosis of DILI (2022) · cites this paper as [2]
In the citing paper
“The lack of a reliable diagnostic biomarker and evidence-based treatment paradigm has resulted in limited guidance on how to manage this aspect of DILI.”
From Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report (2023) · cites this paper as [26]
In the citing paper
“The lack of reliable diagnostic biomarkers and an evidence-based treatment paradigm has resulted in limited guidance on how to manage this aspect of DILI.2,25–27”
From Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report (2023) · cites this paper as [26]
In the citing paper
“Data on corticosteroid use in DILI is scarce with no randomized controlled studies to evaluate their efficacy and safety; however, there are reports of corticosteroids having beneficial effects in patients with moderate or severe DILI.[18,23]”
From Drug-induced liver injury: Diagnosis, management and the role of liver transplantation (2025) · cites this paper as [18]
In the citing paper
“Data on corticosteroid use in DILI is scarce with no randomized controlled studies to evaluate their efficacy and safety; however, there are reports of corticosteroids having beneficial effects in patients with moderate or severe DILI.[18,23]”
From Drug-induced liver injury: Diagnosis, management and the role of liver transplantation (2025) · cites this paper as [18]
In the citing paper
“Although there are some ambiguities regarding how to score certain sections as well as suboptimal reliability, RUCAM can provide systematic and framed guidance for the assessment of patients with suspected DILI and is the most widely used tool [26,27,51,59].”
From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [27]
In the citing paper
“Although there are some ambiguities regarding how to score certain sections as well as suboptimal reliability, RUCAM can provide systematic and framed guidance for the assessment of patients with suspected DILI and is the most widely used tool [26,27,51,59].”
From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [27]
In the citing paper
“There is insufficient evidence suggesting that currently reported drug-and host-related risk factors can increase all-cause susceptibility to iDILI [1,27].”
From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [27]
In the citing paper
“The RUCAM score, combined with expert opinion, may be the best current practical causality assessment method for establishing a diagnosis of HDS-DILI or HILI [27,59].”
From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [27]
In the citing paper
“Therefore, the RUCAM score may show reduced reliability in the causality assessment of suspected HDS-DILI or HILI [27].”
From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [27]
Citations
Cites
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305 · cited 5×
“Summary and strength of recommendations statements that are not amenable to the GRADE process, either because of the structure of the statement or because of the available evidence.”
MethodInfluentialChalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · Hepatology · doi:10.1002/hep.25762 · Cited by 3,859
Self-citationBrahmer, J. R., Lacchetti, C., Schneider, B. J., Atkins, M. B., Brassil, K. J., Caterino, J. M., Chau, I., Ernstoff, M. S., Gardner, J. M., Ginex, P., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.77.6385 · Cited by 3,713
D'Amico, G., Garcia-Tsao, G., & Pagliaro, L. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2005.10.013 · Cited by 2,687
Primary liver cancer: Worldwide incidence and trends
Bosch, F. X., Ribes, J., Díaz, M., & Clèries, R. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.011 · Cited by 2,473
Acetaminophen‐induced acute liver failure
Larson, A. M., Polson, J., Fontana, R. J., Davern, T. J., Lalani, E., Hynan, L. S., REISCH, J. S., Schiødt, F. V., Ostapowicz, G., Shakil, A. O., et al. (2005) · Hepatology · doi:10.1002/hep.20948 · Cited by 1,934
Simplified criteria for the diagnosis of autoimmune hepatitis
Hennes, E. M., Zeniya, M., Czaja, A. J., Parés, A., Dalekos, G. N., Krawitt, E. L., Bittencourt, P. L., Porta, G., Boberg, K. M., Hofer, H., et al. (2008) · Hepatology · doi:10.1002/hep.22322 · Cited by 1,901
Danan, G., & Benichou, C. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90101-6 · Cited by 1,481
Saag, K. G., Teng, G. G., Patkar, N. M., Anuntiyo, J., Finney, C., Curtis, J. R., Paulus, H. E., Mudano, A. S., Pisu, M., Melton, M. E., et al. (2008) · Arthritis Care & Research · doi:10.1002/art.23721 · Cited by 1,465
EASL Clinical Practice Guidelines: Wilson’s disease
European Association for the Study of the Liver (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.11.007 · Cited by 1,239
Research works printed but not linked: 1
- Agarwal, 2010, Important elements for the diagnosis of drug-induced liver injury, Clin Gastroenterol Hepatol, 8, 463, 10.1016/j.cgh.2010.02.008 · DOI
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Zhang, J., Gao, B., Ye, B., Sun, Z., Qian, Z., Yu, L., Bi, Y., Ma, L., Ding, Y., Du, Y., et al. (2023) · Advanced Materials · doi:10.1002/adma.202208571 · Cited by 215
EASL Clinical Practice Guidelines on the management of autoimmune hepatitis
Dalekos, G., Gatselis, N., Drenth, J. P. H., Heneghan, M., Jørgensen, M., Lohse, A. W., Londoño, M., Muratori, L., Papp, M., Samyn, M., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.03.017 · Cited by 175
Andrade, R. J., Aithal, G. P., de Boer, Y. S., Liberal, R., Gerbes, A., Regev, A., Terziroli Beretta-Piccoli, B., Schramm, C., Kleiner, D. E., De Martin, E., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.04.033 · Cited by 166
Self-citationA revised electronic version of RUCAM for the diagnosis of DILI
Hayashi, P. H., Lucena, M. I., Fontana, R. J., Bjornsson, E. S., Aithal, G. P., Barnhart, H., Gonzalez‐Jimenez, A., Yang, Q., Gu, J., Andrade, R. J., et al. (2022) · Hepatology · doi:10.1002/hep.32327 · Cited by 160
Pharmacotherapies for Drug-Induced Liver Injury: A Current Literature Review
Li, M., Luo, Q., Tao, Y., Sun, X., & Liu, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.806249 · Cited by 116
Rani, J., Dhull, S. B., Rose, P. K., & Kidwai, M. K. (2024) · Phytomedicine · doi:10.1016/j.phymed.2023.155142 · Cited by 91
Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs
Zhou, Y., Wang, J., Zhang, D., Liu, J., Wu, Q., Chen, J., Tan, P., Xing, B., Han, Y., Zhang, P., et al. (2021) · Chinese Medicine · doi:10.1186/s13020-021-00543-x · Cited by 82
Cai, C., Ma, H., Peng, J., Shen, X., Zhen, X., Yu, C., Zhang, P., Ji, F., & Wang, J. (2023) · Nature Communications · doi:10.1038/s41467-023-39412-6 · Cited by 76
Björnsson, E. S., Stephens, C., Atallah, E., Robles‐Diaz, M., Alvarez‐Alvarez, I., Gerbes, A., Weber, S., Stirnimann, G., Kullak‐Ublick, G., Cortez‐Pinto, H., et al. (2023) · Liver International · doi:10.1111/liv.15378 · Cited by 69
Li, Q., Zhang, F., Wang, H., Tong, Y., Fu, Y., Wu, K., Li, J., Wang, C., Wang, Z., Jia, Y., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.91284 · Cited by 68
Challenges and Future of Drug-Induced Liver Injury Research—Laboratory Tests
Weber, S., & Gerbes, A. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116049 · Cited by 65
Mechanisms of drug induced liver injury
Skat‐Rørdam, J., Lykkesfeldt, J., Gluud, L. L., & Tveden‐Nyborg, P. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05744-3 · Cited by 64
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Vignali, J. D., Pak, K., Beverley, H. R., DeLuca, J. P., Downs, J. W., Kress, A. T., Sadowski, B. W., & Selig, D. J. (2023) · Journal of Xenobiotics · doi:10.3390/jox13020017 · Cited by 61
Zheng, Y., Zhang, X., Wang, Z., Zhang, R., Wei, H., Xu, Y., Jiang, X., & Yang, L. (2024) · Archiv der Pharmazie · doi:10.1002/ardp.202400459 · Cited by 61
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Zhang, M., Zhou, J., Jiang, X., Shi, T., Jin, X., Ren, Y., Ji, K., Xin, Z., Zhang, Z., Yin, C., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202417125 · Cited by 60
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Tan, C. K., Ho, D., Wang, L. M., & Kumar, R. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i24.2654 · Cited by 59
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Benić, M. S., Nežić, L., Vujić‐Aleksić, V., & Mititelu-Tarțău, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.785790 · Cited by 59
Robles‐Díaz, M., Nežić, L., Vujić‐Aleksić, V., & Bjornsson, E. S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.744488 · Cited by 56
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Yang, T., Wang, H., Wang, X., Li, J., & Jiang, L. (2022) · Biology · doi:10.3390/biology11071057 · Cited by 47
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Cione, E., Abrego-Guandique, D. M., Caroleo, M. C., Luciani, F., Colosimo, M., & Cannataro, R. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb45010006 · Cited by 42
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Mapping the incidence of drug‐induced liver injury: A systematic review and meta‐analysis
Li, M., Wang, Y., Lv, T., Liu, J. M., Kong, Y., Jia, J. D., & Zhao, X. (2023) · Journal of Digestive Diseases · doi:10.1111/1751-2980.13205 · Cited by 43
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Zhao, W., Luo, H., Lin, Z., Huang, L., Pan, Z., Chen, L., Fan, L., Yang, S., Tan, H., Zhong, C., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118364 · Cited by 34
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Rao, A., Rule, J. A., Hameed, B., Ganger, D. R., Fontana, R. J., & Lee, W. M. (2022) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001655 · Cited by 33
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Dara, L., & Martin, E. D. (2025) · Liver International · doi:10.1111/liv.16198 · Cited by 27
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Pinazo-Bandera, J. M., Toro-Ortiz, J. P., Andrade, R. J., & García‐Cortés, M. (2023) · Exploration of Digestive Diseases · doi:10.37349/edd.2023.00027 · Cited by 14
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Xu, R., Hao, Y., Liu, Y., Ji, B., Tian, W., & Zhang, W. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123395 · Cited by 14
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Vincenzi, B., Yimin, M., Andrade, R. J., Castillo, M. M., Akhundova‐Unadkat, G., & Mato, J. M. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1541020 · Cited by 14
Fontana, R. J., Engle, R. E., Hayashi, P. H., Gu, J., Kleiner, D. E., Nguyen, H. V., Barnhart, H. X., Hoofnagle, J. H., & Farci, P. (2022) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001869 · Cited by 14
Palmer, M., Kleiner, D. E., Goodman, Z. D., Brunt, E. M., Avigan, M., Regev, A., Hayashi, P. H., Lewis, J. H., Mehta, R., Harrison, S. A., et al. (2023) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17762 · Cited by 13
Self-citationRecent advances in the diagnosis of drug-induced liver injury
Ahmed, T., & Ahmad, J. (2024) · World Journal of Hepatology · doi:10.4254/wjh.v16.i2.186 · Cited by 13
Multi-Omics Integration to Reveal the Mechanism of Hepatotoxicity Induced by Dictamnine
Tu, C., Xu, Z., Tian, L., Yu, Z., Wang, T., Guo, Z., Zhang, J., & Wang, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.700120 · Cited by 13
Xu, J., Xiong, A., Wang, X., Yan, X., Chen, Y., Ye, X., Wang, Z., Ding, L., & Yang, L. (2023) · Archives of Pharmacal Research · doi:10.1007/s12272-023-01460-3 · Cited by 12
Protective effects and mechanism of Sangyu granule on acetaminophen-induced liver injury in mice
Xiao, K., Li, H., Li, Y., Zhan, B., Fang, X., Zhao, B., Zhang, X., Wu, Y., Wang, F., & Jia, Y. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118282 · Cited by 12
Jiang, A., Wei, C., Zhu, W., Wu, F., & Wu, B. (2024) · Therapeutic Advances in Drug Safety · doi:10.1177/20420986241244585 · Cited by 12
Yang, H., Han, J. W., Lee, J. J., Lee, A., Cho, S. W., Rho, P. R., Kang, M., Jang, J. W., Jung, E. S., Choi, J. Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1138112 · Cited by 12
Song, F., Liu, H., Sun, Y., Xu, T., Li, D., Wang, H., Xin, S., Wang, Y., Cheng, G. Y.-M., Lau, G. K. K., et al. (2023) · iLiver · doi:10.1016/j.iliver.2023.06.001 · Cited by 12
Danjuma, M. I.-M., Naseralallah, L. M. A., Ansari, S., Al-Shebly, R., Elhams, M., Shamari, M. A., Kordi, A., Fituri, N., & Al-Mohammed, A. A. (2023) · Medicine · doi:10.1097/md.0000000000032608 · Cited by 11
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Higher risk of hepatotoxicity associated with cabozantinib in cancer patients
Wang, Z., Jiang, L., Lv, X., Yin, H., Wang, Z., Li, W., & Liu, Y. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104298 · Cited by 11
The effects of alpha‐pinene against paracetamol‐induced liver damage in male rats
Rahimi, K., Rezaie, A., Allahverdi, Y., Shahriari, P., & Mirghaed, M. T. (2025) · Physiological Reports · doi:10.14814/phy2.70227 · Cited by 11
Dayhimi, A., Jazi, K., Bigdeli, Y., Farhoudi, F., Erfanimanesh, M., Esmaeili, M., Gorjipour, F., Ajami, M., & Pazoki–Toroudi, H. (2025) · Technology in Cancer Research & Treatment · doi:10.1177/15330338251365700 · Cited by 11
Tuteja, S., Yu, Z., Wilson, O. D., Chen, H., Wendt, F. R., Chung, C. P., Shah, S. C., Hunt, C. M., Suzuki, A., Chanfreau‐Coffinier, C., et al. (2022) · Clinical and Translational Science · doi:10.1111/cts.13313 · Cited by 11
Dai, W., Pang, X., Peng, W., Zhan, X., Chen, C., Zhao, W., Zeng, C., Quanxi, M., Chen, Q., Kuang, W., et al. (2023) · Molecules · doi:10.3390/molecules28052078 · Cited by 11
Pinazo-Bandera, J. M., Niu, H., Alvarez-Alvarez, I., Medina‐Cáliz, I., Campo‐Herrera, E. D., Ortega‐Alonso, A., Robles‐Díaz, M., Hernández, N. G. M., Paraná, R., Nunes, V., et al. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107183 · Cited by 12
Yang, P., Zhang, H., Li, J., Li, Z., Liu, Z., Wang, M., Zhao, F., Zhao, J., Shen, G., & Zhao, Y. D. (2024) · Therapeutic Advances in Drug Safety · doi:10.1177/20420986241304680 · Cited by 11
Barman, M., Hariri, B. A., Mustafa, A. R., Ambra, N., Amjed, I., Alharafsheh, A. E. N., Illahi, M. N., Hamuda, S., Gaafar, M., & Sharif, M. (2022) · Qatar medical journal · doi:10.5339/qmj.2022.27 · Cited by 11
Comparison of the prognostic models for mortality in idiosyncratic drug-induced liver injury
Wang, Y., Zou, C., Wee, A., Liu, J., Ma, Z., Guo, T., Li, M., Wang, Y., Liu, L., Jia, J., et al. (2023) · Hepatology International · doi:10.1007/s12072-022-10405-9 · Cited by 10
Drug-induced liver injury: diagnosis of exclusion
Maev, I. V., & Te, P. (2023) · Terapevticheskii arkhiv · doi:10.26442/00403660.2023.08.202329 · Cited by 10
Hepatotoxicity of Antibiotics and Antifungals and Their Safe Use in Hepatic Impairment
Ma, J., Bjornsson, E. S., & Chalasani, N. (2024) · Seminars in Liver Disease · doi:10.1055/s-0044-1787062 · Cited by 10
Self-citationVoriconazole-induced liver injury: incidence patterns and risk factors in a retrospective cohort
Lou, Y., Wang, Y., Liu, J., Wang, Y., Wang, J., Ma, S., Yang, Z., Li, J., & Qiu, Y. (2025) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00487-25 · Cited by 10
Liu, Y., Li, H., Huang, L., Wan, C., Wang, H., Jiao, X., Zeng, L., Jia, Z., Cheng, G., Zhang, L., et al. (2023) · BMC Pediatrics · doi:10.1186/s12887-023-04097-9 · Cited by 10
Yu, N., Wu, L., Yin, Q., Du, S., Liu, X., Wu, S., Tong, R., Yan, J., & Bian, Y. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1232334 · Cited by 10
Metadata
- Authors
- Chalasani, N. P., Maddur, H., Russo, M. W., Wong, R. J., Reddy, K. R., & on behalf of the Practice Parameters Committee of the American College of Gastroenterology
- Affiliations
- Indiana University Indianapolis (US)
- Northwestern University (US)
- Carolinas Medical Center (US)
- VA Palo Alto Health Care System (US)
- University of Pennsylvania (US)
- Corresponding author
- Chalasani, Naga P.
- Venue
- American Journal of Gastroenterology
- Published
- 2021-05
- Volume
- 116
- Issue
- 5
- Pages
- 878-898
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W4205136705
- Semantic Scholar
- 2c1e0585092198394e24121ea3fbf9704f76ae03
- Cited by
- 430
- References
- 165
- Citations by year
- 2026: 103 · 2025: 94 · 2024: 85 · 2023: 65 · 2022: 65 · 2021: 18
- FWCI
- 34.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- idiosyncratic drug-induced liver injury, drug-induced liver injury, diagnosis of exclusion, hepatocellular jaundice, cholestatic jaundice, liver failure, chronic hepatitis, antimicrobial agents, herbal and dietary supplements, tyrosine kinase inhibitors, immune checkpoint inhibitors, Model for End-Stage Liver Disease, comorbidity burden, mortality, liver transplantation, corticosteroids
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