Cited by 599Antioxidant Activity and Oxidative StressNitric Oxide and Endothelin EffectsRedox biology and oxidative stress

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Metabolic Syndrome, Aging and Involvement of Oxidative Stress

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Bonomini, Francesca, Rodella, Luigi Fabrizio, Rezzani, Rita·2015·Aging and Disease

DOI 10.14336/ad.2014.0305PMC PMC4365955

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Abstract

The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors associated with obesity and insulin resistance, is dramatically increasing in Western and developing countries. This disorder consists of a cluster of metabolic conditions, such as hypertriglyceridemia, hyper-low-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart diseases. One of the defects in metabolic syndrome and its associated diseases is excess of reactive oxygen species. Reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes. Such toxic reactions contribute significantly to the aging process. In this article we review current understandings of oxidative stress in metabolic syndrome related disease and its possible contribution to accelerated senescence.

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Authors: Bonomini, F., Rodella, L. F., & Rezzani, R.
Affiliations: University of Brescia (IT)
ORCID: Bonomini, Francesca
Rodella, Luigi Fabrizio
Rezzani, Rita
Venue: Aging and Disease
Publisher: Aging and Disease
Published: 2015
Volume: 6
Issue: 2
Pages: 109
ISSN: 2152-5250 (ISSN-L)
DOI: 10.14336/ad.2014.0305
PMC: PMC4365955
OpenAlex: W2019486401
Cited by: 599
References: 142
Citations by year: 2026: 19 · 2025: 46 · 2024: 36 · 2023: 61 · 2022: 61 · 2021: 66 · 2020: 55 · 2019: 52 · 2018: 55 · 2017: 61 · 2016: 57 · 2015: 29
FWCI: 7.06
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Aging and Disease (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: metabolic syndrome, oxidative stress, aging, reactive oxygen species, mitochondrial damage, insulin resistance, obesity, type 2 diabetes, atherosclerosis, vascular inflammation, hypertension, hypertriglyceridemia, accelerated senescence

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Metabolic Syndrome, Aging and Involvement of Oxidative Stress

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