The DOI matches its Crossref record; 141 of the 142 references it cites were found in a registry or an index.
Metabolic Syndrome, Aging and Involvement of Oxidative Stress
Open accessAbstract
The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors associated with obesity and insulin resistance, is dramatically increasing in Western and developing countries. This disorder consists of a cluster of metabolic conditions, such as hypertriglyceridemia, hyper-low-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart diseases. One of the defects in metabolic syndrome and its associated diseases is excess of reactive oxygen species. Reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes. Such toxic reactions contribute significantly to the aging process. In this article we review current understandings of oxidative stress in metabolic syndrome related disease and its possible contribution to accelerated senescence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In contrast, a high-fat diet has been shown to be associated with mitochondrial dysfunction, increased levels of oxidative stress and accelerated cellular senescence [43].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [43]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Harrison's Principles of Internal Medicine.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-499_2 · Cited by 12,528
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,676
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,317
Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883
Eckel, R. H., Grundy, S. M., & Zimmet, P. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66378-7 · Cited by 5,755
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448
Flagged first, then by citations
1 of the 142 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- Paradies G,uggiero FM,Quagliariello E (1992). Age-dependent changes in the activity of anion carriers and in the lipid composition in rat heart mitochondria. Ann NY Acad Sci, 26:160–164. · DOI
- Furukawa S,Fujita T,Shimabukuro M,Iwaki M,Yamada Y,Nakajima Yet al. (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest, 114:1752–1761. · DOI · Paper page
- Keaney JFJr.,Larson MG,Vasan RS,Wilson P W,LIpinska I,Corey Det al. (2003). Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol, 23: 434–439. · DOI · Paper page
- Couillard C,Ruel G,Archer WR,Pomerleau S,Bergeron J,Couture Pet al. (2005). Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity. J Clin Endocrinol Metab, 90:6454–9. · DOI
- Monnier L,Mas E,Ginet C,Michel F,Villon L,Cristol J-Pet al. (2006). Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA, 295:1681–1687. · DOI · Paper page
Cited by
Sorted by citations
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives
Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., et al. (2022) · Cells · doi:10.3390/cells11030552 · Cited by 915
Energy balance and obesity: what are the main drivers?
On behalf of the IARC working group on Energy Balance and Obesity, Romieu, I., Dossus, L., Barquera, S., Blottière, H. M., Franks, P. W., Gunter, M. J., Hwalla, N. C., Hursting, S. D., Leitzmann, M. F., et al. (2017) · Cancer Causes & Control · doi:10.1007/s10552-017-0869-z · Cited by 818
Oxidative stress injury in doxorubicin-induced cardiotoxicity
Mei, S., Hong, L., Xinyong, C., Bin, X., Ping, Z., & Shao, L. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.02.013 · Cited by 571
Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women
Ko, S., & Kim, H. (2020) · Nutrients · doi:10.3390/nu12010202 · Cited by 561
Metadata
- Authors
- Bonomini, F., Rodella, L. F., & Rezzani, R.
- Affiliations
- University of Brescia (IT)
- Venue
- Aging and Disease
- Publisher
- Aging and Disease
- Published
- 2015
- Volume
- 6
- Issue
- 2
- Pages
- 109
- ISSN
- 2152-5250 (ISSN-L)
- PMC
- PMC4365955
- OpenAlex
- W2019486401
- Cited by
- 599
- References
- 142
- Citations by year
- 2026: 19 · 2025: 46 · 2024: 36 · 2023: 61 · 2022: 61 · 2021: 66 · 2020: 55 · 2019: 52 · 2018: 55 · 2017: 61 · 2016: 57 · 2015: 29
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Aging and Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- metabolic syndrome, oxidative stress, aging, reactive oxygen species, mitochondrial damage, insulin resistance, obesity, type 2 diabetes, atherosclerosis, vascular inflammation, hypertension, hypertriglyceridemia, accelerated senescence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
