Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a
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alters the pro-angiogenic ability of exosomes by modulating the expression of exosomal miRNAs, especially miR-146a, thus providing new insights into the correlation between parental cell state and exosome content and function.
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Hydrogen peroxide-induced senescence also triggers inflammation, characterized by the upregulation of pro-inflammatory cytokines such as IL-6, TNF-α, and MCP-1.
“Hydrogen peroxide-induced senescence also triggers inflammation, characterized by the upregulation of pro-inflammatory cytokines such as IL-6, TNF-α, and MCP-1.282,283”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [282]
The Results (Characterization of c-exo and s-exo; page unavailable) show that H2O2 induced senescence in mesenchymal stem cells. The Discussion (page unavailable) identifies IL-6 and IL-8 as senescence-associated inflammatory mediators, but does not show that H2O2-induced senescence upregulated IL-6, TNF-α, or MCP-1. (LLM, conf=0.84)
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Yang, Y., Liu, S., He, C., Lv, T., Zeng, L., Zhang, F., Chen, H., & Zhao, R. C. (2022) · Figshare · doi:10.6084/m9.figshare.19634798
Self-citationBoulestreau, J., Maumus, M., Bertolino, G. M., Toupet, K., Jørgensen, C., & Noël, D. (2024) · Figshare · doi:10.6084/m9.figshare.25844441
Yang, Y., Liu, S., He, C., Lv, T., Zeng, L., Zhang, F., Chen, H., & Zhao, R. C. (2022) · Figshare · doi:10.6084/m9.figshare.19634813
Self-citationYang, Y., Liu, S., He, C., Lv, T., Zeng, L., Zhang, F., Chen, H., & Zhao, R. C. (2022) · Figshare · doi:10.6084/m9.figshare.19634807
Self-citationYang, Y., Liu, S., He, C., Lv, T., Zeng, L., Zhang, F., Chen, H., & Zhao, R. C. (2022) · Figshare · doi:10.6084/m9.figshare.19634810
Self-citationYang, Y., Liu, S., He, C., Lv, T., Zeng, L., Zhang, F., Chen, H., & Zhao, R. C. (2022) · Figshare · doi:10.6084/m9.figshare.19634804
Self-citationYang, Y., Liu, S., He, C., Lv, T., Zeng, L., Zhang, F., Chen, H., & Zhao, R. C. (2022) · Figshare · doi:10.6084/m9.figshare.19634801
Self-citationGottipamula, S., & Venkataramana, N. K. (2026) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj-d-26-00165
- Authors
- Xu, M., Su, X., Xiao, X., Yu, H., Li, X., Keating, A., Wang, S., & Zhao, R. C.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Qingdao University (CN)
- University of Toronto (CA)
- Corresponding author
- Wang, Shihua
- Venue
- Aging and disease
- Publisher
- Aging and Disease
- Published
- 2021
- Volume
- 12
- Issue
- 1
- Pages
- 102
- ISSN
- 2152-5250 (ISSN-L)
- PMC
- PMC7801275
- OpenAlex
- W3119986140
- Cited by
- 50
- References
- 51
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 18 · 2021: 5
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Aging and Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81902848, 2017-I2M-3-007)
- National Key Research and Development Program of China (2016YFA, 2017-I2M-3-007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- hydrogen peroxide, cellular senescence, mesenchymal stem cells, exosomes, wound healing, miR-146a, exosomal microRNAs, angiogenesis, oxidative stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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