Cited by 50Extracellular vesicles in diseaseWound Healing and TreatmentsMesenchymal stem cell research

Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a

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Xu, Meiqian, Su, Xiaodong, Xiao, Xian, Yu, Hongliang, Li, Xiaoxia, Keating, Armand, Wang, Shihua, Zhao, Robert Chunhua·2021·Aging and disease

Abstract

alters the pro-angiogenic ability of exosomes by modulating the expression of exosomal miRNAs, especially miR-146a, thus providing new insights into the correlation between parental cell state and exosome content and function.

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Crossref · 10.14336/ad.2020.0624

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  • Hydrogen peroxide-induced senescence also triggers inflammation, characterized by the upregulation of pro-inflammatory cytokines such as IL-6, TNF-α, and MCP-1.

    “Hydrogen peroxide-induced senescence also triggers inflammation, characterized by the upregulation of pro-inflammatory cytokines such as IL-6, TNF-α, and MCP-1.282,283”

    From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [282]

    The Results (Characterization of c-exo and s-exo; page unavailable) show that H2O2 induced senescence in mesenchymal stem cells. The Discussion (page unavailable) identifies IL-6 and IL-8 as senescence-associated inflammatory mediators, but does not show that H2O2-induced senescence upregulated IL-6, TNF-α, or MCP-1. (LLM, conf=0.84)

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Authors
Xu, M., Su, X., Xiao, X., Yu, H., Li, X., Keating, A., Wang, S., & Zhao, R. C.
Affiliations
  • Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
  • Qingdao University (CN)
  • University of Toronto (CA)
Corresponding author
Wang, Shihua
Venue
Aging and disease
Published
2021
Volume
12
Issue
1
Pages
102
ISSN
2152-5250 (ISSN-L)
OpenAlex
W3119986140
Cited by
50
References
51
Citations by year
2026: 3 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 18 · 2021: 5
FWCI
3.06
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Aging and Disease (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81902848, 2017-I2M-3-007)
  • National Key Research and Development Program of China (2016YFA, 2017-I2M-3-007)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
hydrogen peroxide, cellular senescence, mesenchymal stem cells, exosomes, wound healing, miR-146a, exosomal microRNAs, angiogenesis, oxidative stress

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